DK1019417T3 - Phospholipidanaloge forbindelser - Google Patents

Phospholipidanaloge forbindelser

Info

Publication number
DK1019417T3
DK1019417T3 DK98945258T DK98945258T DK1019417T3 DK 1019417 T3 DK1019417 T3 DK 1019417T3 DK 98945258 T DK98945258 T DK 98945258T DK 98945258 T DK98945258 T DK 98945258T DK 1019417 T3 DK1019417 T3 DK 1019417T3
Authority
DK
Denmark
Prior art keywords
integer
alkyl
carbon atoms
atoms
radical
Prior art date
Application number
DK98945258T
Other languages
English (en)
Inventor
Hans-Joerg Eibl
Original Assignee
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19735776A external-priority patent/DE19735776A1/de
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Application granted granted Critical
Publication of DK1019417T3 publication Critical patent/DK1019417T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • External Artificial Organs (AREA)
DK98945258T 1997-08-18 1998-08-18 Phospholipidanaloge forbindelser DK1019417T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19735776A DE19735776A1 (de) 1996-06-03 1997-08-18 Phospholipidanaloge Verbindungen
PCT/EP1998/005252 WO1999009037A1 (de) 1997-08-18 1998-08-18 Phospholipidanaloge verbindungen

Publications (1)

Publication Number Publication Date
DK1019417T3 true DK1019417T3 (da) 2003-02-17

Family

ID=7839317

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98945258T DK1019417T3 (da) 1997-08-18 1998-08-18 Phospholipidanaloge forbindelser

Country Status (10)

Country Link
US (6) US6344576B1 (da)
EP (1) EP1019417B1 (da)
JP (2) JP4550271B2 (da)
AT (1) ATE226210T1 (da)
AU (1) AU9263298A (da)
DE (1) DE59805997D1 (da)
DK (1) DK1019417T3 (da)
ES (1) ES2181269T3 (da)
PT (1) PT1019417E (da)
WO (1) WO1999009037A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4550271B2 (ja) 1997-08-18 2010-09-22 マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ リン脂質類似化合物
DE19835611A1 (de) 1998-08-06 2000-02-10 Max Planck Gesellschaft Neuartige Phospholipide mit synthetischen, ungesättigten Alkyl- und Acylketten
DE10148066A1 (de) * 2001-09-28 2003-04-24 Max Planck Gesellschaft Liposome enthaltend (Ether)-Lysolecithine
EP1300161A1 (en) * 2001-10-08 2003-04-09 Rubitec Gesellschaft für Innovation und Technologie der Ruhr-Universität Bochum mbH Cationic lipids suitable for gene transfer
ES2184650B1 (es) * 2001-10-10 2004-09-16 Farmaleis, S.L. Utilizacion de colesterol y fosfolipidos en medicamentos para el tratamiento de la leishmaniasis en los canidos.
AU2003220917A1 (en) * 2002-03-29 2003-10-13 Daiichi Pharmaceutical Co., Ltd. Phospholipid derivative
DE10221183A1 (de) * 2002-05-13 2003-12-04 Max Planck Gesellschaft Phosphatidyl-oligo-glycerine und Strukturanaloga
EP1550675B1 (en) * 2002-09-30 2008-01-02 Nof Corporation Phospholipid derivative
CN1742017A (zh) * 2002-10-30 2006-03-01 Mak科学公司 抗原生动物的环取代的磷脂
CA2513144C (en) * 2003-01-06 2012-03-13 Nof Corporation Phospholipid derivative and method for producing the same
US20060116354A1 (en) * 2003-01-09 2006-06-01 Perkins Walter R Antineoplastic ether lipid compounds with modifications at the sn-3 carbon
JP4526479B2 (ja) * 2003-03-20 2010-08-18 日油株式会社 リン脂質誘導体
KR100769546B1 (ko) * 2005-06-28 2007-10-31 주식회사 메디슨 2ｄ 초음파 영상을 이용한 3ｄ 초음파 영상 형성 방법 및초음파 진단 시스템
US9567357B2 (en) 2011-06-24 2017-02-14 Biointeractions Ltd. Biocompatible, biomimetic ampholyte materials

