ES2131206T3 - Un metodo de carga elevada de vesiculas con sustancias biopolimeras. - Google Patents

Un metodo de carga elevada de vesiculas con sustancias biopolimeras.

Info

Publication number
ES2131206T3
ES2131206T3 ES94923714T ES94923714T ES2131206T3 ES 2131206 T3 ES2131206 T3 ES 2131206T3 ES 94923714 T ES94923714 T ES 94923714T ES 94923714 T ES94923714 T ES 94923714T ES 2131206 T3 ES2131206 T3 ES 2131206T3
Authority
ES
Spain
Prior art keywords
substances
vesicles
encapsulated
high loading
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94923714T
Other languages
English (en)
Inventor
Yechezkel Barenholz
Israel Nur
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Opperbas Holding BV
Original Assignee
Opperbas Holding BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Opperbas Holding BV filed Critical Opperbas Holding BV
Application granted granted Critical
Publication of ES2131206T3 publication Critical patent/ES2131206T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN METODO PARA LA CARGA SUPERIOR DE VEJIGUILLAS CON SUSTANCIAS BIOPOLIMERICAS FUNCIONAL EN SISTEMAS BIOQUIMICO O FISIOLOGICO HUMANO DERIVADO DE CUALQUIER FUENTE, DICHAS SUSTANCIAS SIENDO PREFERIBLEMENTE ENZIMAS, PROENZIMAS, COFACTORES, PARTICULAS DE SUBMICRON COMO VIRIONES, FACTORES DE CRECIMIENTO, CITOQUINAS, ROBOSOMAS, ANTIGENO SUPERFICIAL DE HEPATITIS B, OLIGO Y POLINUCLEOTIDOS, ANTICUERPOS Y/O ANTIGENOS, DICHAS VEJIGUILLAS FORMADAS POR SUSTANCIAS ANFIFATICAS QUE COMPRENDE LOS PASOS DE A) UNA MEZCLA DE LIPIDOS ADECUADA PARA FORMAR VEJIGUILLAS DE LIPIDO EN DISOLVENTES ORGANICOS INMISCIBLES EN AGUA, ALTERNATIVAMENTE PUEDE UTILIZARSE LIPIDOS DESECADOS O UNA MEZCLA DE LIPIDO EN CUALQUIER FORMA (POLVO, GRANULAR, ETC.) DIRECTAMENTE; B) ELIMINACION DEL DISOLVENTE EN LA PRESENCIA DE UN SOPORTE SOLIDO; C) LLEVAR EL PRODUCTO DEL PASO B) A UNA SOLUCION DE LAS SUSTANCIAS A ENCAPSULAR EN UNA SOLUCION FISIOLOGICAMENTE COMPATIBLE; D) AÑADIR UN DISOLVENTE ORGANICO QUE TENGA PROPIEDADES DE SOLUBILIZACIONO DISPOSICION, ASI COMO E) DESECAR LA FRACCION OBTENIDA EN EL PASO D) BAJO CONDICIONES QUE RETENGAN LA FUNCION DE LAS SUSTANCIAS A ENCAPSULAR.
ES94923714T 1993-08-06 1994-07-08 Un metodo de carga elevada de vesiculas con sustancias biopolimeras. Expired - Lifetime ES2131206T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93112642 1993-08-06

Publications (1)

Publication Number Publication Date
ES2131206T3 true ES2131206T3 (es) 1999-07-16

Family

ID=8213143

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94923714T Expired - Lifetime ES2131206T3 (es) 1993-08-06 1994-07-08 Un metodo de carga elevada de vesiculas con sustancias biopolimeras.

Country Status (9)

Country Link
EP (2) EP0713388B1 (es)
JP (1) JPH09501169A (es)
AT (1) ATE179599T1 (es)
AU (1) AU7384994A (es)
CA (1) CA2168671C (es)
DE (1) DE69418334T2 (es)
ES (1) ES2131206T3 (es)
IL (1) IL110305A (es)
WO (1) WO1995004524A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9326953B2 (en) 2003-04-25 2016-05-03 The Penn State Research Foundation Method and system for systemic delivery of growth arresting, lipid-derived bioactive compounds

Families Citing this family (32)

