ES2188984T3 - Procedimiento de enriquecimiento en r de epimeros de derivados de 16,17-acetales de derivados de 21-aciloxi-pregnano-1,4-dieno-11-beta, 16alfa-triol-3,20-dionas. - Google Patents

Procedimiento de enriquecimiento en r de epimeros de derivados de 16,17-acetales de derivados de 21-aciloxi-pregnano-1,4-dieno-11-beta, 16alfa-triol-3,20-dionas.

Info

Publication number
ES2188984T3
ES2188984T3 ES97942897T ES97942897T ES2188984T3 ES 2188984 T3 ES2188984 T3 ES 2188984T3 ES 97942897 T ES97942897 T ES 97942897T ES 97942897 T ES97942897 T ES 97942897T ES 2188984 T3 ES2188984 T3 ES 2188984T3
Authority
ES
Spain
Prior art keywords
derivatives
epimeros
16alfa
aciloxi
pregnano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97942897T
Other languages
English (en)
Inventor
Hermann Amschler
Dieter Flockerzi
Beate Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Altana Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7804358&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2188984(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Altana Pharma AG filed Critical Altana Pharma AG
Application granted granted Critical
Publication of ES2188984T3 publication Critical patent/ES2188984T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Abstract

LA INVENCION DESCRBE UN PROCEDIMIENTO DE ENRIQUECIMIENTO DE COMPUESTOS DE FORMULA (I), DONDE R 1 Y R 2 SON TAL Y COMO SE DEFINEN EN LA DESCRIPCION, MEDIANTE CRISTALIZACION FRACCIONADA
ES97942897T 1996-09-03 1997-08-29 Procedimiento de enriquecimiento en r de epimeros de derivados de 16,17-acetales de derivados de 21-aciloxi-pregnano-1,4-dieno-11-beta, 16alfa-triol-3,20-dionas. Expired - Lifetime ES2188984T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19635498A DE19635498A1 (de) 1996-09-03 1996-09-03 Verfahren zur Epimerenanreicherung

Publications (1)

Publication Number Publication Date
ES2188984T3 true ES2188984T3 (es) 2003-07-01

Family

ID=7804358

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97942897T Expired - Lifetime ES2188984T3 (es) 1996-09-03 1997-08-29 Procedimiento de enriquecimiento en r de epimeros de derivados de 16,17-acetales de derivados de 21-aciloxi-pregnano-1,4-dieno-11-beta, 16alfa-triol-3,20-dionas.

Country Status (18)

