ES2144792T3 - Uso de inhibidores de la nadph oxidasa para la preparacion de un medicamento para la prevencion de la aterosclerosis. - Google Patents
Uso de inhibidores de la nadph oxidasa para la preparacion de un medicamento para la prevencion de la aterosclerosis.Info
- Publication number
- ES2144792T3 ES2144792T3 ES96940912T ES96940912T ES2144792T3 ES 2144792 T3 ES2144792 T3 ES 2144792T3 ES 96940912 T ES96940912 T ES 96940912T ES 96940912 T ES96940912 T ES 96940912T ES 2144792 T3 ES2144792 T3 ES 2144792T3
- Authority
- ES
- Spain
- Prior art keywords
- atherosclerosis
- medication
- prevention
- preparation
- nadph oxidase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Steroid Compounds (AREA)
Abstract
SE PROPORCIONA UN METODO PARA LA PREVENCION Y EL TRATAMIENTO DE LA ATEROSCLEROSIS Y ENFERMEDADES RELACIONADAS EN MAMIFEROS, EN EL QUE SE ADMINISTRA UN INHIBIDOR DE LA NADPH OXIDASA. EL INHIBIDOR DE LA NADPH OXIDASA PREVIENE LA PRODUCCION DE ESPECIES DE OXIGENO REACTIVO ANTE LA EXPOSICION DE LAS CELULAS ENDOTELIALES A NIVELES ATEROGENICOS DE LDL, DANDO LUGAR ASI A UNA DISMINUCION DE LA ENDOCITOSIS Y LA HIPERPERMEABILIDAD VASCULAR. LOS INHIBIDORES PREFERIDOS DE LA NADPH OXIDASA SON LOS CORRESPONDIENTES A LA FORMULA (I). ADEMAS, SE PROPORCIONA UN METODO DIAGNOSTICO PARA PREDECIR EL RIESGO DE ENFERMEDADES ATEROSCLEROTICAS PARA UN PACIENTE HUMANO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/562,767 US5763496A (en) | 1995-11-27 | 1995-11-27 | Prevention of atherosclerosis using NADPH oxidase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2144792T3 true ES2144792T3 (es) | 2000-06-16 |
Family
ID=24247689
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96940912T Expired - Lifetime ES2144792T3 (es) | 1995-11-27 | 1996-11-27 | Uso de inhibidores de la nadph oxidasa para la preparacion de un medicamento para la prevencion de la aterosclerosis. |
Country Status (10)
Country | Link |
---|---|
US (2) | US5763496A (es) |
EP (2) | EP0861070B1 (es) |
JP (2) | JPH11507946A (es) |
AT (1) | ATE189957T1 (es) |
AU (1) | AU1085997A (es) |
CA (1) | CA2238098C (es) |
DE (1) | DE69606882T2 (es) |
ES (1) | ES2144792T3 (es) |
GR (1) | GR3033067T3 (es) |
WO (1) | WO1997019679A2 (es) |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU9226198A (en) * | 1997-09-10 | 1999-03-29 | Johns Hopkins University School Of Medicine, The | The use of an nadph-oxidase inhibitor in the treatment of reperfusion injury |
US6242473B1 (en) * | 1999-01-08 | 2001-06-05 | Maxim Pharmaceuticals, Inc. | Treatment and prevention of reactive oxygen metabolite-mediated cellular damage |
NZ509803A (en) * | 2000-02-09 | 2001-08-31 | Paul A | Treatment of fibromyalgia with ubiquinone 10 and succinic acid |
WO2001089517A2 (en) * | 2000-05-19 | 2001-11-29 | Thomas Jefferson University | Inhibition of cell proliferation and matrix synthesis by antioxidants and nad(p)h oxidase inhibitors |
US6492429B1 (en) * | 2000-07-10 | 2002-12-10 | N.V. Nutricia | Composition for the treatment of osteoarthritis |
WO2002030453A1 (en) * | 2000-10-12 | 2002-04-18 | Beth Israel Deaconess Medical Center, Inc. | Methods of inhibiting angiogenesis using nadph oxidase inhibitors |
EP1353676A4 (en) * | 2000-12-29 | 2006-05-31 | Alteon Inc | METHOD FOR THE TREATMENT OF FIBROUS OR OTHER INDICATIONS |
