ES2134207T3 - Procedimiento de preparacion y de utilizacion de la vitamina 1alfa,24-dihidroxi vitamina d2. - Google Patents
Procedimiento de preparacion y de utilizacion de la vitamina 1alfa,24-dihidroxi vitamina d2.Info
- Publication number
- ES2134207T3 ES2134207T3 ES92904947T ES92904947T ES2134207T3 ES 2134207 T3 ES2134207 T3 ES 2134207T3 ES 92904947 T ES92904947 T ES 92904947T ES 92904947 T ES92904947 T ES 92904947T ES 2134207 T3 ES2134207 T3 ES 2134207T3
- Authority
- ES
- Spain
- Prior art keywords
- vitamin
- proportional
- dihydroxy
- dihydroxy vitamin
- converted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Nutrition Science (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Abstract
SE PRESENTA UN COMPUESTO DE 1(ALFA),24-DIHIDROXI VITAMINA D2 QUE ES UTIL COMO COMPUESTO ACTIVO DE COMPOSICIONES FARMACEUTICAS PARA EL TRATAMIENTO DE ENFERMEDADES DEL METABOLISMO DEL CALCIO Y PARA VARIAS ENFERMEDADES DE LA PIEL. LA INVENCION TAMBIEN INCLUYE LA PREPARACION DE LA 1(ALFA),24 DIHIDROXI VITAMINA D2 COMENZANDO A PARTIR DEL ERGOSTEROL QUE SE CONVIERTE EN SEIS PASOS EN 24HIDROXIERGOSTEROL. EL 24-HIDROXIERGOESTEROL SE IRRADIA Y SE CONVIERTE TERMICAMENTE EN 24-HIDROXI VITAMINA D2 QUE SE CONVIERTE EN 5 PASOS EN VITAMINA 1(ALFA),24-DIHIDROXIDA D2. LA SINTESIS TAMBIEN PRODUCE NUEVOS PRODUCTOS INTERMEDIOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63786791A | 1991-01-08 | 1991-01-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2134207T3 true ES2134207T3 (es) | 1999-10-01 |
Family
ID=24557692
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92904947T Expired - Lifetime ES2134207T3 (es) | 1991-01-08 | 1992-01-07 | Procedimiento de preparacion y de utilizacion de la vitamina 1alfa,24-dihidroxi vitamina d2. |
ES98110802T Expired - Lifetime ES2200238T3 (es) | 1991-01-08 | 1992-01-07 | Procedimiento para la preparacion de la 1-alpha-24-dihidroxi vitamina d2. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98110802T Expired - Lifetime ES2200238T3 (es) | 1991-01-08 | 1992-01-07 | Procedimiento para la preparacion de la 1-alpha-24-dihidroxi vitamina d2. |
Country Status (14)
Country | Link |
---|---|
US (1) | US6211168B1 (es) |
EP (2) | EP0550702B1 (es) |
CN (3) | CN1032256C (es) |
AT (2) | ATE240736T1 (es) |
AU (1) | AU1247592A (es) |
DE (2) | DE69229103T2 (es) |
DK (1) | DK0550702T3 (es) |
ES (2) | ES2134207T3 (es) |
GR (1) | GR3030466T3 (es) |
MX (1) | MX9200070A (es) |
NZ (1) | NZ241255A (es) |
PT (1) | PT99998B (es) |
WO (1) | WO1992012165A1 (es) |
ZA (1) | ZA92108B (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5602116A (en) * | 1988-08-02 | 1997-02-11 | Bone Care International, Inc. | Method for treating and preventing secondary hyperparathyroidism |
US20040009958A1 (en) * | 1991-01-08 | 2004-01-15 | Bone Care International, Inc. | Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2 |
US6538037B2 (en) | 1991-01-08 | 2003-03-25 | Bone Care International, Inc. | Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2 |
ATE181062T1 (de) * | 1992-08-28 | 1999-06-15 | Bone Care Int Inc | 1alpha,24(s)-dihydroxy vitamin d2, seine synthese und verwendung |
US5763429A (en) | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
US6242434B1 (en) * | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
US6376479B1 (en) | 1995-04-03 | 2002-04-23 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
US20020128240A1 (en) * | 1996-12-30 | 2002-09-12 | Bone Care International, Inc. | Treatment of hyperproliferative diseases using active vitamin D analogues |
US6566353B2 (en) * | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
US6573256B2 (en) | 1996-12-30 | 2003-06-03 | Bone Care International, Inc. | Method of inhibiting angiogenesis using active vitamin D analogues |
