ES2150494T3 - Derivados sustituidos de quinolina y su utilizacion como inhibidores de la secrecion de acido gastrico. - Google Patents

Derivados sustituidos de quinolina y su utilizacion como inhibidores de la secrecion de acido gastrico.

Info

Publication number
ES2150494T3
ES2150494T3 ES94919046T ES94919046T ES2150494T3 ES 2150494 T3 ES2150494 T3 ES 2150494T3 ES 94919046 T ES94919046 T ES 94919046T ES 94919046 T ES94919046 T ES 94919046T ES 2150494 T3 ES2150494 T3 ES 2150494T3
Authority
ES
Spain
Prior art keywords
pct
gastric acid
acid secretion
quinoline
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94919046T
Other languages
English (en)
Inventor
Carl Ingemar Starke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9302005A external-priority patent/SE9302005D0/xx
Priority claimed from SE9303970A external-priority patent/SE9303970D0/xx
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of ES2150494T3 publication Critical patent/ES2150494T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A NUEVOS DERIVADOS DE QUINOLINA DE FORMULA (I) QUE INHIBEN LA SECRECION DE ACIDO GASTRICO DE MANERA EXOGENA O ENDOGENA Y PUEDEN ASI SER UTILIZADOS EN LA PREVENCION Y TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS GASTROINTESTINALES.
ES94919046T 1993-06-11 1994-06-08 Derivados sustituidos de quinolina y su utilizacion como inhibidores de la secrecion de acido gastrico. Expired - Lifetime ES2150494T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9302005A SE9302005D0 (sv) 1993-06-11 1993-06-11 New active compounds
SE9303970A SE9303970D0 (sv) 1993-11-30 1993-11-30 New active compounds

Publications (1)

Publication Number Publication Date
ES2150494T3 true ES2150494T3 (es) 2000-12-01

Family

ID=26661770

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94919046T Expired - Lifetime ES2150494T3 (es) 1993-06-11 1994-06-08 Derivados sustituidos de quinolina y su utilizacion como inhibidores de la secrecion de acido gastrico.

Country Status (25)

Country Link
US (1) US5889021A (es)
EP (1) EP0702672B1 (es)
JP (1) JP3623794B2 (es)
CN (1) CN1045955C (es)
AT (1) ATE196134T1 (es)
AU (1) AU680516B2 (es)
BR (1) BR9406772A (es)
CA (1) CA2164875A1 (es)
CZ (1) CZ326095A3 (es)
DE (1) DE69425823T2 (es)
EE (1) EE03123B1 (es)
EG (1) EG20435A (es)
ES (1) ES2150494T3 (es)
FI (1) FI955896A (es)
HU (1) HUT75122A (es)
IL (1) IL109685A (es)
IS (1) IS4164A (es)
NO (1) NO305799B1 (es)
NZ (1) NZ267740A (es)
PL (1) PL177766B1 (es)
RU (1) RU2142454C1 (es)
SG (1) SG47820A1 (es)
SK (1) SK154995A3 (es)
TW (1) TW261613B (es)
WO (1) WO1994029274A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556863A (en) * 1993-06-11 1996-09-17 Astra Aktiebolag Compound for gastric acid secretion inhibition
US6077850A (en) * 1997-04-21 2000-06-20 G.D. Searle & Co. Substituted benzopyran analogs for the treatment of inflammation
AU2002950217A0 (en) 2002-07-16 2002-09-12 Prana Biotechnology Limited 8- Hydroxy Quinoline Derivatives
CN106928232B (zh) * 2015-12-31 2019-07-09 上海医药集团股份有限公司 喹啉类化合物及其盐的晶型、制备方法、组合物与应用