DE10104825A1 (de) * | 2001-02-01 | 2002-08-08 | Florian Lang | Screening von Antimalariamitteln |
AU2002353996A1 (en) * | 2001-11-01 | 2003-05-12 | Rensselaer Polytechnic Institute | Solid-phase array-based biocatalytic transformations |
AU2002359790A1 (en) * | 2001-12-21 | 2003-07-15 | Charlotte Mecklenburg Hospital Authority Doing Business As Carolinas Medical Center | Regulation of nad(p)h oxidase growth and transcription in melanoma cells |
US6949586B2 (en) * | 2002-02-11 | 2005-09-27 | Council Of Scientific Research | Synergistic composition of trans-tetracos-15-enoic acid and Apocynin and method of treatment for hepatotoxicity |
AU2003224549A1 (en) * | 2002-04-17 | 2003-10-27 | Biovitrum Ab | Nad)p)h oxidase inhibitors for increased glucose uptake and treatment of type ii diabetes |
AU2003233147B2 (en) * | 2002-05-13 | 2008-03-06 | Arexis Ab | Autoimmune conditions and NADPH oxidase defects |
AU2003262804A1 (en) * | 2002-08-22 | 2004-03-11 | Nutrition 21, Inc. | Arginine silicate inositol complex and use thereof |
US20070037739A1 (en) * | 2003-02-03 | 2007-02-15 | Medlogics Device Corporation | Compounds useful in coating stents to prevent and treat stenosis and restenosis |
AU2004216541A1 (en) * | 2003-02-28 | 2004-09-10 | Howard Florey Institute Of Experimental Physiology And Medicine | Therapeutic compositions |
TW200509886A (en) * | 2003-05-02 | 2005-03-16 | Takara Bio Inc | Therapeutic agent |
WO2005103297A1 (en) * | 2004-03-31 | 2005-11-03 | Georgetown University | METHODS AND COMPOSITIONS RELATED TO MODULATION OF p22phox |
EP1602926A1 (en) | 2004-06-04 | 2005-12-07 | University of Geneva | Novel means and methods for the treatment of hearing loss and phantom hearing |
US20070254900A1 (en) * | 2004-08-11 | 2007-11-01 | Kassab Ghassan S | Treatments for Congestive Heart Failure |
WO2006033965A2 (en) * | 2004-09-16 | 2006-03-30 | The Trustees Of The University Of Pennsylvania | Nadph oxidase inhibition pharmacotherapies for obstructive sleep apnea syndrome and its associated morbidities |
US8067464B2 (en) | 2004-10-04 | 2011-11-29 | Nitromed, Inc. | Compositions and methods using apocynin compounds and nitric oxide donors |
US7825099B2 (en) | 2006-01-20 | 2010-11-02 | Quark Pharmaceuticals, Inc. | Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes |
US20080051451A1 (en) * | 2006-03-15 | 2008-02-28 | Marcel Linschoten | Autoimmune conditions and NADPH oxidase defects |
EP2002835A1 (en) | 2007-06-04 | 2008-12-17 | GenKyo Tex | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
ES2601856T3 (es) | 2007-06-08 | 2017-02-16 | Mannkind Corporation | Inhibidores de la IRE-1A |
KR100989093B1 (ko) * | 2008-01-18 | 2010-10-25 | 한화제약주식회사 | 생강나무 가지의 추출물을 포함하는 심혈관계 질환의 예방 및 치료용 조성물 |
DK2334295T3 (en) | 2008-09-02 | 2017-10-09 | Amarin Pharmaceuticals Ie Ltd | PHARMACEUTICAL COMPOSITION COMPREHENSIVE EICOSAPENTAIC ACID AND NICOTIC ACID AND PROCEDURES FOR USING SAME |
EP2165707A1 (en) | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
EP2166009A1 (en) | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as nadph oxidase inhibitors |
EP2166010A1 (en) | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
WO2010127103A1 (en) | 2009-04-29 | 2010-11-04 | Amarin Pharma, Inc. | Stable pharmaceutical composition and methods of using same |
AU2010241567B2 (en) | 2009-04-29 | 2013-10-31 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical compositions comprising EPA and a cardiovascular agent and methods of using the same |
