ES2531066T3 - Un suplemento intraarticular para uso en el tratamiento de enfermedades y lesiones articulares - Google Patents

Un suplemento intraarticular para uso en el tratamiento de enfermedades y lesiones articulares Download PDF

Info

Publication number
ES2531066T3
ES2531066T3 ES11702660T ES11702660T ES2531066T3 ES 2531066 T3 ES2531066 T3 ES 2531066T3 ES 11702660 T ES11702660 T ES 11702660T ES 11702660 T ES11702660 T ES 11702660T ES 2531066 T3 ES2531066 T3 ES 2531066T3
Authority
ES
Spain
Prior art keywords
solution
intra
diseases
treatment
joint injuries
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11702660T
Other languages
English (en)
Inventor
Yves Henrotin
Christelle Sanchez
Frédéric Oprenyeszk
Pierre Drion
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite de Liege
Kitozyme SA
Original Assignee
Universite de Liege
Kitozyme SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite de Liege, Kitozyme SA filed Critical Universite de Liege
Application granted granted Critical
Publication of ES2531066T3 publication Critical patent/ES2531066T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/734—Alginic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Dispersion Chemistry (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Un método para producir un hidrogel para suplemento intraarticular que comprende las etapas de: - proporcionar una solución de alginato, - proporcionar una solución de quitosano que tiene un Pm inferior a 60 kDa, - mezclar la solución de alginato y la solución de quitosano, en donde la solución mezclada comprende entre el 0,5 y el 0,7 % (p/v) de quitosano y entre el 1 y el 1,4 % de alginato, - introducir gotitas de la solución mezclada en una solución con iones Ca2+ o Sr2+ - aislar las perlas gelificadas de la solución con cationes.
ES11702660T 2010-02-25 2011-02-11 Un suplemento intraarticular para uso en el tratamiento de enfermedades y lesiones articulares Active ES2531066T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10154712A EP2361640A1 (en) 2010-02-25 2010-02-25 Cell cultivation in chitosan alginate hydrogel beads
PCT/EP2011/052020 WO2011104133A1 (en) 2010-02-25 2011-02-11 An intra-articular supplementation method for treating joint diseases and injuries

Publications (1)

Publication Number Publication Date
ES2531066T3 true ES2531066T3 (es) 2015-03-10

Family

ID=42308548

Family Applications (2)

Application Number Title Priority Date Filing Date
ES11702660T Active ES2531066T3 (es) 2010-02-25 2011-02-11 Un suplemento intraarticular para uso en el tratamiento de enfermedades y lesiones articulares
ES11703452.0T Active ES2526592T3 (es) 2010-02-25 2011-02-11 Cultivo celular en esferas de hidrogel con alginato de quitosano

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES11703452.0T Active ES2526592T3 (es) 2010-02-25 2011-02-11 Cultivo celular en esferas de hidrogel con alginato de quitosano

Country Status (10)

Country Link
US (4) US8883733B2 (es)
EP (3) EP2361640A1 (es)
JP (2) JP5270803B2 (es)
KR (2) KR101863533B1 (es)
CN (2) CN102762233B (es)
DK (2) DK2538987T3 (es)
ES (2) ES2531066T3 (es)
PL (2) PL2538986T3 (es)
SG (2) SG183380A1 (es)
WO (2) WO2011104133A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110229565A1 (en) 2008-09-17 2011-09-22 Karp Jeffrey M Drug Delivery Composition Comprising a Self-Assembled Gelator
US20130280334A1 (en) 2010-09-24 2013-10-24 Massachusetts Institute Of Technology Nanostructured Gels Capable of Controlled Release of Encapsulated Agents
CN106470666B (zh) 2014-06-04 2021-01-01 立卡达有限责任公司 微囊封装技术及其产品
FR3024362A1 (fr) * 2014-08-01 2016-02-05 Synolyne Pharma Sa Composition thermogelifiable sterilisee
FR3029116B1 (fr) 2014-12-01 2018-03-30 Advanced Chitosan Solutions Biotech Procede d'obtention d'un gel de cartilage pour la reparation cartilagineuse, comprenant du chitosane et des chondrocytes
FR3029422B1 (fr) * 2014-12-05 2017-01-13 Synolyne Pharma Microbille d'hydrogel
FR3029790B1 (fr) * 2014-12-12 2017-01-13 Synolyne Pharma Microbille d'hydrogel de chitosane
EP3359128A1 (en) 2015-10-08 2018-08-15 The Brigham and Women's Hospital, Inc. Stabilized assembled nanostructures for delivery of encapsulated agents
CN115837006A (zh) * 2016-05-06 2023-03-24 布里格姆及妇女医院股份有限公司 用于向软骨中受控递送被囊封的药剂的二元自组装凝胶
WO2018144991A1 (en) 2017-02-03 2018-08-09 The Brigham And Women's Hospital, Inc. Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof
WO2018208822A1 (en) 2017-05-08 2018-11-15 Alivio Therapeutics, Inc. Formulation of nanostructured gels for increased agent loading and adhesion
JP7323608B2 (ja) 2018-10-11 2023-08-08 アリヴィオ セラピューティクス， インコーポレイテッド スマート放出のための非注射用ヒドロゲル製剤
CN109251887A (zh) * 2018-10-12 2019-01-22 山东麦德克斯生物科技有限公司 一种软骨细胞引物层的制备方法及软骨组织
JP2022526302A (ja) 2019-03-21 2022-05-24 アンテロジェン シーオー．，エルティーディー． 間葉系幹細胞－ヒドロゲルを含有する注射用組成物、並びにその製造、凍結及び解凍方法
CN112481134B (zh) * 2020-11-26 2022-03-18 浙江工业大学 一种利用微生物发酵法提取桑叶多糖的方法
KR20230172282A (ko) * 2022-06-15 2023-12-22 (주)바이오트코리아 자기구동이 가능한 치료물질 전달용 하이드로겔 마이크로비즈의 제조방법, 이에 의해 제조된 하이드로겔 마이크로비즈 및 이를 포함하는 근골격계 질환 치료용 약학 조성물

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2327074B (en) * 1997-07-07 2001-09-12 Norsk Hydro As Improvements in or relating to capsules
WO2002000272A2 (en) * 2000-06-29 2002-01-03 Biosyntech Canada Inc. Composition and method for the repair and regeneration of cartilage and other tissues
FR2819814B1 (fr) * 2001-01-22 2004-10-29 Tbf Lab Composition gelifiable biocompatible et implantable
CN1299653C (zh) * 2004-02-12 2007-02-14 上海大学 仿生人工关节囊及其制备方法
US7767656B2 (en) * 2005-04-25 2010-08-03 Molly S Shoichet Blends of temperature sensitive and anionic polymers for drug delivery
CN100381568C (zh) * 2005-04-27 2008-04-16 中国科学院沈阳应用生态研究所 一种生物微胶囊化的方法
ITPD20060203A1 (it) * 2006-05-22 2007-11-23 Univ Degli Studi Trieste Idrogeli di miscele di polisaccaridi per l'ingegneria tissutale e la veicolazione di composti attivi
ITMI20061726A1 (it) * 2006-09-11 2008-03-12 Fidia Farmaceutici Derivati crosslinkati a base di acido ialuronico reticolato via click chemistry
CN101285053A (zh) * 2008-05-28 2008-10-15 大连理工大学 一种动态悬浮条件下共同培养脐血造血干细胞与间充质干细胞的方法

