ES2045485T3 - Metodo de preparacion de derivados de fenil-6 piperazinilalquil-3 1h, 3h-pirimidinediona-2,4, y su aplicacion en terapeutica. - Google Patents
Metodo de preparacion de derivados de fenil-6 piperazinilalquil-3 1h, 3h-pirimidinediona-2,4, y su aplicacion en terapeutica.Info
- Publication number
- ES2045485T3 ES2045485T3 ES89401330T ES89401330T ES2045485T3 ES 2045485 T3 ES2045485 T3 ES 2045485T3 ES 89401330 T ES89401330 T ES 89401330T ES 89401330 T ES89401330 T ES 89401330T ES 2045485 T3 ES2045485 T3 ES 2045485T3
- Authority
- ES
- Spain
- Prior art keywords
- denotes
- therapeutics
- application
- pirimidinediona
- piperazinilalquil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Indole Compounds (AREA)
Abstract
COMPUESTOS QUE RESPONDEN A LA FORMULA(I), EN LA QUE R1 ES UN H O UN HALOGENO O UN GRUPO METILO O METOCI, R3 ES UN H O UN GRUPO ALQUILO C1 - C4, O UN GRUPO BENCILO, N ES UN NUMERO ENTERO 2, 3 O 4, X ES UN GRUPO CH O UN H Y R3 ES UN H O UN HALOGENO O UN GRUPO METOXI. APLICACION EN TERAPEUTICA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8806568A FR2631625B1 (fr) | 1988-05-17 | 1988-05-17 | Derives de phenyl-6 piperazinylalkyl-3 1h,3h-pyrimidinedione-2,4, leur preparation et leur application en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2045485T3 true ES2045485T3 (es) | 1994-01-16 |
Family
ID=9366355
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89401330T Expired - Lifetime ES2045485T3 (es) | 1988-05-17 | 1989-05-12 | Metodo de preparacion de derivados de fenil-6 piperazinilalquil-3 1h, 3h-pirimidinediona-2,4, y su aplicacion en terapeutica. |
Country Status (20)
Country | Link |
---|---|
US (1) | US4950670A (es) |
EP (1) | EP0343050B1 (es) |
JP (1) | JPH02138266A (es) |
KR (1) | KR890017244A (es) |
AT (1) | ATE82969T1 (es) |
AU (1) | AU614135B2 (es) |
CA (1) | CA1327577C (es) |
DE (1) | DE68903680T2 (es) |
DK (1) | DK235889A (es) |
ES (1) | ES2045485T3 (es) |
FI (1) | FI892344A (es) |
FR (1) | FR2631625B1 (es) |
GR (1) | GR3007118T3 (es) |
HU (1) | HU201057B (es) |
IE (1) | IE891579L (es) |
IL (1) | IL90309A (es) |
NO (1) | NO172437C (es) |
NZ (1) | NZ229144A (es) |
PT (1) | PT90572B (es) |
ZA (1) | ZA893651B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2655988B1 (fr) * | 1989-12-20 | 1994-05-20 | Adir Cie | Nouveaux derives de la napht-1-yl piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
GB9012311D0 (en) * | 1990-06-01 | 1990-07-18 | Wellcome Found | Pharmacologically active cns compounds |
DK148392D0 (da) * | 1992-12-09 | 1992-12-09 | Lundbeck & Co As H | Heterocykliske forbindelser |
JP3329534B2 (ja) * | 1993-10-20 | 2002-09-30 | 株式会社東海理化電機製作所 | シフトレバー装置 |
DE4425143A1 (de) | 1994-07-15 | 1996-01-18 | Basf Ag | Substituierte Pyrimidinverbindungen und deren Verwendung |
US6306909B1 (en) | 1997-03-12 | 2001-10-23 | Queen's University At Kingston | Anti-epileptogenic agents |
EP0957099B1 (en) | 1998-04-15 | 2002-11-20 | Pfizer Products Inc. | Heterocyclic carboxamides |
WO2001055119A2 (en) * | 2000-01-25 | 2001-08-02 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
US7501429B2 (en) * | 2001-04-11 | 2009-03-10 | Queen's University At Kingston | Pyrimidine compounds as anti-ictogenic and/or anti-epileptogenic agents |
EP1397136A1 (en) * | 2001-05-25 | 2004-03-17 | Queen's University At Kingston | Heterocyclic beta-aminoacids and their use as anti-epileptogenic agents |
CA2557541C (en) | 2004-02-26 | 2014-12-16 | Aska Pharmaceutical Co., Ltd. | Pyrimidine derivatives |
CN102140090A (zh) * | 2004-03-15 | 2011-08-03 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
