ES2531480T3 - Péptidos derivados de la proteína bplp humana, polinucleótidos que codifican dichos péptidos y anticuerpos dirigidos contra dichos péptidos - Google Patents
Péptidos derivados de la proteína bplp humana, polinucleótidos que codifican dichos péptidos y anticuerpos dirigidos contra dichos péptidos Download PDFInfo
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- ES2531480T3 ES2531480T3 ES05708768.6T ES05708768T ES2531480T3 ES 2531480 T3 ES2531480 T3 ES 2531480T3 ES 05708768 T ES05708768 T ES 05708768T ES 2531480 T3 ES2531480 T3 ES 2531480T3
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8103—Exopeptidase (E.C. 3.4.11-19) inhibitors
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
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- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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Abstract
Péptido que es un producto de maduración de la proteína lacrimal rica en prolina básica (BPLP) o un derivado peptídico de dicho producto de maduración, en el que: (i) el péptido o derivado peptídico presenta una propiedad moduladora, especialmente inhibidora, contra una metaloectopeptidasa; (ii) el péptido o derivado peptídico tiene, como máximo, aminoácidos de longitud; (iii) el péptido comprende la secuencia X1-X2-Arg-Phe-Ser-Arg, en la que: - X1 representa un átomo de H o un aminoácido Tyr o un aminoácido Cys, - X2 representa Gln o Glp cuando X1 es H, o X2 representa Gln cuando X1 es Tyr o Cys, en el que dicha secuencia X1-X2-Arg-Phe-Ser-Arg es la parte del extremo C de dicho péptido; y (iv) el derivado peptídico deriva de dicho péptido mediante una a dos sustituciones de aminoácidos.
Description
Claims (1)
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imagen1 imagen2 imagen3
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04290754 | 2004-03-19 | ||
EP04290754A EP1577320B1 (en) | 2004-03-19 | 2004-03-19 | Peptides derived from human BPLP protein, polynucleotides coding for said peptides and antibodies directed against said peptides |
PCT/IB2005/000700 WO2005090386A1 (en) | 2004-03-19 | 2005-03-18 | Peptides derived from human bplp protein, polynucleotides coding for said peptides and antibodies directed against said peptides |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2531480T3 true ES2531480T3 (es) | 2015-03-16 |
Family
ID=34833801
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES04290754T Expired - Lifetime ES2390075T3 (es) | 2004-03-19 | 2004-03-19 | Péptidos derivados de la proteína BPLP humana, polinucleótidos que codifican dichos péptidos y anticuerpos dirigidos contra dichos péptidos |
ES05708768.6T Active ES2531480T3 (es) | 2004-03-19 | 2005-03-18 | Péptidos derivados de la proteína bplp humana, polinucleótidos que codifican dichos péptidos y anticuerpos dirigidos contra dichos péptidos |
ES14191558.7T Active ES2685268T3 (es) | 2004-03-19 | 2005-03-18 | Péptidos derivados de la proteína BPLP humana, polinucleótidos que codifican dichos péptidos y anticuerpos dirigidos contra dichos péptidos |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES04290754T Expired - Lifetime ES2390075T3 (es) | 2004-03-19 | 2004-03-19 | Péptidos derivados de la proteína BPLP humana, polinucleótidos que codifican dichos péptidos y anticuerpos dirigidos contra dichos péptidos |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES14191558.7T Active ES2685268T3 (es) | 2004-03-19 | 2005-03-18 | Péptidos derivados de la proteína BPLP humana, polinucleótidos que codifican dichos péptidos y anticuerpos dirigidos contra dichos péptidos |
Country Status (17)
Country | Link |
---|---|
US (4) | US8017571B2 (es) |
EP (3) | EP1577320B1 (es) |
JP (3) | JP5049776B2 (es) |
CN (2) | CN103183726B (es) |
AU (1) | AU2005223492B2 (es) |
CA (1) | CA2559215C (es) |
CY (2) | CY1116087T1 (es) |
DK (3) | DK1577320T3 (es) |
ES (3) | ES2390075T3 (es) |
HK (1) | HK1185894A1 (es) |
HU (2) | HUE016435T4 (es) |
LT (1) | LT2952521T (es) |
PL (3) | PL1577320T3 (es) |
PT (3) | PT1577320E (es) |
SI (2) | SI2952521T1 (es) |
TR (1) | TR201809994T4 (es) |
WO (1) | WO2005090386A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
