ES2170937T3 - Agentes de reticulacion bis-maleimido. - Google Patents

Agentes de reticulacion bis-maleimido.

Info

Publication number
ES2170937T3
ES2170937T3 ES97903949T ES97903949T ES2170937T3 ES 2170937 T3 ES2170937 T3 ES 2170937T3 ES 97903949 T ES97903949 T ES 97903949T ES 97903949 T ES97903949 T ES 97903949T ES 2170937 T3 ES2170937 T3 ES 2170937T3
Authority
ES
Spain
Prior art keywords
maleimido
enzyme
bis
cyclic
linearized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97903949T
Other languages
English (en)
Inventor
Michael J Powell
Lutz F Tietze
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics Corp
Original Assignee
Roche Diagnostics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Corp filed Critical Roche Diagnostics Corp
Application granted granted Critical
Publication of ES2170937T3 publication Critical patent/ES2170937T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

SE DESCRIBE LA FORMACION DE UNA RETICULACION INTRAMOLECULAR EN FRAGMENTOS POLIPEPTIDICOS DADORES DE ENZIMA DE {BE} GALACTOSIDASA, FORMANDO POR TANTO UN DADOR CICLICO DE ENZIMA, CUYA COMPLEMENTACION CON UN FRAGMENTO ACEPTOR DE LA ENZIMA PARA FORMAR LA {BE} ENZIMA CICLICO SE PUEDE LINEALIZAR MEDIANTE ESCISION, PARA RESTABLECER LA CAPACIDAD DE COMPLEMENTACION. SE DESCRIBEN ENSAYOS EN LOS QUE DICHOS DADORES DE ENZIMA CICLICOS SE LINEALIZAN MEDIANTE ANALITOS ESPECIFICOS, ASI COMO NUEVOS AGENTES RETICULANTES BIS HIDROXI O ACETATO.
ES97903949T 1996-01-26 1997-01-23 Agentes de reticulacion bis-maleimido. Expired - Lifetime ES2170937T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59201596A 1996-01-26 1996-01-26

Publications (1)

Publication Number Publication Date
ES2170937T3 true ES2170937T3 (es) 2002-08-16

Family

ID=24368925

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97903949T Expired - Lifetime ES2170937T3 (es) 1996-01-26 1997-01-23 Agentes de reticulacion bis-maleimido.

Country Status (8)

Country Link
US (1) US5976783A (es)
EP (1) EP0817789B1 (es)
JP (1) JP2863638B2 (es)
AT (1) ATE211480T1 (es)
AU (1) AU1837897A (es)
DE (1) DE69709448T2 (es)
ES (1) ES2170937T3 (es)
WO (1) WO1997027203A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999006072A1 (en) * 1997-07-30 1999-02-11 Boehringer Mannheim Corporation Cyclized prodrugs
GB0125658D0 (en) * 2001-10-25 2001-12-19 Ssl Int Plc Medicaments
US7993749B2 (en) * 2005-12-16 2011-08-09 University Of Kansas Nanoparticles comprising a nanoparticle template and a polymer shell having an amide side chain, and method of making thereof
WO2011056799A1 (en) * 2009-11-05 2011-05-12 Sangart, Inc. Methods for preparing polyethylene glycol maleimide using n-(2-hydroxyethyl) maleimide as a starting material
JP6590474B2 (ja) * 2014-09-25 2019-10-16 国立大学法人埼玉大学 化学架橋ペプチドの作製方法、その方法を用いて作製した化学架橋ペプチド及びそのペプチドを用いて構築したｃＤＮＡディスプレイ法によるペプチドライブラリ

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4671958A (en) * 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites
US4493795A (en) * 1983-10-17 1985-01-15 Syntex (U.S.A.) Inc. Synthetic peptide sequences useful in biological and pharmaceutical applications and methods of manufacture
US4708929A (en) * 1984-10-29 1987-11-24 Microgenics Corporation Methods for protein binding enzyme complementation assays
AU592324B2 (en) * 1984-10-29 1990-01-11 Roche Diagnostics Corporation Mehods for protein binding enzyme complementation assays
US4766106A (en) * 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
CA1340387C (en) * 1987-10-30 1999-02-09 Carol A. Schlesinger Heterobifunctional coupling agents
EP0321973B1 (de) * 1987-12-23 1993-11-03 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Expression der viral kodierten Protease P2A des HRV2
EP0444158B1 (en) * 1988-11-18 1996-01-03 The Regents Of The University Of California Conjugated polypeptides and methods for their preparation and use
US5166322A (en) * 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
CA1335707C (en) * 1989-08-15 1995-05-30 Pyare Khanna Drug screening assay
EP0419081A3 (en) * 1989-09-22 1992-07-22 Microgenics Corporation Method for protein binding enzyme complementation assays
US5011910A (en) * 1989-12-28 1991-04-30 Washington University Reagent and method for determining activity of retroviral protease
US5164300A (en) * 1989-12-28 1992-11-17 Washington University Method for determining activity of retroviral protease
EP0497949A1 (de) * 1990-08-28 1992-08-12 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Testsystem zur aktivitätsüberprüfung viraler proteinasen
US5171662A (en) * 1990-09-13 1992-12-15 The Upjohn Company Method of detecting HIV protease activity
CA2068190C (en) * 1991-05-15 1996-12-17 Microgenics Corporation Methods and compositions for enzyme complementation assays using the omega region of beta-galactosidase
CA2075858C (en) * 1991-08-15 1998-05-19 Scott J. Eisenbeis Detection of complementary nucleotide sequences
US5412083A (en) * 1992-04-16 1995-05-02 Northeastern University Carbohydrate heterobifunctional cross-linking reagent
DE4310141A1 (de) * 1993-03-29 1994-10-06 Boehringer Mannheim Gmbh Homobidentale trifunktionelle Linker
US5436131A (en) * 1993-04-02 1995-07-25 Merck & Co., Inc. Color screening assay for identifying inhibitor resistant HIV protease mutants
US5439798A (en) * 1993-12-17 1995-08-08 Boehringer Mannheim Corporation Maleimide adduct conjugates of procainamide and NAPA
US5506115A (en) * 1994-04-29 1996-04-09 G. D. Searle & Co. Reagent and method for determining activity of herpes protease
AU702122B2 (en) * 1994-10-25 1999-02-11 Merck & Co., Inc. Microbial synthesis of HIV protease inhibitors
US5861267A (en) * 1995-05-01 1999-01-19 Vertex Pharmaceuticals Incorporated Methods, nucleotide sequences and host cells for assaying exogenous and endogenous protease activity
AU6754196A (en) * 1995-08-25 1997-03-19 Rational Drug Design Laboratories Novel fluorescent substrate for assaying activity of hepatitis c virus ns3 serine protease

Also Published As

Publication number Publication date
AU1837897A (en) 1997-08-20
US5976783A (en) 1999-11-02
EP0817789B1 (en) 2002-01-02
EP0817789A1 (en) 1998-01-14
JP2863638B2 (ja) 1999-03-03
DE69709448D1 (de) 2002-02-07
DE69709448T2 (de) 2002-09-19
JPH10508040A (ja) 1998-08-04
ATE211480T1 (de) 2002-01-15
WO1997027203A1 (en) 1997-07-31

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