ES2196034T3 - Aparato y procedimiento de deteccion de un ligando blanco. - Google Patents
Aparato y procedimiento de deteccion de un ligando blanco.Info
- Publication number
- ES2196034T3 ES2196034T3 ES94930509T ES94930509T ES2196034T3 ES 2196034 T3 ES2196034 T3 ES 2196034T3 ES 94930509 T ES94930509 T ES 94930509T ES 94930509 T ES94930509 T ES 94930509T ES 2196034 T3 ES2196034 T3 ES 2196034T3
- Authority
- ES
- Spain
- Prior art keywords
- reaction
- chamber
- detection
- detection chamber
- detection unit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0636—Integrated biosensor, microarrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0822—Slides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1838—Means for temperature control using fluid heat transfer medium
- B01L2300/1844—Means for temperature control using fluid heat transfer medium using fans
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0442—Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5082—Test tubes per se
- B01L3/50825—Closing or opening means, corks, bungs
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
- G01N2001/282—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on with mapping; Identification of areas; Spatial correlated pattern
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
- G01N2035/00742—Type of codes
- G01N2035/00752—Type of codes bar codes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Clinical Laboratory Science (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Fire Alarms (AREA)
Abstract
SE PROPORCIONAN METODOS, DISPOSITIVOS, APARATOS Y KITS PARA AMPLIFICAR Y DETECTAR LIGANDOS COMO ACIDOS NUCLEICOS. EL APARATO PUEDE SER UN DISPOSITIVO DE CICLO TERMICO DE DOS FILAS QUE PUEDE OPERAR EN CONJUNCION CON UNA UNIDAD DE REACCION/DETECCION HERMETICA. UNA MUESTRA SE CARGA EN UNA CAMARA DE REACCION DEL DISPOSITIVO QUE A CONTINUACION ES ACOPLADA CON UNA CAMARA DE DETECCION PARA FORMAR LA UNIDAD DE REACCION/DETECCION. LA MEZCLA DE REACCION PUEDE TRANSFERIRSE A LA CAMARA DE DETECCION MEDIANTE UN ELEMENTO DE CALENTAMIENTO Y EXPANSION DE UN FLUIDO. EL LIGANDO DIANA SE INMOVILIZA EN UNA DISPOSICION PREDETERMINADA SOBRE UNA BASE EN LA CAMARA DE DETECCION. UN SISTEMA DE ADQUISICION DE IMAGENES DE VIDEO ASOCIADO AL APARATO DETECTA Y ANALIZA EL LIGANDO INMOVILIZADO. LAS IMAGENES SE CAPTURAN, DIGITALIZAN Y SE SOMETEN A UN ANALISIS ESTADISTICO PARA MEJORAR LA PRECISION DEL METODO DE ADQUISICION DE IMAGENES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14038393A | 1993-10-21 | 1993-10-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2196034T3 true ES2196034T3 (es) | 2003-12-16 |
Family
ID=22490987
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94930509T Expired - Lifetime ES2196034T3 (es) | 1993-10-21 | 1994-09-28 | Aparato y procedimiento de deteccion de un ligando blanco. |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0724725B1 (es) |
JP (1) | JP3457322B2 (es) |
AT (1) | ATE236400T1 (es) |
AU (1) | AU7960494A (es) |
CA (1) | CA2174330C (es) |
DE (1) | DE69432424T2 (es) |
ES (1) | ES2196034T3 (es) |
WO (1) | WO1995011454A1 (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5700695A (en) * | 1994-06-30 | 1997-12-23 | Zia Yassinzadeh | Sample collection and manipulation method |
