ES2196153T3 - Vacunas de conjugados de polisacaridos menmingococicos modificados. - Google Patents

Vacunas de conjugados de polisacaridos menmingococicos modificados.

Info

Publication number
ES2196153T3
ES2196153T3 ES96917303T ES96917303T ES2196153T3 ES 2196153 T3 ES2196153 T3 ES 2196153T3 ES 96917303 T ES96917303 T ES 96917303T ES 96917303 T ES96917303 T ES 96917303T ES 2196153 T3 ES2196153 T3 ES 2196153T3
Authority
ES
Spain
Prior art keywords
modified
polisacarids
polysacarids
menmingococices
vaccines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96917303T
Other languages
English (en)
Inventor
Harold J Jennings
Robert Pon
Michele Lussier
Francis Michon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Council of Canada
Original Assignee
National Research Council of Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Council of Canada filed Critical National Research Council of Canada
Application granted granted Critical
Publication of ES2196153T3 publication Critical patent/ES2196153T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/831—Drug, bio-affecting and body treating compositions involving capsular polysaccharide of bacterium, e.g. polyribosyl ribitol phosphate

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A POLISACARIDOS DEL GRUPO B QUIMICAMENTE MODIFICADOS DE NEISSERIA MENINGITIDIS. LA INVENCION PROPORCIONA ASIMISMO VACUNAS EN LAS QUE LOS CORRESPONDIENTES POLISACARIDOS MODIFICADOS ESTAN CONJUGADOS A UNA PROTEINA VEHICULO Y SIMILARES. MAS ESPECIFICAMENTE, LA PRESENTE INVENCION PROPORCIONA NUEVOS POLISACARIDOS DERIVADOS DE N MENINGOCOCALES DEL GRUPO B, NUEVOS CONJUGADOS DE POLISACARIDOS DERIVADOS DE N COMPOSICIONES FARMACEUTICAS QUE CONTIENEN MOLECULAS CONJUGADAS DE FRAGMENTOS DE POLISACARIDOS DERIVADOS DE N DOS MENINGOCOCALES DEL GRUPO B UNIDOS COVALENTEMENTE A PROTEINAS, Y EL USO DE ESTAS COMPOSICIONES COMO VACUNAS.
ES96917303T 1995-06-07 1996-06-07 Vacunas de conjugados de polisacaridos menmingococicos modificados. Expired - Lifetime ES2196153T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/484,569 US5811102A (en) 1995-06-07 1995-06-07 Modified meningococcal polysaccharide conjugate vaccines

Publications (1)

Publication Number Publication Date
ES2196153T3 true ES2196153T3 (es) 2003-12-16

Family

ID=23924694

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96917303T Expired - Lifetime ES2196153T3 (es) 1995-06-07 1996-06-07 Vacunas de conjugados de polisacaridos menmingococicos modificados.

Country Status (18)

Country Link
US (4) US5811102A (es)
EP (1) EP0831898B1 (es)
JP (2) JP4171068B2 (es)
KR (1) KR100452475B1 (es)
CN (1) CN1163270C (es)
AT (1) ATE238064T1 (es)
AU (1) AU706053B2 (es)
BR (1) BR9609229A (es)
CA (1) CA2223567C (es)
CZ (1) CZ391497A3 (es)
DE (1) DE69627652T2 (es)
ES (1) ES2196153T3 (es)
HU (1) HU224972B1 (es)
IL (3) IL118604A0 (es)
NO (1) NO321705B1 (es)
PL (1) PL184125B1 (es)
WO (1) WO1996040239A1 (es)
ZA (1) ZA964823B (es)

Families Citing this family (30)

