ES2191102T3 - Heterociclos de peptidilo utiles en el tratamiento de las afecciones relacionadas con la trombina. - Google Patents
Heterociclos de peptidilo utiles en el tratamiento de las afecciones relacionadas con la trombina.Info
- Publication number
- ES2191102T3 ES2191102T3 ES96917014T ES96917014T ES2191102T3 ES 2191102 T3 ES2191102 T3 ES 2191102T3 ES 96917014 T ES96917014 T ES 96917014T ES 96917014 T ES96917014 T ES 96917014T ES 2191102 T3 ES2191102 T3 ES 2191102T3
- Authority
- ES
- Spain
- Prior art keywords
- thrombin
- treatment
- heterocicles
- useful peptidyl
- affections
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C07K5/06095—Arg-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
COMPUESTOS DE FORMULA (I) UTILES EN EL TRATAMIENTO DE TRASTORNOS RELACIONADOS CON LA TROMBINA Y LA TRIPSINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/486,473 US5523308A (en) | 1995-06-07 | 1995-06-07 | Peptidyl heterocycles useful in the treatment of thrombin related disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2191102T3 true ES2191102T3 (es) | 2003-09-01 |
Family
ID=23932026
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96917014T Expired - Lifetime ES2191102T3 (es) | 1995-06-07 | 1996-06-03 | Heterociclos de peptidilo utiles en el tratamiento de las afecciones relacionadas con la trombina. |
Country Status (21)
Country | Link |
---|---|
US (1) | US5523308A (es) |
EP (1) | EP0833839B1 (es) |
JP (1) | JPH11506762A (es) |
KR (1) | KR100434667B1 (es) |
CN (1) | CN1146575C (es) |
AT (1) | ATE230757T1 (es) |
AU (1) | AU721079B2 (es) |
CA (1) | CA2224110A1 (es) |
CZ (1) | CZ386997A3 (es) |
DE (1) | DE69625691T2 (es) |
DK (1) | DK0833839T3 (es) |
ES (1) | ES2191102T3 (es) |
IL (1) | IL122436A (es) |
MX (1) | MX9709915A (es) |
NO (1) | NO975747L (es) |
NZ (1) | NZ309523A (es) |
PL (1) | PL184986B1 (es) |
RU (1) | RU2181125C2 (es) |
TW (1) | TW470751B (es) |
WO (1) | WO1996040748A1 (es) |
ZA (1) | ZA964759B (es) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4857633A (en) * | 1984-06-25 | 1989-08-15 | Exxon Research & Engineering Company | Method for high temperature phase separation of solutions containing polymers |
US5919765A (en) * | 1995-06-07 | 1999-07-06 | Cor Therapeutics, Inc. | Inhibitors of factor XA |
US5721214A (en) * | 1995-06-07 | 1998-02-24 | Cor Therapeutics, Inc. | Inhibitors of factor Xa |
US6046169A (en) * | 1995-06-07 | 2000-04-04 | Cor Therapeutics, Inc. | Inhibitors of factor XA |
US5827860A (en) * | 1995-06-07 | 1998-10-27 | Ortho Pharmaceutical Corporation | Peptidyl heterocycles useful in the treatment of thrombin related disorders |
US6069130A (en) * | 1995-06-07 | 2000-05-30 | Cor Therapeutics, Inc. | Ketoheterocyclic inhibitors of factor Xa |
US6022861A (en) * | 1995-06-07 | 2000-02-08 | Cor Therapeutics, Inc. | Ketoheterocyclic inhibitors of factor Xa |
US5827866A (en) * | 1995-06-07 | 1998-10-27 | Ortho Pharmaceutical Corporation | Peptidyl heterocycles useful in the treatment of thrombin related disorders |
