ES2554703T3 - Partículas recombinantes semejantes al virus de la influenza (VLP) producidas en plantas transgénicas que expresan hemaglutinina - Google Patents

Partículas recombinantes semejantes al virus de la influenza (VLP) producidas en plantas transgénicas que expresan hemaglutinina Download PDF

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Publication number
ES2554703T3
ES2554703T3 ES12183854.4T ES12183854T ES2554703T3 ES 2554703 T3 ES2554703 T3 ES 2554703T3 ES 12183854 T ES12183854 T ES 12183854T ES 2554703 T3 ES2554703 T3 ES 2554703T3
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Spain
Prior art keywords
vlp
particles
produced
influenza virus
transgenic plants
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ES12183854.4T
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English (en)
Inventor
Marc-André D'Aoust
Manon Couture
Frédéric ORS
Sonia Trépanier
Pierre-Olivier Lavoie
Michéle Dargis
Louis-Philippe Vézina
Nathalie Landry
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MED Inc
Medicago Inc
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MED Inc
Medicago Inc
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Priority claimed from CA002615372A external-priority patent/CA2615372A1/en
Application filed by MED Inc, Medicago Inc filed Critical MED Inc
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Publication of ES2554703T3 publication Critical patent/ES2554703T3/es
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
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    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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Abstract

Un ácido nucleico que comprende una secuencia de nucleótidos que codifica una hemaglutinina de influenza (HA) en donde la secuencia de nucleótidos comprende un elemento regulador que es operativo en un vegetal, el elemento regulador comprende una región reguladora del Virus del Mosaico del Caupí (CPMV).

Description

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Claims (1)

  1. imagen1
    imagen2
ES12183854.4T 2007-11-27 2009-01-12 Partículas recombinantes semejantes al virus de la influenza (VLP) producidas en plantas transgénicas que expresan hemaglutinina Active ES2554703T3 (es)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US99060307P 2007-11-27 2007-11-27
US1327207P 2007-12-12 2007-12-12
CA002615372A CA2615372A1 (en) 2007-07-13 2008-01-21 Influenza virus-like particles (vlps) comprising hemagglutinin
CA2615372 2008-01-21
US2277508P 2008-01-22 2008-01-22
US22775P 2008-01-22
PCT/CA2008/001281 WO2009009876A1 (en) 2007-07-13 2008-07-11 Influenza virus-like particles (vlps) comprising hemagglutinin produced within a plant
WOPCT/CA2008/001281 2008-07-11

Publications (1)

Publication Number Publication Date
ES2554703T3 true ES2554703T3 (es) 2015-12-22

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ES12183854.4T Active ES2554703T3 (es) 2007-11-27 2009-01-12 Partículas recombinantes semejantes al virus de la influenza (VLP) producidas en plantas transgénicas que expresan hemaglutinina

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US (4) US20100310604A1 (es)
EP (2) EP2610345B1 (es)
JP (4) JP2011509661A (es)
KR (1) KR20100120157A (es)
CN (2) CN103122354B (es)
AU (1) AU2009202819B2 (es)
CA (1) CA2707235C (es)
CR (1) CR11612A (es)
DK (1) DK2610345T3 (es)
ES (1) ES2554703T3 (es)
HK (1) HK1186207A1 (es)
IL (1) IL206967A (es)
IS (1) IS2982B (es)
MA (1) MA32439B1 (es)
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