ES2554703T3 - Partículas recombinantes semejantes al virus de la influenza (VLP) producidas en plantas transgénicas que expresan hemaglutinina - Google Patents
Partículas recombinantes semejantes al virus de la influenza (VLP) producidas en plantas transgénicas que expresan hemaglutinina Download PDFInfo
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- ES2554703T3 ES2554703T3 ES12183854.4T ES12183854T ES2554703T3 ES 2554703 T3 ES2554703 T3 ES 2554703T3 ES 12183854 T ES12183854 T ES 12183854T ES 2554703 T3 ES2554703 T3 ES 2554703T3
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- vlp
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- influenza virus
- transgenic plants
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
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- A61K39/12—Viral antigens
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- A61K39/145—Orthomyxoviridae, e.g. influenza virus
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- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
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- C12Y503/04—Intramolecular oxidoreductases (5.3) transposing S-S bonds (5.3.4)
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- G06F9/46—Multiprogramming arrangements
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- G06F9/5027—Allocation of resources, e.g. of the central processing unit [CPU] to service a request the resource being a machine, e.g. CPUs, Servers, Terminals
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
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- A—HUMAN NECESSITIES
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- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
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- A61K2039/55505—Inorganic adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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Abstract
Un ácido nucleico que comprende una secuencia de nucleótidos que codifica una hemaglutinina de influenza (HA) en donde la secuencia de nucleótidos comprende un elemento regulador que es operativo en un vegetal, el elemento regulador comprende una región reguladora del Virus del Mosaico del Caupí (CPMV).
Description
Claims (1)
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imagen1 imagen2
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99060307P | 2007-11-27 | 2007-11-27 | |
US1327207P | 2007-12-12 | 2007-12-12 | |
CA002615372A CA2615372A1 (en) | 2007-07-13 | 2008-01-21 | Influenza virus-like particles (vlps) comprising hemagglutinin |
CA2615372 | 2008-01-21 | ||
US2277508P | 2008-01-22 | 2008-01-22 | |
US22775P | 2008-01-22 | ||
PCT/CA2008/001281 WO2009009876A1 (en) | 2007-07-13 | 2008-07-11 | Influenza virus-like particles (vlps) comprising hemagglutinin produced within a plant |
WOPCT/CA2008/001281 | 2008-07-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2554703T3 true ES2554703T3 (es) | 2015-12-22 |
Family
ID=40795157
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES12183854.4T Active ES2554703T3 (es) | 2007-11-27 | 2009-01-12 | Partículas recombinantes semejantes al virus de la influenza (VLP) producidas en plantas transgénicas que expresan hemaglutinina |
Country Status (19)
Country | Link |
---|---|
US (4) | US20100310604A1 (es) |
EP (2) | EP2610345B1 (es) |
JP (4) | JP2011509661A (es) |
KR (1) | KR20100120157A (es) |
CN (2) | CN103122354B (es) |
AU (1) | AU2009202819B2 (es) |
CA (1) | CA2707235C (es) |
CR (1) | CR11612A (es) |
DK (1) | DK2610345T3 (es) |
ES (1) | ES2554703T3 (es) |
HK (1) | HK1186207A1 (es) |
IL (1) | IL206967A (es) |
IS (1) | IS2982B (es) |
MA (1) | MA32439B1 (es) |
MX (1) | MX2010007962A (es) |
NZ (1) | NZ587108A (es) |
PT (1) | PT2610345E (es) |
WO (1) | WO2009076778A1 (es) |
ZA (1) | ZA201005917B (es) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
NZ587108A (en) | 2007-11-27 | 2013-04-26 | Medicago Inc | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
CA2730171C (en) * | 2008-07-08 | 2016-10-11 | Medicago Inc. | Soluble recombinant influenza antigens |
ES2593277T3 (es) | 2008-07-18 | 2016-12-07 | Medicago Inc. | Nuevo epítopo de inmunización contra el virus de la influenza |
US8394384B2 (en) | 2008-11-28 | 2013-03-12 | Merial Limited | Recombinant avian influenza vaccine and uses thereof |
EP3009145A1 (en) | 2009-03-30 | 2016-04-20 | Mount Sinai School of Medicine of New York University | Influenza virus vaccines and uses thereof |
MY182643A (en) | 2009-06-24 | 2021-01-27 | Medicago Inc | Chimeric influenza virus-like particles comprising hemagglutinin |
ES2662778T3 (es) * | 2009-09-22 | 2018-04-09 | Medicago Inc. | Método de preparación de proteínas derivadas de plantas |
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