ES2195033T3 - Iso-indolonas condensadas utilizadas como inhibidores de proteina quinasa c. - Google Patents

Iso-indolonas condensadas utilizadas como inhibidores de proteina quinasa c.

Info

Publication number
ES2195033T3
ES2195033T3 ES96943735T ES96943735T ES2195033T3 ES 2195033 T3 ES2195033 T3 ES 2195033T3 ES 96943735 T ES96943735 T ES 96943735T ES 96943735 T ES96943735 T ES 96943735T ES 2195033 T3 ES2195033 T3 ES 2195033T3
Authority
ES
Spain
Prior art keywords
indolones
inhibitors
iso
condensed
quinasa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96943735T
Other languages
English (en)
Inventor
Robert L Hudkins
Neil W Johnson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon LLC
Original Assignee
Cephalon LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26678542&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2195033(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cephalon LLC filed Critical Cephalon LLC
Application granted granted Critical
Publication of ES2195033T3 publication Critical patent/ES2195033T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE DESCRIBEN COMPUESTOS BIOLOGICAMENTE ACTIVOS QUE NO CONTIENEN INDOL DENOMINADOS ISOINDOLONAS FUSIONADAS, QUE ESTAN REPRESENTADOS POR LA FORMULA GENERAL (I). LAS INDOLONAS FUSIONADAS PUEDEN SER OBTENIDAS POR SINTESIS QUIMICA COMPLETA. SE DESCRIBEN METODOS PARA FABRICAR Y UTILIZAR LAS ISOINDOLONAS FUSIONADAS.
ES96943735T 1995-12-11 1996-12-11 Iso-indolonas condensadas utilizadas como inhibidores de proteina quinasa c. Expired - Lifetime ES2195033T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US873395P 1995-12-11 1995-12-11
US08/761,951 US5808060A (en) 1995-12-11 1996-12-09 Fused isoindolones

Publications (1)

Publication Number Publication Date
ES2195033T3 true ES2195033T3 (es) 2003-12-01

Family

ID=26678542

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96943735T Expired - Lifetime ES2195033T3 (es) 1995-12-11 1996-12-11 Iso-indolonas condensadas utilizadas como inhibidores de proteina quinasa c.

Country Status (15)

Country Link
US (1) US5808060A (es)
EP (1) EP0871612B1 (es)
KR (1) KR100534528B1 (es)
CN (1) CN1139573C (es)
AT (1) ATE234284T1 (es)
AU (1) AU701412B2 (es)
BR (1) BR9611947A (es)
CA (1) CA2239282C (es)
DE (1) DE69626680T2 (es)
DK (1) DK0871612T3 (es)
ES (1) ES2195033T3 (es)
HK (1) HK1016599A1 (es)
NZ (1) NZ325073A (es)
PT (1) PT871612E (es)
WO (1) WO1997021677A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6127401A (en) * 1998-06-05 2000-10-03 Cephalon, Inc. Bridged indenopyrrolocarbazoles
US6841567B1 (en) * 1999-02-12 2005-01-11 Cephalon, Inc. Cyclic substituted fused pyrrolocarbazoles and isoindolones
US6399780B1 (en) * 1999-08-20 2002-06-04 Cephalon, Inc. Isomeric fused pyrrolocarbazoles and isoindolones
US6630500B2 (en) 2000-08-25 2003-10-07 Cephalon, Inc. Selected fused pyrrolocarbazoles
US20040098106A1 (en) * 2002-11-14 2004-05-20 Williams Michael S. Intraluminal prostheses and carbon dioxide-assisted methods of impregnating same with pharmacological agents
US7285287B2 (en) * 2002-11-14 2007-10-23 Synecor, Llc Carbon dioxide-assisted methods of providing biocompatible intraluminal prostheses
US6932930B2 (en) * 2003-03-10 2005-08-23 Synecor, Llc Intraluminal prostheses having polymeric material with selectively modified crystallinity and methods of making same
WO2007047646A2 (en) * 2005-10-14 2007-04-26 Janssen Pharmaceutica, N.V. Substituted dihydro-isoindolones useful in treating kinase disorders
US20080021013A1 (en) * 2006-07-21 2008-01-24 Cephalon, Inc. JAK inhibitors for treatment of myeloproliferative disorders
CN103242404A (zh) * 2012-02-03 2013-08-14 复旦大学 N-鼠李糖基苯并咔唑化合物及其合成方法和在制药中的用途

