AR022019A1 - Un compuesto de imidazol y las composiciones farmaceuticas que lo contienen - Google Patents
Un compuesto de imidazol y las composiciones farmaceuticas que lo contienenInfo
- Publication number
- AR022019A1 AR022019A1 ARP990106750A ARP990106750A AR022019A1 AR 022019 A1 AR022019 A1 AR 022019A1 AR P990106750 A ARP990106750 A AR P990106750A AR P990106750 A ARP990106750 A AR P990106750A AR 022019 A1 AR022019 A1 AR 022019A1
- Authority
- AR
- Argentina
- Prior art keywords
- aryl
- optionally substituted
- heterocyclic group
- action
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
- C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se revelan compuestos de imidazol de la formula (1) en la cual: R1 es un grupo arilo o heterocíclico sustituido por un sustituyente que se selecciona entreel grupo que consta de: arilo, grupo heterocíclico, halogeno, halo alquilo (inferior), alquiltio inferior, nitro, alquenilo inferior opcionalmente sustituidopor arilo, alquinilo inferior opcionalmente sustituido por arilo, alcoxi inferior sustituido por cicloalquilo (inferior) o arilo, ariloxi y amino opcionalmentesustituido por carboxi protegido o alquilo inferior; R2 es un alquilo inferior; R3 es un hidrogeno, un halogeno, alquilo inferior o nitro; R4 es un alqueniloinferior opcionalmente sustituido por un grupo arilo o heterocíclico, arilo opcionalmente sustituido por alquenilo inferior, alquilo inferior, grupoheterocíclico opcionalmente sustituido por halogeno; A es un alquileno inferior; y L es alquenileno inferior o alquileno inferior de un solo enlace yopcionalmente sustituido por un grupo arilo o heterocíclico sustituido, o -X-CH2-, en el cual X es -O-, NR5 donde R5 es hidrogeno o alquilo inferior, o -S-, ouna de sus sales. Se revelan además las composiciones farmacéuticas que los contienen. Se trata de compuestos que pueden ser de utilidad como agentes para laprofilaxisy el tratamiento de las enfermedades que se tratan sobre la base de una accion hipoglucemia, y las enfermedades que se tratan sobre la base de laaccion inhibitoria de una cGMP-PDE, una accion relajante de musculo liso, una accion broncodilatadora, una accion vasodilatadora, una accion inhibidora de lascélulas de musculo liso y una accion inhibidora de la alergia.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP36736298 | 1998-12-24 | ||
| JP22883899 | 1999-08-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR022019A1 true AR022019A1 (es) | 2002-09-04 |
Family
ID=26528483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990106750A AR022019A1 (es) | 1998-12-24 | 1999-12-23 | Un compuesto de imidazol y las composiciones farmaceuticas que lo contienen |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7060721B1 (es) |
| EP (1) | EP1142879B1 (es) |
| KR (1) | KR20010094731A (es) |
| CN (1) | CN1170822C (es) |
| AR (1) | AR022019A1 (es) |
| AT (1) | ATE375332T1 (es) |
| AU (1) | AU758325C (es) |
| BR (1) | BR9917112A (es) |
| CA (1) | CA2356838A1 (es) |
| CZ (1) | CZ20012338A3 (es) |
| DE (1) | DE69937307T2 (es) |
| ES (1) | ES2292262T3 (es) |
| HK (1) | HK1043791A1 (es) |
| HU (1) | HUP0104657A3 (es) |
| IL (1) | IL143802A0 (es) |
| RU (1) | RU2238937C2 (es) |
| TR (1) | TR200101865T2 (es) |
| TW (1) | TWI239330B (es) |
| WO (1) | WO2000039097A1 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0009037D0 (en) * | 2000-04-13 | 2000-05-31 | Novartis Ag | Organic compounds |
| US20030181461A1 (en) * | 2002-01-25 | 2003-09-25 | Lautt Wilfred Wayne | Use of phosphodiesterase antagonists to treat insulin resistance |
| AU2012200214B2 (en) * | 2004-05-14 | 2013-10-24 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| ES2249992B1 (es) * | 2004-09-13 | 2007-03-01 | Ferrer Internacional, S.A. | Un procedimiento para fabricar compuestos enantiomericos del imidazol. |
| BRPI0615150A2 (pt) * | 2005-08-10 | 2017-06-20 | Takeda Pharmaceuticals Co | agente para a profilaxia ou tratamento de diabete, sensibilizador de insulina, composto, pró-droga, agente farmacêutico, e, uso do composto ou um sal do mesmo ou uma pró-droga do mesmo |
| WO2007122401A1 (en) * | 2006-04-21 | 2007-11-01 | Astrazeneca Ab | Imidazole derivatives for use as edg-1 antagonists |
| TW200838501A (en) * | 2007-02-02 | 2008-10-01 | Theravance Inc | Dual-acting antihypertensive agents |
| AU2008215490A1 (en) * | 2007-02-09 | 2008-08-21 | Takeda Pharmaceutical Company Limited | Fused ring compounds as partial agonists of PPAR-gamma |
