ES2131015B1 - NEW DERIVATIVES OF 2- (3H) -OXAZOLONE, PROCEDURES FOR ITS PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS. - Google Patents

NEW DERIVATIVES OF 2- (3H) -OXAZOLONE, PROCEDURES FOR ITS PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS.

Info

Publication number
ES2131015B1
ES2131015B1 ES009701928A ES9701928A ES2131015B1 ES 2131015 B1 ES2131015 B1 ES 2131015B1 ES 009701928 A ES009701928 A ES 009701928A ES 9701928 A ES9701928 A ES 9701928A ES 2131015 B1 ES2131015 B1 ES 2131015B1
Authority
ES
Spain
Prior art keywords
oxazolone
pharmaceutical compositions
new derivatives
procedures
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES009701928A
Other languages
Spanish (es)
Other versions
ES2131015A1 (en
Inventor
Duran Carles Puig
Gras Joan Feixas
Mayorga Juan Miguel Jimenez
Crespo Maria Isabel Crespo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almirall SA
Original Assignee
Almirall Prodesfarma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma SA filed Critical Almirall Prodesfarma SA
Priority to ES009701928A priority Critical patent/ES2131015B1/en
Priority to AU96236/98A priority patent/AU9623698A/en
Priority to EP98950000A priority patent/EP1017685A1/en
Priority to JP2000511756A priority patent/JP2001516750A/en
Priority to PCT/EP1998/005694 priority patent/WO1999014205A1/en
Priority to CO98051845A priority patent/CO5011110A1/en
Priority to PE1998000863A priority patent/PE116999A1/en
Priority to ZA988303A priority patent/ZA988303B/en
Priority to ARP980104535A priority patent/AR017097A1/en
Priority to UY25179A priority patent/UY25179A1/en
Publication of ES2131015A1 publication Critical patent/ES2131015A1/en
Application granted granted Critical
Publication of ES2131015B1 publication Critical patent/ES2131015B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
    • C07D263/38—One oxygen atom attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Nuevos derivados de 2-(3H)-oxazolona, procedimientos para su preparación y su empleo en composiciones farmacéuticas. El compuesto 2-(3H)-oxazolona preferido tiene la fórmula (I):en donde los significados de los distintos radicales son como se han indicado en la parte descriptiva. El procedimiento se caracteriza porque por reacciones de diferentes compuestos de partida e intermedios se obtienen los nuevos derivados de 2-(3H)-oxazolona. Estos se pueden emplear como compuestos activos en composiciones farmacéuticas para el tratamiento de enfermedades mediadas por ciclooxigenasa-2.New derivatives of 2- (3H) -oxazolone, procedures for their preparation and their use in pharmaceutical compositions. The preferred 2- (3H) -oxazolone compound has the formula (I): wherein the meanings of the different radicals are as indicated in the descriptive part. The procedure is characterized in that by reactions of different starting and intermediate compounds, the new derivatives of 2- (3H) -oxazolone are obtained. These can be used as active compounds in pharmaceutical compositions for the treatment of cyclooxygenase-2 mediated diseases.

ES009701928A 1997-09-12 1997-09-12 NEW DERIVATIVES OF 2- (3H) -OXAZOLONE, PROCEDURES FOR ITS PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS. Expired - Fee Related ES2131015B1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
ES009701928A ES2131015B1 (en) 1997-09-12 1997-09-12 NEW DERIVATIVES OF 2- (3H) -OXAZOLONE, PROCEDURES FOR ITS PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS.
AU96236/98A AU9623698A (en) 1997-09-12 1998-09-08 New 2-(3h)-oxazolone derivatives
EP98950000A EP1017685A1 (en) 1997-09-12 1998-09-08 New 2-(3h)-oxazolone derivatives
JP2000511756A JP2001516750A (en) 1997-09-12 1998-09-08 Novel 2- (3H) -oxazolone derivatives
PCT/EP1998/005694 WO1999014205A1 (en) 1997-09-12 1998-09-08 New 2-(3h)-oxazolone derivatives
CO98051845A CO5011110A1 (en) 1997-09-12 1998-09-09 NEW DERIVATIVES OF 2- (3H) -OXAZOLONA
PE1998000863A PE116999A1 (en) 1997-09-12 1998-09-10 NEW DERIVATIVES OF 2- (3H) -OXAZOLONA
ZA988303A ZA988303B (en) 1997-09-12 1998-09-10 New 2-(3H)-oxazolone derivatives
ARP980104535A AR017097A1 (en) 1997-09-12 1998-09-11 COMPOUNDS OF 2- (3H) -OXAZOLONA, USEFUL AS SELECTIVE COX-2 INHIBITORS; PROCEDURE TO PREPARE SUCH COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FORMED WITH SUCH COMPOUNDS
UY25179A UY25179A1 (en) 1997-09-12 1998-09-11 NEW DERIVATIVES OF 2- (3H) -OXAZOLONA

