ES2422579T3 - 2,6-Metano-3-benzazocinas 8-carboxamido sustituidas y 3-carboxamido morfanos sustituidos como ligandos de los receptores opioides - Google Patents
2,6-Metano-3-benzazocinas 8-carboxamido sustituidas y 3-carboxamido morfanos sustituidos como ligandos de los receptores opioidesInfo
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- ES2422579T3 ES2422579T3 ES10006594T ES10006594T ES2422579T3 ES 2422579 T3 ES2422579 T3 ES 2422579T3 ES 10006594 T ES10006594 T ES 10006594T ES 10006594 T ES10006594 T ES 10006594T ES 2422579 T3 ES2422579 T3 ES 2422579T3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P1/12—Antidiarrhoeals
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- A61P11/00—Drugs for disorders of the respiratory system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/14—Antitussive agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
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- C—CHEMISTRY; METALLURGY
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- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
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- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
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- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
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- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
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- Chemical & Material Sciences (AREA)
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Abstract
Compuesto de fórmula: **Fórmula** donde **Fórmula** es un residuo arilo o heteroarilo de uno a tres anillos; A es (CH2)n, pudiendo reemplazarse uno o más CH2 por -O-, cicloalquilo o -CR1aR1b; R1a y R1b se seleccionan independientemente entre hidrógeno, halógeno, alquilo inferior, alcoxi inferior y alquiltio inferior; R2 y R2a son ambos hidrógeno o R2 y R2a juntos son >=O; R3 se selecciona entre hidrógeno y un hidrocarburo(C1-C8); R4 se selecciona entre hidrógeno, hidroxilo, amino, alcoxilo inferior, alquilo(C1-C20) y alquilo(C1-C20) sustituido con hidroxi o carbonilo; R7 se selecciona entre hidrógeno e hidroxilo; o R5 y R6 juntos forman un anillo, presentando dicho anillo una sustitución adicional opcional; donde la sustitución adicional opcional significa que hasta tres átomos de H se han reemplazado por halógeno, hidroxilo, alcoxi(C1-C4), carboxi, carboalcoxi; carboxamido, ciano, carbonilo, NO2; -NR1R2; alquiltio, sulfóxido, sulfona, acilamino, amidino, fenilo, bencilo, heteroarilo, fenoxi, benciloxi, heteroariloxi, o fenilo, bencilo, heteroarilo, fenoxi, benciloxi, heteroariloxi sustituidos; R10 es uno o dos grupos seleccionados independientemente entre hidrógeno, hidroxilo, halógeno, 20 alquilo(C1-C6), alcoxi(C1-C6), haloalquilo(C1-C6), haloalcoxi(C1-C6) y alquitio(C1-C6).**Fórmula**
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US70140705P | 2005-07-21 | 2005-07-21 |
Publications (1)
Publication Number | Publication Date |
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ES2422579T3 true ES2422579T3 (es) | 2013-09-12 |
Family
ID=37622091
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES06800266.6T Active ES2480390T3 (es) | 2005-07-21 | 2006-07-21 | 2,6-metano-3-benzazocinas 8-carboxamido sustituidas y morfanos 3-carboxamido sustituidos como ligandos de los receptores opioides |