US6211154B1 (en) | 1995-06-07 | 2001-04-03 | Cor Therapeutics, Inc. | Ketoheterocyclic inhibitors of factor Xa |
IL119466A (en) * | 1995-11-03 | 2001-08-26 | Akzo Nobel Nv | Thrombin inhibitors, their preparation and pharmaceutical compositions containing them |
US5811402A (en) * | 1996-03-22 | 1998-09-22 | Eli Lilly And Company | Antithrombotic diamides |
US6245743B1 (en) | 1996-06-05 | 2001-06-12 | Cor Therapeutics, Inc. | Inhibitors of factor Xa |
WO1998016547A1 (en) * | 1996-10-11 | 1998-04-23 | Cor Therapeutics, Inc. | SELECTIVE FACTOR Xa INHIBITORS |
US6194435B1 (en) * | 1996-10-11 | 2001-02-27 | Cor Therapeutics, Inc. | Lactams as selective factor Xa inhibitors |
CA2268264A1 (en) * | 1996-10-11 | 1998-04-23 | Cor Therapeutics, Inc. | Selective factor xa inhibitors |
US6063794A (en) | 1996-10-11 | 2000-05-16 | Cor Therapeutics Inc. | Selective factor Xa inhibitors |
WO1998016524A1 (en) * | 1996-10-11 | 1998-04-23 | Cor Therapeutics, Inc. | HETEROCYCLIC DERIVATIVES AS FACTOR Xa INHIBITORS |
US6369080B2 (en) | 1996-10-11 | 2002-04-09 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6262047B1 (en) | 1996-10-11 | 2001-07-17 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
NZ500353A (en) | 1997-04-14 | 2002-02-01 | Cor Therapeutics Inc | Cyclic diaza compounds that are selective inhibitors of factor Xa |
WO1998046628A1 (en) * | 1997-04-14 | 1998-10-22 | Cor Therapeutics, Inc. | SELECTIVE FACTOR Xa INHIBITORS |
CA2285659A1 (en) | 1997-04-14 | 1998-10-22 | Cor Therapeutics, Inc. | Selective factor xa inhibitors |
US5877156A (en) * | 1997-04-24 | 1999-03-02 | Akzo Nobel, N.V. | Thrombin inhibitors |
EP0884325A1 (en) * | 1997-04-24 | 1998-12-16 | Akzo Nobel N.V. | Thrombin inhibitors containing a peptidyl heterocycle |
US6214841B1 (en) | 1997-05-15 | 2001-04-10 | Eli Lilly And Company | Antithrombotic compound |
US8039026B1 (en) * | 1997-07-28 | 2011-10-18 | Johnson & Johnson Consumer Companies, Inc | Methods for treating skin pigmentation |
AU2006252275A1 (en) * | 1997-07-28 | 2007-01-25 | Johnson & Johnson Consumer Companies, Inc. | Methods for treating skin pigmentation |
US6333321B1 (en) | 1997-08-11 | 2001-12-25 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6228854B1 (en) | 1997-08-11 | 2001-05-08 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6218382B1 (en) | 1997-08-11 | 2001-04-17 | Cor Therapeutics, Inc | Selective factor Xa inhibitors |
US6323219B1 (en) | 1998-04-02 | 2001-11-27 | Ortho-Mcneil Pharmaceutical, Inc. | Methods for treating immunomediated inflammatory disorders |
US8093293B2 (en) * | 1998-07-06 | 2012-01-10 | Johnson & Johnson Consumer Companies, Inc. | Methods for treating skin conditions |
US6750229B2 (en) | 1998-07-06 | 2004-06-15 | Johnson & Johnson Consumer Companies, Inc. | Methods for treating skin pigmentation |
US8106094B2 (en) | 1998-07-06 | 2012-01-31 | Johnson & Johnson Consumer Companies, Inc. | Compositions and methods for treating skin conditions |
EE200100391A (et) * | 1999-01-27 | 2002-10-15 | Ortho-Mcneil Pharmaceutical, Inc. | Peptidüül-heterotsüklilised ketoonid, nende kasutamine ja farmatseutiline kompositsioon |
