ES2135416T3 - Compuestos de piridopiridazinonas y piridazintionas con actividad inhibidora de la pde iv. - Google Patents
Compuestos de piridopiridazinonas y piridazintionas con actividad inhibidora de la pde iv.Info
- Publication number
- ES2135416T3 ES2135416T3 ES92922090T ES92922090T ES2135416T3 ES 2135416 T3 ES2135416 T3 ES 2135416T3 ES 92922090 T ES92922090 T ES 92922090T ES 92922090 T ES92922090 T ES 92922090T ES 2135416 T3 ES2135416 T3 ES 2135416T3
- Authority
- ES
- Spain
- Prior art keywords
- piridopiridazinones
- piridazinons
- pde
- compounds
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE HA DESCUBIERTO QUE LOS COMPUESTOS DE BENZO O PIRIDOPIRIDAZINONAS Y PIRIDAZINTIONAS DE LA FORMULA (I) EN LA QUE: X E Y SON NITROGENO O CARBONO, SIEMPRE Y CUANDO AL MENOS UNO DE ELLOS SEA CARBONO Y Z ES OXIGENO O AZUFRE; R1 ES HIDROGENO, ALKILO INFERIOR, ARILO, HETEROARILO O ALKILENO INFERIOR HETEROCICLICO; R2, R3, R4, R5 Y R6 SE SELECCIONAN INDEPENDIENTEMENTE DEL HIDROGENO, ALKILO INFERIOR, HALO, CARBOXI, ALCOXICARBONILO, CARBAMILO, ACILO, HALURO DE ACILO, TIOMETILO, TRIFLUOMETILO, CIANO O NITRO; O UN ESTER, ETER O SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS, SON UTILES COMO AGENTES ANTIINFLAMATORIOS, ANTIASMATICOS, INMUNOSUPERSORES, ANTI RECHAZO A LOS ALOINJERTOS, ANTI RECHAZO A LOS INJERTOS FRENTE A HUESPEDES, ENFERMEDADES AUTOINMUNES O ANALGESICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77567991A | 1991-10-09 | 1991-10-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2135416T3 true ES2135416T3 (es) | 1999-11-01 |
Family
ID=25105161
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09201998A Expired - Fee Related ES2105920B1 (es) | 1991-10-09 | 1992-10-08 | Procedimiento para preparar compuestos de benzo-y piridopiridazinona y piridazinationa. |
ES92922090T Expired - Lifetime ES2135416T3 (es) | 1991-10-09 | 1992-10-08 | Compuestos de piridopiridazinonas y piridazintionas con actividad inhibidora de la pde iv. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09201998A Expired - Fee Related ES2105920B1 (es) | 1991-10-09 | 1992-10-08 | Procedimiento para preparar compuestos de benzo-y piridopiridazinona y piridazinationa. |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0612321B1 (es) |
JP (1) | JP3245165B2 (es) |
KR (1) | KR100263494B1 (es) |
AT (1) | ATE183745T1 (es) |
AU (1) | AU670544B2 (es) |
CA (1) | CA2117059C (es) |
DE (1) | DE69229874T2 (es) |
DK (1) | DK0612321T3 (es) |
ES (2) | ES2105920B1 (es) |
FI (1) | FI108229B (es) |
GR (1) | GR3030969T3 (es) |
HU (2) | HUT66969A (es) |
IL (1) | IL103388A (es) |
MX (1) | MX9205794A (es) |
NO (1) | NO302888B1 (es) |
NZ (1) | NZ244660A (es) |
PT (1) | PT100938B (es) |
TW (1) | TW365606B (es) |
WO (1) | WO1993007146A1 (es) |
ZA (1) | ZA927755B (es) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9200689D0 (en) * | 1992-01-14 | 1992-03-11 | Rhone Poulenc Agriculture | New compositions of matter |
GB9314412D0 (en) * | 1993-07-13 | 1993-08-25 | Rhone Poulenc Agriculture | New compositions of matter |
US5665754A (en) * | 1993-09-20 | 1997-09-09 | Glaxo Wellcome Inc. | Substituted pyrrolidines |
US5466697A (en) * | 1994-07-13 | 1995-11-14 | Syntex (U.S.A.) Inc. | 8-phenyl-1,6-naphthyridin-5-ones |
NZ291507A (en) * | 1994-08-29 | 1997-12-19 | Yamanouchi Pharma Co Ltd | 1,8-naphthyridine derivatives; medicaments |
GB9712761D0 (en) * | 1997-06-17 | 1997-08-20 | Chiroscience Ltd | Quinolines and their therapeutic use |
US6069151A (en) * | 1996-11-06 | 2000-05-30 | Darwin Discovery, Ltd. | Quinolines and their therapeutic use |
WO2001013953A2 (en) | 1999-08-21 | 2001-03-01 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Synergistic combination of pde inhibitors and beta 2 adrenoceptor agonist |
ES2137113B1 (es) * | 1997-07-29 | 2000-09-16 | Almirall Prodesfarma Sa | Nuevos derivados de triazolo-piridazinas heterociclicos. |
PL191236B1 (pl) | 1997-12-15 | 2006-04-28 | Altana Pharma Ag | Nowe pochodne dihydrobenzofuranowe, lek zawierający nową pochodną dihydrobenzofuranową oraz zastosowanie tych pochodnych do wytwarzania leków do leczenia schorzeń układu oddechowego lub do leczenia dermatologicznego |
EP0934933A1 (en) * | 1998-02-06 | 1999-08-11 | Byk Gulden Lomberg Chemische Fabrik GmbH | Phthalazinones |
IT1303272B1 (it) | 1998-10-29 | 2000-11-06 | Zambon Spa | Derivati triciclici inibitori della fosfodiesterasi 4 |
JP3270834B2 (ja) | 1999-01-27 | 2002-04-02 | ファイザー・プロダクツ・インク | 抗がん剤として有用なヘテロ芳香族二環式誘導体 |
UA71945C2 (en) * | 1999-01-27 | 2005-01-17 | Pfizer Prod Inc | Substituted bicyclic derivatives being used as anticancer agents |
EA200300836A1 (ru) * | 2001-02-15 | 2004-02-26 | Алтана Фарма Аг | Производные фталазинон-пиперидина в качестве ингибиторов pde4 |
AU2002315311B2 (en) | 2001-04-25 | 2007-12-06 | Altana Pharma Ag | Piperazino-derivatives and their use as PDE4 inhibitor |
HUP0303998A3 (en) | 2001-04-25 | 2007-03-28 | Altana Pharma Ag | Phthalazinones derivatives and pharmaceutical compositions containing them |
ES2195785B1 (es) | 2002-05-16 | 2005-03-16 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
RS51445B (en) | 2002-08-10 | 2011-04-30 | Nycomed Gmbh. | PYROLIDINDION SUBSTITUTED BY PIPERIDINE-PTHALAZONE AS PDE4 INHIBITORS |
PL373597A1 (en) * | 2002-08-10 | 2005-09-05 | Altana Pharma Ag | Piperidine-n-oxide-derivatives |
ES2211344B1 (es) * | 2002-12-26 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
WO2004087211A2 (en) | 2003-04-01 | 2004-10-14 | Applied Research Systems Ars Holding N.V. | Inhibitors of phosphodiesterases in infertility |
AU2005210042B2 (en) | 2004-02-04 | 2011-04-21 | Takeda Gmbh | 2-(piperidin-4-yl) -4, 5-dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors |
ES2251866B1 (es) | 2004-06-18 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
CN103601792B (zh) | 2007-06-04 | 2016-06-29 | 协同医药品公司 | 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂 |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
PL383550A1 (pl) * | 2007-10-15 | 2009-04-27 | Uniwersytet Łódzki | Nowe pochodne benzeno- i pirydopirydazynonów |
EP2328910B1 (en) | 2008-06-04 | 2014-08-06 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
WO2010009319A2 (en) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
KR102034748B1 (ko) | 2011-03-01 | 2019-10-21 | 시너지 파마슈티컬즈 인코포레이티드 | 구아닐레이트 사이클라제 c 작용제의 제조 방법 |
US20130116241A1 (en) * | 2011-11-09 | 2013-05-09 | Abbvie Inc. | Novel inhibitor compounds of phosphodiesterase type 10a |
WO2013097052A1 (en) | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Bromodomain inhibitors |
JP6499591B2 (ja) | 2013-02-25 | 2019-04-10 | シナジー ファーマシューティカルズ インコーポレイテッド | 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト |
WO2014160440A1 (en) | 2013-03-13 | 2014-10-02 | Flatley Discovery Lab | Pyridazinone compounds and methods for the treatment of cystic fibrosis |
CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
JP6606491B2 (ja) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼcの超高純度アゴニスト、その作成および使用方法 |
EP3884935B1 (en) | 2013-08-09 | 2023-06-14 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
