ES2177063T3 - Derivados de la 3-oxo-2(h)-1,2,4-triazina como ligandos de los receptores 5ht1a. - Google Patents
Derivados de la 3-oxo-2(h)-1,2,4-triazina como ligandos de los receptores 5ht1a.Info
- Publication number
- ES2177063T3 ES2177063T3 ES98949061T ES98949061T ES2177063T3 ES 2177063 T3 ES2177063 T3 ES 2177063T3 ES 98949061 T ES98949061 T ES 98949061T ES 98949061 T ES98949061 T ES 98949061T ES 2177063 T3 ES2177063 T3 ES 2177063T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- optionally substituted
- group
- hydrogen
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
Derivados de la 3-oxo-(2H)-1,2,4-triazina que corresponden a la fórmula general I en la cual - R1 representa : hidrógeno, únicamente cuando A es un átomo de nitrógeno eventualmente sustituido. un grupo alcoilo con C1-C4 lineal o ramificado un grupo alcoilo con C1-C4, estando el núcleo fenilo eventualmente sustituido por uno o varios grupos alcoilo con C1-C4, alcoxi con C1-C3, halógeno , trifluorometilo. - R2 representa : hidrógeno un radical alcoilo con C1-C4 lineal o ramificado un grupo fenilo o fenilalcoilo con C1-C4, estando el núcleo fenilo eventualmente sustituido por uno o varios grupos alcoilo con C1-C4, alcoxi con C1-C3, halógeno, trifluorometilo. - A representa un átomo de oxígeno o un átomo de nitrógeno eventualmente sustituido por NR3. - R3 representa el hidrógeno o un grupo metilo. - B representa un grupo del tipo en el cual Ar representa a su vez una estructura aromática fenilo, piridilo o pirimidilo, eventualmente sustituida poruno o varios grupos alcoilo con C1-C3, alcoxi con C1-C3, hidroxi, trifluorometilo o halógeno y n puede tomar los valores enteros de 3 al 5. en el cual Ar es tal como se ha definido en la fórmula
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9712955A FR2769912B1 (fr) | 1997-10-16 | 1997-10-16 | Nouveaux derives de la 3-oxo- (2h)-1,2,4 triazine leur preparation et leur application en therapeutique humaine |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2177063T3 true ES2177063T3 (es) | 2002-12-01 |
Family
ID=9512298
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98949061T Expired - Lifetime ES2177063T3 (es) | 1997-10-16 | 1998-10-14 | Derivados de la 3-oxo-2(h)-1,2,4-triazina como ligandos de los receptores 5ht1a. |
Country Status (14)
Country | Link |
---|---|
US (1) | US6303603B1 (es) |
EP (1) | EP1023287B1 (es) |
JP (1) | JP4413424B2 (es) |
CN (1) | CN1128147C (es) |
AT (1) | ATE219076T1 (es) |
AU (1) | AU761653B2 (es) |
BR (1) | BR9812928B1 (es) |
CA (1) | CA2306428C (es) |
DE (1) | DE69806036T2 (es) |
DK (1) | DK1023287T3 (es) |
ES (1) | ES2177063T3 (es) |
FR (1) | FR2769912B1 (es) |
PT (1) | PT1023287E (es) |
WO (1) | WO1999020622A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001267421A1 (en) * | 2000-05-12 | 2001-11-20 | Solvay Pharmaceuticals B.V. | Use of compounds having combined dopamine d2, 5-ht1a and alpha adrenoreceptor agonistic action for treating cns disorders |
AU2003300031A1 (en) * | 2002-10-11 | 2004-05-04 | Cytokinetics, Inc. | Compounds, compositions, and methods |
US7160888B2 (en) | 2003-08-22 | 2007-01-09 | Warner Lambert Company Llc | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia |
WO2006089053A2 (en) * | 2005-02-17 | 2006-08-24 | Wyeth | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2707294B1 (fr) * | 1993-07-06 | 1995-09-29 | Pf Medicament | Nouveaux dérivés de la 3,5-dioxo-(2H,4H)-1,2,4-triazine, leur préparation et leur application en thérapeutique humaine. |
DE4442229A1 (de) * | 1994-11-28 | 1996-05-30 | Hoechst Schering Agrevo Gmbh | Alkylidenhydrazinophenylsulfonylharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
FR2727682A1 (fr) * | 1994-12-02 | 1996-06-07 | Pf Medicament | Nouveaux derives de 3,5-dioxo-(2h,4h)-1,2,4-triazines, leur preparation et leur application a titre de medicament |
-
1997
- 1997-10-16 FR FR9712955A patent/FR2769912B1/fr not_active Expired - Fee Related
-
1998
- 1998-10-14 PT PT98949061T patent/PT1023287E/pt unknown
- 1998-10-14 US US09/529,728 patent/US6303603B1/en not_active Expired - Lifetime
- 1998-10-14 EP EP98949061A patent/EP1023287B1/fr not_active Expired - Lifetime
- 1998-10-14 DE DE69806036T patent/DE69806036T2/de not_active Expired - Lifetime
- 1998-10-14 DK DK98949061T patent/DK1023287T3/da active
- 1998-10-14 AU AU95457/98A patent/AU761653B2/en not_active Ceased
- 1998-10-14 WO PCT/FR1998/002205 patent/WO1999020622A1/fr active IP Right Grant
- 1998-10-14 BR BRPI9812928-7A patent/BR9812928B1/pt not_active IP Right Cessation
- 1998-10-14 CN CN98811028A patent/CN1128147C/zh not_active Expired - Fee Related
- 1998-10-14 CA CA002306428A patent/CA2306428C/fr not_active Expired - Fee Related
- 1998-10-14 JP JP2000516964A patent/JP4413424B2/ja not_active Expired - Fee Related
- 1998-10-14 ES ES98949061T patent/ES2177063T3/es not_active Expired - Lifetime
- 1998-10-14 AT AT98949061T patent/ATE219076T1/de active
Also Published As
Publication number | Publication date |
---|---|
BR9812928B1 (pt) | 2013-03-19 |
AU761653B2 (en) | 2003-06-05 |
DK1023287T3 (da) | 2002-10-14 |
AU9545798A (en) | 1999-05-10 |
WO1999020622A1 (fr) | 1999-04-29 |
PT1023287E (pt) | 2002-11-29 |
JP4413424B2 (ja) | 2010-02-10 |
DE69806036D1 (de) | 2002-07-18 |
EP1023287B1 (fr) | 2002-06-12 |
CA2306428A1 (fr) | 1999-04-29 |
US6303603B1 (en) | 2001-10-16 |
FR2769912B1 (fr) | 2000-03-10 |
CN1278815A (zh) | 2001-01-03 |
JP2001520226A (ja) | 2001-10-30 |
CN1128147C (zh) | 2003-11-19 |
EP1023287A1 (fr) | 2000-08-02 |
ATE219076T1 (de) | 2002-06-15 |
BR9812928A (pt) | 2000-08-08 |
CA2306428C (fr) | 2010-01-12 |
FR2769912A1 (fr) | 1999-04-23 |
DE69806036T2 (de) | 2003-01-30 |
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