US7985404B1 (en) | 1999-07-27 | 2011-07-26 | Johnson & Johnson Consumer Companies, Inc. | Reducing hair growth, hair follicle and hair shaft size and hair pigmentation |
US7309688B2 (en) * | 2000-10-27 | 2007-12-18 | Johnson & Johnson Consumer Companies | Topical anti-cancer compositions and methods of use thereof |
GB0004686D0 (en) * | 2000-02-28 | 2000-04-19 | Aventis Pharma Ltd | Chemical compounds |
SI20582A (sl) * | 2000-05-05 | 2001-12-31 | Univerza V Ljubljani | Novi inhibitorji trombina, njihova priprava in uporaba |
US6960597B2 (en) * | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
US8431550B2 (en) | 2000-10-27 | 2013-04-30 | Johnson & Johnson Consumer Companies, Inc. | Topical anti-cancer compositions and methods of use thereof |
US7192615B2 (en) | 2001-02-28 | 2007-03-20 | J&J Consumer Companies, Inc. | Compositions containing legume products |
US6555143B2 (en) | 2001-02-28 | 2003-04-29 | Johnson & Johnson Consumer Products, Inc. | Legume products |
KR20030080810A (ko) * | 2002-04-11 | 2003-10-17 | 주식회사 엘지생명과학 | 아미노피리도아릴 그룹을 가진 선택적 트롬빈 억제제 |
US7091360B2 (en) * | 2002-04-16 | 2006-08-15 | Aventis Pharma S.A. | Process for preparing heteroaryl and unsaturated heterocycloalkylmagnesium reagents and uses thereof |
US7375093B2 (en) * | 2002-07-05 | 2008-05-20 | Intrexon Corporation | Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
US20040063593A1 (en) * | 2002-09-30 | 2004-04-01 | Wu Jeffrey M. | Compositions containing a cosmetically active organic acid and a legume product |
US7393920B2 (en) | 2003-06-23 | 2008-07-01 | Cem Corporation | Microwave-assisted peptide synthesis |
US20050176755A1 (en) * | 2003-10-31 | 2005-08-11 | Dyatkin Alexey B. | Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists |
BRPI0506676A (pt) * | 2004-02-10 | 2007-05-15 | Janssen Phamaceutica N V | piridazinona uréias como antagonistas de integrinas alfa4 |
GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
MX2008014838A (es) * | 2006-05-23 | 2008-12-05 | Irm Llc | Metodos y composiciones como inhibidores de proteasa de activacion de canal. |
BRPI0712021A2 (pt) | 2006-05-23 | 2012-01-03 | Irm Llc | composto e composiÇÕes como inibidores da protease ativadora de canal |
TWI389899B (zh) * | 2006-08-08 | 2013-03-21 | Msd Oss Bv | 具口服活性之凝血酶抑制劑 |
MX2009008493A (es) * | 2007-02-09 | 2009-08-20 | Irm Llc | Compuestos y composiciones como inhibidores de la proteasa activadora de canal. |
CN101600428A (zh) * | 2007-02-09 | 2009-12-09 | Irm责任有限公司 | 作为通道活化蛋白酶抑制剂的化合物和组合物 |
US9365853B2 (en) * | 2011-06-02 | 2016-06-14 | SOCPRA Sciences Sante et Humaines S.E.C. | Matriptase inhibitors and uses thereof against orthomyxoviridae infections |
CN104003984B (zh) * | 2014-06-16 | 2016-03-02 | 山东大学 | 噻唑-4-甲酰基哌嗪衍生物及其制备方法与应用 |
KR20170068521A (ko) | 2014-10-06 | 2017-06-19 | 코텍자임, 인코포레이티드 | 리신 진지페인의 억제제 |
EP3374352A4 (en) * | 2015-11-09 | 2019-10-02 | Cortexyme, Inc. | GINGIPAINE ARGININE INHIBITORS |
JP7113815B2 (ja) | 2016-09-16 | 2022-08-05 | コーテクシーミー, インコーポレイテッド | リシンジンジパインのケトン阻害剤 |