US6503893B2 (en) | 1996-12-30 | 2003-01-07 | Bone Care International, Inc. | Method of treating hyperproliferative diseases using active vitamin D analogues |
HUP0002454A2 (hu) | 1997-02-13 | 2000-12-28 | Bone Care International, Inc. | D-Vitamin-molekularésszel rendelkező konjugátumok és ilyen konjugátumokat tartalmazó gyógyászati készítmények |
US20030129194A1 (en) * | 1997-02-13 | 2003-07-10 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
US6087350A (en) * | 1997-08-29 | 2000-07-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
EP1064000B1 (en) * | 1998-03-27 | 2011-07-06 | Oregon Health & Science University | Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders |
DE69910031T2 (de) | 1998-05-29 | 2004-04-29 | Bone Care International Inc., Madison | Verfahren zur herstellung von hydroxy-25-ene vitamin d verbindungen |
JP2004504295A (ja) * | 2000-07-18 | 2004-02-12 | ボーン ケア インターナショナル インコーポレイテッド | 安定化1α−ヒドロキシビタミンD |
JP2005514929A (ja) | 2002-01-10 | 2005-05-26 | テバ ファーマシューティカル インダストリーズ リミティド | エピマービタミンd類似物の酵素による選択的なエステル化及び加溶媒分解及びエピマーの分離 |
US7094775B2 (en) * | 2004-06-30 | 2006-08-22 | Bone Care International, Llc | Method of treating breast cancer using a combination of vitamin D analogues and other agents |
US20060003950A1 (en) * | 2004-06-30 | 2006-01-05 | Bone Care International, Inc. | Method of treating prostatic diseases using a combination of vitamin D analogues and other agents |
JP2008504369A (ja) * | 2004-07-01 | 2008-02-14 | テバ ファーマシューティカル インダストリーズ リミティド | 1,24(s)−ジヒドロキシビタミンd2の結晶形態 |
CN101607931B (zh) * | 2009-07-23 | 2012-01-11 | 青岛正大海尔制药有限公司 | 一种骨化三醇的制备方法 |
CN103122009B (zh) * | 2013-01-09 | 2015-11-25 | 江苏吉贝尔药业股份有限公司 | 两种用于合成他卡西醇支链的重要中间体化合物 |
CN103012463B (zh) * | 2013-01-17 | 2016-02-10 | 南京理工大学 | (s)-3-甲基-2-(叔丁基二甲基硅氧基)-1-溴丁烷的合成方法 |
CN104496871B (zh) * | 2014-12-22 | 2016-03-09 | 上海皓元生物医药科技有限公司 | 一种他卡西醇的制备方法 |
CN109627279A (zh) * | 2019-02-01 | 2019-04-16 | 浙江花园营养科技有限公司 | 一种活性维生素d3中间体的制备方法 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US467190A (en) * | 1892-01-19 | Bernard g | ||
US4670190A (en) * | 1973-01-10 | 1987-06-02 | Hesse Robert H | 1-α-hydroxy vitamin D compounds and process for preparing same |
US3880894A (en) | 1974-05-24 | 1975-04-29 | Wisconsin Alumni Res Found | 1,25-Dihydroxyergocalciferol |
US4022891A (en) * | 1974-06-18 | 1977-05-10 | Teijin Limited | Novel 1α,24-dihydroxycholecalciferol compositions, novel precursors thereof, and processes for preparing them |
US3970676A (en) * | 1974-10-29 | 1976-07-20 | The Upjohn Company | Novel process and intermediate compounds used is preparation of -Δ5,7- steroid dienes |
GB1583749A (en) * | 1976-06-03 | 1981-02-04 | Res Inst Medicine Chem | Vitamin d derivatives |
US4195027A (en) * | 1978-01-16 | 1980-03-25 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxylated compounds |
US4225596A (en) * | 1978-10-13 | 1980-09-30 | Wisconsin Alumni Research Foundation | Method for treating calcium imbalance and improving calcium absorption in mammals |
JPS55136229A (en) * | 1979-04-10 | 1980-10-23 | Teijin Ltd | Adjustment of bone metabolism in warm-blooded animal and drug for it |
US4310511A (en) * | 1980-10-02 | 1982-01-12 | Massachusetts General Hospital | Sunscreen compositions containing Δ5,7 steroidal dienes |
US4338250A (en) * | 1981-04-27 | 1982-07-06 | Wisconsin Alumni Research Foundation | 1-Hydroxylation process |
US4448721A (en) * | 1982-09-20 | 1984-05-15 | Wisconsin Alumni Research Foundation | Hydroxyvitamin D2 compounds and process for preparing same |
US4610978A (en) * | 1983-03-22 | 1986-09-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions containing 1α-hydroxycholecalciferol for topical treatment of skin disorders and methods employing same |
