ES2140620T3 - Derivados de oxopiridinylquinoxalina. - Google Patents
Derivados de oxopiridinylquinoxalina.Info
- Publication number
- ES2140620T3 ES2140620T3 ES95302326T ES95302326T ES2140620T3 ES 2140620 T3 ES2140620 T3 ES 2140620T3 ES 95302326 T ES95302326 T ES 95302326T ES 95302326 T ES95302326 T ES 95302326T ES 2140620 T3 ES2140620 T3 ES 2140620T3
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- substituted
- nitro
- halogen
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
SE PRESENTA UN DERIVADO DE LA OXOPIRIDINILQUINOLAXINA REPRESENTADO POR LA SIGUIENTE FORMULA (I) ASI COMO LAS SALES FARMACOLOGICAMENTE ACEPTABLES DEL MISMO; EN DONDE R1 ES HIDROGENO, HALOGENO, NITRO O TRIHALOMETIL; R2 ES HIDROGENO, HALOGENO, NITRO, CIANO, TRIHALOMETIL, CARBAMOIL, CARBAMOIL SUSTITUIDO CON ALQUIL INFERIOR, SULFAMOIL, O SULFAMOIL SUSTITUIDO CON ALQUIL INFERIOR; R3 ES HIDROGENO, NITRO O HALOGENO; R4 ES HALOGENO; ALQUIL INFERIOR, ALQUIL INFERIOR SUSTITUIDO, CICLOALQUIL INFERIOR, O CICLOALQUIL INFERIOR SUSTITUIDO; R5''S SON SUSTITUYENTE SELECCIONADOS INDEPENDIENTEMENTE ENTRE EL GRUPO QUE CONSTA DE HALOGENO, NITRO, CIANO, ALQUIL INFERIOR, CARBAMOIL Y CARBAMOIL SUSTITUIDO CON ALQUIL INFERIOR; Y N ES UN ENTERO ENTRE 0 Y 4. EL DERIVADO TRABAJA COMO AGENTE ANTAGONISTA CONTRA TANTO LOS RECEPTORES DEL NMDA COMO CONTRA LOS RECEPTORES DEL AMPA, DE MANERA QUE ES EFECTIVO COMO AGENTE TERAPEUTICO PARA ENFERMEDADES NEUROLOGICAS PROVOCADAS POR LA UNION DE AMINOACIDOS EXCITATORIOS A LOS RECEPTORES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7090994 | 1994-04-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2140620T3 true ES2140620T3 (es) | 2000-03-01 |
Family
ID=13445121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95302326T Expired - Lifetime ES2140620T3 (es) | 1994-04-08 | 1995-04-07 | Derivados de oxopiridinylquinoxalina. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5677305A (es) |
EP (1) | EP0676397B1 (es) |
KR (1) | KR100363003B1 (es) |
CN (1) | CN1044241C (es) |
AT (1) | ATE185806T1 (es) |
AU (1) | AU688459B2 (es) |
CA (1) | CA2146478A1 (es) |
DE (1) | DE69512816T2 (es) |
DK (1) | DK0676397T3 (es) |
ES (1) | ES2140620T3 (es) |
GR (1) | GR3032406T3 (es) |
HU (1) | HUT72064A (es) |
TW (1) | TW300894B (es) |
ZA (1) | ZA952841B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU688459B2 (en) * | 1994-04-08 | 1998-03-12 | Shionogi & Co., Ltd. | Oxopyridinylquinoxaline derivative |
AUPN842196A0 (en) * | 1996-03-05 | 1996-03-28 | Fujisawa Pharmaceutical Co., Ltd. | New compound |
CA2302161A1 (en) * | 1997-09-01 | 1999-03-11 | Kyorin Pharmaceutical Co., Ltd. | 6,7-asymmetrically disubstituted quinoxalinecarboxylic acid derivatives, addition salts thereof, and processes for the preparation of both |
KR20010043981A (ko) | 1998-06-01 | 2001-05-25 | 시오노 요시히코 | 시아노이미노퀴녹살린 유도체 |
AU2006262259B2 (en) * | 2005-06-23 | 2013-03-14 | Array Biopharma Inc. | Process for preparing benzimidazole compounds |
