ES2216055T3 - Metodos para reducir o mantener niveles reducidos de lipidos en sangre usando composiciones de proteina ob. - Google Patents
Metodos para reducir o mantener niveles reducidos de lipidos en sangre usando composiciones de proteina ob.Info
- Publication number
- ES2216055T3 ES2216055T3 ES96926873T ES96926873T ES2216055T3 ES 2216055 T3 ES2216055 T3 ES 2216055T3 ES 96926873 T ES96926873 T ES 96926873T ES 96926873 T ES96926873 T ES 96926873T ES 2216055 T3 ES2216055 T3 ES 2216055T3
- Authority
- ES
- Spain
- Prior art keywords
- methods
- lipids
- blood
- reduce
- reduced levels
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
SE PROPORCIONAN METODOS Y COMPOSICIONES RELACIONADAS CON EL USO DE LAS PROTEINAS OB PARA EL TRATAMIENTO DE ESTADOS RELACIONADOS CON LOS NIVELES DE LIPIDOS SANGUINEOS. ESTOS METODOS Y COMPOSICIONES INCLUYEN LOS QUE SON UTILES PARA EL TRATAMIENTO DE COLESTEROL ELEVADO, NIVELES DE TRIGLICERIDOS ELEVADOS, PLACA ARTERIAL, HIPERTENSION, Y PREVENCION DE FORMACION DE PIEDRAS DE LA VESICULA BILIAR.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51626395A | 1995-08-17 | 1995-08-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2216055T3 true ES2216055T3 (es) | 2004-10-16 |
Family
ID=24054813
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96926873T Expired - Lifetime ES2216055T3 (es) | 1995-08-17 | 1996-08-02 | Metodos para reducir o mantener niveles reducidos de lipidos en sangre usando composiciones de proteina ob. |
Country Status (13)
Country | Link |
---|---|
US (1) | US20020147142A1 (es) |
EP (1) | EP0865294B1 (es) |
JP (1) | JP4173913B2 (es) |
AT (1) | ATE259650T1 (es) |
AU (1) | AU6688896A (es) |
CA (1) | CA2229450A1 (es) |
DE (1) | DE69631605T2 (es) |
DK (1) | DK0865294T3 (es) |
ES (1) | ES2216055T3 (es) |
MX (1) | MX9801159A (es) |
PT (1) | PT865294E (es) |
WO (1) | WO1997006816A1 (es) |
ZA (1) | ZA966798B (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6429290B1 (en) | 1994-08-17 | 2002-08-06 | The Rockefeller University | OB polypeptides, modified forms and derivatives |
US6001968A (en) * | 1994-08-17 | 1999-12-14 | The Rockefeller University | OB polypeptides, modified forms and compositions |
JPH11508134A (ja) * | 1995-06-22 | 1999-07-21 | イーライ・リリー・アンド・カンパニー | 肥満症蛋白質中間体およびその製法と使用 |
US5830450A (en) * | 1996-06-19 | 1998-11-03 | Lallone; Roger L. | Compositions of leptin bound to an apolipoprotein |
US7332338B2 (en) | 1996-10-04 | 2008-02-19 | Lexicon Pharmaceuticals, Inc. | Vectors for making genomic modifications |
US20020019352A1 (en) * | 1997-04-17 | 2002-02-14 | David N. Brems | Stable, active, human ob protein compositions and methods |
US6017876A (en) | 1997-08-15 | 2000-01-25 | Amgen Inc. | Chemical modification of granulocyte-colony stimulating factor (G-CSF) bioactivity |
US6436707B1 (en) | 1998-03-27 | 2002-08-20 | Lexicon Genetics Incorporated | Vectors for gene mutagenesis and gene discovery |
US6808921B1 (en) | 1998-03-27 | 2004-10-26 | Lexicon Genetics Incorporated | Vectors for gene mutagenesis and gene discovery |
US6541033B1 (en) | 1998-06-30 | 2003-04-01 | Amgen Inc. | Thermosensitive biodegradable hydrogels for sustained delivery of leptin |
ATE280588T1 (de) * | 1998-08-10 | 2004-11-15 | Amgen Inc | Dextran-leptin konjugate, pharmazeutische zusammentsetzungen und verbundene verfahren |
