ES247446A1 - Procedure for preparing dissulfamilaniline compounds (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Process for preparing disulfamylaniline compounds, which comprises the reaction of a solution of a halonitrobenzene of any of the structures represented by the following two formulas designated as Formulas 3 and 4 in the formula sheet, ** (See formula) ** with an alkali disulphide, to obtain a disulfide of di- (4-X-nitrophenyl) or of di- (2-X-4-nitrophenyl), which is then oxidized with chlorine or sulfonyl chloride with chloride structure 5-X-nitrobenzene-2-sulfonyl or 3-X-nitrobenzene-4-sulfonyl, which is amidated with not less than two equivalents of a compound selected from the group consisting of ammonia and a monolevialkylamine, to form the corresponding sulphonamide, which is reduced by a process chosen between the chemical reduction and the catalytic reduction, to convert the nitro group to the amino group; and the subsequent chlorosulfonation of the aniline compound thus obtained, by reaction with not less than two equivalents of chlorosulfonic acid, followed by amidation by treatment with not less than two equivalents of a compound selected from the group consisting of ammonia and a monolevialkylamine, to form a disulfamilaniline compound adjusted to the general structure represented by the following formula, designated on the formula sheet as Formula 1, ** (See formula) ** where, as in the above formulas, X is selected from the group comprising a halogen, a levyalkyl radical, a levialkoxyl radical and a nitro group; Hal, of the group composed of chlorine and bromine atoms; R1, of the group consisting of halogen, a levyalkyl radical and a levialkoxyl radical, and the nitro and amino groups; and R2, of the group comprising hydrogen and a levyalkyl radical. (Machine-translation by Google Translate, not legally binding)