US8455472B2 (en) | 2009-06-15 | 2013-06-04 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy |
KR101798670B1 (ko) | 2009-09-23 | 2017-11-16 | 아마린 코포레이션 피엘씨 | 오메가-3 지방산 및 스타틴의 히드록시-유도체를 포함하는 제약 조성물 및 그의 사용 방법 |
EP2305679A1 (en) | 2009-09-28 | 2011-04-06 | GenKyoTex SA | Pyrazoline dione derivatives as nadph oxidase inhibitors |
US11712429B2 (en) | 2010-11-29 | 2023-08-01 | Amarin Pharmaceuticals Ireland Limited | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
NZ727980A (en) | 2010-11-29 | 2018-08-31 | Amarin Pharmaceuticals Ie Ltd | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
US11291643B2 (en) | 2011-11-07 | 2022-04-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
US20130131170A1 (en) | 2011-11-07 | 2013-05-23 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
EP2800469B1 (en) | 2012-01-06 | 2021-08-25 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering levels of high-sensitivity (hs-crp) in a subject |
WO2013136277A1 (en) | 2012-03-13 | 2013-09-19 | Unimark Remedies Ltd. | Pharmaceutical compositions for treatment of cardiovascular diseases |
US20140080850A1 (en) * | 2012-06-05 | 2014-03-20 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising an omega-3 fatty acid and a hydroxy-derivative of a statin and methods of using same |
RS61557B1 (sr) | 2012-06-29 | 2021-04-29 | Amarin Pharmaceuticals Ie Ltd | Postupci za smanjenje rizika od kardiovaskularnog događaja kod pacijenta na terapiji statinom primenom etil estra eikozapentaenske kiseline |
WO2014074552A2 (en) | 2012-11-06 | 2014-05-15 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy |
US20140187633A1 (en) | 2012-12-31 | 2014-07-03 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis |
US9452151B2 (en) | 2013-02-06 | 2016-09-27 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing apolipoprotein C-III |
US9624492B2 (en) | 2013-02-13 | 2017-04-18 | Amarin Pharmaceuticals Ireland Limited | Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof |
US9662307B2 (en) | 2013-02-19 | 2017-05-30 | The Regents Of The University Of Colorado | Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof |
US9283201B2 (en) | 2013-03-14 | 2016-03-15 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for treating or preventing obesity in a subject in need thereof |
US20140271841A1 (en) | 2013-03-15 | 2014-09-18 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin |
CA2912302A1 (en) | 2013-05-14 | 2014-11-20 | University Of Prince Edward Island | Compositions and methods for treating cardiometabolic diseases and disorders |
US10966968B2 (en) | 2013-06-06 | 2021-04-06 | Amarin Pharmaceuticals Ireland Limited | Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof |
US20150065572A1 (en) | 2013-09-04 | 2015-03-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing prostate cancer |
US9585859B2 (en) | 2013-10-10 | 2017-03-07 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy |
US10561631B2 (en) | 2014-06-11 | 2020-02-18 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing RLP-C |
US10172818B2 (en) | 2014-06-16 | 2019-01-08 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids |
EP3034500A1 (en) | 2014-12-17 | 2016-06-22 | Genkyotex Sa | Amido thiazole derivatives as NADPH oxidase inhibitors |