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE240020C (da) *
DE2033357C3 (de) 1970-07-06 1980-02-14 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen Palmitoyl-propandioKl 3)-phosphorsäure-S-trimethylaminophenylester und Verfahren zu dessen Herstellung
US4086257A (en) * 1976-10-12 1978-04-25 Sears Barry D Phosphatidyl quaternary ammonium compounds
DE2752553C2 (de) * 1977-11-24 1985-07-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Neue phospholipidartige Verbindungen, ihre Verwendung zur Herstellung von Pflanzenhybriden und Verfahren zu ihrer Herstellung
JPS56135492A (en) * 1979-12-20 1981-10-22 Chiyatsupuman Denisu Biocompatible surfaces
EP0032622B1 (en) 1979-12-20 1985-08-14 Dennis Chapman Polymerisable phospholipids and polymers thereof, methods for their preparation, methods for their use in coating substrates and forming liposomes and the resulting coated substrates and liposome compositions
DE3340950A1 (de) * 1983-11-11 1985-05-23 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur gewinnung von cholesterinesterase
US4774085A (en) * 1985-07-09 1988-09-27 501 Board of Regents, Univ. of Texas Pharmaceutical administration systems containing a mixture of immunomodulators
DD240020A1 (de) * 1985-08-02 1986-10-15 Univ Leipzig Verfahren zur herstellung neuer, pharmakologisch hochwirksamer phospholipide
SE8601457D0 (sv) * 1986-04-01 1986-04-01 Draco Ab Compositions of liposomes and b?712-receptor active substances for inhalation
EP0252004A1 (de) 1986-06-26 1988-01-07 Ciba-Geigy Ag Pharmazeutische Zusammensetzungen für die parenterale Applikation
EP0256989A1 (en) 1986-08-18 1988-02-24 Board Of Regents, The University Of Texas System Pharmaceutical administration systems containing chemotactic peptides
US4916118A (en) * 1986-08-18 1990-04-10 Board Of Regents, The University Of Texas System Pharmaceutical administration systems containing chemotactic peptides
US4931195A (en) * 1987-07-15 1990-06-05 Colgate-Palmolive Company Low viscosity stable non-aqueous suspension containing organophilic clay and low density filler
JPH04504258A (ja) 1989-03-29 1992-07-30 アルコン　ラボラトリーズ　インコーポレイテッド モノアシルホスホグリセリド類を使用して眼薬の角膜への浸透を増強する方法
WO1990015807A1 (en) * 1989-06-22 1990-12-27 Applications Et Transferts De Technologies Avancées Fluorine and phosphorous-containing amphiphilic molecules with surfactant properties
US5270053A (en) * 1990-04-03 1993-12-14 Ciba-Geigy Corp. Parenterally administerable liposome formulation comprising synthetic lipid
JP2869572B2 (ja) * 1990-05-14 1999-03-10 和光純薬工業株式会社 ホスファチジルコリン誘導体の製造方法
EP0467838A3 (en) 1990-07-17 1992-09-02 Ciba-Geigy Ag Process for preparing an injectable liposome dispersion
JPH04356417A (ja) * 1990-09-26 1992-12-10 Kao Corp 静脈注射用脂肪乳剤
EP0639989B1 (en) 1992-04-24 2001-06-27 Biocompatibles Limited Method of reducing microorganism adhesion
JPH06157311A (ja) 1992-11-16 1994-06-03 Eisai Co Ltd 血管病変治療剤
JPH06228012A (ja) * 1993-01-29 1994-08-16 Dai Ichi Seiyaku Co Ltd リポソーム製剤
EP0633024A1 (en) * 1993-07-09 1995-01-11 Ciba-Geigy Ag Topically administrable zinc phthalocyanine compositions
GB9501286D0 (en) 1995-01-24 1995-03-15 Ciba Geigy Ag Pharmaceutical compositions and preparations thereof
DE19505894A1 (de) * 1995-02-21 1996-08-22 Boehringer Mannheim Gmbh Verfahren und Reagenz zur spezifischen Bestimmung von LDL in Serumproben
JP2000506121A (ja) * 1996-02-16 2000-05-23 マツクス―プランク―ゲゼルシヤフト ツール フエルデルング デル ヴイツセンシヤフテン エー フアウ ホスファチジルオリゴグリセリン
US5876480A (en) * 1996-02-20 1999-03-02 The United States Of America As Represented By The Secretary Of The Navy Synthesis of unagglomerated metal nano-particles at membrane interfaces
ID23906A (id) 1996-10-25 2000-05-25 Monsanto Co Komposisi dan metode untuk perlakuan tanaman dengan bahan kimia eksogen
JP4550271B2 (ja) 1997-08-18 2010-09-22 マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ リン脂質類似化合物
US6583251B1 (en) * 1997-09-08 2003-06-24 Emory University Modular cytomimetic biomaterials, transport studies, preparation and utilization thereof

Also Published As

Publication number Publication date
PT1019417E (pt) 2003-03-31
US20050165245A1 (en) 2005-07-28
WO1999009037A1 (de) 1999-02-25
US6545169B1 (en) 2003-04-08
ES2181269T3 (es) 2003-02-16
JP2010018625A (ja) 2010-01-28
EP1019417B1 (de) 2002-10-16
ATE226210T1 (de) 2002-11-15
US6828453B2 (en) 2004-12-07
JP2001515082A (ja) 2001-09-18
AU9263298A (en) 1999-03-08
US7939683B2 (en) 2011-05-10
US7595411B2 (en) 2009-09-29
US20100183705A1 (en) 2010-07-22
US20120009246A1 (en) 2012-01-12
EP1019417A1 (de) 2000-07-19
US6344576B1 (en) 2002-02-05
DE59805997D1 (de) 2002-11-21
JP4550271B2 (ja) 2010-09-22
JP4714289B2 (ja) 2011-06-29
US8497388B2 (en) 2013-07-30
US20030198663A1 (en) 2003-10-23

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