ES2181269T3 - Compuestos analogos a fosfolipidos. - Google Patents
Compuestos analogos a fosfolipidos.Info
- Publication number
- ES2181269T3 ES2181269T3 ES98945258T ES98945258T ES2181269T3 ES 2181269 T3 ES2181269 T3 ES 2181269T3 ES 98945258 T ES98945258 T ES 98945258T ES 98945258 T ES98945258 T ES 98945258T ES 2181269 T3 ES2181269 T3 ES 2181269T3
- Authority
- ES
- Spain
- Prior art keywords
- integer
- alkyl
- carbon atoms
- atoms
- radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002361 compost Substances 0.000 title 1
- 150000003904 phospholipids Chemical class 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- -1 1,2-dihydroxypropyl Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 239000002502 liposome Substances 0.000 abstract 1
- 125000000075 primary alcohol group Chemical group 0.000 abstract 1
- 150000003333 secondary alcohols Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Dispersion Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- External Artificial Organs (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Compuesto de fórmula general **(Fórmulas)** en donde A es **(Fórmulas)** significando R1 y R2, independientemente entre sí, hidrógeno, un resto acilo o alquilo saturado o insaturado, el cual puede estar eventualmente ramificado o/y sustituido, siendo la suma de átomos de carbono en acilo y alquilo de 16 a 44 átomos de C, s = representa un número entero de 0 a 8, c = es un resto de un alcohol primario o secundario de fórmula RO-, significando R un resto alquilo saturado o insaturado, predominantemente con doble enlace cis, de 12 a 30 átomos de carbono, n = representa un número entero de 2 a 8, R3 a = puede ser 1, 2-dihidroxipropilo, o b = puede ser alquilo con 1 a 3 átomos de C, si z es > 0, o c = puede ser alquilo con 1 a 3 átomos de C, si son: n no = 2 y z = 0, x = representa un número entero de 0 a 8 y = es 1 para z = 1 a 5, o = es 1 a 4 para z = 1, z = representa un número entero de 0 a 5.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19735776A DE19735776A1 (de) | 1996-06-03 | 1997-08-18 | Phospholipidanaloge Verbindungen |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2181269T3 true ES2181269T3 (es) | 2003-02-16 |
Family
ID=7839317
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98945258T Expired - Lifetime ES2181269T3 (es) | 1997-08-18 | 1998-08-18 | Compuestos analogos a fosfolipidos. |
Country Status (10)
Country | Link |
---|---|
US (6) | US6344576B1 (es) |
EP (1) | EP1019417B1 (es) |
JP (2) | JP4550271B2 (es) |
AT (1) | ATE226210T1 (es) |
AU (1) | AU9263298A (es) |
DE (1) | DE59805997D1 (es) |
DK (1) | DK1019417T3 (es) |
ES (1) | ES2181269T3 (es) |
PT (1) | PT1019417E (es) |
WO (1) | WO1999009037A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU9263298A (en) * | 1997-08-18 | 1999-03-08 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Phospholipid analogue compounds |
DE19835611A1 (de) * | 1998-08-06 | 2000-02-10 | Max Planck Gesellschaft | Neuartige Phospholipide mit synthetischen, ungesättigten Alkyl- und Acylketten |
DE10148066A1 (de) * | 2001-09-28 | 2003-04-24 | Max Planck Gesellschaft | Liposome enthaltend (Ether)-Lysolecithine |
EP1300161A1 (en) * | 2001-10-08 | 2003-04-09 | Rubitec Gesellschaft für Innovation und Technologie der Ruhr-Universität Bochum mbH | Cationic lipids suitable for gene transfer |
ES2184650B1 (es) * | 2001-10-10 | 2004-09-16 | Farmaleis, S.L. | Utilizacion de colesterol y fosfolipidos en medicamentos para el tratamiento de la leishmaniasis en los canidos. |
WO2003082882A1 (fr) * | 2002-03-29 | 2003-10-09 | Nof Corporation | Derive phospholipidique |
