ES2170937T3 - Agentes de reticulacion bis-maleimido. - Google Patents
Agentes de reticulacion bis-maleimido.Info
- Publication number
- ES2170937T3 ES2170937T3 ES97903949T ES97903949T ES2170937T3 ES 2170937 T3 ES2170937 T3 ES 2170937T3 ES 97903949 T ES97903949 T ES 97903949T ES 97903949 T ES97903949 T ES 97903949T ES 2170937 T3 ES2170937 T3 ES 2170937T3
- Authority
- ES
- Spain
- Prior art keywords
- maleimido
- enzyme
- bis
- cyclic
- linearized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pyrrole Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Abstract
SE DESCRIBE LA FORMACION DE UNA RETICULACION INTRAMOLECULAR EN FRAGMENTOS POLIPEPTIDICOS DADORES DE ENZIMA DE {BE} GALACTOSIDASA, FORMANDO POR TANTO UN DADOR CICLICO DE ENZIMA, CUYA COMPLEMENTACION CON UN FRAGMENTO ACEPTOR DE LA ENZIMA PARA FORMAR LA {BE} ENZIMA CICLICO SE PUEDE LINEALIZAR MEDIANTE ESCISION, PARA RESTABLECER LA CAPACIDAD DE COMPLEMENTACION. SE DESCRIBEN ENSAYOS EN LOS QUE DICHOS DADORES DE ENZIMA CICLICOS SE LINEALIZAN MEDIANTE ANALITOS ESPECIFICOS, ASI COMO NUEVOS AGENTES RETICULANTES BIS HIDROXI O ACETATO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59201596A | 1996-01-26 | 1996-01-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2170937T3 true ES2170937T3 (es) | 2002-08-16 |
Family
ID=24368925
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97903949T Expired - Lifetime ES2170937T3 (es) | 1996-01-26 | 1997-01-23 | Agentes de reticulacion bis-maleimido. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5976783A (es) |
EP (1) | EP0817789B1 (es) |
JP (1) | JP2863638B2 (es) |
AT (1) | ATE211480T1 (es) |
AU (1) | AU1837897A (es) |
DE (1) | DE69709448T2 (es) |
ES (1) | ES2170937T3 (es) |
WO (1) | WO1997027203A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999006072A1 (en) * | 1997-07-30 | 1999-02-11 | Boehringer Mannheim Corporation | Cyclized prodrugs |
GB0125658D0 (en) * | 2001-10-25 | 2001-12-19 | Ssl Int Plc | Medicaments |
US7993749B2 (en) * | 2005-12-16 | 2011-08-09 | University Of Kansas | Nanoparticles comprising a nanoparticle template and a polymer shell having an amide side chain, and method of making thereof |
WO2011056799A1 (en) * | 2009-11-05 | 2011-05-12 | Sangart, Inc. | Methods for preparing polyethylene glycol maleimide using n-(2-hydroxyethyl) maleimide as a starting material |
JP6590474B2 (ja) * | 2014-09-25 | 2019-10-16 | 国立大学法人埼玉大学 | 化学架橋ペプチドの作製方法、その方法を用いて作製した化学架橋ペプチド及びそのペプチドを用いて構築したcDNAディスプレイ法によるペプチドライブラリ |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4671958A (en) * | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
US4493795A (en) * | 1983-10-17 | 1985-01-15 | Syntex (U.S.A.) Inc. | Synthetic peptide sequences useful in biological and pharmaceutical applications and methods of manufacture |
US4708929A (en) * | 1984-10-29 | 1987-11-24 | Microgenics Corporation | Methods for protein binding enzyme complementation assays |
AU592324B2 (en) * | 1984-10-29 | 1990-01-11 | Roche Diagnostics Corporation | Mehods for protein binding enzyme complementation assays |
US4766106A (en) * | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
CA1340387C (en) * | 1987-10-30 | 1999-02-09 | Carol A. Schlesinger | Heterobifunctional coupling agents |
EP0321973B1 (de) * | 1987-12-23 | 1993-11-03 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Expression der viral kodierten Protease P2A des HRV2 |