US11191735B2 (en) | 2015-03-13 | 2021-12-07 | Nutrition 21, Llc | Arginine silicate for periodontal disease |
US20170135969A1 (en) | 2015-11-12 | 2017-05-18 | Jds Therapeutics, Llc | Topical arginine-silicate-inositol for wound healing |
US10406130B2 (en) | 2016-03-15 | 2019-09-10 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids |
US11938117B2 (en) | 2016-09-01 | 2024-03-26 | Nutrition21, LLC | Magnesium biotinate compositions and methods of use |
US10966951B2 (en) | 2017-05-19 | 2021-04-06 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides in a subject having reduced kidney function |
EP3479843A1 (en) | 2017-11-01 | 2019-05-08 | GenKyoTex Suisse SA | Use of nox inhibitors for treatment of cancer |
US11058661B2 (en) | 2018-03-02 | 2021-07-13 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L |
WO2020068163A1 (en) | 2018-09-24 | 2020-04-02 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing the risk of cardiovascular events in a subject |
CA3118583C (en) | 2018-11-02 | 2024-05-14 | Nutrition 21, Llc | Compositions containing inositol-stabilized arginine silicate complexes and inositol for improving cognitive function in video gamers |
EP4076413A1 (en) | 2019-12-16 | 2022-10-26 | Nutrition 21, LLC | Methods of production of arginine-silicate complexes |
KR20240012390A (ko) | 2021-04-21 | 2024-01-29 | 애머린 파마슈티칼스 아일랜드 리미티드 | 심부전의 위험을 감소시키는 방법 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5593966A (en) * | 1989-03-31 | 1997-01-14 | The United States Of America As Represented By The Department Of Health And Human Services | Peptide derivatives of cytochrome b558 and their use as medicaments |
DE4109627A1 (de) * | 1991-03-23 | 1992-09-24 | Boehringer Mannheim Gmbh | Neue phenolether, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten |
GB9200623D0 (en) * | 1992-01-13 | 1992-03-11 | Bayer Ag | Benzofuranyl and thiophenyl-methylthio-alkanecarboxylic acid derivatives |
US5244916A (en) * | 1992-01-31 | 1993-09-14 | The Scripps Research Institute | Inhibition of respiratory burst using posttranslational modification inhibitors |
JPH06135880A (ja) * | 1992-10-30 | 1994-05-17 | Kanebo Ltd | 活性酸素消去剤 |
JP3023254B2 (ja) * | 1992-11-05 | 2000-03-21 | 鐘紡株式会社 | メラニン生成抑制剤 |
JPH06227977A (ja) * | 1993-02-01 | 1994-08-16 | Suntory Ltd | 活性酸素消去剤 |
AU1095695A (en) * | 1993-11-09 | 1995-05-29 | Brigham And Women's Hospital | Hmg-coa reductase inhibitors in the normalization of vascular endothelial dysfunction |
JPH07165575A (ja) * | 1993-12-08 | 1995-06-27 | Nippon Oil & Fats Co Ltd | ヒドロキノン誘導体 |
JP2774063B2 (ja) * | 1993-12-24 | 1998-07-09 | 鐘紡株式会社 | 抗酸化組成物 |
-
1995
- 1995-11-27 US US08/562,767 patent/US5763496A/en not_active Expired - Fee Related
-
1996
- 1996-11-27 AU AU10859/97A patent/AU1085997A/en not_active Abandoned
- 1996-11-27 CA CA002238098A patent/CA2238098C/en not_active Expired - Fee Related
- 1996-11-27 JP JP9520684A patent/JPH11507946A/ja not_active Ceased
- 1996-11-27 AT AT96940912T patent/ATE189957T1/de not_active IP Right Cessation
- 1996-11-27 EP EP96940912A patent/EP0861070B1/en not_active Expired - Lifetime
- 1996-11-27 EP EP99100764A patent/EP0914821A3/en not_active Withdrawn
- 1996-11-27 WO PCT/US1996/019053 patent/WO1997019679A2/en active IP Right Grant
- 1996-11-27 DE DE69606882T patent/DE69606882T2/de not_active Expired - Fee Related
