ES2133769T3 - Procedimiento para la sintesis diastereoselectiva de analogos de nucleosidos. - Google Patents

Procedimiento para la sintesis diastereoselectiva de analogos de nucleosidos.

Info

Publication number
ES2133769T3
ES2133769T3 ES95918579T ES95918579T ES2133769T3 ES 2133769 T3 ES2133769 T3 ES 2133769T3 ES 95918579 T ES95918579 T ES 95918579T ES 95918579 T ES95918579 T ES 95918579T ES 2133769 T3 ES2133769 T3 ES 2133769T3
Authority
ES
Spain
Prior art keywords
procedure
diastereoselective synthesis
nucleosid
analogs
nucleosid analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95918579T
Other languages
English (en)
Inventor
Michael David Goodyear
P Owen Dwyer
Malcolm Leithead Hill
Andrew Jonathan Whitehead
Roy Hornby
Peter Hallett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27267157&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2133769(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB9408112A external-priority patent/GB9408112D0/en
Priority claimed from GB9408091A external-priority patent/GB9408091D0/en
Priority claimed from GB9408103A external-priority patent/GB9408103D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ES2133769T3 publication Critical patent/ES2133769T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Treatment Of Water By Oxidation Or Reduction (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE DESCRIBE UN PROCESO PARA LA PREPARACION DE COMPUESTOS DE FORMULA (I), DONDE W ES S, S=O, SO{SUB,2}, O O; R{SUB,1} ES HIDROGENO O ACILO; Y R{SUB,2} ES UNA BASE DE PURINA O PIRIMIDINA O DERIVADO DE LAS MISMAS.
ES95918579T 1994-04-23 1995-04-21 Procedimiento para la sintesis diastereoselectiva de analogos de nucleosidos. Expired - Lifetime ES2133769T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9408112A GB9408112D0 (en) 1994-04-23 1994-04-23 Process
GB9408091A GB9408091D0 (en) 1994-04-23 1994-04-23 Process
GB9408103A GB9408103D0 (en) 1994-04-23 1994-04-23 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2133769T3 true ES2133769T3 (es) 1999-09-16

Family

ID=27267157

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95918579T Expired - Lifetime ES2133769T3 (es) 1994-04-23 1995-04-21 Procedimiento para la sintesis diastereoselectiva de analogos de nucleosidos.

Country Status (30)

Country Link
US (2) US6051709A (es)
EP (1) EP0757684B1 (es)
JP (2) JP4056558B2 (es)
KR (1) KR100241842B1 (es)
CN (2) CN1290841C (es)
AP (1) AP704A (es)
AT (1) ATE181326T1 (es)
AU (1) AU696612B2 (es)
BG (1) BG62810B1 (es)
BR (1) BR9507499A (es)
CZ (1) CZ293827B6 (es)
DE (1) DE69510347T2 (es)
DK (1) DK0757684T3 (es)
EE (1) EE03442B1 (es)
ES (1) ES2133769T3 (es)
FI (1) FI120401B (es)
GR (1) GR3031043T3 (es)
HK (1) HK1004221A1 (es)
HU (1) HU218044B (es)
IL (1) IL113432A (es)
IS (1) IS1844B (es)
NO (2) NO307179B1 (es)
NZ (1) NZ285396A (es)
PL (1) PL180090B1 (es)
RO (2) RO118714B1 (es)
RU (1) RU2158736C2 (es)
SK (1) SK281327B6 (es)
TW (1) TW487704B (es)
UA (1) UA43362C2 (es)
WO (1) WO1995029174A1 (es)