ES10006594T Active ES2422579T3 (es) | 2005-07-21 | 2006-07-21 | 2,6-Metano-3-benzazocinas 8-carboxamido sustituidas y 3-carboxamido morfanos sustituidos como ligandos de los receptores opioides |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES06800266.6T Active ES2480390T3 (es) | 2005-07-21 | 2006-07-21 | 2,6-metano-3-benzazocinas 8-carboxamido sustituidas y morfanos 3-carboxamido sustituidos como ligandos de los receptores opioides |
Country Status (7)
Country | Link |
---|---|
US (6) | US7557119B2 (es) |
EP (2) | EP2266959B1 (es) |
JP (1) | JP5266051B2 (es) |
AU (1) | AU2006272773B2 (es) |
CA (1) | CA2615774C (es) |
ES (2) | ES2480390T3 (es) |
WO (1) | WO2007014137A2 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1944292B9 (en) * | 2000-10-31 | 2016-07-06 | Rensselaer Polytechnic Institute | 8-substituted-2,6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents |
ES2480390T3 (es) | 2005-07-21 | 2014-07-28 | Rensselaer Polytechnic Institute | 2,6-metano-3-benzazocinas 8-carboxamido sustituidas y morfanos 3-carboxamido sustituidos como ligandos de los receptores opioides |
KR101519682B1 (ko) | 2007-08-09 | 2015-05-19 | 렌슬러 폴리테크닉 인스티튜트 | 4급 오피오이드 카르복스아미드 |
US20100190817A1 (en) * | 2008-07-21 | 2010-07-29 | Rensselaer Polytechnic Institute | Large substituent, non-phenolic amine opioids |
US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
US8563724B2 (en) * | 2009-02-23 | 2013-10-22 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
TR201908514T4 (tr) | 2009-12-04 | 2019-07-22 | Alkermes Pharma Ireland Ltd | İlaç doz aşimi tedavi̇si̇ i̇çi̇n morfi̇nan türevleri̇ |
US8436175B2 (en) * | 2010-03-22 | 2013-05-07 | Rensselaer Polytechnic Institute | Carboxamide bioisosteres of opiates |
AU2011276978B2 (en) | 2010-07-08 | 2015-01-29 | Alkermes Pharma Ireland Limited | Process for the synthesis of substituted morphinans |
PL2608670T3 (pl) | 2010-08-23 | 2019-05-31 | Alkermes Pharma Ireland Ltd | Sposoby leczenia przyrostu masy ciała wywołanego neuroleptykiem |
US9029543B2 (en) | 2011-04-05 | 2015-05-12 | Alkermes, Inc. | Process for the synthesis of quaternary amine compounds |
JP5981992B2 (ja) | 2011-06-29 | 2016-08-31 | アルカーメス,インコーポレイテッド | 末梢作用オピオイド化合物 |
US9211293B2 (en) | 2011-12-15 | 2015-12-15 | Alkermes Pharma Ireland Limited | Opioid agonist antagonist combinations |
EP3003311A2 (en) | 2013-05-24 | 2016-04-13 | Alkermes Pharma Ireland Limited | Methods for treating depressive symptoms |
EP3004114B1 (en) | 2013-05-24 | 2019-12-25 | Alkermes Pharma Ireland Limited | Morphan and morphinan analogues, and methods of use |
CN103992272B (zh) * | 2014-06-09 | 2016-05-11 | 安徽省逸欣铭医药科技有限公司 | 一种盐酸喷他佐辛酯、其制备方法及其用途 |
CN109288840A (zh) * | 2018-11-23 | 2019-02-01 | 中国科学院长春应用化学研究所 | 二元纳曲酮衍生物的应用 |
TWI719740B (zh) * | 2019-12-04 | 2021-02-21 | 大江生醫股份有限公司 | 植物發酵物的製備方法、以及該發酵物及其活性成分的應用 |
WO2022101444A1 (en) | 2020-11-12 | 2022-05-19 | Alkermes Pharma Ireland Limited | Immediate release multilayer tablet |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9912411D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
DE10038709A1 (de) * | 2000-08-09 | 2002-02-28 | Aventis Pharma Gmbh | Substituierte und unsubstituierte Benzooxathiazole sowie daraus abgeleitete Verbindungen |