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US7655699B1 (en) 1992-04-22 2010-02-02 Eisai Inc. Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
US20030157129A1 (en) * 1995-06-23 2003-08-21 Smithkline Beecham Biologicals S.A. Vaccine comprising a polysaccharide antigen - carrier protein conjugate and free carrier protein
ATE252602T1 (de) * 1996-08-27 2003-11-15 Chiron Corp Meningokokkus b-epitop ausbildende monoklonale antikoerper und deren verwendung zur herstellung von impfstoffzusammenstellungen
PT939647E (pt) * 1996-08-27 2002-04-29 Chiron Corp Glicpconjugados do serogrupo b de neisseria meningitidis e metodos de utilizacao dos mesmos
US6299881B1 (en) * 1997-03-24 2001-10-09 Henry M. Jackson Foundation For The Advancement Of Military Medicine Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts
CZ302615B6 (cs) * 1997-12-23 2011-08-03 Baxter Healthcare S.A. Zpusob cištení kapsulárních polysacharidu od bunecných komponent gramnegativních a grampozitivních bakterií a modifikovaný kapsulární polysacharid
HUP0103100A3 (en) * 1998-08-19 2005-11-28 Baxter Healthcare Sa Immunogenic betha-propionamido-linked polysaccharide protein conjugate useful as a vaccine produced using an n-acryloylated polysaccharide
US6585973B1 (en) * 1998-10-29 2003-07-01 Henry M. Jackson Foundation For The Advancement Of Military Medicine Method for preparing solid phase conjugated vaccine
CA2279134A1 (en) * 1999-07-29 2001-01-29 Tianmin Liu Novel strategy for carbohydrate-based therapeutic vaccines
WO2002009744A2 (en) * 2000-07-28 2002-02-07 National Research Council Of Canada Modified sialic acid vaccines
GB0024200D0 (en) * 2000-10-03 2000-11-15 Smithkline Beecham Sa Component vaccine
ES2388848T3 (es) 2001-01-23 2012-10-19 Sanofi Pasteur Inc. Vacuna meningocócica polivalente preparada con un conjugado de polisacárido y proteína
WO2002083711A2 (en) * 2001-04-17 2002-10-24 Chiron Corporation Molecular mimetics of meningococcal b epitopes which elicit functionally active antibodies
GB0115176D0 (en) * 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
GB0130215D0 (en) * 2001-12-18 2002-02-06 Glaxosmithkline Biolog Sa Vaccine
AU2003257003A1 (en) * 2002-07-30 2004-02-16 Baxter Healthcare S.A. Chimeric multivalent polysaccharide conjugate vaccines
DK1587537T3 (da) 2003-01-30 2012-07-16 Novartis Ag Injicerbare vacciner mod multiple meningococ-serogrupper
BRPI0411815A (pt) * 2003-06-23 2006-08-08 Baxter Int vacinas contra neisseria meningitidis do tipo y e suas combinações meningocócicas
KR20070060069A (ko) * 2004-06-23 2007-06-12 칠드런즈 하스피틀 앤드 리써치 센터 앳 오클랜드 다당류 유도체 및 면역반응의 유도에서의 용도
US8148335B2 (en) * 2004-06-23 2012-04-03 Children's Hospital & Research Center Oakland De-N-acetyl sialic acid antigens, antibodies thereto, and methods of use in cancer therapy
EP1863536A4 (en) * 2005-03-14 2011-07-20 Univ Alberta VACCINE BASED ON SYNTHETIC OLIGOSACCHARIDES AGAINST CANDIDA ALBICANS
US20070184072A1 (en) * 2005-04-08 2007-08-09 Wyeth Multivalent pneumococcal polysaccharide-protein conjugate composition
US7709001B2 (en) * 2005-04-08 2010-05-04 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
US20080026002A1 (en) 2006-03-22 2008-01-31 Lisa Danzig Regimens for immunisation with meningococcal conjugates
US10828361B2 (en) * 2006-03-22 2020-11-10 Glaxosmithkline Biologicals Sa Regimens for immunisation with meningococcal conjugates
US8414899B2 (en) * 2006-04-11 2013-04-09 Yeda Research And Development Co. Ltd. Vaccines comprising multimeric HSP60 peptide carriers
GB0611914D0 (en) * 2006-06-15 2006-07-26 Teti Giuseppe Peptides that mimic non-human cross-reactive protective epitopes of the group Bmeningococcal capsulsar polysaccharide
EP2066344B2 (en) 2006-09-07 2016-06-29 GlaxoSmithKline Biologicals S.A. Inactivated Poliovirus combination vaccine
US20100189740A1 (en) * 2007-06-20 2010-07-29 Francis Michon Modified polysaccharides for conjugate vaccines
EP2383035A4 (en) 2008-12-03 2017-11-22 Kaneka Corporation Formyl group-containing porous support, adsorbent using same, method for producing same, and method for producing the adsorbent