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US509804A (en) * 1893-11-28 Hoof-weight
US3470186A (en) * 1967-06-02 1969-09-30 American Cyanamid Co Substituted 4-anilino-3-quinolinecarboxylic acids and esters
US4042702A (en) * 1973-08-16 1977-08-16 Byk Gulden Lomberg Chemische Fabrik Gmbh Halogen pyrazole derivatives, a method for producing these halogen pyrazole derivatives, medicaments containing and methods of using them
LU69428A1 (es) * 1974-02-20 1975-12-09
US4120966A (en) * 1975-02-03 1978-10-17 Smith Kline & French Laboratories Limited Heterocyclic-methylthioethyl-dithiocarbamates and isothioureas
ATA210876A (de) * 1975-03-25 1979-01-15 Byk Gulden Lomberg Chem Fab Verfahren zur herstellung von neuen nidrofuryl- pyrazolderivaten
AT364354B (de) * 1976-10-14 1981-10-12 Byk Gulden Lomberg Chem Fab Verfahren zur herstellung von neuen pyrazol-1yl-phenylessigsaeuren, deren salzen und optischen isomeren
LU78804A1 (de) * 1977-12-30 1979-07-20 Byk Gulden Lomberg Chem Fab N-substituierte w-aminoalkanoyl-w-aminoalkansaeuren,ihre verwendung und verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
US4243678A (en) * 1977-12-30 1981-01-06 Byk Gulden Lomberg Chemische Fabrik Gmbh Acylhydrocarbylaminoalkanoic acids, compositions and uses
YU118379A (en) * 1978-05-24 1983-02-28 Byk Gulden Lomberg Chemischefa Process for preparing phenylaminothiophene acetic acid
US4343804A (en) * 1979-03-26 1982-08-10 A. H. Robins Company, Inc. 4-Amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds
NO802326L (no) * 1979-08-03 1981-02-04 Byk Gulden Lomberg Chem Fab Fremgangsmaate ved fremstilling av substituerte tetraazatricyklen
EP0024638A1 (en) * 1979-08-30 1981-03-11 Byk Gulden Lomberg Chemische Fabrik GmbH Substituted quinolinone-alkanecarboxylic acids, their preparation, and medicaments containing them
EP0025192B1 (de) * 1979-09-07 1983-05-11 Byk Gulden Lomberg Chemische Fabrik GmbH Substituierte Oxirancarbonsäuren, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende Arzneimittel
ES496382A0 (es) * 1979-10-31 1982-03-01 Byk Gulden Lomberg Chem Fab Procedimiento para la preparacion de acidos oxocarboxilicos sustituidos
US4381301A (en) * 1980-05-07 1983-04-26 Byk Gulden Lomberg Chemische Fabrik Gmbh Substituted tricyclic thieno compounds, their synthesis, their use, their compositions and their medicaments
US4337267A (en) * 1980-08-25 1982-06-29 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenalkoxyalkyl- and phenoxyalkyl-substituted oxiranecarboxylic acids, their use and medicaments containing them
EP0046961B1 (de) * 1980-08-29 1985-02-13 Byk Gulden Lomberg Chemische Fabrik GmbH Epoxi-cycloalkylalkancarbonsäuren, Verfahren zu ihrer Herstellung, ihre Verwendung sowie sie enthaltende Arzneimittel
DE3262922D1 (en) * 1981-02-02 1985-05-15 Byk Gulden Lomberg Chem Fab Tricyclic pyrrols, process for their preparation, their use and compositions containing them
FI80022C (fi) * 1982-07-05 1990-04-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av ett nytt, terapeutiskt anvaendbart karbostyrilderivat.
DK585485A (da) * 1984-12-18 1986-08-08 Utsuka Pharm Co Ltd Tetrahydroquinolinderivat, imidazopyridinderivat, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat med mindst en saadan forbindelse
US5250527A (en) * 1985-10-24 1993-10-05 Smithkline & French Laboratories Limited Pyridyl containing benzimidazoles, compositions and use
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds
GB8717644D0 (en) * 1987-07-24 1987-09-03 Smithkline Beckman Intercredit Compounds
GB8804447D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
US5049567A (en) * 1988-02-25 1991-09-17 Smithkline Beckman Intercredit B.V. Substituted 4-aminoquinazoline derivatives and method of use
GB8804444D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804446D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804448D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804443D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804445D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
CA2011086A1 (en) * 1989-03-17 1990-09-17 Karl-Heinz Geiss 2-alkyl-4-arylmethylaminoquinolines, the use thereof and drugs prepared therefrom
GB8908229D0 (en) * 1989-04-12 1989-05-24 Smithkline Beckman Intercredit Compounds
GB8910722D0 (en) * 1989-05-10 1989-06-28 Smithkline Beckman Intercredit Compounds
DE3917233A1 (de) * 1989-05-26 1990-11-29 Basf Ag 8-substituierte 4-(heterocyclylmethylamino)-chinoline, ihre verwendung und daraus hergestellte arzneimittel
GB8918265D0 (en) * 1989-08-10 1989-09-20 Smithkline Beckman Intercredit Compounds
DE69128682T2 (de) * 1990-03-28 1998-06-04 Otsuka Pharma Co Ltd Chinolinderivat, antiulcus-mittel das dieses derivat enthält und darstellung dieses derivates
JPH06504541A (ja) * 1991-01-29 1994-05-26 スミスクライン・ビーチャム・インタークレディット・ビー・ベー ４−アミノ−３−アシルキノリン誘導体の塩およびその胃酸分泌抑制剤としての使用
GB9126438D0 (en) * 1991-12-12 1992-02-12 Smithkline Beecham Intercredit New quinoline derivatives

Also Published As

Publication number Publication date
HUT75122A (en) 1997-04-28
AU680516B2 (en) 1997-07-31
PL177766B1 (pl) 2000-01-31
RU2142454C1 (ru) 1999-12-10
CZ326095A3 (en) 1996-05-15
CA2164875A1 (en) 1994-12-22
NO305799B1 (no) 1999-07-26
EG20435A (en) 1999-04-29
DE69425823D1 (de) 2000-10-12
EE03123B1 (et) 1998-10-15
IL109685A0 (en) 1994-11-28
FI955896A0 (fi) 1995-12-08
AU7012194A (en) 1995-01-03
HU9503529D0 (en) 1996-02-28
US5889021A (en) 1999-03-30
NO954928D0 (no) 1995-12-05
NZ267740A (en) 1997-05-26
JPH09510951A (ja) 1997-11-04
EP0702672A1 (en) 1996-03-27
SK154995A3 (en) 1996-09-04
EP0702672B1 (en) 2000-09-06
JP3623794B2 (ja) 2005-02-23
WO1994029274A1 (en) 1994-12-22
PL311957A1 (en) 1996-03-18
FI955896A (fi) 1995-12-08
IL109685A (en) 1999-03-12
DE69425823T2 (de) 2001-01-18
NO954928L (no) 1995-12-05
ATE196134T1 (de) 2000-09-15
SG47820A1 (en) 1998-04-17
CN1125438A (zh) 1996-06-26
TW261613B (es) 1995-11-01
IS4164A (is) 1994-12-12
BR9406772A (pt) 1996-02-21
CN1045955C (zh) 1999-10-27

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