US6143496A (en) | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
US7348181B2 (en) * | 1997-10-06 | 2008-03-25 | Trustees Of Tufts College | Self-encoding sensor with microspheres |
US6723290B1 (en) | 1998-03-07 | 2004-04-20 | Levine Robert A | Container for holding biologic fluid for analysis |
US8337753B2 (en) | 1998-05-01 | 2012-12-25 | Gen-Probe Incorporated | Temperature-controlled incubator having a receptacle mixing mechanism |
ATE423622T1 (de) | 1998-05-01 | 2009-03-15 | Gen Probe Inc | Automatisches isolierungs- und amplifizierungsverfahren für eine zielnukleinsäuresequenz |
US6845913B2 (en) | 1999-02-11 | 2005-01-25 | Flir Systems, Inc. | Method and apparatus for barcode selection of themographic survey images |
JP3957118B2 (ja) * | 1999-05-18 | 2007-08-15 | 富士フイルム株式会社 | 試験片およびこの試験片からの画像情報読取装置 |
JP4628095B2 (ja) * | 2002-05-29 | 2011-02-09 | オウトジエノミクス・インコーポレーテツド | 統合されたマイクロアレイシステムおよびその製造方法 |
US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
US20070045902A1 (en) | 2004-07-13 | 2007-03-01 | Brauker James H | Analyte sensor |
US8170803B2 (en) | 2004-07-13 | 2012-05-01 | Dexcom, Inc. | Transcutaneous analyte sensor |
EP2322940B1 (en) | 2005-03-10 | 2014-10-29 | Gen-Probe Incorporated | Systems amd methods to perform assays for detecting or quantifing analytes within samples |
JP4854334B2 (ja) | 2006-03-06 | 2012-01-18 | 三洋電機株式会社 | 核酸増幅生成物のリアルタイム検出装置 |
CN1888902B (zh) * | 2006-08-11 | 2011-05-18 | 杭州优思达生物技术有限公司 | 全封闭式靶核酸扩增物快速检测装置 |
CA2715628A1 (en) | 2008-02-21 | 2009-08-27 | Dexcom, Inc. | Systems and methods for processing, transmitting and displaying sensor data |
BRPI1014469A2 (pt) | 2009-04-14 | 2017-06-27 | Biocartis Sa | cavitação induzida hifu com limiar de energia reduzido |
JP5758877B2 (ja) | 2009-04-15 | 2015-08-05 | ビオカルティ ナームローゼ フェノーツハップBiocartis NV | 生体分析試料室の保護 |
WO2010118541A1 (en) | 2009-04-15 | 2010-10-21 | Biocartis Sa | OPTICAL DETECTION SYSTEM FOR MONITORING rtPCR REACTION |
EP2427270B1 (en) | 2009-05-06 | 2015-04-01 | Biocartis NV | Device for cutting a sample carrier |
US9131885B2 (en) | 2009-07-02 | 2015-09-15 | Dexcom, Inc. | Analyte sensors and methods of manufacturing same |
US9351677B2 (en) | 2009-07-02 | 2016-05-31 | Dexcom, Inc. | Analyte sensor with increased reference capacity |
WO2011075667A2 (en) | 2009-12-18 | 2011-06-23 | Abbott Point Of Care, Inc. | Biologic fluid analysis cartridge |
US9199233B2 (en) | 2010-03-31 | 2015-12-01 | Abbott Point Of Care, Inc. | Biologic fluid analysis cartridge with deflecting top panel |
EP2752671A3 (en) | 2010-07-23 | 2016-08-24 | Beckman Coulter, Inc. | System or method of including analytical units |
US9046507B2 (en) | 2010-07-29 | 2015-06-02 | Gen-Probe Incorporated | Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure |
EP2658653B1 (en) | 2010-12-30 | 2015-03-04 | Abbott Point Of Care, Inc. | Biologic fluid analysis cartridge with sample handling portion and analysis chamber portion |
WO2012116308A1 (en) | 2011-02-24 | 2012-08-30 | Gen-Probe Incorporated | Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector |
EP2776843B1 (en) | 2011-11-07 | 2019-03-27 | Beckman Coulter, Inc. | Centrifuge system and workflow |
