ES2333319T3 - Receptores de la neurotoxina botulinica b y su uso. - Google Patents

Receptores de la neurotoxina botulinica b y su uso. Download PDF

Info

Publication number
ES2333319T3
ES2333319T3 ES03816739T ES03816739T ES2333319T3 ES 2333319 T3 ES2333319 T3 ES 2333319T3 ES 03816739 T ES03816739 T ES 03816739T ES 03816739 T ES03816739 T ES 03816739T ES 2333319 T3 ES2333319 T3 ES 2333319T3
Authority
ES
Spain
Prior art keywords
syt
bont
baselineskip
binding
gangliosides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES03816739T
Other languages
English (en)
Spanish (es)
Inventor
Edwin Raymond Chapman
Min Dong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Application granted granted Critical
Publication of ES2333319T3 publication Critical patent/ES2333319T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • External Artificial Organs (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES03816739T 2002-10-31 2003-10-28 Receptores de la neurotoxina botulinica b y su uso. Expired - Lifetime ES2333319T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US42295102P 2002-10-31 2002-10-31
US422951P 2002-10-31
US49812803P 2003-08-27 2003-08-27
US498128P 2003-08-27

Publications (1)

Publication Number Publication Date
ES2333319T3 true ES2333319T3 (es) 2010-02-19

Family

ID=34197667

Family Applications (1)

Application Number Title Priority Date Filing Date
ES03816739T Expired - Lifetime ES2333319T3 (es) 2002-10-31 2003-10-28 Receptores de la neurotoxina botulinica b y su uso.

Country Status (10)

Country Link
US (2) US20040191887A1 (ja)
EP (1) EP1578382B1 (ja)
JP (2) JP2006512090A (ja)
AT (1) ATE442161T1 (ja)
AU (1) AU2003304419A1 (ja)
CA (1) CA2504532C (ja)
DE (1) DE60329225D1 (ja)
ES (1) ES2333319T3 (ja)
IL (1) IL167943A (ja)
WO (1) WO2005016233A2 (ja)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2333319T3 (es) * 2002-10-31 2010-02-19 Wisconsin Alumni Research Foundation Receptores de la neurotoxina botulinica b y su uso.
US7341843B2 (en) * 2003-04-11 2008-03-11 Allergan, Inc. Botulinum toxin A peptides and methods of predicting and reducing immunoresistance to botulinum toxin therapy
US8748106B2 (en) * 2005-04-18 2014-06-10 Bal Ram Singh Methods of identifying a compound that increases or decreases the interaction of Hn-33 with synaptotagmin II
DE102005019302A1 (de) 2005-04-26 2006-11-16 Toxogen Gmbh Carrier zum Targeting von Nervenzellen
US7985554B2 (en) * 2005-10-14 2011-07-26 Wisconsin Alumni Research Foundation Botulinum neurotoxin A receptor and the use thereof
DE102005051789B4 (de) 2005-10-28 2014-08-07 Toxogen Gmbh Der Botulinus Neurotoxin A Proteinrezeptor und seine Anwendungen
EP2208067B1 (en) 2007-09-14 2019-02-06 BioMadison, Inc. Resonance energy transfer assay with cleavage sequence and spacer
US11325954B2 (en) 2011-06-01 2022-05-10 Biomadison, Inc. Compositions and methods for stability testing of botulinum toxin
EP2715355B1 (en) 2011-06-01 2017-03-08 Biomadison, Inc. Non-fret botulinum assay
US10908146B2 (en) 2011-06-01 2021-02-02 Biomadison, Inc. Compositions and methods for improving sensitivity in cell based assays
US9303285B2 (en) 2012-01-04 2016-04-05 Biomadison, Inc. Methods and compounds for increasing sensitivity of botulinum assays
ES2818986T5 (es) 2013-08-09 2024-01-25 Biomadison Inc Ensayo de toxina botulínica con sensibilidad mejorada
WO2023210585A1 (ja) * 2022-04-25 2023-11-02 株式会社Jiksak Bioengineering 標的化剤

