ES2512141T3 - Análogo peptídico de oxintomodulina - Google Patents
Análogo peptídico de oxintomodulina Download PDFInfo
- Publication number
- ES2512141T3 ES2512141T3 ES10799178.8T ES10799178T ES2512141T3 ES 2512141 T3 ES2512141 T3 ES 2512141T3 ES 10799178 T ES10799178 T ES 10799178T ES 2512141 T3 ES2512141 T3 ES 2512141T3
- Authority
- ES
- Spain
- Prior art keywords
- peptide analog
- cys
- oxintomodulin peptide
- oxintomodulin
- peg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Un análogo peptídico de oxintomodulina que comprende la secuencia de aminoácidos:**Fórmula** en la que Xaa38 es Cys, Cys-PEG, o está ausente; Xaa39 es Cys, Cys-PEG, o está ausente; y en el que el aminoácido C-terminal está amidado opcionalmente.
Description
Claims (1)
-
imagen1
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28888409P | 2009-12-22 | 2009-12-22 | |
US288884P | 2009-12-22 | ||
US35256910P | 2010-06-08 | 2010-06-08 | |
US352569P | 2010-06-08 | ||
PCT/US2010/060380 WO2011087671A1 (en) | 2009-12-22 | 2010-12-15 | Oxyntomodulin peptide analogue |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2512141T3 true ES2512141T3 (es) | 2014-10-23 |
Family
ID=43568014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES10799178.8T Active ES2512141T3 (es) | 2009-12-22 | 2010-12-15 | Análogo peptídico de oxintomodulina |
Country Status (27)
Country | Link |
---|---|
US (1) | US8415296B2 (es) |
EP (1) | EP2515927B1 (es) |
JP (1) | JP5717758B2 (es) |
KR (1) | KR101399692B1 (es) |
CN (1) | CN102665752B (es) |
AR (1) | AR079344A1 (es) |
AU (1) | AU2010341650B2 (es) |
BR (1) | BR112012017054A2 (es) |
CA (1) | CA2784668C (es) |
CL (1) | CL2012001685A1 (es) |
CO (1) | CO6551737A2 (es) |
CR (1) | CR20120339A (es) |
DO (1) | DOP2012000175A (es) |
EA (1) | EA201290557A1 (es) |
EC (1) | ECSP12011988A (es) |
ES (1) | ES2512141T3 (es) |
GT (1) | GT201200205A (es) |
HK (1) | HK1170943A1 (es) |
MA (1) | MA33826B1 (es) |
MX (1) | MX2012007449A (es) |
NZ (1) | NZ600732A (es) |
PE (1) | PE20121721A1 (es) |
SG (1) | SG181872A1 (es) |
TN (1) | TN2012000303A1 (es) |
TW (1) | TWI451873B (es) |
UA (1) | UA106399C2 (es) |
WO (1) | WO2011087671A1 (es) |
Families Citing this family (64)
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US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
ES2572952T3 (es) | 2005-11-07 | 2016-06-03 | Indiana University Research And Technology Corporation | Análogos de glucagón que muestran solubilidad y estabilidad fisiológicas |
CN102274557B (zh) | 2006-08-09 | 2014-12-03 | 精达制药公司 | 渗透性递送***和活塞组件 |
WO2008101017A2 (en) | 2007-02-15 | 2008-08-21 | Indiana Unversity Research And Technology Corporation | Glucagon/glp-1 receptor co-agonists |
WO2008133908A2 (en) | 2007-04-23 | 2008-11-06 | Intarcia Therapeutics, Inc. | Suspension formulations of insulinotropic peptides and uses thereof |
EP2214691B1 (en) | 2007-10-30 | 2015-09-30 | Indiana University Research and Technology Corporation | Compounds exhibiting glucagon antagonist and glp-1 agonist activity |
WO2009058662A2 (en) | 2007-10-30 | 2009-05-07 | Indiana University Research And Technology Corporation | Glucagon antagonists |
EP2240155B1 (en) | 2008-02-13 | 2012-06-06 | Intarcia Therapeutics, Inc | Devices, formulations, and methods for delivery of multiple beneficial agents |
WO2010011439A2 (en) | 2008-06-17 | 2010-01-28 | Indiana University Research And Technology Corporation | Gip-based mixed agonists for treatment of metabolic disorders and obesity |
PE20120332A1 (es) | 2008-12-19 | 2012-04-14 | Univ Indiana Res & Tech Corp | Profarmacos de peptido de la superfamilia de glucagon basado en amida |
PE20120914A1 (es) | 2009-06-16 | 2012-08-22 | Univ Indiana Res & Tech Corp | Compuestos glucagon activo de receptor de gip |
