ES2142825T3 - Uso de 1(rs)-(1-trifluoroacetil-2-metilpropil)amida de 4-(4-clorofenil-sulfonilcarbamoil)benzoil-l-valil-l-prolina para la preparacion de un medicamento para el tratamiento de enfermedades vasculares. - Google Patents
Uso de 1(rs)-(1-trifluoroacetil-2-metilpropil)amida de 4-(4-clorofenil-sulfonilcarbamoil)benzoil-l-valil-l-prolina para la preparacion de un medicamento para el tratamiento de enfermedades vasculares.Info
- Publication number
- ES2142825T3 ES2142825T3 ES92911644T ES92911644T ES2142825T3 ES 2142825 T3 ES2142825 T3 ES 2142825T3 ES 92911644 T ES92911644 T ES 92911644T ES 92911644 T ES92911644 T ES 92911644T ES 2142825 T3 ES2142825 T3 ES 2142825T3
- Authority
- ES
- Spain
- Prior art keywords
- chlorophenyl
- proline
- amide
- treatment
- vascular diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Radar Systems Or Details Thereof (AREA)
Abstract
SE PRESENTA EL USO DEL 1(RS)-(1-TRIFLUOROACETIL-2-METILPROPIL)AMIDO DE 4-(4-CLOROFENIL-SULFONILCARBAMOIL)BENZOIL-L-VALIL-L-PROLINA INHIBIDOR DE LA ELASTASA, O DE UNA SAL FARMACEUTICAMENTE ACEPTABLES DEL MISMO, EN EL TRATAMIENTO DE CIERTAS ENFERMEDADES VASCULARES EN LAS QUE ESTAN INVOLUCRADOS NEUTROFILOS, POR EJEMPLO LAS ENFERMEDADES CARDIOVASCULARES TALES COMO LA ISQUEMIA DE MIOCARDIO, ENFERMEDADES CEREBROVASCULARES TALES COMO LOS DERRAMES, ENFERMEDADES VASCULARES PERIFERICAS TALES COMO LA COJERA INTERMITENTE, ASI COMO LOS ESTADOS DE REPERCUSION TALES COMO LOS ASOCIADOS CON LA CIRUGIA VASCULAR RECONSTRUCTIVA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919113164A GB9113164D0 (en) | 1991-06-18 | 1991-06-18 | Pharmaceutical agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2142825T3 true ES2142825T3 (es) | 2000-05-01 |
Family
ID=10696898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92911644T Expired - Lifetime ES2142825T3 (es) | 1991-06-18 | 1992-06-17 | Uso de 1(rs)-(1-trifluoroacetil-2-metilpropil)amida de 4-(4-clorofenil-sulfonilcarbamoil)benzoil-l-valil-l-prolina para la preparacion de un medicamento para el tratamiento de enfermedades vasculares. |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0589937B1 (es) |
| JP (1) | JPH06508826A (es) |
| AT (1) | ATE190493T1 (es) |
| AU (1) | AU667307B2 (es) |
| CA (1) | CA2111846A1 (es) |
| DE (1) | DE69230792T2 (es) |
| DK (1) | DK0589937T3 (es) |
| ES (1) | ES2142825T3 (es) |
| GB (1) | GB9113164D0 (es) |
| GR (1) | GR3032825T3 (es) |
| NO (1) | NO934689D0 (es) |
| WO (1) | WO1992022309A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002161051A (ja) * | 1996-12-24 | 2002-06-04 | Fujisawa Pharmaceut Co Ltd | 脳虚血性疾患等の治療剤 |
| AT406120B (de) * | 1997-08-28 | 2000-02-25 | Immuno Ag | Gewebekleber |
| US6903244B1 (en) * | 1999-02-26 | 2005-06-07 | University Of Utah Research Foundation | Mice which are +/− or −/− for the elastin gene as models for vascular disease |
| CA2368937A1 (en) * | 1999-04-13 | 2000-10-19 | North Shore-Long Island Jewish Research Institute | Prevention of brain damage in stroke |
| IL148924A (en) * | 2002-03-26 | 2015-06-30 | Mor Research Applic Ltd | Use of substances that inhibit intracellular elastase activity in the preparation of a drug for the treatment and / or prevention of necrosis of cells and related diseases |
| US11161859B2 (en) | 2017-03-21 | 2021-11-02 | The Scripps Research Institute | Cu- and Ni-catalyzed decarboxylative borylation reactions |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8600263D0 (en) * | 1985-01-22 | 1986-02-12 | Ici America Inc | Peptide derivatives |
| IE911697A1 (en) * | 1990-05-24 | 1991-12-04 | Zeneca Ltd | Therapeutic agent |
| DK0458537T3 (da) * | 1990-05-24 | 1999-10-18 | Zeneca Ltd | Anvendelse af en terapeutisk forbindelse til behandling af bronkitis |
| US5162348A (en) * | 1990-05-24 | 1992-11-10 | Imperial Chemical Industries Plc | Treatment of cystic fibrosis |
| GB9014132D0 (en) * | 1990-06-25 | 1990-08-15 | Ici Plc | Agent for therapy |
-
1991
- 1991-06-18 GB GB919113164A patent/GB9113164D0/en active Pending
-
1992
- 1992-06-17 AT AT92911644T patent/ATE190493T1/de not_active IP Right Cessation
- 1992-06-17 AU AU19007/92A patent/AU667307B2/en not_active Ceased
- 1992-06-17 CA CA002111846A patent/CA2111846A1/en not_active Abandoned
- 1992-06-17 WO PCT/GB1992/001087 patent/WO1992022309A1/en active IP Right Grant
- 1992-06-17 DK DK92911644T patent/DK0589937T3/da active
- 1992-06-17 EP EP92911644A patent/EP0589937B1/en not_active Expired - Lifetime
- 1992-06-17 ES ES92911644T patent/ES2142825T3/es not_active Expired - Lifetime
- 1992-06-17 JP JP4510795A patent/JPH06508826A/ja active Pending
- 1992-06-17 DE DE69230792T patent/DE69230792T2/de not_active Expired - Fee Related
-
1993
- 1993-12-17 NO NO934689A patent/NO934689D0/no not_active Application Discontinuation
-
2000
- 2000-03-16 GR GR20000400462T patent/GR3032825T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69230792D1 (de) | 2000-04-20 |
| GR3032825T3 (en) | 2000-06-30 |
| NO934689L (no) | 1993-12-17 |
| AU667307B2 (en) | 1996-03-21 |
| EP0589937B1 (en) | 2000-03-15 |
| GB9113164D0 (en) | 1991-08-07 |
| EP0589937A1 (en) | 1994-04-06 |
| ATE190493T1 (de) | 2000-04-15 |
| JPH06508826A (ja) | 1994-10-06 |
| DE69230792T2 (de) | 2000-06-29 |
| WO1992022309A1 (en) | 1992-12-23 |
| CA2111846A1 (en) | 1992-12-23 |
| DK0589937T3 (da) | 2000-07-31 |
| AU1900792A (en) | 1993-01-12 |
| NO934689D0 (no) | 1993-12-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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