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62220196A (ja) * 1986-03-20 1987-09-28 Kyowa Hakko Kogyo Co Ltd 新規物質ｕｃｎ―０１
US4816450A (en) * 1986-09-15 1989-03-28 Duke University Inhibition of protein kinase C by long-chain bases
US4735939A (en) * 1987-02-27 1988-04-05 The Dow Chemical Company Insecticidal activity of staurosporine
US4923986A (en) * 1987-03-09 1990-05-08 Kyowa Hakko Kogyo Co., Ltd. Derivatives of physiologically active substance K-252
JPH07113027B2 (ja) * 1987-12-24 1995-12-06 協和醗酵工業株式会社 Ｋ−２５２誘導体
US5438050A (en) * 1988-02-06 1995-08-01 Godecke Aktiengesellschaft Indolocarbazole derivatives, processes for their preparation and compositions containing them
DE3835842A1 (de) * 1988-10-21 1990-04-26 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
JP3010675B2 (ja) * 1989-03-23 2000-02-21 萬有製薬株式会社 抗腫瘍性物質ｂｅ―１３７９３ｃ
US5618809A (en) * 1989-12-14 1997-04-08 Schering Corporation Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov SCC 1951 ATCC 53856
US5489608A (en) * 1989-12-21 1996-02-06 Goedecke Aktiengesellschaft Indolocarbazole derivatives and the use thereof
US5591842A (en) * 1991-11-29 1997-01-07 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
US6271242B1 (en) * 1992-02-10 2001-08-07 Bristol-Myers Squibb Co. Method for treating cancer using a tyrosine protein kinase inhibitor
EP0630242B1 (en) * 1992-03-20 1999-01-20 The Wellcome Foundation Limited Further indole derivatives with antiviral activity
DE4217963A1 (de) * 1992-05-30 1993-12-02 Goedecke Ag Verwendung von Indolocarbazolen zur Behandlung von AIDS
US5461146A (en) * 1992-07-24 1995-10-24 Cephalon, Inc. Selected protein kinase inhibitors for the treatment of neurological disorders
KR100201343B1 (ko) * 1993-05-28 1999-06-15 바바라 에스 쉴버그 인돌로카르바졸 유도체들의 전립선의 병적상태치료에의 용도
US5468872A (en) * 1993-09-16 1995-11-21 Cephalon, Inc. K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders
US5594009A (en) * 1994-10-14 1997-01-14 Cephalon, Inc. Fused pyrrolocarbazoles
US5591855A (en) * 1994-10-14 1997-01-07 Cephalon, Inc. Fused pyrrolocarbazoles
US5475110A (en) * 1994-10-14 1995-12-12 Cephalon, Inc. Fused Pyrrolocarbazoles
US5705511A (en) * 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles

Also Published As

Publication number Publication date
HK1016599A1 (en) 1999-11-05
NZ325073A (en) 1999-04-29
DK0871612T3 (da) 2003-07-14
PT871612E (pt) 2003-06-30
EP0871612A1 (en) 1998-10-21
AU701412B2 (en) 1999-01-28
AU1289397A (en) 1997-07-03
WO1997021677A1 (en) 1997-06-19
MX9804706A (es) 1998-10-31
DE69626680D1 (de) 2003-04-17
CN1139573C (zh) 2004-02-25
KR100534528B1 (ko) 2006-05-29
ATE234284T1 (de) 2003-03-15
DE69626680T2 (de) 2003-11-06
EP0871612B1 (en) 2003-03-12
KR19990072091A (ko) 1999-09-27
CA2239282A1 (en) 1997-06-19
CN1224417A (zh) 1999-07-28
BR9611947A (pt) 1999-04-06
US5808060A (en) 1998-09-15
CA2239282C (en) 2009-08-18

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