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US5684164A (en) * 1988-04-11 1997-11-04 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
IL113432A (en) * 1994-04-23 2000-11-21 Glaxo Group Ltd Process for the diastereoselective synthesis of nucleoside analogues
CA2203262A1 (en) * 1994-10-22 1996-05-02 Byeong Seon Jeong Nucleoside derivatives and process for preparing thereof
GB9506644D0 (en) * 1995-03-31 1995-05-24 Wellcome Found Preparation of nucleoside analogues
US6113920A (en) * 1996-10-31 2000-09-05 Glaxo Wellcome Inc. Pharmaceutical compositions
KR100856416B1 (ko) * 1998-08-12 2008-09-04 길리애드 사이언시즈, 인코포레이티드 1,3-옥사티올란 뉴클레오시드의 제조 방법
GB9820417D0 (en) * 1998-09-18 1998-11-11 Glaxo Group Ltd Antiviral combinations
US6432966B2 (en) 1999-10-29 2002-08-13 Smithkline Beecham Corporation Antiviral combinations
KR101015510B1 (ko) * 2001-03-01 2011-02-16 길리애드 사이언시즈, 인코포레이티드 시스-ｆｔｃ의 다형 및 기타 결정형
CA2351049C (en) 2001-06-18 2007-03-13 Brantford Chemicals Inc. Process for recovery of the desired cis-1,3-oxathiolane nucleosides from their undesired trans-isomers
WO2003027106A1 (en) * 2001-09-25 2003-04-03 Cadila Healthcar Limited Process for the preparation of crystalline polymorph ii of lamivudine
ITMI20030578A1 (it) * 2003-03-24 2004-09-25 Clariant Lsm Italia Spa Processo ed intermedi per la preparazione di emtricitabina
US20050187913A1 (en) 2003-05-06 2005-08-25 Yoram Nelken Web-based customer service interface
CN101307048B (zh) 2007-05-18 2011-03-23 上海迪赛诺医药发展有限公司 立体选择性制备拉米夫定的方法
WO2009037538A2 (en) * 2007-09-17 2009-03-26 Aurobindo Pharma Ltd Process for the preparation of lamivudine form i
EP2048151A1 (en) * 2007-10-10 2009-04-15 Cilag AG Method for producing nucleosides by direct glycosylation of the nucleoside base
BRPI0820224A2 (pt) * 2007-11-29 2015-06-16 Ranbaxy Lab Ltd Composto de fórmula iii ou seus estereoisômeros; processo para sua preparação e seu uso; uso de um composto de formula iii(a) ou iii(b) em um processo para a preparação de lamivudina de fórmula i(a) ou um composto de fórmula i(c); processo para preparação de lamivudina de fórmula i(a)
CN101918393A (zh) * 2007-11-29 2010-12-15 兰贝克赛实验室有限公司 拉米夫定的晶形i及其制备方法
SI2225232T1 (sl) 2007-11-29 2012-12-31 Ranbaxy Laboratories Limited Postopek za pripravo substituiranih 1,3-oksatiolanov
US8350030B2 (en) * 2007-12-07 2013-01-08 Matrix Laboratories Limited Process for producing 5-fluoro-1-(2R, 5S)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
CN101391997B (zh) * 2008-09-18 2010-12-22 江苏科本医药化学有限公司 一种恩曲他滨中间体的合成方法
CN101362752B (zh) * 2008-09-18 2011-12-28 浙江教育学院 一种拉米夫定中间体的合成方法
US20110282046A1 (en) 2009-01-19 2011-11-17 Rama Shankar Process for preparation of cis-nucleoside derivative
KR101474570B1 (ko) 2009-04-13 2014-12-19 주식회사 대희화학 라미부딘의 신규한 중간체 및 이의 제조방법
CN101544632B (zh) * 2009-04-24 2011-09-07 湖南千金湘江药业股份有限公司 拉米夫定非对映选择合成方法
ES2540074T3 (es) 2009-10-14 2015-07-08 Mylan Laboratories Limited Proceso para la preparación de lamivudina y nuevas sales en la fabricación de la misma
TR201807704T4 (tr) 2010-01-27 2018-06-21 Viiv Healthcare Co Anti-viral tedavi.
WO2011095987A1 (en) 2010-02-03 2011-08-11 Matrix Laboratories Ltd. Novel process for the preparation of cis-nucleoside derivative
CN102167696B (zh) * 2010-02-25 2013-09-18 南京正大天晴制药有限公司 拉米夫定草酸盐及其制备方法
EP2542551B1 (en) * 2010-03-04 2014-08-27 Ranbaxy Laboratories Limited A process for stereoselective synthesis of 5-fluoro-1-(2r,5s)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
CN101830893A (zh) * 2010-05-31 2010-09-15 安徽一帆香料有限公司 一种拉米夫定中间体hdms的合成制备工艺
CN102399213A (zh) * 2010-09-08 2012-04-04 重庆医药工业研究院有限责任公司 拉米夫定单邻苯二甲酸盐及其合成方法
WO2012062835A1 (en) 2010-11-12 2012-05-18 Glaxo Wellcome Manufacturing Pte Ltd Novel pharmaceutical compositions
CN103282369A (zh) 2011-04-08 2013-09-04 劳乐斯实验室私营有限公司 抗逆转录病毒化合物与抗氧化酸的固体形式、其制备方法以及其药物组合物
CN102796088B (zh) * 2012-05-21 2015-06-10 湖南千金湘江药业股份有限公司 一种拉米夫定的制备方法
CN103450166A (zh) * 2012-05-31 2013-12-18 上海迪赛诺药业有限公司 制备核苷化合物的方法
CN103864835A (zh) * 2013-03-26 2014-06-18 安徽贝克联合制药有限公司 一种提高拉米夫定中间体立体选择性制备方法
CN103288806A (zh) * 2013-07-02 2013-09-11 山东大学 一种曲沙他滨的合成方法
CN103694231A (zh) * 2013-11-28 2014-04-02 安徽一帆香料有限公司 一种拉米夫定中间体hdms的合成制备方法
US9571109B2 (en) * 2015-03-27 2017-02-14 International Business Machines Corporation Voltage controlled oscillator runaway prevention
CN106146481A (zh) * 2015-04-07 2016-11-23 江苏普信制药有限公司 一种核苷类似物的制备方法
CN105037340B (zh) * 2015-07-14 2018-08-10 福建广生堂药业股份有限公司 一种拉米夫定关键中间体手性异构体杂质的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5684164A (en) * 1988-04-11 1997-11-04 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5466806A (en) * 1989-02-08 1995-11-14 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
AU3154993A (en) * 1989-02-08 1994-07-19 Biochem Pharma Inc. Process for preparing substituted 1,3-oxathiolanes with antiviral properties
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
GB9009861D0 (en) * 1990-05-02 1990-06-27 Glaxo Group Ltd Chemical compounds
US5587480A (en) * 1990-11-13 1996-12-24 Biochem Pharma, Inc. Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
IL100502A (en) * 1991-01-03 1995-12-08 Iaf Biochem Int PHARMACEUTICAL PREPARATIONS CONTAINING CIS-4-AMINO-1-) 2-HYDROXIMETHIL-1,3-OXETYOLEN-5-IL (-
DK0513917T4 (da) 1991-05-16 2001-06-25 Glaxo Group Ltd Antivirale kombinationer indeholdende nukleosidanaloger
GB9110874D0 (en) * 1991-05-20 1991-07-10 Iaf Biochem Int Medicaments
ZA923640B (en) * 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
GB9116601D0 (en) * 1991-08-01 1991-09-18 Iaf Biochem Int 1,3-oxathiolane nucleoside analogues
IL113432A (en) * 1994-04-23 2000-11-21 Glaxo Group Ltd Process for the diastereoselective synthesis of nucleoside analogues

