ES2169690B1 - Trimeros de n-alquilglicina capaces de proteger a neuronas contra agresiones excitotoxicas, y composiciones que los contienen. - Google Patents
Trimeros de n-alquilglicina capaces de proteger a neuronas contra agresiones excitotoxicas, y composiciones que los contienen.Info
- Publication number
- ES2169690B1 ES2169690B1 ES200002414A ES200002414A ES2169690B1 ES 2169690 B1 ES2169690 B1 ES 2169690B1 ES 200002414 A ES200002414 A ES 200002414A ES 200002414 A ES200002414 A ES 200002414A ES 2169690 B1 ES2169690 B1 ES 2169690B1
- Authority
- ES
- Spain
- Prior art keywords
- ethyl
- excitotox
- alquilglicina
- aggressions
- quarters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Trímeros de n-alquilglicinas capaces de proteger a neuronas contra agresiones excitotóxicas, y composiciones que los contienen. Los trímeros de N-alquilglicina (I), donde R1, R2 y R3, independientemente entre sí, se seleccionan entre ciclopropilo, sec-butilo, 2-metoxietilo, 3-metilbutilo, ciclohexilo, 2- (N-pirrolidinil) etilo, 2- (metilcarbonilamino) etilo, 3- (2-oxo-N-pirrolidinil) propilo, 2- (2- piridil) etilo, 2-feniletilo, 2- (2-tetrahidrofuril) etilo, 2- (N- imidazolil) etilo, 2- (4-metoxifenil) etilo, 2- (3,4- dimetoxifenil) etilo, 2- (2,4-diclorofenil) etilo, 2- [2- (N- metil) pirrolidinil] etilo, 2- (4-aminosulfonilfenil) etilo, 2- (morfolino) etilo, 3- (N,N-dietilamino) propilo, 3,3-difenil- propilo, 3- (N,N-dimetilamino) propilo, y 2- (N,N-dietilamino) etilo, son capaces de bloquear los receptores de L-glutamato, y son adecuados para tratar trastornos mediados por dichos receptores.
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200002414A ES2169690B1 (es) | 2000-10-06 | 2000-10-06 | Trimeros de n-alquilglicina capaces de proteger a neuronas contra agresiones excitotoxicas, y composiciones que los contienen. |
AU2001291906A AU2001291906B2 (en) | 2000-10-06 | 2001-10-05 | N-alkylglycine trimeres capable of protecting neurons against excitotoxic aggressions and compositions containing said trimeres |
DK01972113T DK1338604T3 (da) | 2000-10-06 | 2001-10-05 | N-Alkylglycintrimerer i stand til beskyttelse af neuroner mod excitotoksiske aggressioner og sammensætninger indeholdende de nævnte trimerer |
US10/398,467 US6992064B2 (en) | 2000-10-06 | 2001-10-05 | N-alkylglycine trimeres capable of protecting neurons against excitotoxic aggressions and compositions containing such trimeres |
AT01972113T ATE332913T1 (de) | 2000-10-06 | 2001-10-05 | N-alkylglycintrimeres, das dazu in der lage ist, neuronen gegen excitotoxische aggressionen zu schützen, und zusammensetzungen, die dieses trimere enthalten |
MXPA03003157A MXPA03003157A (es) | 2000-10-06 | 2001-10-05 | Trimeros de n-alquilglicina capaces de proteger a neuronas contra agresiones excitoxicas y composiciones que lo contienen. |
EP01972113A EP1338604B9 (en) | 2000-10-06 | 2001-10-05 | N-alkylglycine trimeres capable of protecting neurons against excitotoxic aggressions and compositions containing said trimeres |
AU9190601A AU9190601A (en) | 2000-10-06 | 2001-10-05 | N-alkylglycine trimeres capable of protecting neurons against excitotoxic aggressions and compositions containing said trimeres |
PT01972113T PT1338604E (pt) | 2000-10-06 | 2001-10-05 | Trímeros de n-alquilglicina com a capacidade de proteger os neurónios contra as agressões excitotóxicas e composições contendo os ditos trímeros |
BR0114660-2A BR0114660A (pt) | 2000-10-06 | 2001-10-05 | Trìmeros de n-alquilglicina capazes de proteger os neurÈnios contra agressões excitotóxicas e composições que os contêm |
