ES2182507T3 - Sistema terapeutico que puede ser activado por la humedad. - Google Patents
Sistema terapeutico que puede ser activado por la humedad.Info
- Publication number
- ES2182507T3 ES2182507T3 ES99914523T ES99914523T ES2182507T3 ES 2182507 T3 ES2182507 T3 ES 2182507T3 ES 99914523 T ES99914523 T ES 99914523T ES 99914523 T ES99914523 T ES 99914523T ES 2182507 T3 ES2182507 T3 ES 2182507T3
- Authority
- ES
- Spain
- Prior art keywords
- skin
- mucous membrane
- active agent
- activating agent
- diffusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Sistema terapéutico para la administración controlada de al menos un principio activo terapéutico a un organismo humano o animal mediante difusión a través de la piel o de las mucosas, de manera que, durante la fabricación y el almacenamiento, dicho principio activo se encuentra en un primer estado en que es químicamente estable y carece de la permeabilidad suficiente para la piel o las mucosas, mientras que en el lugar de aplicación, y debido a la penetración de humedad, dicho principio activo pasa a un segundo estado en que ya es apto para la difusión a través de la piel o de las mucosas y puede ser absorbido por el organismo. Este principio activo se caracteriza porque, en el primer estado, se encuentra en el sistema en forma de sal apta para uso farmacéutico, como sólido no disperso y disuelto. Con la entrada de humedad, y por la acción del agente activador también contenido en el sistema, el principio activo experimenta una transformación química y pasa a un segundo estado de ácido o base que el organismo absorbe, a través de la piel o las mucosas, más rápido y en mayor cantidad que la forma salina. El agente activador es una sustancia sólida de reacción ácida o básica en solución acuosa o una mezcla de varias sustancias de este tipo y contiene una proporción de agua de al menos el 5 % alojada en o ligada a su estructura de sólido. El principio activo en forma de sal y el agente activador están separados el uno del otro.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19814087A DE19814087A1 (de) | 1998-03-30 | 1998-03-30 | Feuchtigkeitsaktivierbares therapeutisches System |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2182507T3 true ES2182507T3 (es) | 2003-03-01 |
Family
ID=7862905
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99914523T Expired - Lifetime ES2182507T3 (es) | 1998-03-30 | 1999-03-18 | Sistema terapeutico que puede ser activado por la humedad. |
Country Status (13)
Country | Link |
---|---|
US (1) | US7175853B1 (es) |
EP (1) | EP1069892B1 (es) |
JP (1) | JP4252212B2 (es) |
KR (1) | KR100550886B1 (es) |
AT (1) | ATE221774T1 (es) |
AU (1) | AU3331299A (es) |
CA (1) | CA2326662C (es) |
DE (2) | DE19814087A1 (es) |
DK (1) | DK1069892T3 (es) |
ES (1) | ES2182507T3 (es) |
NO (1) | NO20004835D0 (es) |
PT (1) | PT1069892E (es) |
WO (1) | WO1999049853A1 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10137162A1 (de) * | 2001-07-30 | 2003-02-20 | Hexal Ag | Matrixkontrolliertes transdermales therapeutisches System zur Anwendung von Pramiprexol und Ropinirol |
DE10159745A1 (de) | 2001-12-05 | 2003-07-03 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit verbessertem Langzeittragekomfort |
DE102007041734A1 (de) * | 2006-12-20 | 2008-06-26 | Tesa Ag | Repulpierbare Klebmassen |
ES2778724T3 (es) * | 2008-02-27 | 2020-08-11 | Hisamitsu Pharmaceutical Co | Parche |
EP2255802B1 (en) * | 2008-02-27 | 2018-01-17 | Hisamitsu Pharmaceutical Co., Inc. | Adhesive skin patch and packaged product |
DE102008013701A1 (de) * | 2008-03-11 | 2009-09-17 | Lts Lohmann Therapie-Systeme Ag | Transdermales Therapeutisches System mit stabilisierter Membran |
ES2589008T3 (es) * | 2009-04-24 | 2016-11-08 | Hisamitsu Pharmaceutical Co., Inc. | Bolsa de envase que contiene parche adhesivo y método para almacenar parche adhesivo |
ES2513691T3 (es) * | 2009-05-21 | 2014-10-27 | Hisamitsu Pharmaceutical Co., Inc. | Preparación transdérmica |
DE102009022915A1 (de) * | 2009-05-27 | 2010-12-09 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit gesteuertem Wirkstofffluss |
EP2500038A4 (en) * | 2009-11-12 | 2015-03-11 | Univ Nihon | PHATMACEUTICAL COMPOSITION FOR EXTERNAL USE / |
JP6083734B2 (ja) * | 2009-12-22 | 2017-02-22 | リュイェ ファーマ アーゲーLuye Pharma AG | リバスチグミンまたはその誘導体を投与するための経皮治療システム |
US10076502B2 (en) | 2009-12-22 | 2018-09-18 | Luye Pharma Ag | Transdermal therapeutic system for administering rivastigmine or derivatives thereof |