US6210924B1 (en) | 1998-08-11 | 2001-04-03 | Amgen Inc. | Overexpressing cyclin D 1 in a eukaryotic cell line |
US6420339B1 (en) | 1998-10-14 | 2002-07-16 | Amgen Inc. | Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility |
US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
US8106098B2 (en) | 1999-08-09 | 2012-01-31 | The General Hospital Corporation | Protein conjugates with a water-soluble biocompatible, biodegradable polymer |
WO2001021647A2 (en) * | 1999-09-22 | 2001-03-29 | Genset | Methods of screening for compounds that modulate the lsr-leptin interaction and their use in the prevention and treatment of obesity-related diseases |
WO2003034996A2 (en) | 2001-10-22 | 2003-05-01 | Amgen, Inc. | Use of leptin for treating human lipoatrophy and method of determining predisposition to said treatment |
NZ534757A (en) | 2002-03-12 | 2006-07-28 | Merck & Co Inc | Substituted amides |
US20030191056A1 (en) | 2002-04-04 | 2003-10-09 | Kenneth Walker | Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins |
GB0307367D0 (en) * | 2003-03-29 | 2003-05-07 | Twg | Composition and method for treating the gastro-intestinal tract |
EP1462116A1 (en) * | 2003-03-29 | 2004-09-29 | Villitech SARL | Composition for treating the gastrointestinal tract |
JP2007517042A (ja) | 2003-12-30 | 2007-06-28 | デュレクト コーポレーション | 活性物質、好ましくはgnrhの制御放出のための、好ましくはpegおよびplgの混合物を含有するポリマーインプラント |
US8394765B2 (en) | 2004-11-01 | 2013-03-12 | Amylin Pharmaceuticals Llc | Methods of treating obesity with two different anti-obesity agents |
EP1814590B2 (en) | 2004-11-01 | 2013-12-11 | Amylin Pharmaceuticals, Inc. | Treatment of obesity and related disorders |
US7629315B2 (en) * | 2005-03-09 | 2009-12-08 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Compositions for blocking the inhibitory effect of human CRP on human leptin |
WO2009149379A2 (en) | 2008-06-05 | 2009-12-10 | Regents Of The University Of Michigan | Use of leptin for the treatment of fatty liver diseases and conditions |
WO2012050925A2 (en) | 2010-09-28 | 2012-04-19 | Amylin Pharmaceuticals, Inc. | Highly soluble leptins |
RS58010B1 (sr) | 2012-09-27 | 2019-02-28 | Childrens Medical Ct Corp | Jedinjenja za lečenje gojaznosti i postupci za njihovu upotrebu |
AU2014354831B2 (en) | 2013-11-26 | 2017-10-26 | The Children's Medical Center Corporation | Compounds for the treatment of obesity and methods of use thereof |
US20170209408A1 (en) | 2014-04-03 | 2017-07-27 | The Children's Medical Center Corporation | Hsp90 inhibitors for the treatment of obesity and methods of use thereof |
CA3036551A1 (en) | 2016-09-12 | 2018-03-15 | Aegerion Pharmaceuticals, Inc. | Methods of detecting anti-leptin neutralizing antibodies |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6309853B1 (en) * | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
-
1996
- 1996-08-02 CA CA002229450A patent/CA2229450A1/en not_active Abandoned
- 1996-08-02 PT PT96926873T patent/PT865294E/pt unknown
- 1996-08-02 AT AT96926873T patent/ATE259650T1/de not_active IP Right Cessation
- 1996-08-02 EP EP96926873A patent/EP0865294B1/en not_active Expired - Lifetime
- 1996-08-02 AU AU66888/96A patent/AU6688896A/en not_active Abandoned
- 1996-08-02 DE DE69631605T patent/DE69631605T2/de not_active Expired - Fee Related
