ES2195653T3 - Compuesto de s-oxido que disminuyen los lipidos. - Google Patents
Compuesto de s-oxido que disminuyen los lipidos.Info
- Publication number
- ES2195653T3 ES2195653T3 ES99964594T ES99964594T ES2195653T3 ES 2195653 T3 ES2195653 T3 ES 2195653T3 ES 99964594 T ES99964594 T ES 99964594T ES 99964594 T ES99964594 T ES 99964594T ES 2195653 T3 ES2195653 T3 ES 2195653T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- hydrogen
- formula
- lipides
- decrease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de fórmula (I) **(Fórmula)** sus N - óxidos, sus formas estereoquímicamente isómeras, y sus sales de adición de ácido farmacéuticamente aceptables, en la cual n es 1 ó 2; R1 es hidrógeno, C1-6 alquilo o halo; R2 es hidrógeno o halo; R3 es C1-8 alquilo o C 3 - 6 cicloalquilo; Het es un radical de fórmula **(Fórmula)** en las cuales R4 es hidrógeno, C1-4 alquilo, trifluorometilo, amino o hidroxi; R5 es hidrógeno o C1-4 alquilo; R6 es hidrógeno o C1-4 alquilo; y - A - B - es un radical bivalente de fórmula - CH=CH - (b - 1) - N=CH - (b -2) - CH=N - (b - 3) en las cuales opcionalmente uno de los átomos de hidrógeno está reemplazado por C1-4 alquilo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98204410 | 1998-12-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2195653T3 true ES2195653T3 (es) | 2003-12-01 |
Family
ID=8234538
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99964594T Expired - Lifetime ES2195653T3 (es) | 1998-12-22 | 1999-12-14 | Compuesto de s-oxido que disminuyen los lipidos. |
Country Status (12)
Country | Link |
---|---|
US (1) | US6451802B1 (es) |
EP (1) | EP1140917B1 (es) |
JP (1) | JP2002533339A (es) |
AR (1) | AR021969A1 (es) |
AT (1) | ATE235487T1 (es) |
AU (1) | AU761032B2 (es) |
CA (1) | CA2355822A1 (es) |
DE (1) | DE69906376T2 (es) |
ES (1) | ES2195653T3 (es) |
MY (1) | MY130851A (es) |
NZ (1) | NZ512891A (es) |
WO (1) | WO2000037463A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080280922A1 (en) * | 2004-04-09 | 2008-11-13 | Marc Alois Celine Maria Engelen | Intermittent Dosing Regimen For Overweight and Obese Subjects |
CA2609783A1 (en) * | 2005-05-27 | 2006-12-07 | Pfizer Products Inc. | Combination of a cannabinoid-1- receptor-antagonist and a microsomal triglyceride transfer protein inhibitor for treating obesity or mainataining weight loss |
ES2348530T3 (es) | 2007-05-25 | 2010-12-09 | Janssen Pharmaceutica, N.V. | Síntesis mejorada de metanosulfonato de (2s-cis)-2-(bromometil)-2-(4-clorofenil)-1,3 dioxolan-4-metanol (éster). |
US9790104B2 (en) * | 2012-02-17 | 2017-10-17 | Hydrafact Limited | Water treatment |
EP3066098A1 (de) | 2013-11-08 | 2016-09-14 | Bayer Pharma Aktiengesellschaft | Substituierte uracile und ihre verwendung |
CN111100112B (zh) * | 2018-10-29 | 2021-05-04 | 浙江京新药业股份有限公司 | 苯并噻吩衍生物及其制备方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996013499A1 (en) * | 1994-10-27 | 1996-05-09 | Janssen Pharmaceutica N.V. | Apolipoprotein-b synthesis inhibitors |
-
1999
- 1999-12-14 EP EP99964594A patent/EP1140917B1/en not_active Expired - Lifetime
- 1999-12-14 US US09/857,838 patent/US6451802B1/en not_active Expired - Fee Related
- 1999-12-14 WO PCT/EP1999/010065 patent/WO2000037463A1/en active IP Right Grant
- 1999-12-14 ES ES99964594T patent/ES2195653T3/es not_active Expired - Lifetime
- 1999-12-14 AT AT99964594T patent/ATE235487T1/de not_active IP Right Cessation
- 1999-12-14 DE DE69906376T patent/DE69906376T2/de not_active Expired - Fee Related
- 1999-12-14 AU AU30395/00A patent/AU761032B2/en not_active Ceased
- 1999-12-14 JP JP2000589534A patent/JP2002533339A/ja not_active Withdrawn
- 1999-12-14 CA CA002355822A patent/CA2355822A1/en not_active Abandoned
- 1999-12-14 NZ NZ512891A patent/NZ512891A/xx unknown
- 1999-12-17 MY MYPI99005553A patent/MY130851A/en unknown
- 1999-12-21 AR ARP990106645A patent/AR021969A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU3039500A (en) | 2000-07-12 |
EP1140917A1 (en) | 2001-10-10 |
EP1140917B1 (en) | 2003-03-26 |
DE69906376T2 (de) | 2004-02-12 |
WO2000037463A1 (en) | 2000-06-29 |
MY130851A (en) | 2007-07-31 |
ATE235487T1 (de) | 2003-04-15 |
US6451802B1 (en) | 2002-09-17 |
AU761032B2 (en) | 2003-05-29 |
AR021969A1 (es) | 2002-09-04 |
NZ512891A (en) | 2003-01-31 |
JP2002533339A (ja) | 2002-10-08 |
DE69906376D1 (de) | 2003-04-30 |
CA2355822A1 (en) | 2000-06-29 |
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