US20190309020A1 (en) * | 2016-11-22 | 2019-10-10 | Ohio State Innovation Foundation | Cell-penetrating peptide sequences |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0503203A1 (en) * | 1991-03-15 | 1992-09-16 | Merrell Dow Pharmaceuticals Inc. | Novel thrombin inhibitors |
PT626968E (pt) * | 1992-02-13 | 2002-03-28 | Merrell Pharma Inc | Derivados de piperidinilo tiaciclicos |
JPH0820597A (ja) * | 1994-07-07 | 1996-01-23 | Meiji Seika Kaisha Ltd | トロンビン阻害作用を有する複素環カルボニル化合物 |
-
1995
- 1995-06-07 US US08/486,473 patent/US5523308A/en not_active Expired - Lifetime
-
1996
- 1996-06-03 PL PL96323825A patent/PL184986B1/pl not_active IP Right Cessation
- 1996-06-03 DK DK96917014T patent/DK0833839T3/da active
- 1996-06-03 NZ NZ309523A patent/NZ309523A/xx unknown
- 1996-06-03 WO PCT/US1996/008456 patent/WO1996040748A1/en not_active Application Discontinuation
- 1996-06-03 RU RU98100420/04A patent/RU2181125C2/ru not_active IP Right Cessation
- 1996-06-03 CA CA002224110A patent/CA2224110A1/en not_active Abandoned
- 1996-06-03 EP EP96917014A patent/EP0833839B1/en not_active Expired - Lifetime
- 1996-06-03 DE DE69625691T patent/DE69625691T2/de not_active Expired - Fee Related
- 1996-06-03 ES ES96917014T patent/ES2191102T3/es not_active Expired - Lifetime
- 1996-06-03 AT AT96917014T patent/ATE230757T1/de not_active IP Right Cessation
- 1996-06-03 JP JP9501056A patent/JPH11506762A/ja not_active Ceased
- 1996-06-03 CN CNB961961031A patent/CN1146575C/zh not_active Expired - Fee Related
- 1996-06-03 CZ CZ973869A patent/CZ386997A3/cs unknown
- 1996-06-03 KR KR1019970709049A patent/KR100434667B1/ko not_active IP Right Cessation
- 1996-06-03 AU AU59713/96A patent/AU721079B2/en not_active Ceased
- 1996-06-03 IL IL12243696A patent/IL122436A/en not_active IP Right Cessation
- 1996-06-06 ZA ZA9604759A patent/ZA964759B/xx unknown
- 1996-07-08 TW TW085108206A patent/TW470751B/zh not_active IP Right Cessation
-
1997
- 1997-12-05 NO NO975747A patent/NO975747L/no not_active Application Discontinuation
- 1997-12-08 MX MX9709915A patent/MX9709915A/es not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
MX9709915A (es) | 1998-08-30 |
RU2181125C2 (ru) | 2002-04-10 |
IL122436A (en) | 2004-06-20 |
EP0833839B1 (en) | 2003-01-08 |
DE69625691D1 (de) | 2003-02-13 |
CA2224110A1 (en) | 1996-12-19 |
NZ309523A (en) | 1999-11-29 |
AU721079B2 (en) | 2000-06-22 |
DE69625691T2 (de) | 2003-10-23 |
CN1192747A (zh) | 1998-09-09 |
CZ386997A3 (cs) | 1998-07-15 |
ZA964759B (en) | 1997-12-08 |
WO1996040748A1 (en) | 1996-12-19 |
PL323825A1 (en) | 1998-04-27 |
CN1146575C (zh) | 2004-04-21 |
KR100434667B1 (ko) | 2004-09-24 |
KR19990022568A (ko) | 1999-03-25 |
EP0833839A1 (en) | 1998-04-08 |
DK0833839T3 (da) | 2003-04-14 |
US5523308A (en) | 1996-06-04 |
PL184986B1 (pl) | 2003-01-31 |
AU5971396A (en) | 1996-12-30 |
NO975747D0 (no) | 1997-12-05 |
NO975747L (no) | 1998-02-03 |
TW470751B (en) | 2002-01-01 |
ATE230757T1 (de) | 2003-01-15 |
JPH11506762A (ja) | 1999-06-15 |
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