CN104040352B (zh) | 2011-11-07 | 2016-09-07 | 贝克曼考尔特公司 | 机械臂 |
EP2776844B1 (en) | 2011-11-07 | 2020-09-30 | Beckman Coulter, Inc. | Specimen container detection |
BR112014010955A2 (pt) | 2011-11-07 | 2017-06-06 | Beckman Coulter Inc | sistema e método para processar amostras |
JP2014532881A (ja) | 2011-11-07 | 2014-12-08 | ベックマン コールター, インコーポレイテッド | 標本輸送システムのための磁気制動 |
JP6190380B2 (ja) | 2011-11-07 | 2017-08-30 | ベックマン コールター, インコーポレイテッド | 等分機システムおよびワークフロー |
EP3605107A4 (en) * | 2017-04-28 | 2020-12-30 | Ezdia Tech Inc. | AUTOMATED IMMUNOASSAY DEVICE AND METHOD USING A LARGE MAGNETIC COMPLEX OF PARTICLES |
DE102018106601A1 (de) * | 2018-03-21 | 2019-09-26 | Fragol Ag | Vorrichtung und Verfahren zur thermischen Lagerung von Proben |
US11061045B2 (en) * | 2019-03-12 | 2021-07-13 | Picodya Technologies Ltd. | Sample analysis system and method |
JPWO2022203018A1 (es) * | 2021-03-24 | 2022-09-29 | ||
DE102021110828A1 (de) * | 2021-04-28 | 2022-11-03 | Innovative Sensor Technology Ist Ag | System, Verfahren und Verbrauchsprodukt für ein chemisches, bio- oder immunchemisches Nachweisverfahren |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0387696B1 (en) * | 1989-03-17 | 1997-08-27 | Abbott Laboratories | Method and device for improved reaction kinetics in nucleic acid hybridizations |
US5120662A (en) * | 1989-05-09 | 1992-06-09 | Abbott Laboratories | Multilayer solid phase immunoassay support and method of use |
US5244815A (en) * | 1990-01-19 | 1993-09-14 | Lamina Ltd. | Fingerprint test pad and method for fingerprinting using particle based immunoassay |
WO1992010588A1 (en) * | 1990-12-06 | 1992-06-25 | Affymax Technologies N.V. | Sequencing by hybridization of a target nucleic acid to a matrix of defined oligonucleotides |
AU1999092A (en) * | 1991-05-24 | 1992-12-30 | Walter Gilbert | Method and apparatus for rapid nucleic acid sequencing |
CA2109943A1 (en) * | 1991-06-13 | 1992-12-23 | Herbert S. Chow | Automated specimen analyzing apparatus and method |
DE69329641T2 (de) * | 1992-03-31 | 2001-06-21 | Abbott Lab | Verfahren zur mehrfachen ligase-kettenreaktion |
-
1994
- 1994-09-28 JP JP51184895A patent/JP3457322B2/ja not_active Expired - Fee Related
- 1994-09-28 DE DE69432424T patent/DE69432424T2/de not_active Expired - Fee Related
- 1994-09-28 WO PCT/US1994/011015 patent/WO1995011454A1/en active IP Right Grant
- 1994-09-28 AT AT94930509T patent/ATE236400T1/de not_active IP Right Cessation
- 1994-09-28 ES ES94930509T patent/ES2196034T3/es not_active Expired - Lifetime
- 1994-09-28 EP EP94930509A patent/EP0724725B1/en not_active Expired - Lifetime
- 1994-09-28 AU AU79604/94A patent/AU7960494A/en not_active Abandoned
- 1994-09-28 CA CA002174330A patent/CA2174330C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2174330C (en) | 2003-09-23 |
JPH09504610A (ja) | 1997-05-06 |
WO1995011454A1 (en) | 1995-04-27 |
AU7960494A (en) | 1995-05-08 |
DE69432424D1 (de) | 2003-05-08 |
EP0724725A1 (en) | 1996-08-07 |
DE69432424T2 (de) | 2004-03-18 |
CA2174330A1 (en) | 1995-04-27 |
ATE236400T1 (de) | 2003-04-15 |
JP3457322B2 (ja) | 2003-10-14 |
EP0724725B1 (en) | 2003-04-02 |
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