ES2197792B1 - Formulaciones farmaceuticas que contienen morfina intranasal. - Google Patents
Formulaciones farmaceuticas que contienen morfina intranasal.Info
- Publication number
- ES2197792B1 ES2197792B1 ES200150086A ES200150086A ES2197792B1 ES 2197792 B1 ES2197792 B1 ES 2197792B1 ES 200150086 A ES200150086 A ES 200150086A ES 200150086 A ES200150086 A ES 200150086A ES 2197792 B1 ES2197792 B1 ES 2197792B1
- Authority
- ES
- Spain
- Prior art keywords
- morphine
- formulation
- formulations containing
- pharmaceutical formulations
- pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title abstract 10
- 229960005181 morphine Drugs 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000013011 aqueous formulation Substances 0.000 abstract 1
- 239000006071 cream Substances 0.000 abstract 1
- 239000002270 dispersing agent Substances 0.000 abstract 1
- 239000003623 enhancer Substances 0.000 abstract 1
- 239000000499 gel Substances 0.000 abstract 1
- 239000003906 humectant Substances 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229940124531 pharmaceutical excipient Drugs 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000002562 thickening agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Formulaciones farmacéuticas que contienen morfina
intranasal.
Formulación farmacéutica para la administración
intranasal que contiene morfina op una sal farmacéuticamente
aceptable de la misma, con un pH que oscila entre 3,0 y 7,0, y que
en cantidad terapéuticamente eficaz sirve para obtener una
respuesta analfésica o anestésica en un mamífero. Dicha formulación
puede contener morfina o sal farmacéuticamente aceptable de la
misma, en combinación con un sistema de administración nasal,
dispersante en una formulación acuosa o no acuosa, suspensiones,
soluciones, polvos, geles, ungüentos y cremas. El sistema de
administración nasal comprende un tempón para mantener el pH de la
morfina o de una sal farmacéuticamente aceptable de la misma, un
agente espesante, un humectante, un intensificador de la absorción
y combinaciones de los mismos. La formulación comprende además uno
o más excipientes farmacéuticos y un conservante.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33453799A | 1999-06-16 | 1999-06-16 | |
US09/334537 | 1999-06-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2197792A1 ES2197792A1 (es) | 2004-01-01 |
ES2197792B1 true ES2197792B1 (es) | 2005-05-01 |
Family
ID=23307687
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200150086A Expired - Lifetime ES2197792B1 (es) | 1999-06-16 | 2000-05-23 | Formulaciones farmaceuticas que contienen morfina intranasal. |
Country Status (30)
Country | Link |
---|---|
US (1) | US6677346B1 (es) |
EP (2) | EP1419774A1 (es) |
JP (1) | JP2003501467A (es) |
KR (1) | KR20020016831A (es) |
AU (1) | AU774175B2 (es) |
BG (1) | BG106221A (es) |
BR (1) | BR0012082A (es) |
CA (1) | CA2374877C (es) |
CZ (1) | CZ20014399A3 (es) |
DE (1) | DE10084709T1 (es) |
DK (1) | DK200101859A (es) |
EE (1) | EE200100677A (es) |
ES (1) | ES2197792B1 (es) |
FI (1) | FI20012462A (es) |
GB (1) | GB2367005A (es) |
HR (1) | HRP20010926A2 (es) |
HU (1) | HUP0201856A3 (es) |
IS (1) | IS6202A (es) |
LT (1) | LT4976B (es) |
LU (1) | LU90859B1 (es) |
LV (1) | LV12859B (es) |
MX (1) | MXPA01012879A (es) |
NO (1) | NO20015931L (es) |
NZ (1) | NZ515783A (es) |
PL (1) | PL352556A1 (es) |
SE (1) | SE0104203L (es) |
SI (1) | SI20850A (es) |
SK (1) | SK18172001A3 (es) |
TR (1) | TR200103613T2 (es) |
WO (1) | WO2000076506A1 (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9924797D0 (en) | 1999-10-20 | 1999-12-22 | West Pharm Serv Drug Res Ltd | Compound |