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009701928A ES2131015B1 (en) 1997-09-12 1997-09-12 NEW DERIVATIVES OF 2- (3H) -OXAZOLONE, PROCEDURES FOR ITS PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS.

Publications (2)

Publication Number Publication Date
ES2131015A1 ES2131015A1 (en) 1999-07-01
ES2131015B1 true ES2131015B1 (en) 2000-03-01

Family

ID=8300586

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009701928A Expired - Fee Related ES2131015B1 (en) 1997-09-12 1997-09-12 NEW DERIVATIVES OF 2- (3H) -OXAZOLONE, PROCEDURES FOR ITS PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS.

Country Status (10)

Country Link
EP (1) EP1017685A1 (en)
JP (1) JP2001516750A (en)
AR (1) AR017097A1 (en)
AU (1) AU9623698A (en)
CO (1) CO5011110A1 (en)
ES (1) ES2131015B1 (en)
PE (1) PE116999A1 (en)
UY (1) UY25179A1 (en)
WO (1) WO1999014205A1 (en)
ZA (1) ZA988303B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
ES2166710B1 (en) * 2000-04-25 2004-10-16 J. URIACH & CIA, S.A. NEW HETEROCICLIC COMPOUNDS WITH ANTI-INFLAMMATORY ACTIVITY.
US20030105144A1 (en) 2001-04-17 2003-06-05 Ping Gao Stabilized oral pharmaceutical composition
US6673818B2 (en) 2001-04-20 2004-01-06 Pharmacia Corporation Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation
ES2213485B1 (en) 2003-02-13 2005-12-16 Almirall Prodesfarma, S.A. DERIVATIVES OF 2-FENILPIRAN-4-ONA.
IL305573A (en) 2021-03-15 2023-10-01 Saul Yedgar HYALURONIC ACID-CONJUGATED DIPALMITOYL PHOSPHATIDYL ETHANOLAMINE IN COMBINATION WITH NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) FOR TREATING OR ALLEVIATING INFLAMMATORY DISEASES

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380738A (en) * 1993-05-21 1995-01-10 Monsanto Company 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
WO1996036617A1 (en) * 1995-05-19 1996-11-21 G.D. Searle & Co. Substituted oxazoles for the treatment of inflammation
ES2125161B1 (en) * 1996-03-21 1999-11-16 Grupo Farmaceutico Almirall S NEW DERIVATIVES OF 2- (3H) -OXAZOLONA.
FR2753449B1 (en) * 1996-09-13 1998-12-04 Union Pharma Scient Appl NOVEL 3,4-DIARYLOXAZOLONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND THERAPEUTIC USES

Also Published As

Publication number Publication date
WO1999014205A1 (en) 1999-03-25
AU9623698A (en) 1999-04-05
EP1017685A1 (en) 2000-07-12
CO5011110A1 (en) 2001-02-28
ES2131015A1 (en) 1999-07-01
UY25179A1 (en) 2000-12-29
PE116999A1 (en) 1999-12-13
ZA988303B (en) 1999-03-11
AR017097A1 (en) 2001-08-22
JP2001516750A (en) 2001-10-02

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