ES2136209T3 - Nuevos nitronilfenoles estericamente impedidos utiles como captadores de radicales libres. - Google Patents
Nuevos nitronilfenoles estericamente impedidos utiles como captadores de radicales libres.Info
- Publication number
- ES2136209T3 ES2136209T3 ES94931977T ES94931977T ES2136209T3 ES 2136209 T3 ES2136209 T3 ES 2136209T3 ES 94931977 T ES94931977 T ES 94931977T ES 94931977 T ES94931977 T ES 94931977T ES 2136209 T3 ES2136209 T3 ES 2136209T3
- Authority
- ES
- Spain
- Prior art keywords
- nitronyl
- new
- phenols
- esterically
- impaired
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA INVENCION ES EL USO DE FENOLES TRABADOS SUSTITUIDOS CON NITRONILO COMO ANTIOXIDANTES EN APLICACIONES TERAPEUTICAS. EN LA REALIZACION PREFERIDA, LAS COMPOSICIONES TIENEN LA FORMULA GENERAL (I), EN DONDE R{SUB,1} ES HIDROGENO, UN ALQUILO O UN ARILO Y R{SUB,2} ES UN ALQUILO O UN ARILO; R{SUB,3} ES UN ALQUILO; Y R{SUB,4} ES UN ALQUILO. ADEMAS, LA INVENCION SE REFIERE A NUEVAS COMPOSICIONES UTILES COMO ANTIOXIDANTES. LOS NUEVOS COMPUESTOS INCLUYEN: 2,6-DI-TERT-BUTIL-4-(N-TERT-OCTIL) NITRONILFENOL (DBONP); 2-6-DIMETIL-4-(N-TERT-OCTIL()) NITRONILFENOL (DMONP); (N-TERT-OCTIL)-C-FENILNITRONA (OPN).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/141,241 US5455272A (en) | 1993-10-22 | 1993-10-22 | Spin trap nitronyl hindered phenols |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2136209T3 true ES2136209T3 (es) | 1999-11-16 |
Family
ID=22494820
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94931977T Expired - Lifetime ES2136209T3 (es) | 1993-10-22 | 1994-10-20 | Nuevos nitronilfenoles estericamente impedidos utiles como captadores de radicales libres. |
Country Status (6)
Country | Link |
---|---|
US (4) | US5455272A (es) |
EP (1) | EP0724565B1 (es) |
AU (1) | AU696451B2 (es) |
DE (1) | DE69420146T2 (es) |
ES (1) | ES2136209T3 (es) |
WO (1) | WO1995011227A1 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5723502A (en) * | 1985-07-18 | 1998-03-03 | Proctor; Peter H. | Topical spin trap composition and method |
CA2231812C (en) * | 1995-09-11 | 2002-08-06 | Hoechst Marion Roussel, Inc. | Cyclic nitrones and pharmaceutical compositions containing them |
EP0910370B1 (en) * | 1996-04-23 | 2004-04-07 | Centaur Pharmaceuticals, Inc. | Compositions comprising a nitrone compound for use in treating uveitis |
NZ333705A (en) * | 1996-07-19 | 2000-09-29 | Centaur Pharmaceuticals Inc | Furan nitrone derivatives and medicaments thereof |
TW429241B (en) * | 1996-09-26 | 2001-04-11 | Sumitomo Pharma | Nitrone derivatives |
MA26553A1 (fr) | 1997-10-17 | 2004-12-20 | Centaur Pharmaceuticals Inc | Alpha-aryl-n-alkylnitrones et compositions pharmaceutiques contenant ceux-la |
US5998469A (en) * | 1998-01-16 | 1999-12-07 | Centaur Pharmaceuticals, Inc. | Thioether furan nitrone compounds |
ATE228123T1 (de) * | 1998-01-16 | 2002-12-15 | Centaur Pharmaceuticals Inc | Thiophennitronderivate |
EP1079820A1 (en) | 1998-05-19 | 2001-03-07 | Centaur Pharmaceuticals, Inc. | Benzamide therapeutics for the treatment of inflammatory bowel disease |
EP1077696A1 (en) * | 1998-05-19 | 2001-02-28 | Centaur Pharmaceuticals, Inc. | Furan nitrone therapeutics for the treatment of inflammatory bowel disease |
US6083989A (en) | 1999-05-18 | 2000-07-04 | Centaur Pharmaceuticals, Inc. | Aryl nitrone therapeutics for the treatment of inflammatory bowel disease |
DE69918826T2 (de) * | 1998-05-19 | 2004-12-02 | Renovis, Inc., South San Francisco | Arylnitron therapeutische mittel zur behandlung von entzündlichen darmerkrankungen |
FR2780404B1 (fr) * | 1998-06-26 | 2001-04-13 | Adir | Nouveaux derives de nitrone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
JP2002520386A (ja) * | 1998-07-17 | 2002-07-09 | セントアー ファーマシューティカルズ インコーポレイテッド | 炎症を処置するためのα−(2−ヒドロキシフェニル)ニトロン化合物、α−(2−ヒドロキシフェニル)ニトロン化合物を含む薬学的組成物およびそれらの使用 |
US6730700B2 (en) | 1998-12-02 | 2004-05-04 | Renovis, Inc. | 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same |
UA66401C2 (en) * | 1998-12-02 | 2004-05-17 | Sentor Pharmaceuticals Inc | 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same |
IT1312537B1 (it) * | 1999-04-16 | 2002-04-22 | Euphar Group Srl | Derivati del (-)- verbenone. |
AU2002253857A1 (en) * | 2001-01-08 | 2002-09-04 | Centaur Pharmaceuticals, Inc. | Use of aryl nitrone compounds in methods for treating neuropathic pain |
FR2846968B1 (fr) * | 2002-11-08 | 2005-02-04 | Salles Jean Pierre | Nouveaux derives amphiphiles de l'alpha-c-phenyl-n-tert- butyl nitrone |
US20050059638A1 (en) * | 2003-08-04 | 2005-03-17 | Kelly Michael G. | Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders |
US20050182060A1 (en) * | 2004-02-13 | 2005-08-18 | Kelly Michael G. | 2-Substituted and 4-substituted aryl nitrone compounds |
WO2005087214A1 (en) * | 2004-03-09 | 2005-09-22 | Renovis, Inc. | Methods for treating multiple sclerosis and pharmaceutical compositions therefor |
ES2367330T3 (es) * | 2007-11-15 | 2011-11-02 | Rohm And Haas Company | Preparación de nitronas. |
JP4996575B2 (ja) * | 2007-11-15 | 2012-08-08 | ローム アンド ハース カンパニー | ニトロンの製造 |
US9034926B2 (en) | 2010-12-30 | 2015-05-19 | Nicholas V. Perricone | Topical nitrone spin trap compositions for psoriasis |
US8986739B2 (en) | 2011-02-28 | 2015-03-24 | Nicholas V. Perricone | Treatment of urinary incontinence using nitrone spin traps |
IN2014DN02926A (es) | 2011-11-30 | 2015-05-15 | Angus Chemical | |
CN106061941B (zh) | 2014-03-07 | 2018-05-08 | 陶氏环球技术有限责任公司 | 硝酮化合物及其在个人护理中的使用 |
WO2015175310A1 (en) | 2014-05-12 | 2015-11-19 | Dow Global Technologies Llc | Nitrone compounds and their use in personal care |
US10064804B2 (en) | 2014-06-30 | 2018-09-04 | Dow Global Technologies Llc | Polymeric nitrones and their use in personal care |
US10137071B2 (en) | 2015-03-20 | 2018-11-27 | Dow Global Technologies Llc | Nitrone inhibition of oxidation of unsaturated fats |
JP6734290B2 (ja) * | 2015-03-20 | 2020-08-05 | ダウ グローバル テクノロジーズ エルエルシー | 不飽和脂肪の酸化のニトロン抑制 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3903049A (en) * | 1974-01-30 | 1975-09-02 | Goodyear Tire & Rubber | Oxidation resistant sulfur curable rubbery polymers |
GB2137619A (en) * | 1983-03-30 | 1984-10-10 | Gerald Scott | Nitrone compounds and stabilised rubber compositions containing them |
US5025032A (en) * | 1989-10-17 | 1991-06-18 | Oklahoma Medical Research Foundation | Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage |
US5036097A (en) * | 1989-10-17 | 1991-07-30 | Oklahoma Medical Research Foundation | Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration |
JP2797559B2 (ja) * | 1989-11-30 | 1998-09-17 | 住友化学工業株式会社 | ニトロン化合物およびその製造法 |
ATE209908T1 (de) * | 1991-06-18 | 2001-12-15 | Oklahoma Med Res Found | RADIKALFÄNGER (ßSPIN TRAPSß) ZUR BEHANDLUNG VON MIT OXIDATION VON LIPIDEN UND PROTEINEN VERBUNDENEN ERKRANKUNGEN |
-
1993
- 1993-10-22 US US08/141,241 patent/US5455272A/en not_active Ceased
-
1994
- 1994-10-20 EP EP94931977A patent/EP0724565B1/en not_active Expired - Lifetime
- 1994-10-20 ES ES94931977T patent/ES2136209T3/es not_active Expired - Lifetime
- 1994-10-20 WO PCT/US1994/012107 patent/WO1995011227A1/en active IP Right Grant
- 1994-10-20 AU AU80869/94A patent/AU696451B2/en not_active Ceased
- 1994-10-20 DE DE69420146T patent/DE69420146T2/de not_active Expired - Fee Related
-
1995
- 1995-04-10 US US08/419,159 patent/US5532277A/en not_active Expired - Lifetime
- 1995-04-10 US US08/419,157 patent/US5527828A/en not_active Expired - Lifetime
-
1997
- 1997-10-02 US US08/942,494 patent/USRE36594E/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5455272A (en) | 1995-10-03 |
AU696451B2 (en) | 1998-09-10 |
DE69420146D1 (de) | 1999-09-23 |
WO1995011227A1 (en) | 1995-04-27 |
EP0724565B1 (en) | 1999-08-18 |
DE69420146T2 (de) | 2000-04-20 |
US5527828A (en) | 1996-06-18 |
AU8086994A (en) | 1995-05-08 |
USRE36594E (en) | 2000-02-29 |
EP0724565A1 (en) | 1996-08-07 |
US5532277A (en) | 1996-07-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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