ES2192584T3 - Derivado pirimidinilpirazol. - Google Patents

Derivado pirimidinilpirazol.

Info

Publication number
ES2192584T3
ES2192584T3 ES95932229T ES95932229T ES2192584T3 ES 2192584 T3 ES2192584 T3 ES 2192584T3 ES 95932229 T ES95932229 T ES 95932229T ES 95932229 T ES95932229 T ES 95932229T ES 2192584 T3 ES2192584 T3 ES 2192584T3
Authority
ES
Spain
Prior art keywords
group
hydrogen atom
pyrimidinyl
chem
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95932229T
Other languages
English (en)
Inventor
Akio Ejima
Masamichi Sugimori
Ikuo Mitsui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2192584T3 publication Critical patent/ES2192584T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA UN NUEVO COMPUESTO, REPRESENTADO POR LA FORMULA (I): (I) EN DONDE LOS EJEMPLOS PREFERIDOS DE R{SUP,1} A R{SUP,6}, SON SEGUN SE LOS DESCRIBE A CONTINUACION; R{SUP,1} Y R{SUP,2} SON CADA UNO UN GRUPO ALQUINILO, OPCIONALMENTE SUSTITUIDO POR UN ATOMO DE HALOGENO, UN GRUPO AMINO, HIDROXILO, ALCOXILO O TIOL, UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO, O UN GRUPO ALCOXILO; R{SUP,3} ES UN ATOMO DE HIDROGENO; R{SUP,4} ES UN GRUPO METILO; R{SUP,5} ES UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO; Y R{SUP,6} ES UN GRUPO DE FORMULA: DONDE Z ES UN GRUPO FENILO. DICHO COMPUESTO TIENE EFECTO ANTITUMORAL.
ES95932229T 1994-09-26 1995-09-25 Derivado pirimidinilpirazol. Expired - Lifetime ES2192584T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22942294 1994-09-26
JP13501095 1995-06-01

Publications (1)

Publication Number Publication Date
ES2192584T3 true ES2192584T3 (es) 2003-10-16

Family

ID=26468965

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95932229T Expired - Lifetime ES2192584T3 (es) 1994-09-26 1995-09-25 Derivado pirimidinilpirazol.

Country Status (14)

Country Link
US (1) US5852019A (es)
EP (1) EP0784055B1 (es)
KR (1) KR100388568B1 (es)
CN (1) CN1071754C (es)
AT (1) ATE232528T1 (es)
CA (1) CA2201110A1 (es)
DE (2) DE69529619D1 (es)
DK (1) DK0784055T3 (es)
ES (1) ES2192584T3 (es)
FI (1) FI971227A (es)
HK (1) HK1001396A1 (es)
NO (1) NO313196B1 (es)
TW (1) TW312694B (es)
WO (1) WO1996010024A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6169086B1 (en) 1997-01-27 2001-01-02 Daiichi Pharmaceutical Co., Ltd. Pyrazole derivatives
CN1105707C (zh) * 1997-01-27 2003-04-16 第一制药株式会社 吡唑衍生物
AU4800299A (en) * 1998-07-24 2000-02-14 Daiichi Pharmaceutical Co., Ltd. Pyrazole derivatives and salts thereof
JP4709388B2 (ja) * 1999-01-25 2011-06-22 全薬工業株式会社 複素環式化合物及びそれを有効成分とする抗腫瘍剤
CN1310907C (zh) * 2001-04-27 2007-04-18 全药工业株式会社 杂环化合物和以其为有效成分的抗肿瘤药
WO2003011837A1 (en) * 2001-08-01 2003-02-13 Merck & Co., Inc. Tyrosine kinase inhibitors
US20050130989A1 (en) * 2003-01-28 2005-06-16 Aventis Pharma S. A. N-arylheteroaromatic products compositions containing them and use thereof
EP1590329A1 (fr) * 2003-01-28 2005-11-02 Aventis Pharma S.A. Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation
FR2850379B1 (fr) * 2003-01-28 2006-11-17 Aventis Pharma Sa Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation
US7223759B2 (en) * 2003-09-15 2007-05-29 Anadys Pharmaceuticals, Inc. Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds
CA2561406C (en) * 2004-03-31 2012-07-03 Zenyaku Kogyo Kabushiki Kaisha Heterocyclic compound and anti-malignant-tumor agent comprising the same as effective component
JP5089377B2 (ja) 2005-03-11 2012-12-05 全薬工業株式会社 複素環式化合物を有効成分とする免疫抑制剤及び抗腫瘍剤
US20070244110A1 (en) * 2006-04-14 2007-10-18 Zenyaku Kogyo Kabushiki Kaisha Treatment of prostate cancer, melanoma or hepatic cancer
CL2007002904A1 (es) 2006-10-10 2008-06-06 Amgen Inc Soc Organizada Bajo Compuestos derivados de pirazolopirimidina; composicion farmaceutica; y uso para tratar una enfermedad seleccionada de diabetes, obesidad, asma y artritis entre otras.
EP3285581B1 (en) * 2015-03-26 2021-08-11 Merck Sharp & Dohme Corp. Pyrazolyl pyrimidinone compounds as pde2 inhibitors
WO2017059191A1 (en) 2015-09-30 2017-04-06 Quartet Medicine, Inc. Heteroaryl derivatives as sepiapterin reductase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3778433A (en) * 1969-04-18 1973-12-11 Sumitomo Chemical Co Process for producing benzodiazepine derivatives
JPS4842072A (es) * 1971-09-29 1973-06-19
JPS61129129A (ja) * 1984-11-28 1986-06-17 Kureha Chem Ind Co Ltd 抗腫瘍剤
US5102893A (en) * 1986-07-07 1992-04-07 Warner-Lambert Company Trans-6-(2-(n-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl- or ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis

Also Published As

Publication number Publication date
TW312694B (es) 1997-08-11
NO971384L (no) 1997-05-23
NO313196B1 (no) 2002-08-26
CN1071754C (zh) 2001-09-26
EP0784055A4 (en) 1998-01-07
US5852019A (en) 1998-12-22
CN1166833A (zh) 1997-12-03
WO1996010024A1 (en) 1996-04-04
DE69529619D1 (en) 2003-03-20
ATE232528T1 (de) 2003-02-15
DE69529619T4 (de) 2005-01-27
KR100388568B1 (ko) 2003-10-04
HK1001396A1 (en) 1998-06-19
DK0784055T3 (da) 2003-06-02
CA2201110A1 (en) 1996-04-04
FI971227A (fi) 1997-05-23
EP0784055B1 (en) 2003-02-12
KR970706275A (ko) 1997-11-03
NO971384D0 (no) 1997-03-24
FI971227A0 (fi) 1997-03-24
EP0784055A1 (en) 1997-07-16
DE69529619T2 (de) 2003-12-18

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