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US6004534A (en) * 1993-07-23 1999-12-21 Massachusetts Institute Of Technology Targeted polymerized liposomes for improved drug delivery
WO1995003035A1 (en) * 1993-07-23 1995-02-02 Massachusetts Institute Of Technology Polymerized liposomes with enhanced stability for oral delivery
DE4416166C2 (de) * 1994-05-06 1997-11-20 Immuno Ag Stabiles Präparat zur Behandlung von Blutgerinnungsstörungen
DE4416180C2 (de) * 1994-05-06 1997-08-14 Immuno Ag Stabiles Präparat zur Behandlung von Blutgerinnungsstörungen und Verfahren zur Herstellung dieses Präparats
US6017891A (en) * 1994-05-06 2000-01-25 Baxter Aktiengesellschaft Stable preparation for the treatment of blood coagulation disorders
GB9422990D0 (en) * 1994-11-15 1995-01-04 Cortecs Ltd Immunogenic compositions
NZ331693A (en) * 1996-05-10 2000-04-28 Yamanouchi Europ Bv reversed vesicules containing powder having one or more non ionic surfactant
US5919480A (en) * 1996-06-24 1999-07-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposomal influenza vaccine composition and method
US7384923B2 (en) 1999-05-14 2008-06-10 Lipoxen Technologies Limited Liposomes
WO1998010748A1 (en) * 1996-09-13 1998-03-19 The School Of Pharmacy Liposomes
US6024925A (en) * 1997-01-23 2000-02-15 Sequenom, Inc. Systems and methods for preparing low volume analyte array elements
EP1460083B1 (en) * 1996-11-06 2006-01-18 Sequenom, Inc. Analysing method and apparatus
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US6060082A (en) 1997-04-18 2000-05-09 Massachusetts Institute Of Technology Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
EP1332000B1 (en) 2000-10-30 2012-06-20 Sequenom, Inc. Method for delivery of submicroliter volumes onto a substrate
US8110218B2 (en) 2000-11-30 2012-02-07 The Research Foundation Of State University Of New York Compositions and methods for less immunogenic protein-lipid complexes
US7625584B2 (en) * 2000-11-30 2009-12-01 The Research Foundation Of State University Of New York Method of complexing a protein by the use of a dispersed system and proteins thereof
AU2003267984A1 (en) * 2002-07-03 2004-01-23 Receptor Biologix, Inc. Liposomal vaccine
AU2006235507B2 (en) 2005-04-12 2012-08-30 Duke University Method of inducing neutralizing antibodies to human immunodeficiency virus
US8956627B2 (en) 2007-04-13 2015-02-17 Duke University Method of inducing antibodies to human immunodeficiency virus involving the administration of MPER peptide-liposome conjugates
US20090180931A1 (en) 2007-09-17 2009-07-16 Sequenom, Inc. Integrated robotic sample transfer device
WO2015048635A1 (en) 2013-09-27 2015-04-02 Duke University Mper-liposome conjugates and uses thereof
GB201417589D0 (en) 2014-10-06 2014-11-19 Cantab Biopharmaceuticals Patents Ltd Pharmaceutical Formulations
WO2016125163A1 (en) 2015-02-04 2016-08-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. LIPID ASSEMBLIES AND USES THEREOF AND SOME pH AND ELECTROSTATIC MODULATING LIPIDS TO BE USED IN SAID ASSEMBLIES
GB201518170D0 (en) 2015-10-14 2015-11-25 Cantab Biopharmaceuticals Patents Ltd Colloidal particles for subcutaneous administration with intravenous administration of therapeutic agent
GB201518171D0 (en) 2015-10-14 2015-11-25 Cantab Biopharmaceuticals Patents Ltd Colloidal particles for topical administration with therapeutic agent
GB201518172D0 (en) 2015-10-14 2015-11-25 Cantab Biopharmaceuticals Patents Ltd Colloidal particles for use in medicine
US10159720B2 (en) 2015-12-08 2018-12-25 Omrix Biopharmaceuticals Ltd Thrombin microcapsules, preparation and uses thereof
IL242984A0 (en) 2015-12-08 2016-02-29 Omrix Biopharmaceuticals Ltd Thrombin microcapsules, their preparation and how to use them
GB202111757D0 (en) 2021-08-17 2021-09-29 Cantab Biopharmaceuticals Patents Ltd Modified colloidal particles for use in the treatment of haemophilia A
GB202111758D0 (en) 2021-08-17 2021-09-29 Cantab Biopharmaceuticals Patents Ltd Modified colloidal particles for use in the treatment of haemophilia A
GB202111759D0 (en) 2021-08-17 2021-09-29 Cantab Biopharmaceuticals Patents Ltd Modified colloidal particles

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
NL7900459A (nl) * 1979-01-19 1980-07-22 Hendrik Coenraad Hemker Prof D Farmaceutisch preparaat en werkwijze ter bereiding daarvan.
US4348384A (en) * 1980-10-17 1982-09-07 Dainippon Pharmaceutical Co., Ltd. Pharmaceutical composition for oral administration containing coagulation factor VIII or IX
US4485054A (en) * 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
GB2135647A (en) * 1983-02-15 1984-09-05 Squibb & Sons Inc Method of preparing liposomes and products produced thereby
US4873035A (en) * 1987-11-25 1989-10-10 Abbott Laboratories Preparation of sized populations of liposomes

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9326953B2 (en) 2003-04-25 2016-05-03 The Penn State Research Foundation Method and system for systemic delivery of growth arresting, lipid-derived bioactive compounds

Also Published As

Publication number Publication date
IL110305A (en) 1998-12-06
ATE179599T1 (de) 1999-05-15
EP0713388A1 (en) 1996-05-29
AU7384994A (en) 1995-02-28
WO1995004524A1 (en) 1995-02-16
DE69418334D1 (de) 1999-06-10
CA2168671C (en) 2007-04-10
CA2168671A1 (en) 1995-02-16
EP0713388B1 (en) 1999-05-06
IL110305A0 (en) 1994-10-21
JPH09501169A (ja) 1997-02-04
EP0815852A1 (en) 1998-01-07
DE69418334T2 (de) 2000-01-27

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