US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
AU2010298733B2 (en) | 2009-09-28 | 2014-10-09 | Intarcia Therapeutics, Inc. | Rapid establishment and/or termination of substantial steady-state drug delivery |
AR079345A1 (es) * | 2009-12-22 | 2012-01-18 | Lilly Co Eli | Analogo peptidico de oxintomodulina |
IN2012DN06437A (es) | 2010-01-27 | 2015-10-09 | Univ Indiana Res & Tech Corp | |
EP2568993A4 (en) | 2010-05-13 | 2014-02-19 | Univ Indiana Res & Tech Corp | GLUCAGON SUPERFAMILY PEPTIDES EXPRESSING G PROTEIN-COUPLED RECEPTOR ACTIVITY |
KR20130062931A (ko) | 2010-05-13 | 2013-06-13 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | 핵 호르몬 수용체 활성을 나타내는 글루카곤 슈퍼패밀리 펩티드 |
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BR112013030933A2 (pt) * | 2011-06-02 | 2018-04-24 | Prolor Biotech Inc | agonistas do receptor de glp-1/glucágon de ação prolongada |
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PE20140765A1 (es) | 2011-06-10 | 2014-06-14 | Hanmi Science Co Ltd | Derivados de oxintomodulina novedosos y composicion farmaceutica para tratar la obesidad que comprende los mismos |
ES2710356T3 (es) | 2011-06-17 | 2019-04-24 | Hanmi Science Co Ltd | Conjugado que comprende oxintomodulina y un fragmento de inmunoglobulina, y uso del mismo |
CA2839867A1 (en) | 2011-06-22 | 2012-12-27 | Indiana University Research And Technology Corporation | Glucagon/glp-1 receptor co-agonists |
US9156902B2 (en) | 2011-06-22 | 2015-10-13 | Indiana University Research And Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
RU2014117678A (ru) | 2011-11-17 | 2015-12-27 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Пептиды глюкагонового суперсемейства, обладающие глюкокортикоидной рецепторной активностью |
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-
2010
- 2010-12-09 AR ARP100104554A patent/AR079344A1/es unknown
- 2010-12-10 TW TW099143355A patent/TWI451873B/zh not_active IP Right Cessation
- 2010-12-15 WO PCT/US2010/060380 patent/WO2011087671A1/en active Application Filing
- 2010-12-15 BR BR112012017054A patent/BR112012017054A2/pt not_active IP Right Cessation
- 2010-12-15 SG SG2012046223A patent/SG181872A1/en unknown
- 2010-12-15 EP EP10799178.8A patent/EP2515927B1/en active Active
- 2010-12-15 CA CA2784668A patent/CA2784668C/en active Active
- 2010-12-15 NZ NZ600732A patent/NZ600732A/en not_active IP Right Cessation
- 2010-12-15 UA UAA201207074A patent/UA106399C2/ru unknown
- 2010-12-15 EA EA201290557A patent/EA201290557A1/ru unknown
- 2010-12-15 AU AU2010341650A patent/AU2010341650B2/en not_active Ceased
- 2010-12-15 CN CN201080058422.4A patent/CN102665752B/zh active Active
- 2010-12-15 US US12/968,388 patent/US8415296B2/en active Active
- 2010-12-15 JP JP2012546033A patent/JP5717758B2/ja active Active
- 2010-12-15 PE PE2012000855A patent/PE20121721A1/es not_active Application Discontinuation
- 2010-12-15 KR KR1020127016092A patent/KR101399692B1/ko active IP Right Grant
- 2010-12-15 ES ES10799178.8T patent/ES2512141T3/es active Active
- 2010-12-15 MX MX2012007449A patent/MX2012007449A/es active IP Right Grant
-
2012
- 2012-06-14 TN TNP2012000303A patent/TN2012000303A1/en unknown
- 2012-06-14 MA MA34969A patent/MA33826B1/fr unknown
- 2012-06-20 GT GT201200205A patent/GT201200205A/es unknown
- 2012-06-20 EC ECSP12011988 patent/ECSP12011988A/es unknown
- 2012-06-20 DO DO2012000175A patent/DOP2012000175A/es unknown
- 2012-06-21 CL CL2012001685A patent/CL2012001685A1/es unknown
- 2012-06-21 CO CO12104387A patent/CO6551737A2/es active IP Right Grant
- 2012-06-22 CR CR20120339A patent/CR20120339A/es not_active Application Discontinuation
- 2012-11-19 HK HK12111774.5A patent/HK1170943A1/xx not_active IP Right Cessation
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