EP3265453B1 (en) * | 2015-03-05 | 2022-06-29 | Boehringer Ingelheim International GmbH | New pyridinones and isoquinolinones as inhibitors of the bromodomain brd9 |
JP6837052B2 (ja) * | 2016-03-09 | 2021-03-03 | 日本曹達株式会社 | ピリジン化合物およびその用途 |
KR102250415B1 (ko) | 2016-04-15 | 2021-05-11 | 애브비 인코포레이티드 | 브로모도메인 저해제 |
EP3972599A1 (en) | 2019-05-21 | 2022-03-30 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
FR3105254B1 (fr) | 2019-12-19 | 2022-08-12 | Syctom Lagence Metropolitaine Des Dechets Menagers | Installation et procédé de gazéification hydrothermale de biomasse |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2805344B2 (ja) * | 1989-07-11 | 1998-09-30 | 昭和電工株式会社 | オレフィン重合触媒の製造方法およびオレフィンの重合方法 |
JP3120857B2 (ja) * | 1990-02-19 | 2000-12-25 | 中外製薬株式会社 | 新規な縮合複素環化合物とこれを用いた抗喘息剤 |
-
1992
- 1992-10-08 ZA ZA927755A patent/ZA927755B/xx unknown
- 1992-10-08 WO PCT/US1992/008398 patent/WO1993007146A1/en active IP Right Grant
- 1992-10-08 DE DE69229874T patent/DE69229874T2/de not_active Expired - Fee Related
- 1992-10-08 AT AT92922090T patent/ATE183745T1/de not_active IP Right Cessation
- 1992-10-08 HU HU9400949A patent/HUT66969A/hu unknown
- 1992-10-08 EP EP92922090A patent/EP0612321B1/en not_active Expired - Lifetime
- 1992-10-08 MX MX9205794A patent/MX9205794A/es not_active IP Right Cessation
- 1992-10-08 DK DK92922090T patent/DK0612321T3/da active
- 1992-10-08 ES ES09201998A patent/ES2105920B1/es not_active Expired - Fee Related
- 1992-10-08 KR KR1019940701129A patent/KR100263494B1/ko not_active IP Right Cessation
- 1992-10-08 CA CA002117059A patent/CA2117059C/en not_active Expired - Fee Related
- 1992-10-08 AU AU27815/92A patent/AU670544B2/en not_active Ceased
- 1992-10-08 ES ES92922090T patent/ES2135416T3/es not_active Expired - Lifetime
- 1992-10-08 NZ NZ244660A patent/NZ244660A/en unknown
- 1992-10-08 JP JP50707893A patent/JP3245165B2/ja not_active Expired - Fee Related
- 1992-10-08 TW TW081108015A patent/TW365606B/zh active
- 1992-10-08 IL IL103388A patent/IL103388A/xx not_active IP Right Cessation
- 1992-10-08 PT PT100938A patent/PT100938B/pt not_active IP Right Cessation
-
1994
- 1994-04-05 NO NO941210A patent/NO302888B1/no not_active IP Right Cessation
- 1994-04-06 FI FI941567A patent/FI108229B/fi active
-
1995
- 1995-04-24 HU HU95P/P00113P patent/HU210814A9/hu unknown
-
1999
- 1999-08-26 GR GR990401632T patent/GR3030969T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
FI941567A (fi) | 1994-04-06 |
NO302888B1 (no) | 1998-05-04 |
IL103388A0 (en) | 1993-03-15 |
NZ244660A (en) | 1995-05-26 |
JPH07500321A (ja) | 1995-01-12 |
WO1993007146A1 (en) | 1993-04-15 |
PT100938B (pt) | 1999-10-29 |
EP0612321B1 (en) | 1999-08-25 |
ES2105920A1 (es) | 1997-10-16 |
AU2781592A (en) | 1993-05-03 |
NO941210L (no) | 1994-04-05 |
HUT66969A (en) | 1995-01-30 |
KR100263494B1 (ko) | 2000-08-01 |
DE69229874T2 (de) | 1999-12-09 |
JP3245165B2 (ja) | 2002-01-07 |
NO941210D0 (no) | 1994-04-05 |
ATE183745T1 (de) | 1999-09-15 |
AU670544B2 (en) | 1996-07-25 |
HU9400949D0 (en) | 1994-06-28 |
IL103388A (en) | 1997-09-30 |
GR3030969T3 (en) | 1999-11-30 |
HU210814A9 (en) | 1995-08-28 |
DE69229874D1 (de) | 1999-09-30 |
DK0612321T3 (da) | 1999-12-13 |
PT100938A (pt) | 1993-10-29 |
CA2117059C (en) | 2003-05-20 |
MX9205794A (es) | 1993-04-01 |
EP0612321A1 (en) | 1994-08-31 |
CA2117059A1 (en) | 1993-04-15 |
FI941567A0 (fi) | 1994-04-06 |
KR940702868A (ko) | 1994-09-17 |
FI108229B (fi) | 2001-12-14 |
ZA927755B (en) | 1994-04-08 |
TW365606B (en) | 1999-08-01 |
ES2105920B1 (es) | 1998-07-01 |
Similar Documents
Publication | Publication Date | Title |
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