US20040115133A1 (en) * | 2000-05-10 | 2004-06-17 | Wermeling Daniel P. | Intranasal opioid compositions |
US20060083691A1 (en) * | 2000-05-10 | 2006-04-20 | Wermeling Daniel P | Intranasal opioid compositions, delivery devices and methods of using same |
AU2001291159A1 (en) * | 2000-09-20 | 2002-04-02 | Shahinian Jr., Lee | Self-preserved nasal, inhalable, and topical ophthalmic preparations and medications |
AU2002303148A1 (en) * | 2001-06-29 | 2003-03-03 | Leon J. Lewandowski | Individualized addiction cessation therapy |
GB0210264D0 (en) * | 2002-05-03 | 2002-06-12 | Arakis Ltd | The treatment of pain and migraine headache |
US20040102476A1 (en) * | 2002-11-25 | 2004-05-27 | Chan Tai Wah | High concentration formulations of opioids and opioid derivatives |
US20050175679A1 (en) * | 2004-02-10 | 2005-08-11 | Michael Moshman | Controlled release formulations |
US20140162965A1 (en) | 2004-08-25 | 2014-06-12 | Aegis Therapeutics, Inc. | Compositions for oral drug administration |
US9895444B2 (en) | 2004-08-25 | 2018-02-20 | Aegis Therapeutics, Llc | Compositions for drug administration |
DK2522365T3 (en) | 2004-11-24 | 2017-02-06 | Meda Pharmaceuticals Inc | Compositions comprising azelastine and methods for its use |
US9415034B2 (en) * | 2005-01-05 | 2016-08-16 | National Defense Medical Center | Inhibitors and enhancers of uridine diphosphate-glucuronosyltransferase 2B (UGT2B) |
ES2277743B2 (es) * | 2005-06-02 | 2008-12-16 | Universidade De Santiago De Compostela | Nanoparticulas que comprenden quitosano y ciclodextrina. |
JP2009506076A (ja) * | 2005-08-26 | 2009-02-12 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・レランド・スタンフォード・ジュニア・ユニバーシティ | 三叉神経疼痛のための薬物送達のための治療手順 |
US20070212307A1 (en) * | 2006-02-10 | 2007-09-13 | Daniel Wermeling | Pharmaceutical Compositions Comprising an Opioid Receptor Antagonist and Methods of Using Same |
US8226949B2 (en) | 2006-06-23 | 2012-07-24 | Aegis Therapeutics Llc | Stabilizing alkylglycoside compositions and methods thereof |
BRPI0720434A2 (pt) * | 2006-12-22 | 2014-01-07 | Sigma Tau Ind Farmaceuti | Gel útil para liberação de fármacos oftálmicos |
GB2477545B (en) * | 2010-02-05 | 2011-12-21 | Special Products Ltd | A liquid morphine composition for buccal administration |
ME02958B (me) | 2011-05-13 | 2018-07-20 | Euro Celtique Sa | Intranazalni farmaceutski dozni oblici коji obuhvataju nalokson |
WO2014016653A1 (en) | 2012-07-26 | 2014-01-30 | Wockhardt Limited | Pharmaceutical composition comprising diamorphine for intranasal administration |
EP3082817A4 (en) * | 2013-12-18 | 2017-06-21 | Aegis Therapeutics, LLC | Compositions for drug administration |
US11135155B2 (en) | 2014-07-08 | 2021-10-05 | Hikma Pharmaceuticals Usa Inc. | Liquid naloxone spray |
RS65034B1 (sr) | 2015-01-07 | 2024-02-29 | Tonix Pharma Ltd | Formulacije oksitocina koje sadrže magnezijum i postupci za njihovu upotrebu |
AU2017345765A1 (en) * | 2016-10-21 | 2019-06-06 | Somniferum Labs LLC | Compositions, methods and kits for the safe inhaled delivery of targeted opioids for the treatment of pain and addiction |
KR102660711B1 (ko) * | 2017-10-20 | 2024-04-26 | 키에시 파르마슈티시 엣스. 피. 에이. | 활성 성분으로서 오피오이드 수용체 효능제를 포함하는 약제학적 제제, 그의 제조 방법 및 치료적 사용 |
EA202091615A1 (ru) | 2018-12-21 | 2021-03-05 | Аегис Терапьютикс, Ллс | Интраназальные составы на основе эпинефрина и способы лечения заболевания |
CN115804754A (zh) * | 2022-12-16 | 2023-03-17 | 广州新济药业科技有限公司 | ***鼻喷剂及其制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4464378A (en) | 1981-04-28 | 1984-08-07 | University Of Kentucky Research Foundation | Method of administering narcotic antagonists and analgesics and novel dosage forms containing same |