Also Published As

Publication number Publication date
EP2538987B1 (en) 2014-09-24
DK2538987T3 (da) 2014-12-08
KR20130027470A (ko) 2013-03-15
WO2011104133A1 (en) 2011-09-01
CN102753205A (zh) 2012-10-24
DK2538986T3 (da) 2015-03-02
PL2538987T3 (pl) 2015-04-30
EP2538986B1 (en) 2014-12-03
SG183379A1 (en) 2012-09-27
EP2361640A1 (en) 2011-08-31
WO2011104131A1 (en) 2011-09-01
US8889158B2 (en) 2014-11-18
US20150072013A1 (en) 2015-03-12
KR20130020769A (ko) 2013-02-28
PL2538986T3 (pl) 2015-05-29
CN102762233B (zh) 2016-02-24
US20120321678A1 (en) 2012-12-20
US20150056266A1 (en) 2015-02-26
EP2538986A1 (en) 2013-01-02
JP5208332B2 (ja) 2013-06-12
KR101740298B1 (ko) 2017-05-26
US20120315307A1 (en) 2012-12-13
EP2538987A1 (en) 2013-01-02
JP5270803B2 (ja) 2013-08-21
ES2526592T3 (es) 2015-01-13
CN102762233A (zh) 2012-10-31
JP2013520188A (ja) 2013-06-06
US9480648B2 (en) 2016-11-01
JP2013520258A (ja) 2013-06-06
US8883733B2 (en) 2014-11-11
SG183380A1 (en) 2012-09-27
CN102753205B (zh) 2016-02-10
KR101863533B1 (ko) 2018-06-04
US9561180B2 (en) 2017-02-07

Similar Documents

Publication Publication Date Title
ES2531066T3 (es) Un suplemento intraarticular para uso en el tratamiento de enfermedades y lesiones articulares
EP3562506A4 (en) METHOD OF MODULATION OF INFLAMMATORY SOMACTIVITY AND INFLAMMATION OF THE LUNG
AR112286A2 (es) Sistema polimérico de lágrimas artificiales
BR112013018352A2 (pt) composição de minociclina tópica e método
ECSP15013179A (es) Nanopartículas terapéuticas que comprenden un agente terapéutico y métodos para realizarlas y usarlas
BR112013006649A2 (pt) método para produção de um polidieno
EP3578573A4 (en) HYDROGEL USING AS A SUBSTRATE A HYALURONIC ACID DERIVATIVE MODIFIED BY A GALLOL GROUP, AND ASSOCIATED USE
EP2578622A3 (en) Enhanced oilfield swellable elastomers and methods for making and using same
WO2011110894A3 (en) A fluid composition comprising a hyaluronan polymer and mannitol for improving skin condition
WO2012040623A3 (en) Nanostructured gels capable of controlled release of encapsulated agents
WO2012104655A3 (en) Compostions and methods for treating chronic inflammation and inflammatory diseases
EP2456400A4 (en) LASER SYSTEM AND METHOD FOR IMPLEMENTING AND SEALING LEATHER FRAME IN EYE
BR112014017241A8 (pt) processo para a preparação de um poliéter-éster poliol, poliéter-éster poliol, e, uso de um poliéter-éster poliol
BR112012028194A2 (pt) composição, e, processo para preparação da composição
MY162773A (en) Gel composition comprising low-methoxy pectin
WO2007087350A3 (en) Methods for regulating gelation of polysaccharide solutions and uses thereof
CL2013002033A1 (es) Preparacion oral de desintegracion rapida que comprende granulos que comprenden un medicamento, un agente de desintegracion, un aglutinador, un agente de enmascaramiento y un agente de solubilizacion; metodo de preparacion; su uso para la profilaxis y/o tratamiento de un padecimiento bipolar.
WO2014046753A3 (en) Method and system for treatment of biological tissue
AR090930A1 (es) Composiciones oftalmicas con proteccion mejorada contra la desecacion y retencion
MX2014011042A (es) Producto acuoso que comprende microcapsulas que contienen aceite y metodo para su fabricacion.
BRPI0910403A2 (pt) Uso de um agente traçador de mpi, e, método para o monitoramento visual de um produto biocompatível.
ECSP16058769A (es) Composicion para la administracion oral de agente bioactivos
CO6630089A2 (es) Composicion de encapsulamiento de liberacion rapida
CL2012001835A1 (es) Uso de una formulacion que comprende un agente viscogenico y moxifloxacina para preparar un medicamento util para tratar el oido medio.
BR112012015449A2 (pt) suspensão de monoidrato de calcipotriol, monoidrato de calcipotriol, processo para preparar nanocristais de monoidrato de calcipotriol, e, composição farmacêutica