WO2010053757A1 (en) | 2008-10-29 | 2010-05-14 | Gilead Palo Alto, Inc. | 2 -oxoquinoxalin blockers of the late sodium channel |
WO2010074807A1 (en) | 2008-10-30 | 2010-07-01 | Gilead Palo Alto, Inc. | 3, 4-dihydroquinolin-2 ( 1h ) -one derivatives as sodium channel modulators |
EP2338492A1 (en) | 2009-12-24 | 2011-06-29 | Universidad del Pais Vasco | Methods and compositions for the treatment of alzheimer |
CN103664806B (zh) * | 2013-12-16 | 2016-06-29 | 山东汇海医药化工有限公司 | 一种n-乙酰乙酰基-6-甲氧基-7-氨基喹喔啉-2,3-二酮的制备方法 |
EP3589616A1 (en) | 2017-02-28 | 2020-01-08 | Universitat Autònoma de Barcelona | (nitro-phenyl)-nitropyridine compounds for treating synucleinopathies |
WO2019161917A1 (en) | 2018-02-23 | 2019-08-29 | Universitat Autonoma De Barcelona | 4-substituted 1-ethenylsulfonyl-2-nitrobenzene compounds for treating synucleinopathies |
WO2024083850A1 (en) | 2022-10-18 | 2024-04-25 | ETH Zürich | Electrocatalyst |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE66149B1 (en) * | 1986-09-16 | 1995-12-13 | Novo Nordisk As | Quinoxaline compounds and their preparation and use |
JP2635662B2 (ja) * | 1987-03-23 | 1997-07-30 | ノボ・ノルデイスク・アクツイエルスカブ | ヘテロ環状化合物,その製造方法及びその使用法 |
NO179551C (no) * | 1987-11-10 | 1996-10-30 | Novo Nordisk As | Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser |
DK160941C (da) * | 1988-06-28 | 1991-10-21 | Novo Nordisk As | Kondenserede 2,3-dihydroxypyraziner, fremgangsmaade til deres fremstilling og farmaceutiske praeparater, hvori forbindelserne indgaar |
DK716188D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Quinoxalinforbindelser, deres fremstilling og anvendelse |
US5153195A (en) * | 1988-12-22 | 1992-10-06 | Novo Nordisk A/S | Quinoxaline compounds and their preparation and use |
DK715888D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Quinoxalinforbindelser, deres fremstilling og anvendelse |
RU2095352C1 (ru) * | 1990-11-06 | 1997-11-10 | Яманоути Фармасьютикал Ко., Лтд. | Производное сконденсированного пиразина |
JPH04193876A (ja) * | 1990-11-26 | 1992-07-13 | Sumitomo Chem Co Ltd | キノキザリン誘導体、その製造法およびそれを有効成分とする除草剤 |
DK73091D0 (da) * | 1991-04-22 | 1991-04-22 | Novo Nordisk As | Quinoxalinforbindelser, deres fremstilling og anvendelse |
DE4217952A1 (de) * | 1992-05-30 | 1993-12-02 | Basf Ag | Chinoxalin-2,3(1H,4H)-dione |
JPH06228112A (ja) * | 1993-02-05 | 1994-08-16 | Yamanouchi Pharmaceut Co Ltd | (1h,4h)キノキサリン誘導体 |
AU688459B2 (en) * | 1994-04-08 | 1998-03-12 | Shionogi & Co., Ltd. | Oxopyridinylquinoxaline derivative |
-
1995
- 1995-04-05 AU AU16256/95A patent/AU688459B2/en not_active Ceased
- 1995-04-06 CA CA002146478A patent/CA2146478A1/en not_active Abandoned
- 1995-04-06 ZA ZA952841A patent/ZA952841B/xx unknown
- 1995-04-07 EP EP95302326A patent/EP0676397B1/en not_active Expired - Lifetime
- 1995-04-07 ES ES95302326T patent/ES2140620T3/es not_active Expired - Lifetime
- 1995-04-07 AT AT95302326T patent/ATE185806T1/de not_active IP Right Cessation
- 1995-04-07 DE DE69512816T patent/DE69512816T2/de not_active Expired - Fee Related
