ES2153434T3 - Inhibidores de la proteasa del vih y sus intermedios. - Google Patents
Inhibidores de la proteasa del vih y sus intermedios.Info
- Publication number
- ES2153434T3 ES2153434T3 ES94931802T ES94931802T ES2153434T3 ES 2153434 T3 ES2153434 T3 ES 2153434T3 ES 94931802 T ES94931802 T ES 94931802T ES 94931802 T ES94931802 T ES 94931802T ES 2153434 T3 ES2153434 T3 ES 2153434T3
- Authority
- ES
- Spain
- Prior art keywords
- hiv
- intermediates
- inhibitors
- proteasa
- hiv protease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
ESTA INVENCION CONSISTE EN INHIBIDORES DE LA PROTEASA DEL VIH Y EN INTERMEDIARIOS PARA PREPARAR INHIBIDORES DE LA PROTEASA DEL VIH. LA ENZIMA PROTEASA DEL VIH REPRESENTA UN BLANCO VIABLE PARA LA INHIBICION DE LA REPLICACION VIRAL DEL VIH, PROPORCIONANDO ASI UN METODO PARA EL TRATAMIENTO O LA PREVENCION DE LAS INFECCIONES POR VIH.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19080994A | 1994-02-02 | 1994-02-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2153434T3 true ES2153434T3 (es) | 2001-03-01 |
Family
ID=22702879
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94931802T Expired - Lifetime ES2153434T3 (es) | 1994-02-02 | 1994-10-06 | Inhibidores de la proteasa del vih y sus intermedios. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5734057A (es) |
EP (1) | EP0746320B1 (es) |
JP (1) | JPH09508416A (es) |
AT (1) | ATE198985T1 (es) |
AU (1) | AU8074894A (es) |
BR (1) | BR9408531A (es) |
CA (1) | CA2182090A1 (es) |
DE (1) | DE69426655T2 (es) |
DK (1) | DK0746320T3 (es) |
ES (1) | ES2153434T3 (es) |
GR (1) | GR3035716T3 (es) |
HU (1) | HUT74685A (es) |
PT (1) | PT746320E (es) |
WO (1) | WO1995020965A1 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5480887A (en) * | 1994-02-02 | 1996-01-02 | Eli Lilly And Company | Protease inhibitors |
JP4921466B2 (ja) * | 2005-07-12 | 2012-04-25 | マサチューセッツ インスティテュート オブ テクノロジー | 無線非放射型エネルギー転送 |
WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
WO2014007951A2 (en) | 2012-06-13 | 2014-01-09 | Incyte Corporation | Substituted tricyclic compounds as fgfr inhibitors |
US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
KR102469849B1 (ko) | 2013-04-19 | 2022-11-23 | 인사이트 홀딩스 코포레이션 | Fgfr 저해제로서 이환식 헤테로사이클 |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
EA038045B1 (ru) | 2015-02-20 | 2021-06-28 | Инсайт Корпорейшн | Бициклические гетероциклы в качестве ингибиторов fgfr |
MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
PE20210919A1 (es) | 2018-05-04 | 2021-05-19 | Incyte Corp | Sales de un inhibidor de fgfr |
MX2020011718A (es) | 2018-05-04 | 2021-02-15 | Incyte Corp | Formas solidas de un inhibidor de receptores del factor de crecimiento de fibroblastos (fgfr) y procesos para prepararlas. |
WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
IL291901A (en) | 2019-10-14 | 2022-06-01 | Incyte Corp | Bicyclyl heterocycles as fgr suppressors |
US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
JP2023505257A (ja) | 2019-12-04 | 2023-02-08 | インサイト・コーポレイション | Fgfr阻害剤の誘導体 |
EP4069696A1 (en) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
JP2024522189A (ja) | 2021-06-09 | 2024-06-11 | インサイト・コーポレイション | Fgfr阻害剤としての三環式ヘテロ環 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2395271A1 (fr) * | 1977-06-21 | 1979-01-19 | Parcor | Procede de preparation de thieno (2,3-c) et thieno (3,2-c) pyridines |