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EP1577320B1 (en) | 2004-03-19 | 2012-07-18 | Institut Pasteur | Peptides derived from human BPLP protein, polynucleotides coding for said peptides and antibodies directed against said peptides |
EP2111410A2 (en) | 2007-02-02 | 2009-10-28 | Greenpharma | Peptide inhibitors of metallo- ectopeptidases, compositions comprising said compounds and their pharmaceutical and cosmetic uses |
WO2009090265A1 (en) * | 2008-01-18 | 2009-07-23 | Institut Pasteur | Method for identifying bplp and opiorphin agonists or antagonists |
US8889827B2 (en) * | 2008-04-07 | 2014-11-18 | Institut Pasteur | Opiorphin peptide derivatives as potent inhibitors of enkephalin-degrading ectopeptidases |
FR2931362B1 (fr) * | 2008-05-26 | 2017-08-18 | Pasteur Institut | L'opiorphine pour une utilisation en tant que psychostimulant. |
WO2010028671A1 (en) * | 2008-09-09 | 2010-03-18 | Mondobiotech Laboratories Ag | Use of opiorphin as a therapeutic agent |
EP2344913B1 (en) * | 2008-10-02 | 2015-02-18 | Ramot at Tel-Aviv University Ltd. | Method and system for emitting light |
CA2645452A1 (en) * | 2008-11-28 | 2010-05-28 | Institut Pasteur | Use of basic prolin-rich lacrimal gene products, such as opiorphin, as a biomarker |
FR2968560A1 (fr) * | 2010-12-13 | 2012-06-15 | Oreal | Utilisation de l'ide comme biomarqueur d'un etat du cuir chevelu |
CA3032775C (en) * | 2016-08-16 | 2024-01-23 | National Institute Of Advanced Industrial Science And Technology | Malignant tumor target peptide |
CN113284553B (zh) * | 2021-05-28 | 2023-01-10 | 南昌大学 | 一种用于治疗药物成瘾的药物靶点结合能力测试方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2637600B1 (fr) * | 1988-10-11 | 1992-03-06 | Pasteur Institut | Peptides et polypeptides provenant de la glande sous maxillaire du rat, anticorps monoclonaux et polyclonaux correspondants, hybridomes correspondants et applications de ces produits au diagnostic, a la detection ou a des fins therapeutiques |
FR2707169B1 (fr) | 1993-06-04 | 1995-09-01 | Pasteur Institut | Antigène cellulaire CD26 impliqué dans l'infection par un rétrovirus hiv. nouveaux inhibiteurs de l'infection par HIV. * (Dipeptidyl-peptidase IV). |
CA2187818A1 (en) | 1994-04-15 | 1995-10-26 | Robert W. Overell | Gene delivery fusion proteins |
CN1096834C (zh) | 1996-09-20 | 2002-12-25 | 霍华德基金会 | 含黄酮醇的食品增补剂 |
US6589750B2 (en) | 1997-02-20 | 2003-07-08 | Institut Pasteur | Therapeutic use of the SMR1 protein, the SMR1 maturation products, specifically the QHNPR pentapeptide as well as its biologically active derivatives |
IT1291113B1 (it) | 1997-03-20 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Composizione nutritiva terapeutica per soggetti affetti da diabete mellito |
AU6154700A (en) * | 1999-06-23 | 2001-01-31 | Centre National De La Recherche Scientifique (C.N.R.S.) | Therapeutic methods and compositions for the treatment of impaired interpersonal and behavioral disorders |
US6812248B2 (en) | 2000-07-05 | 2004-11-02 | John Hopkins University School Of Medicine | Prevention and treatment of degenerative diseases by glutathione and phase II detoxification enzymes |
PT1216707E (pt) | 2000-12-22 | 2005-06-30 | Pasteur Institut | Novas utilizacoes terapeuticas para um smr-1-peptideo |
US7119110B2 (en) | 2001-10-05 | 2006-10-10 | Interhealth Nutraceuticals Incorporated | Method and composition for preventing or reducing the symptoms of insulin resistance syndrome |
EP1577320B1 (en) | 2004-03-19 | 2012-07-18 | Institut Pasteur | Peptides derived from human BPLP protein, polynucleotides coding for said peptides and antibodies directed against said peptides |
WO2009090265A1 (en) | 2008-01-18 | 2009-07-23 | Institut Pasteur | Method for identifying bplp and opiorphin agonists or antagonists |
US8889827B2 (en) | 2008-04-07 | 2014-11-18 | Institut Pasteur | Opiorphin peptide derivatives as potent inhibitors of enkephalin-degrading ectopeptidases |
FR2931362B1 (fr) | 2008-05-26 | 2017-08-18 | Pasteur Institut | L'opiorphine pour une utilisation en tant que psychostimulant. |
CA2645452A1 (en) | 2008-11-28 | 2010-05-28 | Institut Pasteur | Use of basic prolin-rich lacrimal gene products, such as opiorphin, as a biomarker |
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