Country Link
US (1) US6787533B1 (es)
EP (1) EP0929566B1 (es)
JP (1) JP3807509B2 (es)
AT (1) ATE229539T1 (es)
AU (1) AU736840B2 (es)
CA (1) CA2264863C (es)
CL (1) CL2004001297A1 (es)
CY (2) CY2454B1 (es)
CZ (1) CZ298789B6 (es)
DE (2) DE19635498A1 (es)
DK (1) DK0929566T3 (es)
EE (1) EE03927B1 (es)
ES (1) ES2188984T3 (es)
HU (1) HU228766B1 (es)
IL (1) IL128535A (es)
PL (1) PL186063B1 (es)
PT (1) PT929566E (es)
WO (1) WO1998009982A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6264923B1 (en) * 1998-05-13 2001-07-24 3M Innovative Properties Company Medicinal aerosol formulation of ciclesonide and related compounds
CZ303885B6 (cs) 2000-11-10 2013-06-12 Takeda Gmbh Zpusob výroby 16,17-[(cyklohexylmethylen)bis(oxy)]-11,21-dihydroxypregna-1,4-dien-3,20-dionu nebo jeho 21-isobutyrátu
DE10055820C1 (de) * 2000-11-10 2002-07-25 Byk Gulden Lomberg Chem Fab Verfahren zur Herstellung eines Glucocorticoids
WO2004033478A2 (en) 2002-10-08 2004-04-22 Sepracor Inc. Fatty acid modified forms of glucocorticoids and their use as anti-inflammatory
AU2003293833B2 (en) 2002-12-12 2009-10-01 Covis Pharma B.V. Combination medicament
MY143936A (en) * 2003-03-27 2011-07-29 Nycomed Gmbh Process for preparing crystalline ciclesonide with defined particle size
PL1670482T5 (pl) 2003-09-16 2022-10-03 Covis Pharma Gmbh Zastosowanie cyklezonidu w leczeniu chorób układu oddechowego
PE20050941A1 (es) 2003-12-16 2005-11-08 Nycomed Gmbh Suspensiones acuosas de ciclesonida para nebulizacion
CN100345864C (zh) * 2004-10-29 2007-10-31 天津药业研究院有限公司 一种治疗呼吸道疾病的甾体药物的制备方法及其中间体
US20070135398A1 (en) * 2005-11-02 2007-06-14 Pierluigi Rossetto Process for the preparation of ciclesonide
EP1904514A2 (en) * 2006-02-08 2008-04-02 Sicor, Inc. Crystalline forms of ciclesonide
WO2008015696A2 (en) * 2006-05-23 2008-02-07 Cadila Healthcare Limited Process for preparing ciclesonide
WO2008062450A2 (en) * 2006-09-18 2008-05-29 Cadila Healthcare Limited Crystalline polymorphs of ciclesonide
US8158780B2 (en) * 2006-09-19 2012-04-17 Cipla Limited Processes for the preparation of ciclesonide and its crystal modification
IT1397499B1 (it) * 2009-01-09 2013-01-16 Farmabios Spa Processo per la preparazione di ciclesonide
EP2262823B1 (en) * 2008-03-13 2013-01-23 Farmabios S.p.A. Process for the preparation of pregnane derivatives
US20100120737A1 (en) * 2008-11-10 2010-05-13 Martin Feth Amorphous ciclesonide
US9109005B2 (en) 2012-02-23 2015-08-18 Boehringer Ingelheim International Gmbh Method for manufacturing of ciclesonide
MY194619A (en) 2016-06-02 2022-12-07 Abbvie Inc Glucocorticoid receptor agonist and immunoconjugates thereof
TWI803542B (zh) 2017-12-01 2023-06-01 美商艾伯維有限公司 糖皮質激素受體激動劑及其免疫結合物
CN109293730A (zh) * 2018-10-23 2019-02-01 山东泰华生物科技股份有限公司 一种环索奈德的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992534A (en) * 1972-05-19 1976-11-16 Ab Bofors Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
SE378110B (es) * 1972-05-19 1975-08-18 Bofors Ab
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
US4036831A (en) * 1975-10-28 1977-07-19 Steroid Development Company Establishment Trimethyl siloxane steroid intermediates
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
GR1001529B (el) * 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
PL164294B1 (pl) * 1990-12-20 1994-07-29 Inst Farmaceutyczny Sposób otrzymywania diastereoizomeru /22R/-16a , 17a-butylidenodioksy-11 ß 21-dihydroksy-1,4-pregnadien-3,20-dionu PL
US5482935A (en) 1993-01-05 1996-01-09 American Home Product Corporation Anti-atherosclerotic use of 17 alpha-dihydroequilin
WO1994022899A1 (de) * 1993-04-02 1994-10-13 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue prednisolonderivate
US5728826A (en) * 1994-03-09 1998-03-17 Byk Gulden Lomberg Chemische Fabrik Gmbh Silyl Compounds and their use

Also Published As

Publication number Publication date
PL186063B1 (pl) 2003-09-30
AU736840B2 (en) 2001-08-02
CY2009010I2 (el) 2010-07-28
CY2009010I1 (el) 2010-07-28
DE69717836D1 (de) 2003-01-23
CZ298789B6 (cs) 2008-01-30
PT929566E (pt) 2003-04-30
CA2264863C (en) 2007-07-31
EP0929566B1 (en) 2002-12-11
JP2000517330A (ja) 2000-12-26
HUP9904127A3 (en) 2001-02-28
IL128535A0 (en) 2000-01-31
JP3807509B2 (ja) 2006-08-09
ATE229539T1 (de) 2002-12-15
HU228766B1 (hu) 2013-05-28
PL331699A1 (en) 1999-08-02
CY2454B1 (en) 2005-06-03
DK0929566T3 (da) 2003-04-07
CZ72799A3 (cs) 1999-09-15
WO1998009982A1 (en) 1998-03-12
EE03927B1 (et) 2002-12-16
CA2264863A1 (en) 1998-03-12
HUP9904127A2 (hu) 2000-04-28
US6787533B1 (en) 2004-09-07
IL128535A (en) 2003-07-06
AU4456797A (en) 1998-03-26
EP0929566A1 (en) 1999-07-21
EE9900079A (et) 1999-10-15
DE19635498A1 (de) 1998-03-26
CL2004001297A1 (es) 2005-04-15
DE69717836T2 (de) 2003-09-18

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