- 1995-04-07 DK DK95302326T patent/DK0676397T3/da active
- 1995-04-07 US US08/418,196 patent/US5677305A/en not_active Expired - Fee Related
- 1995-04-07 HU HU9501026A patent/HUT72064A/hu unknown
- 1995-04-08 TW TW084103375A patent/TW300894B/zh active
- 1995-04-08 KR KR1019950008201A patent/KR100363003B1/ko not_active IP Right Cessation
- 1995-04-08 CN CN95105155A patent/CN1044241C/zh not_active Expired - Fee Related
-
2000
- 2000-01-19 GR GR20000400103T patent/GR3032406T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN1123792A (zh) | 1996-06-05 |
KR950032171A (ko) | 1995-12-20 |
CA2146478A1 (en) | 1995-10-09 |
AU1625695A (en) | 1995-10-19 |
KR100363003B1 (ko) | 2003-02-11 |
EP0676397B1 (en) | 1999-10-20 |
AU688459B2 (en) | 1998-03-12 |
ZA952841B (en) | 1995-12-18 |
GR3032406T3 (en) | 2000-05-31 |
DK0676397T3 (da) | 2000-04-03 |
DE69512816D1 (de) | 1999-11-25 |
US5677305A (en) | 1997-10-14 |
EP0676397A1 (en) | 1995-10-11 |
ATE185806T1 (de) | 1999-11-15 |
HUT72064A (en) | 1996-03-28 |
HU9501026D0 (en) | 1995-06-28 |
TW300894B (es) | 1997-03-21 |
CN1044241C (zh) | 1999-07-21 |
DE69512816T2 (de) | 2000-04-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO913750L (no) | Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske derivater. | |
DE69418704D1 (de) | Anthranilsäure derivate | |
DE69716226D1 (de) | Difluoroprostaglandin-Derivate und ihre Anwendung | |
EP0767170A4 (en) | 4,6-DIARYLPYRIMIDINE DERIVATIVES AND THEIR SALTS | |
ATE139233T1 (de) | Annelierte thiophen-derivate, ihre herstellung und verwendung | |
ES2173074T3 (es) | Derivados de xantina, procedimiento para su preparacion y su uso farmaceutico. | |
CA2160444A1 (en) | Aroyl-piperdine derivatives | |
DE69418243D1 (de) | N-Heteroaryl-N'-Phenylharnstoffderivate, ihre Herstellung und Verwendung | |
ES2140620T3 (es) | Derivados de oxopiridinylquinoxalina. | |
NZ238956A (en) | 3-arylindole or 3-arylindazole derivatives and medicaments thereof. | |
DE69834500D1 (de) | Xanthinderivative zur behandlung von hirnischämie | |
CA2119662A1 (fr) | Nouveaux derives bicycliques azotes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
ATE246686T1 (de) | Pyrrolocarbazolderivate | |
DE69828197D1 (de) | Amidderivate zur behandlung neurodegenerativer erkrankungen der netzhaut | |
ATE219486T1 (de) | Trizyklische indol-2-carbonsäure derivate als selektive nmda rezeptor antagonisten | |
NO910904D0 (no) | Fremgangsmaate for fremstilling av en substituert aminforbindelse. | |
HU9602534D0 (en) | Use of biphenyl methyl imidazole derivatives for producing pharmaceutical compositions having ocular tension derpessant activity | |
ES2141134T3 (es) | Derivados de carbamoil pirrolidona para el tratamiento de la depresion y de los trastornos cerebrovasculares. | |
ES2002325A6 (es) | Un procedimiento para preparar un derivado de dihidropiridina | |
DE69007777D1 (de) | Derivate der p-Guanidinobenzoesäure zur Behandlung der zerebrovaskulären Kontraktion. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 676397 Country of ref document: ES |