US4749692A (en) * | 1977-06-22 | 1988-06-07 | Sanofi, S.A. | Therapeutic compositions having anti-thrombotic and anti-blood-platelet-aggregating activity |
FR2397417A1 (fr) * | 1977-07-12 | 1979-02-09 | Parcor | Procede de preparation de derives de la thienopyridine |
US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
IL89900A0 (en) * | 1988-04-12 | 1989-12-15 | Merck & Co Inc | Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them |
CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
EP0361341A3 (en) * | 1988-09-28 | 1991-07-03 | Miles Inc. | Therapeutics for aids based on inhibitors of hiv protease |
US5026700A (en) * | 1989-05-16 | 1991-06-25 | Merrell Dow Pharmaceuticals | Certain quinolines and thienopyridines as excitatory amino acid antagonists |
US5232928A (en) * | 1989-07-25 | 1993-08-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Tetrahydroisoquinoline amides |
GB8927913D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
ATE164839T1 (de) * | 1990-11-19 | 1998-04-15 | Monsanto Co | Retrovirale proteaseinhibitoren |
AU647239B2 (en) * | 1991-02-08 | 1994-03-17 | Sankyo Company Limited | New beta-amino- alpha-hydroxycarboxylic acids and their use |
WO1993008184A1 (en) * | 1991-10-23 | 1993-04-29 | Merck & Co., Inc. | Hiv protease inhibitors |
WO1993013066A1 (en) * | 1991-12-20 | 1993-07-08 | Syntex (U.S.A.) Inc. | Cyclic amides of 3-amino-2-hydroxy-carboxylic acids as hiv-protease inhibitors |
US5484926A (en) * | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
US5480887A (en) * | 1994-02-02 | 1996-01-02 | Eli Lilly And Company | Protease inhibitors |
-
1994
- 1994-10-06 EP EP94931802A patent/EP0746320B1/en not_active Expired - Lifetime
- 1994-10-06 AT AT94931802T patent/ATE198985T1/de not_active IP Right Cessation
- 1994-10-06 WO PCT/US1994/011361 patent/WO1995020965A1/en active IP Right Grant
- 1994-10-06 AU AU80748/94A patent/AU8074894A/en not_active Abandoned
- 1994-10-06 CA CA002182090A patent/CA2182090A1/en not_active Abandoned
- 1994-10-06 JP JP7520585A patent/JPH09508416A/ja active Pending
- 1994-10-06 PT PT94931802T patent/PT746320E/pt unknown
- 1994-10-06 ES ES94931802T patent/ES2153434T3/es not_active Expired - Lifetime
- 1994-10-06 HU HU9602106A patent/HUT74685A/hu unknown
- 1994-10-06 DK DK94931802T patent/DK0746320T3/da active
- 1994-10-06 DE DE69426655T patent/DE69426655T2/de not_active Expired - Fee Related
- 1994-10-06 BR BR9408531A patent/BR9408531A/pt not_active Application Discontinuation
-
1996
- 1996-08-05 US US08/695,150 patent/US5734057A/en not_active Expired - Fee Related
-
2001
- 2001-04-06 GR GR20010400567T patent/GR3035716T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0746320A4 (en) | 1997-06-11 |
HUT74685A (en) | 1997-01-28 |
AU8074894A (en) | 1995-08-21 |
DK0746320T3 (da) | 2001-02-19 |
JPH09508416A (ja) | 1997-08-26 |
BR9408531A (pt) | 1997-08-05 |
WO1995020965A1 (en) | 1995-08-10 |
CA2182090A1 (en) | 1995-08-10 |
HU9602106D0 (en) | 1996-09-30 |
ATE198985T1 (de) | 2001-02-15 |
PT746320E (pt) | 2001-05-31 |
DE69426655T2 (de) | 2001-06-13 |
GR3035716T3 (en) | 2001-07-31 |
DE69426655D1 (de) | 2001-03-08 |
EP0746320B1 (en) | 2001-01-31 |
EP0746320A1 (en) | 1996-12-11 |
US5734057A (en) | 1998-03-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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