US4719205A (en) | 1984-01-30 | 1988-01-12 | Wisconsin Alumini Research Foundation | Side-chain unsaturated 1-hydroxyvitamin D compounds |
US4588528A (en) * | 1984-05-31 | 1986-05-13 | Wisconsin Alumni Research Foundation | 1,24-dihydroxy-Δ22 -vitamin D3 and process for preparing same |
US4728643A (en) * | 1984-11-02 | 1988-03-01 | The General Hospital Corporation | Method of treating psoriasis |
JPH07100685B2 (ja) * | 1985-08-02 | 1995-11-01 | レオ・ファ−マシュ−ティカル・プロダクツ・リミテッド・エイ/エス(レ−ベンス・ケミスケ・ファブリック・プロデュクチオンスアクチ−セルスカブ) | 新規ビタミンd類似体 |
JPH0755960B2 (ja) * | 1986-11-14 | 1995-06-14 | 日清製粉株式会社 | ステロイド誘導体およびその製造方法 |
US4804502A (en) * | 1988-01-20 | 1989-02-14 | Hoffmann-La Roche Inc. | Vitamin D compounds |
US5104864A (en) * | 1988-08-02 | 1992-04-14 | Bone Care International, Inc. | Method for treating and preventing loss of bone mass |
US5242824A (en) * | 1988-12-22 | 1993-09-07 | Oncogen | Monoclonal antibody to human carcinomas |
US5098899A (en) * | 1989-03-06 | 1992-03-24 | Trustees Of Boston University | Method for therapeutically treating psoriatic arthritis using vitamin D analogues and metabolites |
-
1992
- 1992-01-07 AU AU12475/92A patent/AU1247592A/en not_active Abandoned
- 1992-01-07 EP EP92904947A patent/EP0550702B1/en not_active Expired - Lifetime
- 1992-01-07 DE DE69229103T patent/DE69229103T2/de not_active Expired - Lifetime
- 1992-01-07 ES ES92904947T patent/ES2134207T3/es not_active Expired - Lifetime
- 1992-01-07 ES ES98110802T patent/ES2200238T3/es not_active Expired - Lifetime
- 1992-01-07 AT AT98110802T patent/ATE240736T1/de not_active IP Right Cessation
- 1992-01-07 AT AT92904947T patent/ATE179604T1/de not_active IP Right Cessation
- 1992-01-07 DE DE69233074T patent/DE69233074T2/de not_active Expired - Lifetime
- 1992-01-07 EP EP98110802A patent/EP0914825B1/en not_active Expired - Lifetime
- 1992-01-07 DK DK92904947T patent/DK0550702T3/da active
- 1992-01-07 WO PCT/US1992/000313 patent/WO1992012165A1/en active IP Right Grant
- 1992-01-08 ZA ZA92108A patent/ZA92108B/xx unknown
- 1992-01-08 MX MX9200070A patent/MX9200070A/es unknown
- 1992-01-08 PT PT99998A patent/PT99998B/pt not_active IP Right Cessation
- 1992-01-08 CN CN92100866A patent/CN1032256C/zh not_active Expired - Lifetime
- 1992-01-08 NZ NZ241255A patent/NZ241255A/xx not_active IP Right Cessation
-
1995
- 1995-06-07 US US08/483,371 patent/US6211168B1/en not_active Expired - Lifetime
- 1995-11-10 CN CN95118187A patent/CN1078072C/zh not_active Expired - Lifetime
- 1995-11-10 CN CN95118188A patent/CN1071574C/zh not_active Expired - Lifetime
-
1999
- 1999-06-09 GR GR990401539T patent/GR3030466T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0914825A3 (en) | 1999-05-19 |
CN1143500A (zh) | 1997-02-26 |
US6211168B1 (en) | 2001-04-03 |
PT99998B (pt) | 1999-06-30 |
EP0914825B1 (en) | 2003-05-21 |
PT99998A (pt) | 1993-01-29 |
CN1032256C (zh) | 1996-07-10 |
NZ241255A (en) | 1999-05-28 |
ES2200238T3 (es) | 2004-03-01 |
CN1078072C (zh) | 2002-01-23 |
CN1071574C (zh) | 2001-09-26 |
ATE179604T1 (de) | 1999-05-15 |
EP0550702A4 (en) | 1994-06-08 |
DE69233074T2 (de) | 2004-03-18 |
DE69233074D1 (de) | 2003-06-26 |
CN1067243A (zh) | 1992-12-23 |
AU1247592A (en) | 1992-08-17 |
DK0550702T3 (da) | 1999-11-01 |
WO1992012165A1 (en) | 1992-07-23 |
ATE240736T1 (de) | 2003-06-15 |
EP0550702A1 (en) | 1993-07-14 |
CN1133712A (zh) | 1996-10-23 |
EP0550702B1 (en) | 1999-05-06 |
ZA92108B (en) | 1992-10-28 |
GR3030466T3 (en) | 1999-10-29 |
MX9200070A (es) | 1992-07-01 |
DE69229103D1 (de) | 1999-06-10 |
EP0914825A2 (en) | 1999-05-12 |
DE69229103T2 (de) | 1999-10-14 |
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Legal Events
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