NZ601077A (en) | 2010-01-14 | 2014-07-25 | Novartis Ag | Use of an adrenal hormone-modifying agent |
UA103851C2 (en) | 2010-04-30 | 2013-11-25 | ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. | Propylaminoindan transdermal composition |
DE102010024105A1 (de) * | 2010-06-17 | 2011-12-22 | Grünenthal GmbH | Transdermale Verabreichung von Memantin |
CN103476404B (zh) | 2011-03-24 | 2017-09-29 | 帝国制药美国公司 | 包含活性剂层和活性剂转化层的透皮组合物 |
WO2012165254A1 (ja) * | 2011-05-31 | 2012-12-06 | 久光製薬株式会社 | ロピニロール含有貼付剤及びその包装体 |
EP2776020B1 (en) | 2011-11-09 | 2019-09-11 | Teikoku Seiyaku Co., Ltd. | Methods for the treatment of skin neoplasms |
US9481777B2 (en) | 2012-03-30 | 2016-11-01 | The Procter & Gamble Company | Method of dewatering in a continuous high internal phase emulsion foam forming process |
AU2013338243B2 (en) | 2012-11-02 | 2016-09-29 | Teikoku Seiyaku Co., Ltd. | Propynylaminoindan transdermal compositions |
WO2015137872A1 (en) * | 2014-03-13 | 2015-09-17 | Innovator Skåne Ab | Tubular or sheet-shaped drug delivery system |
CA3048897A1 (en) * | 2016-12-29 | 2018-07-05 | Pure Ratios Holdings, Inc. | Modular transdermal delivery system and associated methods of manufacture and use |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2028074T3 (es) * | 1986-06-13 | 1992-07-01 | Alza Corporation | Activacion por humedad de un sistema de suministro transdermico de farmacos. |
US4781924A (en) * | 1987-11-09 | 1988-11-01 | Alza Corporation | Transdermal drug delivery device |
US4837027A (en) * | 1987-11-09 | 1989-06-06 | Alza Corporation | Transdermal drug delivery device |
AT392587B (de) | 1988-03-03 | 1991-04-25 | Sandoz Ag | Pharmazeutische zusammensetzung enthaltend phenylcarbamate |
DE3905051A1 (de) | 1989-02-18 | 1990-08-30 | Lohmann Therapie Syst Lts | Therapeutisches system zur verzoegerten und gesteuerten transdermalen oder transmucosalen verabreichung von wirkstoffen (i) |
DE3905050A1 (de) * | 1989-02-18 | 1990-08-30 | Lohmann Therapie Syst Lts | Therapeutisches system zur verzoegerten und gesteuerten transdermalen oder transmucosalen verabreichung von wirkstoffen (ii) |
DE3910543A1 (de) * | 1989-04-01 | 1990-10-11 | Lohmann Therapie Syst Lts | Transdermales therapeutisches system mit erhoehtem wirkstofffluss und verfahren zu seiner herstellung |
JPH04124128A (ja) * | 1990-09-13 | 1992-04-24 | Lion Corp | 肛門部疾患治療用貼付剤 |
US5989586A (en) | 1992-10-05 | 1999-11-23 | Cygnus, Inc. | Two-phase matrix for sustained release drug delivery device |
GB2290964A (en) * | 1994-07-08 | 1996-01-17 | Arto Olavi Urtti | Transdermal drug delivery system |
US5807570A (en) | 1995-09-29 | 1998-09-15 | Cygnus, Inc. | Transdermal administration of ropinirole and analogs thereof |
-
1998
- 1998-03-30 DE DE19814087A patent/DE19814087A1/de not_active Withdrawn
-
1999
- 1999-03-18 AT AT99914523T patent/ATE221774T1/de active
- 1999-03-18 ES ES99914523T patent/ES2182507T3/es not_active Expired - Lifetime
- 1999-03-18 DK DK99914523T patent/DK1069892T3/da active
- 1999-03-18 DE DE59902270T patent/DE59902270D1/de not_active Expired - Lifetime
- 1999-03-18 CA CA002326662A patent/CA2326662C/en not_active Expired - Lifetime
- 1999-03-18 PT PT99914523T patent/PT1069892E/pt unknown
- 1999-03-18 KR KR1020007010629A patent/KR100550886B1/ko not_active IP Right Cessation
- 1999-03-18 EP EP99914523A patent/EP1069892B1/de not_active Expired - Lifetime
- 1999-03-18 AU AU33312/99A patent/AU3331299A/en not_active Abandoned
- 1999-03-18 JP JP2000540819A patent/JP4252212B2/ja not_active Expired - Lifetime
- 1999-03-18 US US09/647,289 patent/US7175853B1/en not_active Expired - Lifetime
- 1999-03-18 WO PCT/EP1999/001802 patent/WO1999049853A1/de active IP Right Grant
-
2000
- 2000-09-26 NO NO20004835A patent/NO20004835D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US7175853B1 (en) | 2007-02-13 |
ATE221774T1 (de) | 2002-08-15 |
JP4252212B2 (ja) | 2009-04-08 |
CA2326662A1 (en) | 1999-10-07 |
PT1069892E (pt) | 2002-12-31 |
EP1069892B1 (de) | 2002-08-07 |
JP2002509879A (ja) | 2002-04-02 |
NO20004835L (no) | 2000-09-26 |
EP1069892A1 (de) | 2001-01-24 |
DE59902270D1 (de) | 2002-09-12 |
NO20004835D0 (no) | 2000-09-26 |
DE19814087A1 (de) | 1999-10-14 |
KR20010042173A (ko) | 2001-05-25 |
DK1069892T3 (da) | 2002-12-02 |
WO1999049853A1 (de) | 1999-10-07 |
KR100550886B1 (ko) | 2006-02-10 |
AU3331299A (en) | 1999-10-18 |
CA2326662C (en) | 2007-01-16 |
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