ES2178038T3 - Nuevos derivados de ciclosporina, su preparacion y las composiciones farmaceuticas que los contienen. - Google Patents

Nuevos derivados de ciclosporina, su preparacion y las composiciones farmaceuticas que los contienen.

Info

Publication number
ES2178038T3
ES2178038T3 ES97952999T ES97952999T ES2178038T3 ES 2178038 T3 ES2178038 T3 ES 2178038T3 ES 97952999 T ES97952999 T ES 97952999T ES 97952999 T ES97952999 T ES 97952999T ES 2178038 T3 ES2178038 T3 ES 2178038T3
Authority
ES
Spain
Prior art keywords
rent
bencilo
links
alkyl
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97952999T
Other languages
English (en)
Inventor
Jean-Claude Barriere
Georges Bashiardes
Jean-Christophe Carry
Michel Evers
Bruno Filoche
Serge Mignani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Application granted granted Critical
Publication of ES2178038T3 publication Critical patent/ES2178038T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LA INVENCION SE REFIERE A DERIVADOS DE CICLOSPORINA DE FORMULA GENERAL (I) EN LA QUE ALK ES ALQUILENO DE 2 A 6 C EN CADENA RECTA O RAMIFICADA O CICLOALQUILENO QUE CONTIENE DE 3 A 6 C Y R ES: BIEN OH, COOH O ALQUILOXICARBONILO, O BIEN NR 1 R 2 PARA EL CUAL R 1 , R 2 IDENTICOS O DIFERENTES SON H, O ALQUILO, ALCENILO (2 A 4 C), CICLOALQUILO (3 A 6 C), FENILO OPCIONALMENTE SUSTITUIDO (POR HALOGENO, ALQUILOXILO, ALQUILOXICARBONILO, AMINO, ALQUILAMINO O DIALQUILAMINO) O SON RADICALES BENCILO O HETEROCICLILO SATURADO O INSATURADO QUE CONTIENE 5 O 6 ESLABONES Y 1 A 3 HETEROATOMOS O PARA EL CUAL R SUB,1 Y R 2 FORMAN CON EL ATOMO DE NITROGENO AL QUE ESTAN U NIDOS UN HETEROCICLO QUE CONTIENE DE 4 A 6 ESLABONES QUE PUEDEN CONTENER OTRO HETEROATOMO ELEGIDO ENTRE N, O O S Y OPCIONALMENTE SUSTITUIDO POR ALQUILO, FENILO O BENCILO, BIEN UN RADICAL DE FORMULA GENERAL (I'') PARA EL CUAL R 1 Y R 2 ESTAN DEFINIDO COMO ANTERIORMENTE, R 3 ES H O ALQUILO Y N ES UN NUMERO ENTERO DE 2 A 4, SIENDO LAS PARTES O RADICALES DE ALQUILO DEFINIDOS ANTERIORMENTE RECTOS O RAMIFICADOS Y CONTENIENDO ENTRE 1 Y 4 ATOMOS DE CARBONO, ASI COMO SUS SALES FARMACEUTICAMENTE ACEPTABLES CUANDO EXISTEN. ESTOS NUEVOS PRODUCTOS SON PARTICULARMENTE UTILES PARA EL TRATAMIENTO Y/O LA PROFILAXIS DE LAS INFECCIONES CON RETROVIRUS.
ES97952999T 1996-12-24 1997-12-23 Nuevos derivados de ciclosporina, su preparacion y las composiciones farmaceuticas que los contienen. Expired - Lifetime ES2178038T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9615955A FR2757521B1 (fr) 1996-12-24 1996-12-24 Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ES2178038T3 true ES2178038T3 (es) 2002-12-16

Family

ID=9499088

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97952999T Expired - Lifetime ES2178038T3 (es) 1996-12-24 1997-12-23 Nuevos derivados de ciclosporina, su preparacion y las composiciones farmaceuticas que los contienen.