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6994995B1 (en) * 2001-03-16 2006-02-07 Lexicon Genetics Incorporated Human synaptotagmin and polynucleotides encoding the same
US8022172B2 (en) * 2001-08-28 2011-09-20 Allergan, Inc. Luminescence resonance energy transfer (LRET) assays for clostridial toxin activity
US7176278B2 (en) * 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
ES2333319T3 (es) * 2002-10-31 2010-02-19 Wisconsin Alumni Research Foundation Receptores de la neurotoxina botulinica b y su uso.
EP2502930B1 (en) * 2003-12-19 2016-06-29 Wisconsin Alumni Research Foundation Method and compositions for detecting botulinum neurotoxin
ATE483158T1 (de) * 2005-04-05 2010-10-15 Allergan Inc Clostridientoxinaktivitätstests
ES2426194T3 (es) * 2005-08-02 2013-10-21 Planet Biotechnology, Inc. Proteínas quiméricas del receptor de toxina mejoradas y proteínas quiméricas del receptor de toxina para el tratamiento y la prevención de anthrax
US7985554B2 (en) * 2005-10-14 2011-07-26 Wisconsin Alumni Research Foundation Botulinum neurotoxin A receptor and the use thereof
WO2013011055A1 (en) * 2011-07-19 2013-01-24 ETH Zürich Means and methods for determining clostridial neurotoxins

Also Published As

Publication number Publication date
EP1578382A2 (en) 2005-09-28
DE60329225D1 (de) 2009-10-22
JP2006512090A (ja) 2006-04-13
IL167943A (en) 2010-12-30
US20120082672A1 (en) 2012-04-05
CA2504532C (en) 2014-09-16
JP2010006833A (ja) 2010-01-14
AU2003304419A1 (en) 2005-03-07
EP1578382A4 (en) 2007-08-29
EP1578382B1 (en) 2009-09-09
CA2504532A1 (en) 2005-02-24
US20040191887A1 (en) 2004-09-30
ATE442161T1 (de) 2009-09-15
US8617573B2 (en) 2013-12-31
WO2005016233A3 (en) 2005-08-18
AU2003304419A8 (en) 2005-03-07
WO2005016233A2 (en) 2005-02-24

Similar Documents

Publication Publication Date Title
US8617573B2 (en) Botulinum neurotoxin B receptors and use thereof
Dong et al. Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells
Wilde et al. The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is mediated by its tethered agonist
Rummel et al. The HCC‐domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction
US8450277B2 (en) Methods for reducing botulinum neurotoxin A toxicity
Ando et al. IRBIT, a novel inositol 1, 4, 5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor
Peng et al. Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors
Liu et al. Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2
US20140322730A1 (en) Botulinum Neurotoxin E Receptors and Uses Thereof
Zvaritch et al. A signal for endoplasmic reticulum retention located at the carboxyl terminus of the plasma membrane Ca2+-ATPase isoform 4CI
WO2017024204A1 (en) Engineered enzyme for enzyme replacement therapy
Sullivan et al. PACE-1, a novel protein that interacts with the C-terminal domain of ezrin
Yelin et al. Glycosylation of a vesicular monoamine transporter: a mutation in a conserved proline residue affects the activity, glycosylation, and localization of the transporter
US20230126796A1 (en) Functional and therapeutic effects of par4 cleavage by cathepsin g
JP4445291B2 (ja) 新規タンパク質およびそのｄｎａ
Rothemund et al. Lilian M. Demberg1, Jana Winkler1, Caroline Wilde1, Kay-Uwe Simon1, Julia Schön1, Sven
US20150268247A1 (en) Assay for Screening of Anti-Viral Compounds That Inhibit Specific Interaction Interfaces Between Cullin5 and an ElonginB/ElonginC/ CBF-beta/HIV-1 Vif Complex
Al Tobi Consequences of tyrosine phosphorylation of Syntaxin4 and Munc18c on GLUT4 trafficking
WO2021225781A2 (en) Aberrant post-translational modifications (ptms) in methyl- and propionic acidemia and a mutant sirtuin (sirt) to metabolize ptms
EP1536011A1 (en) Preventives/remedies for neurodegenerative diseases
Callan Early events in the biosynthesis of torsinA
Oran Defining sites of interaction in the Ã-chain of C3 for factor H, membrane cofactor protein (MCP), and complement receptor 1 (CR1)
CA2461065A1 (en) Transductin-1 and transductin-2 and applications to hereditary deafness