DE10221183A1 (de) * | 2002-05-13 | 2003-12-04 | Max Planck Gesellschaft | Phosphatidyl-oligo-glycerine und Strukturanaloga |
JP4808403B2 (ja) * | 2002-09-30 | 2011-11-02 | 日油株式会社 | リン脂質誘導体 |
AU2003285071A1 (en) | 2002-10-30 | 2004-06-07 | Nikolaos Avlonitis | Antiprotozoal ring-substituted phospholipids |
JP4403303B2 (ja) * | 2003-01-06 | 2010-01-27 | 日油株式会社 | リン脂質誘導体及びその製造方法 |
WO2004062594A2 (en) * | 2003-01-09 | 2004-07-29 | Zeneus Pharma Limited | Antineoplastic ether lipid compounds with modifications at the sn-3 carbon |
WO2004083219A1 (ja) * | 2003-03-20 | 2004-09-30 | Nof Corporation | リン脂質誘導体 |
KR100769546B1 (ko) * | 2005-06-28 | 2007-10-31 | 주식회사 메디슨 | 2d 초음파 영상을 이용한 3d 초음파 영상 형성 방법 및초음파 진단 시스템 |
US9567357B2 (en) | 2011-06-24 | 2017-02-14 | Biointeractions Ltd. | Biocompatible, biomimetic ampholyte materials |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE240020C (es) * | ||||
DE2033357C3 (de) | 1970-07-06 | 1980-02-14 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen | Palmitoyl-propandioKl 3)-phosphorsäure-S-trimethylaminophenylester und Verfahren zu dessen Herstellung |
US4086257A (en) * | 1976-10-12 | 1978-04-25 | Sears Barry D | Phosphatidyl quaternary ammonium compounds |
DE2752553C2 (de) * | 1977-11-24 | 1985-07-25 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Neue phospholipidartige Verbindungen, ihre Verwendung zur Herstellung von Pflanzenhybriden und Verfahren zu ihrer Herstellung |
EP0032622B1 (en) | 1979-12-20 | 1985-08-14 | Dennis Chapman | Polymerisable phospholipids and polymers thereof, methods for their preparation, methods for their use in coating substrates and forming liposomes and the resulting coated substrates and liposome compositions |
JPS56135492A (en) * | 1979-12-20 | 1981-10-22 | Chiyatsupuman Denisu | Biocompatible surfaces |
DE3340950A1 (de) * | 1983-11-11 | 1985-05-23 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur gewinnung von cholesterinesterase |
US4774085A (en) * | 1985-07-09 | 1988-09-27 | 501 Board of Regents, Univ. of Texas | Pharmaceutical administration systems containing a mixture of immunomodulators |
DD240020A1 (de) * | 1985-08-02 | 1986-10-15 | Univ Leipzig | Verfahren zur herstellung neuer, pharmakologisch hochwirksamer phospholipide |
SE8601457D0 (sv) * | 1986-04-01 | 1986-04-01 | Draco Ab | Compositions of liposomes and b?712-receptor active substances for inhalation |
EP0252004A1 (de) | 1986-06-26 | 1988-01-07 | Ciba-Geigy Ag | Pharmazeutische Zusammensetzungen für die parenterale Applikation |
EP0256989A1 (en) | 1986-08-18 | 1988-02-24 | Board Of Regents, The University Of Texas System | Pharmaceutical administration systems containing chemotactic peptides |
US4916118A (en) * | 1986-08-18 | 1990-04-10 | Board Of Regents, The University Of Texas System | Pharmaceutical administration systems containing chemotactic peptides |
US4931195A (en) * | 1987-07-15 | 1990-06-05 | Colgate-Palmolive Company | Low viscosity stable non-aqueous suspension containing organophilic clay and low density filler |
EP0465580A4 (en) | 1989-03-29 | 1992-03-18 | Alcon Laboratories Inc | Use of monoacyl phosphoglycerides to enhance the corneal penetration of ophthalmic drugs |
ES2060184T3 (es) * | 1989-06-22 | 1994-11-16 | Atta | Moleculas anfifilicas conteniendo fluor y fosforo con propiedades tensoactivas. |
US5270053A (en) * | 1990-04-03 | 1993-12-14 | Ciba-Geigy Corp. | Parenterally administerable liposome formulation comprising synthetic lipid |
JP2869572B2 (ja) * | 1990-05-14 | 1999-03-10 | 和光純薬工業株式会社 | ホスファチジルコリン誘導体の製造方法 |
EP0467838A3 (en) | 1990-07-17 | 1992-09-02 | Ciba-Geigy Ag | Process for preparing an injectable liposome dispersion |