US4464376A (en) | 1982-07-22 | 1984-08-07 | Richardson-Vicks, Inc. | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
GB8514665D0 (en) * | 1985-06-11 | 1985-07-10 | Eroceltique Sa | Oral pharmaceutical composition |
US5202128A (en) | 1989-01-06 | 1993-04-13 | F. H. Faulding & Co. Limited | Sustained release pharmaceutical composition |
GB9202464D0 (en) * | 1992-02-05 | 1992-03-18 | Danbiosyst Uk | Composition for nasal administration |
ATE290864T1 (de) * | 1993-03-26 | 2005-04-15 | Franciscus Wilhelmus He Merkus | Pharmazeutische zusammensetzungen zur intranasalen verabreichung von dihydroergotamin |
GB9426102D0 (en) | 1994-12-23 | 1995-02-22 | Merck Sharp & Dohme | Pharmacuetical compositions |
US5874450A (en) * | 1996-09-27 | 1999-02-23 | Nastech Pharmaceutical Company, Inc. | Intranasal formulations for promoting sleep and method of using the same |
-
2000
- 2000-05-23 DE DE10084709T patent/DE10084709T1/de not_active Ceased
- 2000-05-23 NZ NZ515783A patent/NZ515783A/en unknown
- 2000-05-23 SI SI200020030A patent/SI20850A/sl not_active IP Right Cessation
- 2000-05-23 TR TR2001/03613T patent/TR200103613T2/xx unknown
- 2000-05-23 HU HU0201856A patent/HUP0201856A3/hu unknown
- 2000-05-23 EP EP04001252A patent/EP1419774A1/en not_active Withdrawn
- 2000-05-23 AU AU51561/00A patent/AU774175B2/en not_active Ceased
- 2000-05-23 PL PL00352556A patent/PL352556A1/xx not_active Application Discontinuation
- 2000-05-23 MX MXPA01012879A patent/MXPA01012879A/es unknown
- 2000-05-23 EE EEP200100677A patent/EE200100677A/xx unknown
- 2000-05-23 CZ CZ20014399A patent/CZ20014399A3/cs unknown
- 2000-05-23 SK SK1817-2001A patent/SK18172001A3/sk unknown
- 2000-05-23 ES ES200150086A patent/ES2197792B1/es not_active Expired - Lifetime
- 2000-05-23 WO PCT/US2000/014157 patent/WO2000076506A1/en not_active Application Discontinuation
- 2000-05-23 EP EP00936212A patent/EP1183027A4/en not_active Withdrawn
- 2000-05-23 JP JP2001502839A patent/JP2003501467A/ja active Pending
- 2000-05-23 KR KR1020017016009A patent/KR20020016831A/ko not_active Application Discontinuation
- 2000-05-23 CA CA002374877A patent/CA2374877C/en not_active Expired - Fee Related
- 2000-05-23 GB GB0128383A patent/GB2367005A/en not_active Withdrawn
- 2000-05-23 BR BR0012082-0A patent/BR0012082A/pt not_active IP Right Cessation
- 2000-06-15 US US09/594,916 patent/US6677346B1/en not_active Expired - Fee Related
-
2001
- 2001-12-04 NO NO20015931A patent/NO20015931L/no not_active Application Discontinuation
- 2001-12-12 DK DK200101859A patent/DK200101859A/da not_active Application Discontinuation
- 2001-12-13 HR HR20010926A patent/HRP20010926A2/hr not_active Application Discontinuation
- 2001-12-13 FI FI20012462A patent/FI20012462A/fi not_active IP Right Cessation
- 2001-12-13 LT LT2001119A patent/LT4976B/lt not_active IP Right Cessation
- 2001-12-13 LU LU90859A patent/LU90859B1/en active
- 2001-12-14 IS IS6202A patent/IS6202A/is unknown
- 2001-12-14 SE SE0104203A patent/SE0104203L/ not_active Application Discontinuation
- 2001-12-14 BG BG106221A patent/BG106221A/xx unknown
-
2002
- 2002-01-18 LV LVP-01-169A patent/LV12859B/en unknown
Non-Patent Citations (1)
Title |
---|
VERWEIJ, S.L. et al. Can morphine be administered nasally?. Ziekenhuisfarmacie, 1988, nº 4, páginas 73-77. * |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 20040101 Kind code of ref document: A1 |
|
FG2A | Definitive protection |
Ref document number: 2197792B1 Country of ref document: ES |
|
FA2A | Application withdrawn |
Effective date: 20051018 |