EP1944292B9 (en) * | 2000-10-31 | 2016-07-06 | Rensselaer Polytechnic Institute | 8-substituted-2,6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents |
WO2004007449A1 (en) * | 2002-07-16 | 2004-01-22 | Rensselaer Polytechnic Institute | Process for conversion of phenols to carboxamides via the succinimide esters |
EP1532132B1 (en) * | 2002-07-29 | 2008-03-19 | F.Hoffmann-La Roche Ag | Novel benzodioxoles |
WO2005042491A1 (en) * | 2003-10-22 | 2005-05-12 | Arena Pharmaceuticals, Inc. | Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases |
BRPI0513075A (pt) | 2004-08-05 | 2008-04-22 | Janssen Pharmaceutica Nv | moduladores gama-opióides tricìclicos |
PT2251330E (pt) | 2004-11-05 | 2012-07-20 | Rensselaer Polytech Inst | 4-hidroxibenzomorfanos |
BRPI0518563A2 (pt) | 2004-12-22 | 2008-11-25 | Janssen Pharmaceutica Nv | moduladores de delta-opiàide tricÍclicos |
CN101243079A (zh) | 2005-06-16 | 2008-08-13 | 詹森药业有限公司 | 三环阿片调节剂 |
ES2480390T3 (es) * | 2005-07-21 | 2014-07-28 | Rensselaer Polytechnic Institute | 2,6-metano-3-benzazocinas 8-carboxamido sustituidas y morfanos 3-carboxamido sustituidos como ligandos de los receptores opioides |
US8436175B2 (en) * | 2010-03-22 | 2013-05-07 | Rensselaer Polytechnic Institute | Carboxamide bioisosteres of opiates |
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2006
- 2006-07-21 ES ES06800266.6T patent/ES2480390T3/es active Active
- 2006-07-21 ES ES10006594T patent/ES2422579T3/es active Active
- 2006-07-21 JP JP2008523037A patent/JP5266051B2/ja active Active
- 2006-07-21 CA CA2615774A patent/CA2615774C/en active Active
- 2006-07-21 EP EP10006594.5A patent/EP2266959B1/en active Active
- 2006-07-21 WO PCT/US2006/028634 patent/WO2007014137A2/en active Application Filing
- 2006-07-21 EP EP06800266.6A patent/EP1924559B1/en active Active
- 2006-07-21 US US11/459,203 patent/US7557119B2/en active Active
- 2006-07-21 AU AU2006272773A patent/AU2006272773B2/en active Active
-
2009
- 2009-06-03 US US12/477,223 patent/US8026252B2/en active Active
-
2011
- 2011-08-23 US US13/215,392 patent/US8541586B2/en active Active
-
2013
- 2013-08-23 US US13/974,216 patent/US8901148B2/en active Active
-
2014
- 2014-10-31 US US14/529,832 patent/US9156821B2/en active Active
-
2015
- 2015-10-08 US US14/878,526 patent/US20160257677A1/en not_active Abandoned
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EP1924559A2 (en) | 2008-05-28 |
EP2266959B1 (en) | 2013-05-01 |
ES2480390T3 (es) | 2014-07-28 |
AU2006272773B2 (en) | 2012-03-08 |
US20160257677A1 (en) | 2016-09-08 |
US20070021457A1 (en) | 2007-01-25 |
US8541586B2 (en) | 2013-09-24 |
CA2615774C (en) | 2014-12-09 |
CA2615774A1 (en) | 2007-02-01 |
EP2266959A1 (en) | 2010-12-29 |
US20130345251A1 (en) | 2013-12-26 |
US20150051194A1 (en) | 2015-02-19 |
WO2007014137A3 (en) | 2007-03-29 |
EP1924559B1 (en) | 2014-04-16 |
US8901148B2 (en) | 2014-12-02 |
JP2009502808A (ja) | 2009-01-29 |
US9156821B2 (en) | 2015-10-13 |
US8026252B2 (en) | 2011-09-27 |
US7557119B2 (en) | 2009-07-07 |
US20110306603A1 (en) | 2011-12-15 |
US20090247562A1 (en) | 2009-10-01 |
AU2006272773A1 (en) | 2007-02-01 |
JP5266051B2 (ja) | 2013-08-21 |
WO2007014137A2 (en) | 2007-02-01 |
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