- 1996-08-02 WO PCT/US1996/012674 patent/WO1997006816A1/en active IP Right Grant
- 1996-08-02 ES ES96926873T patent/ES2216055T3/es not_active Expired - Lifetime
- 1996-08-02 JP JP50931997A patent/JP4173913B2/ja not_active Expired - Fee Related
- 1996-08-02 DK DK96926873T patent/DK0865294T3/da active
- 1996-08-02 MX MX9801159A patent/MX9801159A/es not_active IP Right Cessation
- 1996-08-12 ZA ZA9606798A patent/ZA966798B/xx unknown
-
2001
- 2001-05-07 US US09/850,433 patent/US20020147142A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
PT865294E (pt) | 2004-07-30 |
US20020147142A1 (en) | 2002-10-10 |
AU6688896A (en) | 1997-03-12 |
EP0865294A1 (en) | 1998-09-23 |
JPH11511165A (ja) | 1999-09-28 |
DK0865294T3 (da) | 2004-06-28 |
EP0865294B1 (en) | 2004-02-18 |
MX9801159A (es) | 1998-05-31 |
CA2229450A1 (en) | 1997-02-27 |
ATE259650T1 (de) | 2004-03-15 |
WO1997006816A1 (en) | 1997-02-27 |
ZA966798B (en) | 1997-02-19 |
DE69631605D1 (de) | 2004-03-25 |
DE69631605T2 (de) | 2005-01-05 |
JP4173913B2 (ja) | 2008-10-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2216055T3 (es) | Metodos para reducir o mantener niveles reducidos de lipidos en sangre usando composiciones de proteina ob. | |
ATE202706T1 (de) | Verwendung von 9-deoxyprostaglandinderivaten zur behandlung von glaukom | |
DE69625691D1 (de) | Verabreichung von peptidylheterocyclen zur behandlung von thrombin in zusammenhang stehenden krankheiten | |
ATE198050T1 (de) | Therapeutische anwendungen von bpi-protein- produkten zur behandlung von humaner meningococcämia | |
ATE238038T1 (de) | Liposomale formulierungen von mitoxantron | |
CY1112927T1 (el) | Αντισωματα κατα της ανθρωπινης il-12 | |
MXPA03006771A (es) | Anticuerpos modificados y metodos de uso. | |
DK1329458T3 (da) | Peptider som sænker blodglucoseniveauer | |
WO1998033509A3 (en) | Useful properties of human lactoferrin and variants thereof | |
ATE116848T1 (de) | Verwendung von baclofen zur herstellung von arzneimitteln zur behandlung von angina pectoris. | |
DE69806801T2 (de) | Galenische präparation zur prävention und behandlung von hepatokarzinomen | |
DE69822496D1 (de) | Lipidkomplex-lyophilisat von wasserunlöslichen porphyrinen | |
DK0858504T3 (da) | Diagnostiske midler mod og behandlinger af periodontale sygdomme | |
DE69405919T2 (de) | Zusammensetzungen zur Behandlung von Keratinfasern | |
MX9101958A (es) | Inhibidores de acat de urea de aminosulfonilo | |
DE69739190D1 (de) | Arzneimittel zur behandlung von oculären kreislauferkrankungen | |
DE69829995D1 (de) | Multivalente rekombinante antikörper zur behandlung von hrv infektionen | |
ATE211650T1 (de) | Verwendung von topische präparationen mit glyceryl trinitrat und lanolin zur behandlung von erektilen funktionsstörungen | |
DE59805246D1 (de) | Tissue-faktor zur beeinflussung von gefässbildung | |
DE69734349D1 (de) | Behandlung von knochenleiden mit adrenomedullin | |
NO992531L (no) | Fremgangsmåter ved fremstilling av rekombinant protein | |
EA199800953A1 (ru) | Компонент в, используемый в качестве рубцующего агента, содержащая его фармацевтическая композиция и способ лечения | |
ITMI940414A0 (it) | Procedimento per la coniugazione di proteine di interesse terapeutico o diagnostico | |
UA9703A (uk) | Антипротеіназний засіб | |
DE9321428U1 (de) | Konservierte Polysiloxanemulsionen zur Behandlung von Tissues |