ES2449517T3 - Compuestos imidazo-3-il-amina bicíclicos sustituidos - Google Patents

Compuestos imidazo-3-il-amina bicíclicos sustituidos Download PDF

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ES2449517T3
ES2449517T3 ES05784773.3T ES05784773T ES2449517T3 ES 2449517 T3 ES2449517 T3 ES 2449517T3 ES 05784773 T ES05784773 T ES 05784773T ES 2449517 T3 ES2449517 T3 ES 2449517T3
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unsubstituted
monosubstituted
fused
nitrogen atom
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Sven KÜHNERT
Stefan OBERBÖRSCH
Corinna Sundermann
Michael Haurand
Ruth Jostock
Klaus Schiene
Thomas Tzschentke
Thomas Christoph
Dagmar Kaulartz
Saskia Zemolka
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Gruenenthal GmbH
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
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Abstract

Compuestos imidazo-3-il-amina bicíclicos sustituidos de fórmula general I, **Fórmula** donde A1 representa un átomo de nitrógeno o un grupo C-R1a, A2 representa un átomo de nitrógeno o un grupo C-R1b, A3 representa un átomo de nitrógeno o un grupo C-R1c, A4 representa un átomo de nitrógeno o un grupo C-R1d; R1a, R1b, R1c, R1d, independientemente entre sí, representan en cada caso un grupo hidrógeno, un grupo halógeno; -NO2; -CN; -NH2; -NHR4; -NR5R6; -NH-C(>=O)-R7; -C(>=O)-R8, -C(>=O)-NH2; -C(>=O)-NHR9; -C(>=O)- NR10R11; -C(>=O)-OR12; -(CH2)m-C(>=O)-OR13 con m >= 1, 2, 3, 4 ó 5; -O-C(>=O)-R14; -(CH2)n-O-C(>=O)-R15 con n >= 1, 2, 3, 4 ó 5; -OR16; -(CH2)o-O-R17 con o >= 1, 2, 3, 4 ó 5; -SR18; -(CH2)p-S(>=O)t-R19 con p >= 1, 2, 3, 4 ó 5 y t >= 0, 1 ó 2; -NH-S(>=O)2-R26R27; -S(>=O)2-NR28R29, -SF5; un grupo alifático lineal o ramificado, saturado o insaturado, no sustituido o al menos monosustituido; un grupo cicloalifático saturado o insaturado, no sustituido o al menos monosustituido, que opcionalmente incluye al menos un heteroátomo como miembro del anillo y que puede estar unido a través de un grupo alquileno lineal o ramificado y/o que puede estar condensado con un sistema de anillo mono- o policíclico, no sustituido o al menos monosustituido; o un grupo arilo o heteroarilo no sustituido o al menos monosustituido y que puede estar unido a través de un grupo alquileno lineal o ramificado y/o puede estar condensado con un sistema de anillo mono- o policíclico, no sustituido o al menos monosustituido; o, en cada caso, R1a y R1b junto con el enlace C-C, forman un grupo fenilo fusionado, no sustituido o al menos monosustituido; o, en cada caso, R1b y R1c junto con el enlace C-C forman un grupo fenilo fusionado, no sustituido o al menos monosustituido; o, en cada caso, R1c y R1d junto con el enlace C-C forman un grupo fenilo fusionado, no sustituido o al menos monosustituido.
ES05784773.3T 2004-09-14 2005-09-08 Compuestos imidazo-3-il-amina bicíclicos sustituidos Active ES2449517T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004044884A DE102004044884A1 (de) 2004-09-14 2004-09-14 Substituierte bizyklische Imidazo-3-yl-amin-Verbindungen
DE102004044884 2004-09-14
PCT/EP2005/054436 WO2006029980A1 (de) 2004-09-14 2005-09-08 Substituierte bizyklische imidazo-3-yl-amin-verbindungen

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ES2449517T3 true ES2449517T3 (es) 2014-03-20

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US (1) US7420056B2 (es)
EP (1) EP1791840B1 (es)
JP (1) JP5001840B2 (es)
KR (1) KR20070104514A (es)
CN (1) CN101061118A (es)
AU (1) AU2005284131B2 (es)
BR (1) BRPI0515473A (es)
CA (1) CA2580251A1 (es)
DE (1) DE102004044884A1 (es)
EC (1) ECSP077316A (es)
ES (1) ES2449517T3 (es)
IL (1) IL181848A (es)
MX (1) MX2007003108A (es)
NO (1) NO20071901L (es)
NZ (1) NZ553937A (es)
RU (1) RU2435770C2 (es)
WO (1) WO2006029980A1 (es)
ZA (1) ZA200703008B (es)

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JP6629740B2 (ja) 2014-01-21 2020-01-15 ヤンセン ファーマシューティカ エヌ．ベー． 代謝型グルタミン酸作動性受容体サブタイプ２の正のアロステリック調節因子またはオルトステリックアゴニストを含む組み合わせ、およびそれらの使用
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AU2005284131A1 (en) 2006-03-23
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