EA200100107A1 - Новые 2,3,3a,4,9,9a-гексагидро-8-гидрокси-1h-бенз[f]индолы, способ их получения и их применение в качестве лекарственных средств - Google Patents

Новые 2,3,3a,4,9,9a-гексагидро-8-гидрокси-1h-бенз[f]индолы, способ их получения и их применение в качестве лекарственных средств

Info

Publication number
EA200100107A1
EA200100107A1 EA200100107A EA200100107A EA200100107A1 EA 200100107 A1 EA200100107 A1 EA 200100107A1 EA 200100107 A EA200100107 A EA 200100107A EA 200100107 A EA200100107 A EA 200100107A EA 200100107 A1 EA200100107 A1 EA 200100107A1
Authority
EA
Eurasian Patent Office
Prior art keywords
benz
hexahydro
hydroxy
preparation
indols
Prior art date
Application number
EA200100107A
Other languages
English (en)
Other versions
EA003370B1 (ru
Inventor
Маттиас Грауерт
Кристоф Хёнке
Адриан Картер
Вольф-Дитрих Бехтель
Томас Вайзер
Райнер Паллук
Уве Пшорн
Original Assignee
Бёрингер Ингельхайм Фарма Кг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бёрингер Ингельхайм Фарма Кг filed Critical Бёрингер Ингельхайм Фарма Кг
Publication of EA200100107A1 publication Critical patent/EA200100107A1/ru
Publication of EA003370B1 publication Critical patent/EA003370B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

В заявке описаны замещенные производные 2,3,3a,4,9,9a-гексагидро-8-гидрокси-1H-бенз[f]индола, способ их получения, а также их применение в качестве лекарственных средств. Производные индола согласно изобретению соответствуют общей формуле (1).Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100107A 1998-07-31 1999-07-22 Новые 2,3,3a,4,9,9a-гексагидро-8-гидрокси-1h-бенз[f]индолы, способ их получения и их применение в качестве лекарственных средств EA003370B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19834714A DE19834714A1 (de) 1998-07-31 1998-07-31 Neue 2,3,3a,4,9,9a-Hexahydro-8-hydroxy-1H-ben[f]indole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PCT/EP1999/005222 WO2000007986A1 (de) 1998-07-31 1999-07-22 Neue 2,3,3a,4,9,9a-hexahydro-8-hydroxy-1h-benz[f]indole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
EA200100107A1 true EA200100107A1 (ru) 2001-08-27
EA003370B1 EA003370B1 (ru) 2003-04-24

Family

ID=7876092

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100107A EA003370B1 (ru) 1998-07-31 1999-07-22 Новые 2,3,3a,4,9,9a-гексагидро-8-гидрокси-1h-бенз[f]индолы, способ их получения и их применение в качестве лекарственных средств

Country Status (30)

Country Link
US (1) US6051583A (ru)
EP (1) EP1100780B1 (ru)
JP (1) JP2002522418A (ru)
KR (1) KR20010072142A (ru)
CN (1) CN1147470C (ru)
AT (1) ATE360611T1 (ru)
AU (1) AU763834B2 (ru)
BG (1) BG105178A (ru)
BR (1) BR9912605A (ru)
CA (1) CA2336783C (ru)
CO (1) CO5080748A1 (ru)
DE (2) DE19834714A1 (ru)
EA (1) EA003370B1 (ru)
EE (1) EE200100062A (ru)
ES (1) ES2285851T3 (ru)
HK (1) HK1038017A1 (ru)
HU (1) HUP0103518A3 (ru)
ID (1) ID28292A (ru)
IL (1) IL140863A0 (ru)
MY (1) MY133085A (ru)
NO (1) NO20010513L (ru)
NZ (1) NZ510246A (ru)
PL (1) PL345808A1 (ru)
SK (1) SK1502001A3 (ru)
TR (1) TR200100316T2 (ru)
TW (1) TW464643B (ru)
UA (1) UA68388C2 (ru)
WO (1) WO2000007986A1 (ru)
YU (1) YU5501A (ru)
ZA (1) ZA200007770B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0002666D0 (en) 2000-02-04 2000-03-29 Univ London Blockade of voltage dependent sodium channels
ATE359783T1 (de) * 2001-12-27 2007-05-15 Ortho Mcneil Pharm Inc Aroylpyrrolheteroeryl und methanole zur behandlung von störungen des zentralnervensystems

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0482084B1 (en) * 1989-07-13 1997-05-07 PHARMACIA & UPJOHN COMPANY (1,2n) and (3,2n)-carbocyclic-2-amino tetralin derivatives
JPH06507906A (ja) * 1991-05-20 1994-09-08 ジ・アップジョン・カンパニー カルボキサミド−（３，２ｎ）−カルボサイクリック−２−アミノテトラリン誘導体
GB9612153D0 (en) * 1996-06-11 1996-08-14 Smithkline Beecham Plc Compounds

Also Published As

Publication number Publication date
IL140863A0 (en) 2002-02-10
CN1147470C (zh) 2004-04-28
BR9912605A (pt) 2001-05-02
KR20010072142A (ko) 2001-07-31
DE59914314D1 (de) 2007-06-06
SK1502001A3 (en) 2001-09-11
ATE360611T1 (de) 2007-05-15
AU5162699A (en) 2000-02-28
EP1100780A1 (de) 2001-05-23
EA003370B1 (ru) 2003-04-24
DE19834714A1 (de) 2000-02-03
CA2336783C (en) 2009-04-28
UA68388C2 (en) 2004-08-16
NO20010513D0 (no) 2001-01-30
EE200100062A (et) 2002-06-17
HUP0103518A2 (hu) 2002-01-28
YU5501A (sh) 2003-04-30
AU763834B2 (en) 2003-07-31
HK1038017A1 (en) 2002-03-01
US6051583A (en) 2000-04-18
NO20010513L (no) 2001-01-30
NZ510246A (en) 2003-08-29
EP1100780B1 (de) 2007-04-25
CO5080748A1 (es) 2001-09-25
PL345808A1 (en) 2002-01-02
BG105178A (en) 2001-12-29
TW464643B (en) 2001-11-21
HUP0103518A3 (en) 2002-12-28
MY133085A (en) 2007-10-31
TR200100316T2 (tr) 2001-07-23
CN1310707A (zh) 2001-08-29
CA2336783A1 (en) 2000-02-17
WO2000007986A1 (de) 2000-02-17
ID28292A (id) 2001-05-10
JP2002522418A (ja) 2002-07-23
ZA200007770B (en) 2002-01-17
ES2285851T3 (es) 2007-11-16

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Legal Events

Date Code Title Description
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU