ES2134808T3 - Compuestos antivirales oralmente activos. - Google Patents
Compuestos antivirales oralmente activos.Info
- Publication number
- ES2134808T3 ES2134808T3 ES92913416T ES92913416T ES2134808T3 ES 2134808 T3 ES2134808 T3 ES 2134808T3 ES 92913416 T ES92913416 T ES 92913416T ES 92913416 T ES92913416 T ES 92913416T ES 2134808 T3 ES2134808 T3 ES 2134808T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- compounds
- halogen
- substituted
- orively
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
- C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/28—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Dental Preparations (AREA)
Abstract
SE PRESENTA UN COMPUESTO REPRESENTADO POR LA FORMULA (I) AR1-O-M-OAR2 EN DONDE AR1 Y AR2 SON INDEPENDIENTEMENTE FENIL SUSTITUIDO O PIRIDINIL SUSTITUIDO, LOS SUSTITUYENTES SOBRE DICHO FENIL O PIRIDINIL SE SELECCIONAN INDEPENDIENTEMENTE ENTRE 1, 2 O 3 DE ALCOXIDO C1-C10, ALQUIL C1-C10, HALOGENO, CARBAMIL, DIALQUILCARBAMIL, ALCOXICARBONIL C1-C10, OXAZOIL, Y ALQUIL C1-C10 SUSTITUIDO POR HALOGENO, ALCOXIDO C1-C10, HIDROXIDO O ALCOXICARBONIL C1-C10; M ES M-1, M-2, M-3 O M-4, ALQUILENO C4-C8, ALQUENILENO C4-C8 O ALQUINILENO C4-C8; O ES OXIGENO; R'' ES ALQUIL C1-C3 O H; A ES OXIGENO O SULFURO; Q SE SELECCIONA ENTRE HIDROGENO, HALOGENO, NITRO, ALQUIL C1-C6, PERHALOALQUIL C1-C6, ALQUILTIO C1-C6, ALQUILSULFONIL C1-C6; LAS LINEAS PUNTEADAS EN M-3 Y M-4 ENTRE LOS CARBONOS 2 Y 3, 3 Y 4, Y 4 Y 5 SIGNIFICAN LOS ENLACES ENTRE LOS CARBONOS 2 Y 3, Y 3 Y 4, Y 5 Y 6, CADA UNO DE ELLOS PUEDE SER UN ENLACE SIMPLE O UN DOBLE ENLACE; N = 1 O 2, M = 1 O 2, P = 0 O 1; TAMBIEN SE PRESENTAN LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS COMPUESTOS ASI COMO COMPOSICIONES FARMACEUTICAS QUE CONTIENEN LOS COMPUESTOS Y EL USO DE LOS COMPUESTOS DE LA FORMULA (I) PARA LA PREPARACION DE MEDICAMENTOS PARA METODOS PARA TRATAR O PREVENIR INFECCIONES VIRALES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71745191A | 1991-06-19 | 1991-06-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2134808T3 true ES2134808T3 (es) | 1999-10-16 |
Family
ID=24882086
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92913416T Expired - Lifetime ES2134808T3 (es) | 1991-06-19 | 1992-06-17 | Compuestos antivirales oralmente activos. |
Country Status (23)
Country | Link |
---|---|
US (4) | US5559133A (es) |
EP (2) | EP0590026B1 (es) |
JP (1) | JP2625258B2 (es) |
KR (1) | KR960004887B1 (es) |
AT (1) | ATE182874T1 (es) |
AU (1) | AU674657B2 (es) |
CA (1) | CA2111854C (es) |
CZ (1) | CZ279793A3 (es) |
DE (1) | DE69229733T2 (es) |
ES (1) | ES2134808T3 (es) |
FI (1) | FI935690A (es) |
IE (1) | IE921971A1 (es) |
IL (1) | IL102241A0 (es) |
MX (1) | MX9203068A (es) |
MY (1) | MY107993A (es) |
NZ (1) | NZ243180A (es) |
OA (1) | OA09828A (es) |
PL (1) | PL169699B1 (es) |
SK (1) | SK144293A3 (es) |
TW (1) | TW260658B (es) |
WO (1) | WO1992022520A1 (es) |
YU (1) | YU63392A (es) |
ZA (1) | ZA924445B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0590026B1 (en) * | 1991-06-19 | 1999-08-04 | Schering Corporation | Orally active antiviral compounds |
MXPA94001379A (es) * | 1993-02-26 | 2011-09-26 | Schering Corp | Tratamiento selectivo de infecciones causadas por enterovirus en seres humanos. |
JP2001519808A (ja) * | 1997-04-10 | 2001-10-23 | ファルマシア・アンド・アップジョン・カンパニー | ポリ芳香族抗菌組成物 |
WO2001009118A2 (en) * | 1999-07-29 | 2001-02-08 | Patrick T Prendergast | Dithiolthione compounds for the treatment of neurological disorders and for memory enhancement |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2418571A1 (de) * | 1973-04-18 | 1974-11-14 | Ciba Geigy Ag | Phenyl-aralkyl-aether, diphenyle und benzophenone, verfahren zu ihrer herstellung und ihre verwendung |
JPS509785A (es) * | 1973-05-31 | 1975-01-31 | ||
JPS5922697B2 (ja) * | 1976-01-13 | 1984-05-28 | エーザイ株式会社 | ビス−(メタ−アミジノフエノキシ)−化合物 |
