ES2186127T3 - Sintesis de derivados de nucleosidos aciclicos. - Google Patents

Sintesis de derivados de nucleosidos aciclicos.

Info

Publication number
ES2186127T3
ES2186127T3 ES98906239T ES98906239T ES2186127T3 ES 2186127 T3 ES2186127 T3 ES 2186127T3 ES 98906239 T ES98906239 T ES 98906239T ES 98906239 T ES98906239 T ES 98906239T ES 2186127 T3 ES2186127 T3 ES 2186127T3
Authority
ES
Spain
Prior art keywords
derivatives
aciclic
nucleosid
synthesis
monounsaturated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98906239T
Other languages
English (en)
Inventor
M Robert Leanna
Steven M Hannick
Michael Rasmussen
Jien-Heh J Tien
Lakshmi Bhagavatula
Pulla Reddy Singam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medivir AB
Original Assignee
Medivir AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/798,216 external-priority patent/US5869493A/en
Application filed by Medivir AB filed Critical Medivir AB
Application granted granted Critical
Publication of ES2186127T3 publication Critical patent/ES2186127T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Procedimientos y nuevos intermedios para la preparación de derivados de nucleósido acíclico de fórmula (I) en la que uno de R{sub,1} y R{sub,2} es un grupo acilo aminoácido y el otro de R{sub,1} y R{sub,2} es un C(O)C{sub,3-21} saturado o monosaturado, alquilo opcionalmente sustituido y R{sub,3} es OH o H o un sal farmacéuticamente aceptable de los mismos.
ES98906239T 1997-02-10 1998-02-06 Sintesis de derivados de nucleosidos aciclicos. Expired - Lifetime ES2186127T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3751797P 1997-02-10 1997-02-10
US08/798,216 US5869493A (en) 1996-02-16 1997-02-10 Acyclic nucleoside derivatives
US90875497A 1997-08-08 1997-08-08

Publications (1)

Publication Number Publication Date
ES2186127T3 true ES2186127T3 (es) 2003-05-01

Family

ID=27365230

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98906239T Expired - Lifetime ES2186127T3 (es) 1997-02-10 1998-02-06 Sintesis de derivados de nucleosidos aciclicos.

Country Status (7)

Country Link
EP (1) EP0971923B1 (es)
JP (1) JP4425352B2 (es)
AT (1) ATE227289T1 (es)
CA (2) CA2572577C (es)
DE (1) DE69809205T2 (es)
ES (1) ES2186127T3 (es)
WO (1) WO1998034917A2 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184376B1 (en) 1997-02-10 2001-02-06 Mediver Ab Synthesis of acyclic nucleoside derivatives
SE0102273D0 (sv) * 2001-06-26 2001-06-26 Medivir Ab Improved synthesis of branched acyclic nucleosides
PT1371658E (pt) * 2002-06-13 2007-10-23 Oreal Derivado da glucose e de vitamina f, composições que o compreendem, utilizações e processo de preparação
US20100240681A1 (en) * 2007-09-21 2010-09-23 Epiphany Biosciences, Inc. Valomaciclovir polymorphs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8801729D0 (sv) * 1988-05-06 1988-05-06 Astra Ab Purine derivatives for use in therapy
WO1995022330A1 (en) * 1994-02-17 1995-08-24 Commonwealth Scientific And Industrial Research Organisation Antiviral agents
PE32296A1 (es) * 1994-07-28 1996-08-07 Hoffmann La Roche Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives

Also Published As

Publication number Publication date
WO1998034917A2 (en) 1998-08-13
DE69809205T2 (de) 2003-05-28
JP2001512442A (ja) 2001-08-21
EP0971923A2 (en) 2000-01-19
ATE227289T1 (de) 2002-11-15
CA2277151A1 (en) 1998-08-13
JP4425352B2 (ja) 2010-03-03
CA2277151C (en) 2007-04-17
CA2572577C (en) 2011-04-05
WO1998034917A3 (en) 1999-01-14
DE69809205D1 (de) 2002-12-12
EP0971923B1 (en) 2002-11-06
CA2572577A1 (en) 1998-08-13

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