DE60329225D1 - Botulinumneurotoxin-b-rezeptoren und ihreverwendung - Google Patents

Botulinumneurotoxin-b-rezeptoren und ihreverwendung

Info

Publication number
DE60329225D1
DE60329225D1 DE60329225T DE60329225T DE60329225D1 DE 60329225 D1 DE60329225 D1 DE 60329225D1 DE 60329225 T DE60329225 T DE 60329225T DE 60329225 T DE60329225 T DE 60329225T DE 60329225 D1 DE60329225 D1 DE 60329225D1
Authority
DE
Germany
Prior art keywords
bont
syt
methods
binding
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60329225T
Other languages
English (en)
Inventor
Edwin Raymond Chapman
Min Dong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Application granted granted Critical
Publication of DE60329225D1 publication Critical patent/DE60329225D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • External Artificial Organs (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60329225T 2002-10-31 2003-10-28 Botulinumneurotoxin-b-rezeptoren und ihreverwendung Expired - Lifetime DE60329225D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42295102P 2002-10-31 2002-10-31
US49812803P 2003-08-27 2003-08-27
PCT/US2003/034348 WO2005016233A2 (en) 2002-10-31 2003-10-28 Botulinum neurotoxin b receptors and use thereof

Publications (1)

Publication Number Publication Date
DE60329225D1 true DE60329225D1 (de) 2009-10-22

Family

ID=34197667

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60329225T Expired - Lifetime DE60329225D1 (de) 2002-10-31 2003-10-28 Botulinumneurotoxin-b-rezeptoren und ihreverwendung

Country Status (10)

Country Link
US (2) US20040191887A1 (de)
EP (1) EP1578382B1 (de)
JP (2) JP2006512090A (de)
AT (1) ATE442161T1 (de)
AU (1) AU2003304419A1 (de)
CA (1) CA2504532C (de)
DE (1) DE60329225D1 (de)
ES (1) ES2333319T3 (de)
IL (1) IL167943A (de)
WO (1) WO2005016233A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2333319T3 (es) * 2002-10-31 2010-02-19 Wisconsin Alumni Research Foundation Receptores de la neurotoxina botulinica b y su uso.
US7341843B2 (en) * 2003-04-11 2008-03-11 Allergan, Inc. Botulinum toxin A peptides and methods of predicting and reducing immunoresistance to botulinum toxin therapy
US8748106B2 (en) * 2005-04-18 2014-06-10 Bal Ram Singh Methods of identifying a compound that increases or decreases the interaction of Hn-33 with synaptotagmin II
DE102005019302A1 (de) 2005-04-26 2006-11-16 Toxogen Gmbh Carrier zum Targeting von Nervenzellen
US7985554B2 (en) * 2005-10-14 2011-07-26 Wisconsin Alumni Research Foundation Botulinum neurotoxin A receptor and the use thereof
DE102005051789B4 (de) 2005-10-28 2014-08-07 Toxogen Gmbh Der Botulinus Neurotoxin A Proteinrezeptor und seine Anwendungen
EP2208067B1 (de) 2007-09-14 2019-02-06 BioMadison, Inc. Resonanzenergietransfer-testverfahren mit spaltsequenz und spacer
US11325954B2 (en) 2011-06-01 2022-05-10 Biomadison, Inc. Compositions and methods for stability testing of botulinum toxin
EP2715355B1 (de) 2011-06-01 2017-03-08 Biomadison, Inc. Nicht auf "fret" beruhender botulismusassay
US10908146B2 (en) 2011-06-01 2021-02-02 Biomadison, Inc. Compositions and methods for improving sensitivity in cell based assays
US9303285B2 (en) 2012-01-04 2016-04-05 Biomadison, Inc. Methods and compounds for increasing sensitivity of botulinum assays
ES2818986T5 (es) 2013-08-09 2024-01-25 Biomadison Inc Ensayo de toxina botulínica con sensibilidad mejorada
WO2023210585A1 (ja) * 2022-04-25 2023-11-02 株式会社Jiksak Bioengineering 標的化剤

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6994995B1 (en) * 2001-03-16 2006-02-07 Lexicon Genetics Incorporated Human synaptotagmin and polynucleotides encoding the same
US8022172B2 (en) * 2001-08-28 2011-09-20 Allergan, Inc. Luminescence resonance energy transfer (LRET) assays for clostridial toxin activity
US7176278B2 (en) * 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
ES2333319T3 (es) * 2002-10-31 2010-02-19 Wisconsin Alumni Research Foundation Receptores de la neurotoxina botulinica b y su uso.
EP2502930B1 (de) * 2003-12-19 2016-06-29 Wisconsin Alumni Research Foundation Verfahren und zusammensetzungen zum nachweis von botulinum-neurotoxin
ATE483158T1 (de) * 2005-04-05 2010-10-15 Allergan Inc Clostridientoxinaktivitätstests
ES2426194T3 (es) * 2005-08-02 2013-10-21 Planet Biotechnology, Inc. Proteínas quiméricas del receptor de toxina mejoradas y proteínas quiméricas del receptor de toxina para el tratamiento y la prevención de anthrax
US7985554B2 (en) * 2005-10-14 2011-07-26 Wisconsin Alumni Research Foundation Botulinum neurotoxin A receptor and the use thereof
WO2013011055A1 (en) * 2011-07-19 2013-01-24 ETH Zürich Means and methods for determining clostridial neurotoxins

Also Published As

Publication number Publication date
EP1578382A2 (de) 2005-09-28
JP2006512090A (ja) 2006-04-13
IL167943A (en) 2010-12-30
US20120082672A1 (en) 2012-04-05
CA2504532C (en) 2014-09-16
JP2010006833A (ja) 2010-01-14
AU2003304419A1 (en) 2005-03-07
EP1578382A4 (de) 2007-08-29
ES2333319T3 (es) 2010-02-19
EP1578382B1 (de) 2009-09-09
CA2504532A1 (en) 2005-02-24
US20040191887A1 (en) 2004-09-30
ATE442161T1 (de) 2009-09-15
US8617573B2 (en) 2013-12-31
WO2005016233A3 (en) 2005-08-18
AU2003304419A8 (en) 2005-03-07
WO2005016233A2 (en) 2005-02-24

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