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
US4057685A (en) * 1972-02-02 1977-11-08 Abbott Laboratories Chemically modified endotoxin immunizing agent
US4356170A (en) * 1981-05-27 1982-10-26 Canadian Patents & Development Ltd. Immunogenic polysaccharide-protein conjugates
US4902506A (en) * 1983-07-05 1990-02-20 The University Of Rochester Immunogenic conjugates
US4673574A (en) * 1981-08-31 1987-06-16 Anderson Porter W Immunogenic conjugates
US4644059A (en) * 1982-07-06 1987-02-17 Connaught Laboratories, Inc. Haemophilus influenzae B polysaccharide-diptheria toxoid conjugate vaccine
US4496538A (en) * 1982-07-06 1985-01-29 Connaught Laboratories, Inc. Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine
US4619828A (en) * 1982-07-06 1986-10-28 Connaught Laboratories, Inc. Polysaccharide exotoxoid conjugate vaccines
NZ214503A (en) * 1984-12-20 1990-02-26 Merck & Co Inc Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins, and methods of preparing such polysaccharides and conjugates
US4601903A (en) 1985-05-01 1986-07-22 The United States Of America As Represented By The Department Of Health And Human Services Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease
US4727136A (en) * 1985-10-01 1988-02-23 Canadian Patents And Development Ltd. Modified meningococcal group B polysaccharide for conjugate vaccine
US5034516A (en) * 1987-08-04 1991-07-23 University Of Ottawa Synthetic antigens of sialic acid and derivatives thereof
ATE120093T1 (de) 1988-12-19 1995-04-15 Praxis Biolog Inc Meningococcales klasse i-aussenmembranprotein- vakzin.
DK0504202T3 (da) * 1989-12-14 1995-10-02 Ca Nat Research Council Forbedret meningokok-polysaccharid-konjugat vaccine
FI903414A (fi) 1990-07-06 1992-01-07 Kansanterveyslaitos Produktion av proteiner i grampositiva bakterier.
FR2682388B1 (fr) * 1991-10-10 1995-06-09 Pasteur Merieux Serums Vacc Procede de preparation d'un oligoside par depolymerisation d'un polyoside issu d'un agent pathogene, oligoside ainsi obtenu et son utilisation notamment comme agent vaccinal.
US5425946A (en) * 1992-08-31 1995-06-20 North American Vaccine, Inc. Vaccines against group C Neisseria meningitidis
US5780606A (en) * 1995-06-07 1998-07-14 Connaught Laboratories Limited Neisseria meningitidis capsular polysaccharide conjugates
ATE252602T1 (de) * 1996-08-27 2003-11-15 Chiron Corp Meningokokkus b-epitop ausbildende monoklonale antikoerper und deren verwendung zur herstellung von impfstoffzusammenstellungen

Also Published As

Publication number Publication date
HUP9802664A3 (en) 1999-12-28
ZA964823B (en) 1997-08-01
JPH11506491A (ja) 1999-06-08
CN1187136A (zh) 1998-07-08
US6596283B2 (en) 2003-07-22
HUP9802664A2 (hu) 1999-02-01
IL147121A0 (en) 2002-08-14
IL147121A (en) 2009-07-20
JP4171068B2 (ja) 2008-10-22
NO975547L (no) 1998-02-09
US6350449B1 (en) 2002-02-26
US20020031511A1 (en) 2002-03-14
ATE238064T1 (de) 2003-05-15
BR9609229A (pt) 1999-07-27
WO1996040239A1 (en) 1996-12-19
AU706053B2 (en) 1999-06-10
HU224972B1 (en) 2006-04-28
IL118604A0 (en) 1996-10-16
KR100452475B1 (ko) 2004-12-30
US5811102A (en) 1998-09-22
PL323862A1 (en) 1998-04-27
AU5993796A (en) 1996-12-30
PL184125B1 (pl) 2002-09-30
JP2008285675A (ja) 2008-11-27
NO321705B1 (no) 2006-06-26
CN1163270C (zh) 2004-08-25
DE69627652T2 (de) 2004-02-12
DE69627652D1 (de) 2003-05-28
EP0831898B1 (en) 2003-04-23
CA2223567C (en) 2009-02-03
NO975547D0 (no) 1997-12-02
CA2223567A1 (en) 1996-12-19
EP0831898A1 (en) 1998-04-01
KR19990022748A (ko) 1999-03-25
CZ391497A3 (cs) 1998-05-13
US5969130A (en) 1999-10-19

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