| TWI448284B (zh) | 2007-04-24 | 2014-08-11 | Theravance Inc | 雙效抗高血壓劑 |
| TWI406850B (zh) | 2007-06-05 | 2013-09-01 | Theravance Inc | 雙效苯并咪唑抗高血壓劑 |
| KR100868898B1 (ko) * | 2007-07-30 | 2008-11-14 | 한국기계연구원 | 적층형 ｐｚｔ를 이용한 압전펌프 |
| JP2010538071A (ja) | 2007-09-07 | 2010-12-09 | セラヴァンス， インコーポレーテッド | 二重作用性降圧剤 |
| CA2705921A1 (en) | 2007-12-11 | 2009-06-18 | Theravance, Inc. | Dual-acting benzoimidazole derivatives and their use as antihypertensive agents |
| WO2009134741A1 (en) | 2008-04-29 | 2009-11-05 | Theravance, Inc. | Dual-acting antihypertensive agents |
| US8124636B2 (en) * | 2008-04-30 | 2012-02-28 | Hoffmann-La Roche Inc. | Imidazolidinone derivatives as 11B-HSD1 inhibitors |
| WO2010011821A2 (en) | 2008-07-24 | 2010-01-28 | Theravance, Inc. | Dual-acting antihypertensive agents |
| JP5706397B2 (ja) * | 2009-05-15 | 2015-04-22 | サノフイ | ＴＡＦＩａの阻害剤として有用な化合物の製造方法 |
| WO2011005674A1 (en) | 2009-07-07 | 2011-01-13 | Theravance, Inc. | Dual-acting pyrazole antihypertensive agents |
| US8372984B2 (en) | 2009-07-22 | 2013-02-12 | Theravance, Inc. | Dual-acting oxazole antihypertensive agents |
| EP2526095A1 (en) | 2010-01-19 | 2012-11-28 | Theravance, Inc. | Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents |
| MX2021002311A (es) | 2018-09-04 | 2021-04-28 | Chugai Pharmaceutical Co Ltd | Metodo para producir un compuesto tetraciclico. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5215994A (en) | 1990-09-25 | 1993-06-01 | Fujisawa Pharmaceutical Co., Ltd. | Angiotenin II antagonizing heterocyclic derivatives |
| TW235963B (es) | 1992-01-16 | 1994-12-11 | Shionogi & Co | |
| WO1997024334A1 (fr) | 1995-12-28 | 1997-07-10 | Fujisawa Pharmaceutical Co., Ltd. | Derives du benzimidazole |
| BR9810456A (pt) | 1997-06-27 | 2001-09-25 | Fujisawa Pharmaceutical Co | Composto de sulfonamida, método para sua obtenção e seu uso farmacêutico |
| US6242474B1 (en) * | 1997-06-27 | 2001-06-05 | Fujisawa Pharmaceutical Co., Ltd. | Aromatic ring derivatives |
-
1999
- 1999-12-20 DE DE69937307T patent/DE69937307T2/de not_active Expired - Fee Related
- 1999-12-20 WO PCT/JP1999/007160 patent/WO2000039097A1/ja not_active Application Discontinuation
- 1999-12-20 US US09/869,135 patent/US7060721B1/en not_active Expired - Fee Related
- 1999-12-20 CN CNB998163600A patent/CN1170822C/zh not_active Expired - Fee Related
- 1999-12-20 EP EP99959929A patent/EP1142879B1/en not_active Expired - Lifetime
- 1999-12-20 ES ES99959929T patent/ES2292262T3/es not_active Expired - Lifetime
- 1999-12-20 HU HU0104657A patent/HUP0104657A3/hu unknown
- 1999-12-20 BR BR9917112-0A patent/BR9917112A/pt not_active IP Right Cessation
- 1999-12-20 KR KR1020017008097A patent/KR20010094731A/ko not_active Application Discontinuation
- 1999-12-20 AT AT99959929T patent/ATE375332T1/de not_active IP Right Cessation
- 1999-12-20 IL IL14380299A patent/IL143802A0/xx unknown
- 1999-12-20 RU RU2001120723A patent/RU2238937C2/ru not_active IP Right Cessation
- 1999-12-20 TR TR2001/01865T patent/TR200101865T2/xx unknown
- 1999-12-20 CZ CZ20012338A patent/CZ20012338A3/cs unknown
- 1999-12-20 CA CA002356838A patent/CA2356838A1/en not_active Abandoned
- 1999-12-20 AU AU16905/00A patent/AU758325C/en not_active Ceased
- 1999-12-22 TW TW088122630A patent/TWI239330B/zh not_active IP Right Cessation
- 1999-12-23 AR ARP990106750A patent/AR022019A1/es unknown
-
2002
- 2002-07-18 HK HK02105326A patent/HK1043791A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69937307T2 (de) | 2008-02-07 |
| KR20010094731A (ko) | 2001-11-01 |
| TWI239330B (en) | 2005-09-11 |
| AU758325C (en) | 2004-10-07 |
| CZ20012338A3 (cs) | 2001-12-12 |
| EP1142879A4 (en) | 2002-02-06 |
| CN1335837A (zh) | 2002-02-13 |
| ES2292262T3 (es) | 2008-03-01 |
| HUP0104657A2 (hu) | 2002-05-29 |
| ATE375332T1 (de) | 2007-10-15 |
| BR9917112A (pt) | 2002-01-29 |
| DE69937307D1 (de) | 2007-11-22 |
| RU2238937C2 (ru) | 2004-10-27 |
| CA2356838A1 (en) | 2000-07-06 |
| CN1170822C (zh) | 2004-10-13 |
| EP1142879B1 (en) | 2007-10-10 |
| IL143802A0 (en) | 2002-04-21 |
| US7060721B1 (en) | 2006-06-13 |
| TR200101865T2 (tr) | 2001-12-21 |
| EP1142879A1 (en) | 2001-10-10 |
| HUP0104657A3 (en) | 2002-07-29 |
| AU758325B2 (en) | 2003-03-20 |
| AU1690500A (en) | 2000-07-31 |
| WO2000039097A1 (fr) | 2000-07-06 |
| HK1043791A1 (en) | 2002-09-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |