ES2136018B1 - Compuestos inhibidores selectivos de la ciclooxigenasa-i y su utilizacion como analgesicos, antiinflamatorios y antiartriticos. - Google Patents
Compuestos inhibidores selectivos de la ciclooxigenasa-i y su utilizacion como analgesicos, antiinflamatorios y antiartriticos.Info
- Publication number
- ES2136018B1 ES2136018B1 ES9701315A ES9701315A ES2136018B1 ES 2136018 B1 ES2136018 B1 ES 2136018B1 ES 9701315 A ES9701315 A ES 9701315A ES 9701315 A ES9701315 A ES 9701315A ES 2136018 B1 ES2136018 B1 ES 2136018B1
- Authority
- ES
- Spain
- Prior art keywords
- analgesics
- cyclooxygenase
- antiarthritic
- inflammatories
- inhibitor compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compuestos inhibidores selectivos de la ciclooxigenasa-I y su utilización como analgésicos, antiinflamatorios y antiartríticos.La presente invención se refiere a compuestos de fórmula general I,Inhibidores selectivos del isoenzima ciclooxigenasa-I, a sussales y solvatos farmacéuticamente aceptables, y a las composiciones farmacéuticas que las contienen. Los compuestos presentan una acción analgésica, antiinflamatoria y antiartrítica a la vez que, en animales con úlceras o trastornos gastrointestinales, no producen una mayor incidencia o gravedad de los mismos, ni retrasan su curación.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9701315A ES2136018B1 (es) | 1997-06-17 | 1997-06-17 | Compuestos inhibidores selectivos de la ciclooxigenasa-i y su utilizacion como analgesicos, antiinflamatorios y antiartriticos. |
AU83376/98A AU8337698A (en) | 1997-06-17 | 1998-06-17 | Cyclooxygenase-i selective inhibitors and the use thereof as analgesic, antiinflammatory and antiarthritic agents |
PCT/EP1998/003636 WO1998057910A2 (en) | 1997-06-17 | 1998-06-17 | Cyclooxygenase-i selective inhibitors and the use thereof as analgesic, antiinflammatory and antiarthritic agents |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9701315A ES2136018B1 (es) | 1997-06-17 | 1997-06-17 | Compuestos inhibidores selectivos de la ciclooxigenasa-i y su utilizacion como analgesicos, antiinflamatorios y antiartriticos. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2136018A1 ES2136018A1 (es) | 1999-11-01 |
ES2136018B1 true ES2136018B1 (es) | 2000-07-01 |
Family
ID=8299706
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9701315A Expired - Fee Related ES2136018B1 (es) | 1997-06-17 | 1997-06-17 | Compuestos inhibidores selectivos de la ciclooxigenasa-i y su utilizacion como analgesicos, antiinflamatorios y antiartriticos. |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU8337698A (es) |
ES (1) | ES2136018B1 (es) |
WO (1) | WO1998057910A2 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7183306B2 (en) | 2002-12-02 | 2007-02-27 | Astellas Pharma Inc. | Pyrazole derivatives |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2137211B1 (es) * | 1971-05-17 | 1974-08-02 | Bouchara Emile | |
DE2253466A1 (de) * | 1972-10-31 | 1974-05-09 | Diamalt Ag | Verfahren zur herstellung von 4-allyloxy-3-chlor-phenylessigsaeure |
US4082707A (en) * | 1973-01-08 | 1978-04-04 | Societa Italo-Britannica L. Manetti-H. Roberts & Co. | 2-(4-isobutylphenyl)-propiohydroxamic acid and a procedure for its preparation |
GB1480971A (en) * | 1975-04-03 | 1977-07-27 | Prodotti Antibiotici Spa | Preparation of isobutylphenyl compounds |
JPS54163545A (en) * | 1978-06-10 | 1979-12-26 | Taisho Pharmaceutical Co Ltd | Organic carboxylic acid derivative |
JPS60155144A (ja) * | 1984-01-24 | 1985-08-15 | Central Glass Co Ltd | ヘキサフルオロイソプチルベンゼン誘導体及びそれを含む抗炎症鎮痛剤 |
CS274344B1 (en) * | 1989-08-14 | 1991-04-11 | Protiva Miroslav | Method of 2-/4-(2-propylthio)phenyl/propionic acid's preparation |
GB2306191A (en) * | 1995-10-11 | 1997-04-30 | Delta 3 Ltd | A device for securing portable equipment |
-
1997
- 1997-06-17 ES ES9701315A patent/ES2136018B1/es not_active Expired - Fee Related
-
1998
- 1998-06-17 AU AU83376/98A patent/AU8337698A/en not_active Abandoned
- 1998-06-17 WO PCT/EP1998/003636 patent/WO1998057910A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
ES2136018A1 (es) | 1999-11-01 |
WO1998057910A2 (en) | 1998-12-23 |
WO1998057910A3 (en) | 1999-03-11 |
AU8337698A (en) | 1999-01-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19991101 Kind code of ref document: A1 Effective date: 19991101 |
|
FD1A | Patent lapsed |
Effective date: 20070618 |