Also Published As

Publication number Publication date
NZ285396A (en) 1998-10-28
BR9507499A (pt) 1997-09-23
JP4056558B2 (ja) 2008-03-05
DE69510347D1 (de) 1999-07-22
NO307179B1 (no) 2000-02-21
CZ293827B6 (cs) 2004-08-18
HK1004221A1 (en) 1998-11-20
HU218044B (hu) 2000-05-28
IL113432A0 (en) 1995-07-31
SK281327B6 (sk) 2001-02-12
BG62810B1 (bg) 2000-08-31
FI964251A0 (fi) 1996-10-22
PL180090B1 (pl) 2000-12-29
RO117916B1 (ro) 2002-09-30
IS4366A (is) 1996-09-27
UA43362C2 (uk) 2001-12-17
SK135596A3 (en) 1997-07-09
NO964487D0 (no) 1996-10-22
GR3031043T3 (en) 1999-12-31
HU9602925D0 (en) 1996-12-30
NO313096B1 (no) 2002-08-12
CN1500782A (zh) 2004-06-02
CZ309696A3 (en) 1997-04-16
US6329522B1 (en) 2001-12-11
FI964251A (fi) 1996-10-22
AU696612B2 (en) 1998-09-17
TW487704B (en) 2002-05-21
AU2447195A (en) 1995-11-16
BG100916A (en) 1997-07-31
US6051709A (en) 2000-04-18
FI120401B (fi) 2009-10-15
CN1149871A (zh) 1997-05-14
ATE181326T1 (de) 1999-07-15
DE69510347T2 (de) 1999-11-18
NO964487L (no) 1996-12-17
JP2007217425A (ja) 2007-08-30
WO1995029174A1 (en) 1995-11-02
NO995646D0 (no) 1999-11-17
PL316904A1 (en) 1997-02-17
HUT76296A (en) 1997-07-28
RO118714B1 (ro) 2003-09-30
DK0757684T3 (da) 2000-01-17
AP9600871A0 (en) 1996-10-31
CN1290841C (zh) 2006-12-20
RU2158736C2 (ru) 2000-11-10
KR100241842B1 (ko) 2000-03-02
NO995646L (no) 1999-11-17
EP0757684B1 (en) 1999-06-16
EP0757684A1 (en) 1997-02-12
IL113432A (en) 2000-11-21
IS1844B (is) 2003-01-30
JPH10502615A (ja) 1998-03-10
EE03442B1 (et) 2001-06-15
AP704A (en) 1998-12-04
EE9600134A (et) 1997-04-15
CN1151146C (zh) 2004-05-26

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