ES2159303T3 - Peptidos activos como inhibidores de la agregacion de plaquetas. - Google Patents

Peptidos activos como inhibidores de la agregacion de plaquetas.

Info

Publication number
ES2159303T3
ES2159303T3 ES94927800T ES94927800T ES2159303T3 ES 2159303 T3 ES2159303 T3 ES 2159303T3 ES 94927800 T ES94927800 T ES 94927800T ES 94927800 T ES94927800 T ES 94927800T ES 2159303 T3 ES2159303 T3 ES 2159303T3
Authority
ES
Spain
Prior art keywords
amino
aggregation
inhibitors
plates
active peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94927800T
Other languages
English (en)
Inventor
Yoshimi Sato
Yoshio Hayashi
Jun Katada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Steel Corp
Original Assignee
Nippon Steel Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Steel Corp filed Critical Nippon Steel Corp
Application granted granted Critical
Publication of ES2159303T3 publication Critical patent/ES2159303T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA COMPUESTOS O SALES DE LOS MISMOS, QUE ESTAN REPRESENTADOS POR LA FORMULA GENERAL (I): PROSER-A-B-ASP-C-D, DONDE A ES UN AMINO ACIDO QUE NO SEAN AMINO ACIDOS CON UN GRUPO GUANIDINO EN UNA CADENA SECUNDARIA, B ES UN AMINO ACIDO, C ES UN AMINO ACIDO CON UN GRUPO HIDROFOBICO EN UNA CADENA SECUNDARIA Y D ES UN GRUPO HIDROXI O AMINO. LOS COMPUESTOS Y SALES DE LOS MISMOS DE LA PRESENTE INVENCION SON UTILES PUES POSEEN ACTIVIDADES EXCELENTES DE INHIBICION DE LA AGREGACION DE PLAQUETAS Y COAGULACION SANGUINEA Y SON ALTAMENTE SEGUROS.
ES94927800T 1993-09-30 1994-09-29 Peptidos activos como inhibidores de la agregacion de plaquetas. Expired - Lifetime ES2159303T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP24554193 1993-09-30
JP5060294 1994-03-22

Publications (1)

Publication Number Publication Date
ES2159303T3 true ES2159303T3 (es) 2001-10-01

Family

ID=26391074

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94927800T Expired - Lifetime ES2159303T3 (es) 1993-09-30 1994-09-29 Peptidos activos como inhibidores de la agregacion de plaquetas.

Country Status (10)

Country Link
US (1) US5721213A (es)
EP (1) EP0721468B1 (es)
KR (1) KR100186656B1 (es)
CN (1) CN1056619C (es)
AU (1) AU673466B2 (es)
CA (1) CA2168964C (es)
DE (1) DE69427363T2 (es)
DK (1) DK0721468T3 (es)
ES (1) ES2159303T3 (es)
WO (1) WO1995009185A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE465747T1 (de) * 2003-03-28 2010-05-15 Fujifilm Mfg Europe Bv Rgd-angereicherte gelatineähnliche proteine zur verhinderung der blutplättchenaggregation
US20100204115A1 (en) * 2007-09-11 2010-08-12 Dorian Bevec Use of acetyl- (ala10, 11)-rantes (1-14) and/or calcitonin as anti-angiogenic agents
US20120252730A1 (en) * 2009-09-03 2012-10-04 University Of Chicago Platelet aggregation inhibitors
CN102241735B (zh) * 2011-06-23 2014-01-22 陕西麦科奥特科技有限公司 用于预防及治疗急性冠脉综合症及抗凝抗血栓治疗的多肽及其应用
CN106317191B (zh) * 2015-06-23 2019-09-17 首都医科大学 Thr-Val-Gly-Cys-Ser,其合成,活性和应用
WO2017066454A2 (en) 2015-10-14 2017-04-20 X-Therma, Inc. Compositions and methods for reducing ice crystal formation
CN107137757A (zh) * 2017-04-26 2017-09-08 浙江大学 一种rgd噬菌体/丝素复合止血材料及其制备方法
CN108610394B (zh) * 2018-05-07 2021-08-31 深圳市维琪医药研发有限公司 一种拟肽类化合物的制备纯化方法以及应用
CN111647043B (zh) * 2019-08-07 2022-03-22 中国农业大学 含有Hyp-Gly序列的一类抗血小板和抗血栓功能的寡肽

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952562A (en) * 1989-09-29 1990-08-28 Rorer Pharmaceutical Corporation Anti-thrombotic peptides and pseudopeptides
JPH06192291A (ja) * 1992-09-07 1994-07-12 Nippon Steel Corp 新規ペプチドとそれを用いた血小板凝集抑制剤及び血液凝固抑制剤

Also Published As

Publication number Publication date
EP0721468B1 (en) 2001-05-30
CA2168964C (en) 2000-08-22
EP0721468A1 (en) 1996-07-17
KR100186656B1 (ko) 1999-04-01
WO1995009185A1 (en) 1995-04-06
DE69427363T2 (de) 2002-03-14
CN1132515A (zh) 1996-10-02
CN1056619C (zh) 2000-09-20
AU7707694A (en) 1995-04-18
KR960704935A (ko) 1996-10-09
DK0721468T3 (da) 2001-09-17
AU673466B2 (en) 1996-11-07
DE69427363D1 (de) 2001-07-05
US5721213A (en) 1998-02-24

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