AR017097A1 - COMPOUNDS OF 2- (3H) -OXAZOLONA, USEFUL AS SELECTIVE COX-2 INHIBITORS; PROCEDURE TO PREPARE SUCH COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FORMED WITH SUCH COMPOUNDS - Google Patents

COMPOUNDS OF 2- (3H) -OXAZOLONA, USEFUL AS SELECTIVE COX-2 INHIBITORS; PROCEDURE TO PREPARE SUCH COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FORMED WITH SUCH COMPOUNDS

Info

Publication number
AR017097A1
AR017097A1 ARP980104535A ARP980104535A AR017097A1 AR 017097 A1 AR017097 A1 AR 017097A1 AR P980104535 A ARP980104535 A AR P980104535A AR P980104535 A ARP980104535 A AR P980104535A AR 017097 A1 AR017097 A1 AR 017097A1
Authority
AR
Argentina
Prior art keywords
compounds
useful
pharmaceutical compositions
inhibitors
oxazolona
Prior art date
Application number
ARP980104535A
Other languages
Spanish (es)
Original Assignee
Almirall Prodesfarma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma Sa filed Critical Almirall Prodesfarma Sa
Publication of AR017097A1 publication Critical patent/AR017097A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
    • C07D263/38—One oxygen atom attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Se trata de compuestos de 2-(3H)-oxazolona de formula (I) donde: r1 es alquilo o un grupo amino; R2 es naftilo, un grupo fenilo o fenilo no sustituido,sustituido desde 1 a 3 átomos de halogeno o alquilo, alcoxi o grupos trifluorometilo; y R3 es hidrogeno o un grupo alquilo. Dichos compuestos son utiles comoinhibidores selectivos de la COX-2 (ciclooxigenasa-2), utiles para el tratamiento de enfermedades mediadas por la COX-2, sin la manifestacion de efectosulcerogénicos. También se propone un procedimiento para preparar dichos compuestos de formula (I), y composiciones farmacéuticas que los incluyen como agenteactivo.These are 2- (3H) -oxazolone compounds of formula (I) where: r1 is alkyl or an amino group; R2 is naphthyl, an unsubstituted phenyl or phenyl group, substituted from 1 to 3 halogen or alkyl, alkoxy or trifluoromethyl groups; and R3 is hydrogen or an alkyl group. These compounds are useful as selective inhibitors of COX-2 (cyclooxygenase-2), useful for the treatment of diseases mediated by COX-2, without the manifestation of ulcer effects. A process is also proposed for preparing said compounds of formula (I), and pharmaceutical compositions that include them as active agent.

ARP980104535A 1997-09-12 1998-09-11 COMPOUNDS OF 2- (3H) -OXAZOLONA, USEFUL AS SELECTIVE COX-2 INHIBITORS; PROCEDURE TO PREPARE SUCH COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FORMED WITH SUCH COMPOUNDS AR017097A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009701928A ES2131015B1 (en) 1997-09-12 1997-09-12 NEW DERIVATIVES OF 2- (3H) -OXAZOLONE, PROCEDURES FOR ITS PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS.

Publications (1)

Publication Number Publication Date
AR017097A1 true AR017097A1 (en) 2001-08-22

Family

ID=8300586

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980104535A AR017097A1 (en) 1997-09-12 1998-09-11 COMPOUNDS OF 2- (3H) -OXAZOLONA, USEFUL AS SELECTIVE COX-2 INHIBITORS; PROCEDURE TO PREPARE SUCH COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FORMED WITH SUCH COMPOUNDS

Country Status (10)

Country Link
EP (1) EP1017685A1 (en)
JP (1) JP2001516750A (en)
AR (1) AR017097A1 (en)
AU (1) AU9623698A (en)
CO (1) CO5011110A1 (en)
ES (1) ES2131015B1 (en)
PE (1) PE116999A1 (en)
UY (1) UY25179A1 (en)
WO (1) WO1999014205A1 (en)
ZA (1) ZA988303B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
ES2166710B1 (en) * 2000-04-25 2004-10-16 J. URIACH & CIA, S.A. NEW HETEROCICLIC COMPOUNDS WITH ANTI-INFLAMMATORY ACTIVITY.
US20030105144A1 (en) 2001-04-17 2003-06-05 Ping Gao Stabilized oral pharmaceutical composition
US6673818B2 (en) 2001-04-20 2004-01-06 Pharmacia Corporation Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation
ES2213485B1 (en) 2003-02-13 2005-12-16 Almirall Prodesfarma, S.A. DERIVATIVES OF 2-FENILPIRAN-4-ONA.
CA3209491A1 (en) 2021-03-15 2022-09-22 Saul Yedgar Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380738A (en) * 1993-05-21 1995-01-10 Monsanto Company 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
EP0825989A1 (en) * 1995-05-19 1998-03-04 G.D. Searle & Co. Substituted oxazoles for the treatment of inflammation
ES2125161B1 (en) * 1996-03-21 1999-11-16 Grupo Farmaceutico Almirall S NEW DERIVATIVES OF 2- (3H) -OXAZOLONA.
FR2753449B1 (en) * 1996-09-13 1998-12-04 Union Pharma Scient Appl NOVEL 3,4-DIARYLOXAZOLONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND THERAPEUTIC USES

Also Published As

Publication number Publication date
EP1017685A1 (en) 2000-07-12
ZA988303B (en) 1999-03-11
AU9623698A (en) 1999-04-05
WO1999014205A1 (en) 1999-03-25
UY25179A1 (en) 2000-12-29
ES2131015B1 (en) 2000-03-01
PE116999A1 (en) 1999-12-13
JP2001516750A (en) 2001-10-02
ES2131015A1 (en) 1999-07-01
CO5011110A1 (en) 2001-02-28

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