Country Status (14)

Country Link
US (1) US5994299A (es)
EP (1) EP0951474B1 (es)
JP (1) JP4146518B2 (es)
AT (1) ATE218582T1 (es)
AU (1) AU5669398A (es)
DE (1) DE69713152D1 (es)
DK (1) DK0951474T3 (es)
ES (1) ES2178038T3 (es)
FR (1) FR2757521B1 (es)
MA (1) MA26458A1 (es)
PT (1) PT951474E (es)
TN (1) TNSN97212A1 (es)
WO (1) WO1998028330A1 (es)
ZA (1) ZA9711607B (es)

Families Citing this family (53)

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Publication number Priority date Publication date Assignee Title
MXPA00012218A (es) * 1998-06-12 2002-04-24 Chem Ag C Ciclosporinas novedosas.
FR2780061B1 (fr) * 1998-06-22 2001-09-07 Rhone Poulenc Rorer Sa Nouveau procede de preparation de derives de cyclosporine
CN1218958C (zh) 1998-07-01 2005-09-14 德比奥药物股份有限公司 活性范围改善的环孢菌素
US6254860B1 (en) 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
CA2381425A1 (en) 1999-08-24 2001-03-01 Cellgate, Inc. Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties
KR100465012B1 (ko) * 2001-05-11 2005-01-13 주식회사 엘지생활건강 모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제
CA2461740C (en) 2001-10-19 2013-02-12 Isotechnika Inc. Synthesis of cyclosporin analogs
DK1435910T3 (da) * 2001-10-19 2009-11-09 Isotechnika Inc Nye cyclosporinanaloge mikroemulsionsprækoncentrater
US6987090B2 (en) * 2002-05-09 2006-01-17 Lg Household & Health Care Ltd. Use of 3-position cyclosporin derivatives for hair growth
KR20040039622A (ko) * 2002-11-04 2004-05-12 주식회사 엘지생활건강 모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제
EP1603512A2 (en) * 2003-03-17 2005-12-14 Albany Molecular Research, Inc. Novel cyclosporins
GB0320638D0 (en) * 2003-09-03 2003-10-01 Novartis Ag Organic compounds
US7780973B2 (en) * 2003-12-15 2010-08-24 Ethicon Endo-Surgery, Inc. Method and device for minimally invasive implantation of biomaterial
US20050142161A1 (en) * 2003-12-30 2005-06-30 Freeman Lynetta J. Collagen matrix for soft tissue augmentation
ATE497775T1 (de) * 2004-07-14 2011-02-15 Novartis Pharma Gmbh Verwendung einer kombination von cyclosporin und pegylierten interferonen zur behandlung von hepatitis c (hcv)
KR100597309B1 (ko) 2004-09-17 2006-07-05 주식회사 핸슨바이오텍 세베키아 베니하나를 이용한 [감마 히드록실메틸루신4] 사이클로스포린 a의 제조방법
WO2006039163A2 (en) * 2004-09-29 2006-04-13 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
EP1804823A4 (en) * 2004-09-29 2010-06-09 Amr Technology Inc NEW CYCLOSPORIN ANALOGUE AND ITS PHARMACEUTICAL APPLICATIONS
US7196161B2 (en) 2004-10-01 2007-03-27 Scynexis Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
PT1802650E (pt) * 2004-10-01 2011-12-30 Scynexis Inc Derivados da ciclosporina 3-éter e 3-tioéter substituída para o tratamento e prevenção da infecção de hepatite c
WO2006041631A2 (en) * 2004-10-06 2006-04-20 Amr Technology, Inc. Novel cyclosporin alkynes and their utility as pharmaceutical agents
US7691812B2 (en) 2004-11-04 2010-04-06 Trustees Of The University Of Pennsylvania Methods for inhibiting growth of prolactin-responsive cancer cells with cyclosporine A or other cyclophilin inhibitors
BRPI0519345A2 (pt) * 2004-12-23 2009-01-20 Novartis Ag composiÇço para tratamento do hcv
BRPI0519355A2 (pt) * 2004-12-23 2009-01-20 Novartis Ag compostos para tratamento contra flaviviridae
WO2007041631A1 (en) 2005-09-30 2007-04-12 Scynexis, Inc. ARYIiALKYL AND HETEROARYLALKYL DERIVATIVES OF CYCLOSPORINE A FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTION
KR20080059270A (ko) * 2005-09-30 2008-06-26 싸이넥시스, 인크. Ｃ형 간염 감염의 치료 및 예방을 위한 방법 및 제약조성물