JPS5651423A (en) * | 1979-09-13 | 1981-05-09 | Wellcome Found | Antiviral agent |
DE3362750D1 (en) * | 1982-01-29 | 1986-05-07 | Toray Industries | Process for preparing alpha,omega-bis(2-chlorophenoxy)-alkane-4,4'-dicarboxylic acid or its lower alkyl ester |
US4851423A (en) * | 1986-12-10 | 1989-07-25 | Schering Corporation | Pharmaceutically active compounds |
JPH0621083B2 (ja) * | 1986-12-22 | 1994-03-23 | 株式会社三光開発科学研究所 | ジ(アリ−ルオキシ)アルカンの製造方法 |
US4891449A (en) * | 1988-06-30 | 1990-01-02 | Great Lakes Chemical Corporation | Halogenated unsymmetrical higher alkyl phenoxy alkanes |
IE902465A1 (en) | 1989-07-07 | 1991-02-13 | Schering Corp | Pharmaceutically active compounds |
EP0590026B1 (en) * | 1991-06-19 | 1999-08-04 | Schering Corporation | Orally active antiviral compounds |
-
1992
- 1992-06-17 EP EP92913416A patent/EP0590026B1/en not_active Expired - Lifetime
- 1992-06-17 PL PL92301825A patent/PL169699B1/pl unknown
- 1992-06-17 ES ES92913416T patent/ES2134808T3/es not_active Expired - Lifetime
- 1992-06-17 SK SK1442-93A patent/SK144293A3/sk unknown
- 1992-06-17 MY MYPI92001031A patent/MY107993A/en unknown
- 1992-06-17 AU AU22213/92A patent/AU674657B2/en not_active Ceased
- 1992-06-17 CZ CS932797A patent/CZ279793A3/cs unknown
- 1992-06-17 YU YU63392A patent/YU63392A/sh unknown
- 1992-06-17 TW TW081104731A patent/TW260658B/zh active
- 1992-06-17 ZA ZA924445A patent/ZA924445B/xx unknown
- 1992-06-17 CA CA002111854A patent/CA2111854C/en not_active Expired - Lifetime
- 1992-06-17 IL IL102241A patent/IL102241A0/xx unknown
- 1992-06-17 EP EP92305551A patent/EP0519702A1/en active Pending
- 1992-06-17 JP JP5501035A patent/JP2625258B2/ja not_active Expired - Lifetime
- 1992-06-17 DE DE69229733T patent/DE69229733T2/de not_active Expired - Lifetime
- 1992-06-17 AT AT92913416T patent/ATE182874T1/de active
- 1992-06-17 WO PCT/US1992/004961 patent/WO1992022520A1/en active IP Right Grant
- 1992-06-17 US US08/167,812 patent/US5559133A/en not_active Expired - Lifetime
- 1992-06-17 KR KR1019930703932A patent/KR960004887B1/ko not_active IP Right Cessation
- 1992-06-17 NZ NZ243180A patent/NZ243180A/en unknown
- 1992-06-19 MX MX9203068A patent/MX9203068A/es active IP Right Grant
- 1992-07-01 IE IE197192A patent/IE921971A1/en not_active Application Discontinuation
-
1993
- 1993-03-26 US US08/039,532 patent/US5350772A/en not_active Expired - Lifetime
- 1993-12-17 FI FI935690A patent/FI935690A/fi not_active Application Discontinuation
- 1993-12-17 OA OA60450A patent/OA09828A/en unknown
-
1994
- 1994-08-08 US US08/287,325 patent/US5449782A/en not_active Expired - Lifetime
-
1995
- 1995-05-19 US US08/444,583 patent/US5618849A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5449782A (en) | 1995-09-12 |
IE921971A1 (en) | 1992-12-30 |
DE69229733D1 (de) | 1999-09-09 |
EP0590026B1 (en) | 1999-08-04 |
US5350772A (en) | 1994-09-27 |
EP0519702A1 (en) | 1992-12-23 |
IL102241A0 (en) | 1993-01-14 |
AU2221392A (en) | 1993-01-12 |
JPH06503839A (ja) | 1994-04-28 |
TW260658B (es) | 1995-10-21 |
US5618849A (en) | 1997-04-08 |
CZ279793A3 (en) | 1994-05-18 |
MX9203068A (es) | 1993-07-01 |
MY107993A (en) | 1996-07-15 |
AU674657B2 (en) | 1997-01-09 |
ZA924445B (en) | 1993-02-24 |
PL169699B1 (en) | 1996-08-30 |
SK144293A3 (en) | 1994-06-08 |
FI935690A0 (fi) | 1993-12-17 |
YU63392A (sh) | 1994-11-15 |
EP0590026A1 (en) | 1994-04-06 |
CA2111854A1 (en) | 1992-12-23 |
KR960004887B1 (ko) | 1996-04-16 |
WO1992022520A1 (en) | 1992-12-23 |
OA09828A (en) | 1994-04-15 |
FI935690A (fi) | 1993-12-17 |
DE69229733T2 (de) | 1999-12-02 |
ATE182874T1 (de) | 1999-08-15 |
CA2111854C (en) | 2001-01-09 |
NZ243180A (en) | 1995-08-28 |
US5559133A (en) | 1996-09-24 |
JP2625258B2 (ja) | 1997-07-02 |
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Legal Events
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