EP0444158B1 (en) * | 1988-11-18 | 1996-01-03 | The Regents Of The University Of California | Conjugated polypeptides and methods for their preparation and use |
US5166322A (en) * | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
CA1335707C (en) * | 1989-08-15 | 1995-05-30 | Pyare Khanna | Drug screening assay |
EP0419081A3 (en) * | 1989-09-22 | 1992-07-22 | Microgenics Corporation | Method for protein binding enzyme complementation assays |
US5011910A (en) * | 1989-12-28 | 1991-04-30 | Washington University | Reagent and method for determining activity of retroviral protease |
US5164300A (en) * | 1989-12-28 | 1992-11-17 | Washington University | Method for determining activity of retroviral protease |
EP0497949A1 (de) * | 1990-08-28 | 1992-08-12 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Testsystem zur aktivitätsüberprüfung viraler proteinasen |
US5171662A (en) * | 1990-09-13 | 1992-12-15 | The Upjohn Company | Method of detecting HIV protease activity |
CA2068190C (en) * | 1991-05-15 | 1996-12-17 | Microgenics Corporation | Methods and compositions for enzyme complementation assays using the omega region of beta-galactosidase |
CA2075858C (en) * | 1991-08-15 | 1998-05-19 | Scott J. Eisenbeis | Detection of complementary nucleotide sequences |
US5412083A (en) * | 1992-04-16 | 1995-05-02 | Northeastern University | Carbohydrate heterobifunctional cross-linking reagent |
DE4310141A1 (de) * | 1993-03-29 | 1994-10-06 | Boehringer Mannheim Gmbh | Homobidentale trifunktionelle Linker |
US5436131A (en) * | 1993-04-02 | 1995-07-25 | Merck & Co., Inc. | Color screening assay for identifying inhibitor resistant HIV protease mutants |
US5439798A (en) * | 1993-12-17 | 1995-08-08 | Boehringer Mannheim Corporation | Maleimide adduct conjugates of procainamide and NAPA |
US5506115A (en) * | 1994-04-29 | 1996-04-09 | G. D. Searle & Co. | Reagent and method for determining activity of herpes protease |
AU702122B2 (en) * | 1994-10-25 | 1999-02-11 | Merck & Co., Inc. | Microbial synthesis of HIV protease inhibitors |
US5861267A (en) * | 1995-05-01 | 1999-01-19 | Vertex Pharmaceuticals Incorporated | Methods, nucleotide sequences and host cells for assaying exogenous and endogenous protease activity |
AU6754196A (en) * | 1995-08-25 | 1997-03-19 | Rational Drug Design Laboratories | Novel fluorescent substrate for assaying activity of hepatitis c virus ns3 serine protease |
-
1997
- 1997-01-23 JP JP9527023A patent/JP2863638B2/ja not_active Expired - Fee Related
- 1997-01-23 WO PCT/US1997/001130 patent/WO1997027203A1/en active IP Right Grant
- 1997-01-23 ES ES97903949T patent/ES2170937T3/es not_active Expired - Lifetime
- 1997-01-23 EP EP97903949A patent/EP0817789B1/en not_active Expired - Lifetime
- 1997-01-23 AU AU18378/97A patent/AU1837897A/en not_active Abandoned
- 1997-01-23 DE DE69709448T patent/DE69709448T2/de not_active Expired - Fee Related
- 1997-01-23 AT AT97903949T patent/ATE211480T1/de active
- 1997-06-26 US US08/883,632 patent/US5976783A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU1837897A (en) | 1997-08-20 |
US5976783A (en) | 1999-11-02 |
EP0817789B1 (en) | 2002-01-02 |
EP0817789A1 (en) | 1998-01-14 |
JP2863638B2 (ja) | 1999-03-03 |
DE69709448D1 (de) | 2002-02-07 |
DE69709448T2 (de) | 2002-09-19 |
JPH10508040A (ja) | 1998-08-04 |
ATE211480T1 (de) | 2002-01-15 |
WO1997027203A1 (en) | 1997-07-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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