CN101316606B (zh) * 2005-09-30 2015-05-27 西尼克斯公司 治疗和预防丙型肝炎感染的方法和药物组合物
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
ATE502633T1 (de) 2006-05-19 2011-04-15 Scynexis Inc Cyclosporins zur behandlung und vorbeugung von augenerkrankungen
WO2007141395A1 (fr) * 2006-06-02 2007-12-13 Claude Annie Perrichon Gestion des electrons actifs
CN101557819A (zh) * 2006-10-12 2009-10-14 诺瓦提斯公司 修饰的环孢素的用途
US7576057B2 (en) 2006-11-20 2009-08-18 Scynexis, Inc. Cyclic peptides
US20080255038A1 (en) * 2007-04-11 2008-10-16 Samuel Earl Hopkins Pharmaceutical compositions
NZ584356A (en) 2007-09-26 2011-10-28 Univ Oregon Health & Science Cyclic undecapeptides and derivatives as multiple sclerosis therapies
CN102083852A (zh) 2008-06-06 2011-06-01 西尼克斯公司 环孢菌素类似物及其在治疗hcv感染中的应用
US20090306033A1 (en) * 2008-06-06 2009-12-10 Keqiang Li Novel cyclic peptides
BRPI0915552A2 (pt) * 2008-07-10 2017-06-20 Allergan Inc derivados de ciclosporina, seu uso e sua composição farmacêutica
DE102008060549A1 (de) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
US8536114B2 (en) 2008-12-31 2013-09-17 Scynexis, Inc. Macrocycles
AU2010203656A1 (en) * 2009-01-07 2011-07-21 Scynexis, Inc. Cyclosporine derivative for use in the treatment of HCV and HIV infection
CA2763207A1 (en) 2009-05-27 2010-12-02 Allergan, Inc. Cyclosporin derivatives for treating inflammatory diseases and conditions
CA2785978A1 (en) 2009-12-30 2011-07-07 Scynexis, Inc. Cyclosporine analogues
CN107007815A (zh) 2010-07-16 2017-08-04 美国科技环球有限公司 新颖的环孢霉素a衍生物在病毒感染的治疗和预防中的应用
WO2012021796A2 (en) 2010-08-12 2012-02-16 S&T Global, Inc. Novel cyclosporin derivatives for the treatment and prevention of a viral infection
WO2012051193A1 (en) 2010-10-12 2012-04-19 Allergan, Inc. Cyclosporin analogs
US20120088734A1 (en) 2010-10-12 2012-04-12 Allergan, Inc. Cyclosporin Analogs
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
PL2651965T3 (pl) 2010-12-15 2019-04-30 Contravir Pharmaceuticals Inc Cząsteczki analogów cyklosporyny modyfikowane w aminokwasach 1 i 3
EP2705856A1 (en) 2012-09-07 2014-03-12 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. Compounds for the treatment of neurodegenerative disorders
WO2020037530A1 (en) * 2018-08-22 2020-02-27 Waterstone Pharmaceuticals (Wuhan) Co., Ltd. Crystalline form of compound and uses thereof in medicine
WO2020118715A1 (en) * 2018-12-14 2020-06-18 Waterstone Pharmaceuticals (Wuhan) Co., Ltd. Salts of scy-635 and uses thereof in medicine
EP3893914B1 (en) * 2018-12-14 2024-03-20 Waterstone Pharmaceuticals (Wuhan) Co., Ltd. Maleate of scy-635 and uses thereof in medicine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194972B1 (en) * 1985-03-11 1992-07-29 Sandoz Ag Novel cyclosporins
US4814323A (en) * 1986-03-25 1989-03-21 Andrieu J M Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus
DK0484281T4 (da) * 1990-11-02 2001-02-05 Novartis Ag Cyclosporiner
CN1141317C (zh) * 1995-07-17 2004-03-10 碳化学公司 有抗人体免疫缺损病毒作用的环孢菌素衍生物

Also Published As

Publication number Publication date
JP2001507347A (ja) 2001-06-05
MA26458A1 (fr) 2004-12-20
WO1998028330A1 (fr) 1998-07-02
FR2757521B1 (fr) 1999-01-29
DE69713152D1 (de) 2002-07-11
EP0951474A1 (fr) 1999-10-27
EP0951474B1 (fr) 2002-06-05
AU5669398A (en) 1998-07-17
FR2757521A1 (fr) 1998-06-26
TNSN97212A1 (fr) 2005-03-15
DK0951474T3 (da) 2002-09-16
ZA9711607B (en) 1998-06-24
US5994299A (en) 1999-11-30
JP4146518B2 (ja) 2008-09-10
ATE218582T1 (de) 2002-06-15
PT951474E (pt) 2002-11-29

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