PCT/ES2001/000369 WO2002028885A1 (es) | 2000-10-06 | 2001-10-05 | Trímeros de n-alquilglicina capaces de proteger a neuronas contra agresiones excitotóxicas, y composiciones que los contienen |
DE60121464T DE60121464T2 (de) | 2000-10-06 | 2001-10-05 | N-alkylglycintrimeres, das dazu in der lage ist, neuronen gegen excitotoxische aggressionen zu schützen, und zusammensetzungen, die dieses trimere enthalten |
CA2427072A CA2427072C (en) | 2000-10-06 | 2001-10-05 | N-alkylglycine trimers capable of protecting neurons against excitotoxic aggressions and compositions containing said trimers |
KR1020037004884A KR100849739B1 (ko) | 2000-10-06 | 2001-10-05 | 흥분독소 공격에 대하여 신경을 보호하는 능력을 갖는 n-알킬글리신 트리머 및 그 트리머를 포함하는 조성물 |
ES01972113T ES2267816T3 (es) | 2000-10-06 | 2001-10-05 | Trimeros de n-alquilglicina que pueden proteger neuronas frente a agresiones excitotoxicas y composiciones que contienen dichos trimeros. |
JP2002532467A JP3925712B2 (ja) | 2000-10-06 | 2001-10-05 | 興奮性侵襲に対するニューロンの保護が可能なn−アルキルグリシン三量体および該三量体を含有する組成物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200002414A ES2169690B1 (es) | 2000-10-06 | 2000-10-06 | Trimeros de n-alquilglicina capaces de proteger a neuronas contra agresiones excitotoxicas, y composiciones que los contienen. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2169690A1 ES2169690A1 (es) | 2002-07-01 |
ES2169690B1 true ES2169690B1 (es) | 2004-03-16 |
Family
ID=8495179
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200002414A Expired - Fee Related ES2169690B1 (es) | 2000-10-06 | 2000-10-06 | Trimeros de n-alquilglicina capaces de proteger a neuronas contra agresiones excitotoxicas, y composiciones que los contienen. |
ES01972113T Expired - Lifetime ES2267816T3 (es) | 2000-10-06 | 2001-10-05 | Trimeros de n-alquilglicina que pueden proteger neuronas frente a agresiones excitotoxicas y composiciones que contienen dichos trimeros. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES01972113T Expired - Lifetime ES2267816T3 (es) | 2000-10-06 | 2001-10-05 | Trimeros de n-alquilglicina que pueden proteger neuronas frente a agresiones excitotoxicas y composiciones que contienen dichos trimeros. |
Country Status (14)
Country | Link |
---|---|
US (1) | US6992064B2 (es) |
EP (1) | EP1338604B9 (es) |
JP (1) | JP3925712B2 (es) |
KR (1) | KR100849739B1 (es) |
AT (1) | ATE332913T1 (es) |
AU (2) | AU2001291906B2 (es) |
BR (1) | BR0114660A (es) |
CA (1) | CA2427072C (es) |
DE (1) | DE60121464T2 (es) |
DK (1) | DK1338604T3 (es) |
ES (2) | ES2169690B1 (es) |
MX (1) | MXPA03003157A (es) |
PT (1) | PT1338604E (es) |
WO (1) | WO2002028885A1 (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2296484A1 (es) * | 2005-11-23 | 2008-04-16 | Fundacion De La Comunidad Valenciana Centro De Investigacion Principe Felipe (90%) | Composicion farmaceutica para inhibir apoptosis. |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060229255A1 (en) * | 2003-04-15 | 2006-10-12 | Gema Tarrason | Identification of n-alkylglycine trimers for induction of apoptosis |
EP1627869B1 (en) | 2003-05-20 | 2012-05-02 | Ajinomoto Co., Inc. | Vanilloid receptor modulators |
ES2293834B1 (es) | 2006-07-20 | 2009-02-16 | Consejo Superior Investig. Cientificas | Compuesto con actividad inhibidora de las interacciones ubc13-uev, composiciones farmaceuticas que lo comprenden y sus aplicaciones terapeuticas. |
EP2401264A4 (en) * | 2009-02-24 | 2013-08-07 | Univ New York | PEPTOID OLIGOMERS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME |
EP2289886A1 (en) * | 2009-08-31 | 2011-03-02 | Institut d'Investigacions Biomédiques August PI I Sunyer | Peptoid agonists of nerve growth factor and their use as medicaments |
WO2011156003A2 (en) | 2010-06-09 | 2011-12-15 | New York University | Peptoid and synthetic oligomers, pharmaceutical compositions and methods of using same |
CA2809774C (en) * | 2010-08-31 | 2019-03-05 | Pablo Villoslada | Agonists of neurotrophin receptors and their use as medicaments |
US20120089291A1 (en) * | 2010-10-12 | 2012-04-12 | Halder Bibhrajit | Autonomous machine control system |
JP7011830B2 (ja) | 2015-10-14 | 2022-01-27 | エックス-サーマ インコーポレイテッド | 氷晶形成を低減するための組成物および方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5747458A (en) * | 1995-06-07 | 1998-05-05 | Chiron Corporation | Urokinase receptor ligands |
US6391871B1 (en) * | 1996-09-20 | 2002-05-21 | John W. Olney | Preventing neuronal degeneration in Alzheimer's disease |
DE19751062A1 (de) * | 1997-11-18 | 1999-07-08 | Univ Ludwigs Albert | An 4-Stellung substituierte 2-Pyrrolidinon-Derivate zur Verringerung des extrazellulären Glutamat-Spiegels |
US6124361A (en) * | 1997-12-31 | 2000-09-26 | Pfizer Inc | Bicyclo[3.1.0]hexanes and related compounds |
-
2000
- 2000-10-06 ES ES200002414A patent/ES2169690B1/es not_active Expired - Fee Related
-
2001
- 2001-10-05 PT PT01972113T patent/PT1338604E/pt unknown
- 2001-10-05 AU AU2001291906A patent/AU2001291906B2/en not_active Ceased
- 2001-10-05 MX MXPA03003157A patent/MXPA03003157A/es active IP Right Grant
- 2001-10-05 EP EP01972113A patent/EP1338604B9/en not_active Expired - Lifetime
- 2001-10-05 DK DK01972113T patent/DK1338604T3/da active
- 2001-10-05 CA CA2427072A patent/CA2427072C/en not_active Expired - Fee Related
- 2001-10-05 KR KR1020037004884A patent/KR100849739B1/ko not_active IP Right Cessation
- 2001-10-05 DE DE60121464T patent/DE60121464T2/de not_active Expired - Lifetime
- 2001-10-05 WO PCT/ES2001/000369 patent/WO2002028885A1/es active IP Right Grant
- 2001-10-05 US US10/398,467 patent/US6992064B2/en not_active Expired - Fee Related
- 2001-10-05 JP JP2002532467A patent/JP3925712B2/ja not_active Expired - Fee Related
- 2001-10-05 BR BR0114660-2A patent/BR0114660A/pt not_active IP Right Cessation
- 2001-10-05 ES ES01972113T patent/ES2267816T3/es not_active Expired - Lifetime
- 2001-10-05 AT AT01972113T patent/ATE332913T1/de active
- 2001-10-05 AU AU9190601A patent/AU9190601A/xx active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2296484A1 (es) * | 2005-11-23 | 2008-04-16 | Fundacion De La Comunidad Valenciana Centro De Investigacion Principe Felipe (90%) | Composicion farmaceutica para inhibir apoptosis. |
Also Published As
Publication number | Publication date |
---|---|
DE60121464T2 (de) | 2007-04-12 |
CA2427072A1 (en) | 2003-04-04 |
ATE332913T1 (de) | 2006-08-15 |
MXPA03003157A (es) | 2004-12-06 |
EP1338604B1 (en) | 2006-07-12 |
US6992064B2 (en) | 2006-01-31 |
AU9190601A (en) | 2002-04-15 |
EP1338604A1 (en) | 2003-08-27 |
ES2169690A1 (es) | 2002-07-01 |
BR0114660A (pt) | 2003-07-01 |
CA2427072C (en) | 2011-03-22 |
DE60121464D1 (de) | 2006-08-24 |
AU2001291906B2 (en) | 2007-05-31 |
KR20030081313A (ko) | 2003-10-17 |
KR100849739B1 (ko) | 2008-08-01 |
EP1338604B9 (en) | 2008-07-09 |
JP2004510782A (ja) | 2004-04-08 |
DK1338604T3 (da) | 2006-11-06 |
JP3925712B2 (ja) | 2007-06-06 |
ES2267816T3 (es) | 2007-03-16 |
WO2002028885A1 (es) | 2002-04-11 |
US20040029811A1 (en) | 2004-02-12 |
PT1338604E (pt) | 2006-12-29 |
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