MXPA06013520A (es) * | 2004-05-21 | 2007-01-26 | Pfizer Prod Inc | Tetrahironaftilpiperazinas como antagonistas, agonistas inversos y agonistas parciales de 5-ht1b. |
KR102103768B1 (ko) | 2018-04-04 | 2020-04-23 | 한양대학교 에리카산학협력단 | 5-ht2c 항진제로서의 활성을 가지는 광학 활성의 2-아미노-4-알콕시 피리미딘 유도체 |
EP4400502A2 (en) * | 2021-04-14 | 2024-07-17 | Shionogi & Co., Ltd | Triazine derivatives having virus replication inhibitory activity and pharmaceutical composition comprising the same |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4625028A (en) * | 1983-07-11 | 1986-11-25 | The Upjohn Company | 6-aryluracils and selected novel intermediates used in the preparation thereof |
MX173362B (es) * | 1987-03-02 | 1994-02-23 | Pfizer | Compuestos de piperazinil heterociclicos y procedimiento para su preparacion |
CA1331757C (en) * | 1988-02-29 | 1994-08-30 | Janssen Pharmaceutica Naamloze Vennootschap | 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols |
US4845221A (en) * | 1988-04-15 | 1989-07-04 | American Home Products Corporation | Serotonergic substituted piperazinyl tetralins |
-
1988
- 1988-05-17 FR FR8806568A patent/FR2631625B1/fr not_active Expired - Fee Related
-
1989
- 1989-05-12 ES ES89401330T patent/ES2045485T3/es not_active Expired - Lifetime
- 1989-05-12 AT AT89401330T patent/ATE82969T1/de not_active IP Right Cessation
- 1989-05-12 DE DE8989401330T patent/DE68903680T2/de not_active Expired - Fee Related
- 1989-05-12 EP EP89401330A patent/EP0343050B1/fr not_active Expired - Lifetime
- 1989-05-16 US US07/352,342 patent/US4950670A/en not_active Expired - Fee Related
- 1989-05-16 CA CA000599796A patent/CA1327577C/en not_active Expired - Fee Related
- 1989-05-16 NZ NZ229144A patent/NZ229144A/en unknown
- 1989-05-16 JP JP1122706A patent/JPH02138266A/ja active Pending
- 1989-05-16 HU HU892428A patent/HU201057B/hu not_active IP Right Cessation
- 1989-05-16 KR KR1019890006530A patent/KR890017244A/ko not_active Application Discontinuation
- 1989-05-16 IL IL9030989A patent/IL90309A/en unknown
- 1989-05-16 AU AU34843/89A patent/AU614135B2/en not_active Ceased
- 1989-05-16 PT PT90572A patent/PT90572B/pt not_active IP Right Cessation
- 1989-05-16 NO NO891949A patent/NO172437C/no unknown
- 1989-05-16 DK DK235889A patent/DK235889A/da not_active Application Discontinuation
- 1989-05-16 IE IE891579A patent/IE891579L/xx unknown
- 1989-05-16 FI FI892344A patent/FI892344A/fi not_active Application Discontinuation
- 1989-05-16 ZA ZA893651A patent/ZA893651B/xx unknown
-
1993
- 1993-02-19 GR GR930400354T patent/GR3007118T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE68903680D1 (de) | 1993-01-14 |
PT90572B (pt) | 1994-08-31 |
FR2631625A1 (fr) | 1989-11-24 |
FR2631625B1 (fr) | 1992-10-16 |
FI892344A (fi) | 1989-11-18 |
NO891949L (no) | 1989-11-20 |
HUT50164A (en) | 1989-12-28 |
KR890017244A (ko) | 1989-12-15 |
ATE82969T1 (de) | 1992-12-15 |
US4950670A (en) | 1990-08-21 |
PT90572A (pt) | 1989-11-30 |
GR3007118T3 (es) | 1993-07-30 |
NO172437B (no) | 1993-04-13 |
DE68903680T2 (de) | 1993-06-17 |
DK235889A (da) | 1989-11-17 |
CA1327577C (en) | 1994-03-08 |
IE891579L (en) | 1989-11-16 |
IL90309A (en) | 1994-02-27 |
IL90309A0 (en) | 1989-12-15 |
NO891949D0 (no) | 1989-05-16 |
NZ229144A (en) | 1990-10-26 |
AU3484389A (en) | 1989-11-23 |
HU201057B (en) | 1990-09-28 |
AU614135B2 (en) | 1991-08-22 |
NO172437C (no) | 1993-07-21 |
FI892344A0 (fi) | 1989-05-16 |
EP0343050B1 (fr) | 1992-12-02 |
ZA893651B (en) | 1990-01-31 |
DK235889D0 (da) | 1989-05-16 |
JPH02138266A (ja) | 1990-05-28 |
EP0343050A1 (fr) | 1989-11-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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