JPH04356417A (ja) * | 1990-09-26 | 1992-12-10 | Kao Corp | 静脈注射用脂肪乳剤 |
AU675063B2 (en) | 1992-04-24 | 1997-01-23 | Biocompatibles Uk Limited | Method of reducing microorganism adhesion |
JPH06157311A (ja) | 1992-11-16 | 1994-06-03 | Eisai Co Ltd | 血管病変治療剤 |
JPH06228012A (ja) * | 1993-01-29 | 1994-08-16 | Dai Ichi Seiyaku Co Ltd | リポソーム製剤 |
US5616602A (en) * | 1993-07-09 | 1997-04-01 | Ciba-Geigy Corporation | Topically administrable zinc phthalocyanine compositions |
GB9501286D0 (en) | 1995-01-24 | 1995-03-15 | Ciba Geigy Ag | Pharmaceutical compositions and preparations thereof |
DE19505894A1 (de) * | 1995-02-21 | 1996-08-22 | Boehringer Mannheim Gmbh | Verfahren und Reagenz zur spezifischen Bestimmung von LDL in Serumproben |
ATE244254T1 (de) * | 1996-02-16 | 2003-07-15 | Max Planck Gesellschaft | Phosphatidyloligoglycerine |
US5876480A (en) * | 1996-02-20 | 1999-03-02 | The United States Of America As Represented By The Secretary Of The Navy | Synthesis of unagglomerated metal nano-particles at membrane interfaces |
DK0936860T3 (da) | 1996-10-25 | 2002-06-10 | Monsanto Technology Llc | Sammensætning og fremgangsmåde til behandling af planter med exogene kemikalier |
AU9263298A (en) | 1997-08-18 | 1999-03-08 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Phospholipid analogue compounds |
US6583251B1 (en) * | 1997-09-08 | 2003-06-24 | Emory University | Modular cytomimetic biomaterials, transport studies, preparation and utilization thereof |
-
1998
- 1998-08-18 AU AU92632/98A patent/AU9263298A/en not_active Abandoned
- 1998-08-18 US US09/486,039 patent/US6344576B1/en not_active Expired - Lifetime
- 1998-08-18 ES ES98945258T patent/ES2181269T3/es not_active Expired - Lifetime
- 1998-08-18 DK DK98945258T patent/DK1019417T3/da active
- 1998-08-18 WO PCT/EP1998/005252 patent/WO1999009037A1/de active IP Right Grant
- 1998-08-18 DE DE59805997T patent/DE59805997D1/de not_active Expired - Lifetime
- 1998-08-18 EP EP98945258A patent/EP1019417B1/de not_active Expired - Lifetime
- 1998-08-18 PT PT98945258T patent/PT1019417E/pt unknown
- 1998-08-18 JP JP2000509716A patent/JP4550271B2/ja not_active Expired - Fee Related
- 1998-08-18 AT AT98945258T patent/ATE226210T1/de not_active IP Right Cessation
-
2001
- 2001-12-26 US US10/025,778 patent/US6545169B1/en not_active Expired - Lifetime
-
2003
- 2003-03-04 US US10/377,617 patent/US6828453B2/en not_active Expired - Fee Related
-
2004
- 2004-10-21 US US10/969,020 patent/US7595411B2/en not_active Expired - Fee Related
-
2009
- 2009-09-24 JP JP2009219177A patent/JP4714289B2/ja not_active Expired - Fee Related
- 2009-09-28 US US12/567,992 patent/US7939683B2/en not_active Expired - Fee Related
-
2011
- 2011-04-12 US US13/084,876 patent/US8497388B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US8497388B2 (en) | 2013-07-30 |
AU9263298A (en) | 1999-03-08 |
US7595411B2 (en) | 2009-09-29 |
JP2010018625A (ja) | 2010-01-28 |
PT1019417E (pt) | 2003-03-31 |
EP1019417A1 (de) | 2000-07-19 |
JP4550271B2 (ja) | 2010-09-22 |
US6828453B2 (en) | 2004-12-07 |
EP1019417B1 (de) | 2002-10-16 |
US20120009246A1 (en) | 2012-01-12 |
DK1019417T3 (da) | 2003-02-17 |
US7939683B2 (en) | 2011-05-10 |
WO1999009037A1 (de) | 1999-02-25 |
US20030198663A1 (en) | 2003-10-23 |
US6344576B1 (en) | 2002-02-05 |
DE59805997D1 (de) | 2002-11-21 |
JP2001515082A (ja) | 2001-09-18 |
ATE226210T1 (de) | 2002-11-15 |
US20100183705A1 (en) | 2010-07-22 |
US20050165245A1 (en) | 2005-07-28 |
US6545169B1 (en) | 2003-04-08 |
JP4714289B2 (ja) | 2011-06-29 |
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