- 1996-11-27 ES ES96940912T patent/ES2144792T3/es not_active Expired - Lifetime
-
1997
- 1997-05-23 US US08/862,515 patent/US5902831A/en not_active Expired - Fee Related
-
2000
- 2000-03-27 GR GR20000400756T patent/GR3033067T3/el not_active IP Right Cessation
-
2002
- 2002-11-27 JP JP2002343442A patent/JP2003176224A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO1997019679A3 (en) | 1997-08-28 |
US5902831A (en) | 1999-05-11 |
CA2238098C (en) | 2001-01-30 |
EP0914821A3 (en) | 2000-04-26 |
CA2238098A1 (en) | 1997-06-05 |
AU1085997A (en) | 1997-06-19 |
DE69606882D1 (de) | 2000-04-06 |
US5763496A (en) | 1998-06-09 |
GR3033067T3 (en) | 2000-08-31 |
EP0861070A2 (en) | 1998-09-02 |
WO1997019679A2 (en) | 1997-06-05 |
DE69606882T2 (de) | 2000-08-17 |
EP0914821A2 (en) | 1999-05-12 |
ATE189957T1 (de) | 2000-03-15 |
EP0861070B1 (en) | 2000-03-01 |
JPH11507946A (ja) | 1999-07-13 |
JP2003176224A (ja) | 2003-06-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2144792T3 (es) | Uso de inhibidores de la nadph oxidasa para la preparacion de un medicamento para la prevencion de la aterosclerosis. | |
FI872756A (fi) | Med laserstraolning fungerande terapeutisk anordning. | |
DZ2375A1 (fr) | Prévention de la perte et restauration de la masseosseuse par certains agonistes des prostaglandine s. | |
DE69619448D1 (de) | Blutdruckmessgerät | |
DE68903516D1 (de) | Mittel zur senkung des blutdrucks. | |
KR970000401U (ko) | 채혈용 란셋 | |
AU4594796A (en) | System and method for diagnosis of living tissue diseases | |
IT8567350A1 (it) | Dispositivo per la fabbricazione di corpi assorbenti, particolarmente per la fabbricazione di assorbenti igienici e simili. | |
DE60043587D1 (de) | Mittel für erkrankungen assoziert mit knochensubstanzverlust | |
NO975319D0 (no) | System for måling av oksygennivå i blod | |
ES2110414T3 (es) | Derivados de sacarina utiles como inhibidores de enzimas proteoliticas y su preparacion. | |
ES2138729T3 (es) | Metodos de diagnostico de la preeclampsia. | |
AU8439998A (en) | Compounds | |
ES2176778T3 (es) | Metodo de diagnostico para la aterosclerosis. | |
NO963108L (no) | Substituerte kanelsyreguanidider, fremgangsmåte for fremstilling, anvendelse som medikament eller diagnostikum som inneholder disse | |
EP0758021A3 (en) | Method for determining the therapeutic activity of metalloproteinase inhibitor compounds, new inhibitor compounds, and the therapeutic use thereof | |
DE69620088D1 (de) | Blutdruckmessgerät | |
IT8721115A0 (it) | Fitopreparato per la cura di affezioni cutanee. | |
AU2909495A (en) | Evaluation of blood coagulation activity | |
DE69405284D1 (de) | Manschette für Blutdruckmesser | |
ES2179867T3 (es) | Entrecruzamientos de piridinolina como marcadores de actividad de enfermedad periodontal o peri-implante. | |
FI861093A0 (fi) | Bioelektrisk patientmonitor. | |
NO980564D0 (no) | Sulfonamid-substituerte forbindelser, fremgangsmåte for fremstilling, anvendelse som medikament eller diagnostikum samt oppnådd medikament er beskrevet | |
DE69013139D1 (de) | Mittel zur Vorbeugung, Diagnose und Therapie von rheumatischen, autoimmunen, Haut- und Bindegewebekrankheiten von unbekannter Aetiologie und Verfahren zu seiner Herstellung und Verwendung. | |
ES1032126Y (es) | Juego esterilizable para la autoinyeccion de drogas. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 861070 Country of ref document: ES |