ES2174770T1 - Peptidos diseñados para el diagnostico y el tratamiento de artritis reumatoide. - Google Patents

Peptidos diseñados para el diagnostico y el tratamiento de artritis reumatoide.

Info

Publication number
ES2174770T1
ES2174770T1 ES00983355T ES00983355T ES2174770T1 ES 2174770 T1 ES2174770 T1 ES 2174770T1 ES 00983355 T ES00983355 T ES 00983355T ES 00983355 T ES00983355 T ES 00983355T ES 2174770 T1 ES2174770 T1 ES 2174770T1
Authority
ES
Spain
Prior art keywords
rheumatoid arthritis
diagnosis
treatment
amino acids
peptides designed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES00983355T
Other languages
English (en)
Inventor
Ann Union
Henri Moereels
Lydie Meheus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujirebio Europe NV SA
Original Assignee
Innogenetics NV SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innogenetics NV SA filed Critical Innogenetics NV SA
Publication of ES2174770T1 publication Critical patent/ES2174770T1/es
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Péptido que comprende una secuencia de menos de 50 aminoácidos, caracterizado porque contiene una vuelta de péptido que comprende por lo menos un residuo de citrulina y contiene menos de 12 aminoácidos entre dos residuos de cisteína, siendo dicho residuo de citrulina uno de los aminoácidos dispuestos entre dichos residuos de cisteína y dichopéptido es reconocido específicamente por anticuerpos autoinmunes procedentes de pacientes que padecen de artritis reumatoide.
ES00983355T 1999-12-21 2000-12-20 Peptidos diseñados para el diagnostico y el tratamiento de artritis reumatoide. Pending ES2174770T1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99870280 1999-12-21
EP00870195 2000-09-08

Publications (1)

Publication Number Publication Date
ES2174770T1 true ES2174770T1 (es) 2002-11-16

Family

ID=26074285

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00983355T Pending ES2174770T1 (es) 1999-12-21 2000-12-20 Peptidos diseñados para el diagnostico y el tratamiento de artritis reumatoide.

Country Status (7)

Country Link
US (1) US20020143143A1 (es)
EP (1) EP1240180A2 (es)
AU (1) AU2012301A (es)
CA (1) CA2391356A1 (es)
DE (1) DE1240180T1 (es)
ES (1) ES2174770T1 (es)
WO (1) WO2001046222A2 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1019540C2 (nl) 2001-12-11 2003-07-01 Stichting Tech Wetenschapp Werkwijze voor het detecteren van auto-antilichamen van patienten die lijden aan reumatoïde artritis, peptide en assaykit.
DK1882946T3 (da) 2003-12-23 2010-05-31 Hoffmann La Roche Fremgangsmåde til at bedømme rheumatold arthritis ved at måle anti-CCP og interleukin 6
CA2552420A1 (en) 2004-02-27 2005-09-15 F. Hoffmann-La Roche Ag Method of assessing rheumatoid arthritis by measuring anti-ccp and serum amyloid a
WO2008037420A1 (en) 2006-09-29 2008-04-03 Roche Diagnostics Gmbh Assessing the risk of disease progression for a patient with rheumatoid arthritis
US20100047256A1 (en) 2007-01-25 2010-02-25 Imperial Innovations Limited Methods
US8323656B2 (en) 2007-06-25 2012-12-04 Yijun Xu Antigen determinant of rheumatoid arthritis-specific autoantibody and use thereof
ES2390394T3 (es) 2007-12-03 2012-11-12 Sqi Diagnostics Systems Inc. Péptidos sintéticos inmunorreactivos con los autoanticuerpos de la artritis reumatoide
GB0803107D0 (en) 2008-02-20 2008-03-26 Axis Shield Diagnostics Ltd Method
EP2307451B1 (en) 2008-03-21 2016-05-25 Universiteit Hasselt Biomarkers for rheumatoid arthritis
JP5528436B2 (ja) 2008-06-04 2014-06-25 モディクエスト べー．フェー． 抗炎症剤
EP2288616B1 (en) * 2008-06-16 2012-11-21 Chiralix B.V. Peptidylarginine deiminase (pad) inhibitors
EP2325195A1 (en) 2009-11-23 2011-05-25 Toscana Biomarkers S.r.l. Viral citrullinated peptides and uses thereof
EP2336769A1 (en) 2009-12-18 2011-06-22 F. Hoffmann-La Roche AG Trigger assay for differentiating between rheumatic and non-rheumatic disorders
EP2402368A1 (en) 2010-07-02 2012-01-04 Toscana Biomarkers S.r.l. Histone citrullinated peptides and uses thereof
EP2527841A1 (en) 2011-05-25 2012-11-28 Toscana Biomarkers S.r.l. Methods for the diagnosis of rheumatoid arthritis
EP3256854A1 (en) 2015-02-13 2017-12-20 F. Hoffmann-La Roche AG Method of assessing rheumatoid arthritis by measuring anti-ccp and anti-pik3cd
EP3056903A1 (en) 2015-02-13 2016-08-17 F. Hoffmann-La Roche AG Method of assessing rheumatoid arthritis by measuring anti-CCP and anti-Casp8
EP3056904A1 (en) 2015-02-13 2016-08-17 F. Hoffmann-La Roche AG Method of assessing rheumatoid arthritis by measuring anti-CCP and anti-MCM3
CN106405103A (zh) * 2016-08-31 2017-02-15 杨世东 一种检测类风湿关节炎的胶体金免疫层析试剂盒及其制备方法
CN108948174B (zh) * 2018-05-22 2020-12-01 北京蛋白质组研究中心 一种瓜氨酸修饰肽及其应用
CN111868073B (zh) * 2019-05-31 2021-04-30 广州市雷德生物科技有限公司 一种类风湿关节炎相关的特异性多肽及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE511116T1 (de) * 1991-04-26 1993-04-29 Clonatec S.A., Paris Antigene, die von polyarthritis rheumatoide antikoerpern erkannt werden, ihre herstellung und ihre anwendungen.
US5994306A (en) * 1995-11-22 1999-11-30 Intrabiotics Pharmaceuticals, Inc. Fine-tuned protegrins
FR2752842B1 (fr) * 1996-08-30 1998-11-06 Biomerieux Sa Antigenes derives des filaggrines et leur utilisation pour le diagnostic de la polyarthrite rhumatoide
NL1004539C2 (nl) * 1996-11-15 1998-05-20 Stichting Tech Wetenschapp Peptide afgeleid van een door auto-antilichamen van patiënten met reumatoïde artritis herkend antigeen, antilichaam daartegen en werkwijze voor het detecteren van auto-immuunantilichamen.
SE9701161D0 (sv) * 1997-03-27 1997-03-27 Karolinska Innovations Ab New use I
WO1999028344A2 (en) * 1997-11-28 1999-06-10 Innogenetics N.V. Synthetic peptides containing citrulline recognized by rheumatoid arthritis sera as tools for diagnosis and treatment
FR2773157B1 (fr) * 1997-12-30 2001-10-05 Bio Merieux Epitopes peptidiques reconnus par des auto-anticorps antifilaggrine presents dans le serum des patients atteints de polyarthrite rhumatoide

Also Published As

Publication number Publication date
AU2012301A (en) 2001-07-03
EP1240180A2 (en) 2002-09-18
WO2001046222A2 (en) 2001-06-28
CA2391356A1 (en) 2001-06-28
US20020143143A1 (en) 2002-10-03
WO2001046222A3 (en) 2002-01-17
DE1240180T1 (de) 2003-08-14

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