ES2130980A1 - Enzyme process for the preparation of lipoamino acids of the alkyl amide and ester type - Google Patents

Enzyme process for the preparation of lipoamino acids of the alkyl amide and ester type

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Publication number
ES2130980A1
ES2130980A1 ES09700520A ES9700520A ES2130980A1 ES 2130980 A1 ES2130980 A1 ES 2130980A1 ES 09700520 A ES09700520 A ES 09700520A ES 9700520 A ES9700520 A ES 9700520A ES 2130980 A1 ES2130980 A1 ES 2130980A1
Authority
ES
Spain
Prior art keywords
preparation
alkyl
ester type
chain
chr1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09700520A
Other languages
Spanish (es)
Other versions
ES2130980B1 (en
Inventor
Saborit Pere Clapes
Badenas Carmen Moran
Martinez Pardo M Rosa Infante
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consejo Superior de Investigaciones Cientificas CSIC
Original Assignee
Consejo Superior de Investigaciones Cientificas CSIC
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Publication date
Application filed by Consejo Superior de Investigaciones Cientificas CSIC filed Critical Consejo Superior de Investigaciones Cientificas CSIC
Priority to ES9700520A priority Critical patent/ES2130980B1/en
Publication of ES2130980A1 publication Critical patent/ES2130980A1/en
Application granted granted Critical
Publication of ES2130980B1 publication Critical patent/ES2130980B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Abstract

Enzyme process for the preparation of lipoamino acids of the alkyl amide and ester type. This relates to a process for the synthesis of single- chain lipid derivatives of amino acids of general formula H2N-CHR1-CO-NH-R2 and H2N-CHR1-CO-O-R2, where R1 may be a hydrogen, a straight or branched optionally substituted saturated or unsaturated chain or an optionally substituted aromatic group and R2 is an alkyl chain of any length. It involves the use of hydrolytic enzyme to form amide and ester links between an amino acid derivative and an alkyl amine or alcohol respectively. The advantages offered are fundamentally that it eliminates the production of undesirable by-products, that it is stereospecific (regionally selective and enantioselective), the operating conditions are mild and it can be scaled to industrial level. For this reason this new process can be an alternative to the conventional synthesis for the preparation of these surfactants of natural origin and low toxicity.
ES9700520A 1997-03-10 1997-03-10 ENZYMATIC PROCEDURE FOR THE PREPARATION OF LIPOAMINOACIDOS OF THE ALKYL AMID AND ESTER TYPE. Expired - Fee Related ES2130980B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9700520A ES2130980B1 (en) 1997-03-10 1997-03-10 ENZYMATIC PROCEDURE FOR THE PREPARATION OF LIPOAMINOACIDOS OF THE ALKYL AMID AND ESTER TYPE.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9700520A ES2130980B1 (en) 1997-03-10 1997-03-10 ENZYMATIC PROCEDURE FOR THE PREPARATION OF LIPOAMINOACIDOS OF THE ALKYL AMID AND ESTER TYPE.

Publications (2)

Publication Number Publication Date
ES2130980A1 true ES2130980A1 (en) 1999-07-01
ES2130980B1 ES2130980B1 (en) 2000-04-01

Family

ID=8298575

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9700520A Expired - Fee Related ES2130980B1 (en) 1997-03-10 1997-03-10 ENZYMATIC PROCEDURE FOR THE PREPARATION OF LIPOAMINOACIDOS OF THE ALKYL AMID AND ESTER TYPE.

Country Status (1)

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ES (1) ES2130980B1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001058860A1 (en) * 2000-02-11 2001-08-16 Consejo Superior De Investigaciones Cientificas 1-o-l-arginyl ester 3-o-monoacyl glycerides and 1-o-l-arginyl ester 2,3-o-diacyl glycerides type surface active agents
WO2001058849A1 (en) * 2000-02-11 2001-08-16 Consejo Superior De Investigaciones Cientificas SURFACE ACTIVE AGENTS DERIVED FROM 1-O-Nα-ACETYL-L-AMINOACYL ESTER 3-O-MONOACYL GLYCERIDES AND 1-O-Nα-ACETYL L-AMINOACYL ESTER 2,3-O-DIACYL GLYCERIDES TYPE AMINO ACIDS AND THE PREPARATION THEREOF
ES2163368A1 (en) * 2000-02-11 2002-01-16 Consejo Superior Investigacion 1-O-L-arginyl ester 3-O-monoacyl glycerides and 1-O-L-arginyl ester 2,3-O-diacyl glycerides type surface active agents
ES2163367A1 (en) * 2000-02-11 2002-01-16 Consejo Superior Investigacion New 1-O-N-acetylaminoacyl-glycerol ester derivatives are useful as antimicrobials with high surfactant activity and adjustable properties

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2254554A1 (en) * 1973-12-12 1975-07-11 Ajinomoto Kk
ES8303312A1 (en) * 1982-05-28 1983-02-16 Consejo Superior Investigacion New procedure for the preparation of N-acil-alkylaminoguanidic acids and any of their salts, as surgical agents of antimicrobial action. (Machine-translation by Google Translate, not legally binding)
WO1990014429A1 (en) * 1989-05-25 1990-11-29 Novo Nordisk A/S An enzyme-catalyzed process for preparing n-acyl amino acids and n-acyl amino acid amides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2254554A1 (en) * 1973-12-12 1975-07-11 Ajinomoto Kk
ES8303312A1 (en) * 1982-05-28 1983-02-16 Consejo Superior Investigacion New procedure for the preparation of N-acil-alkylaminoguanidic acids and any of their salts, as surgical agents of antimicrobial action. (Machine-translation by Google Translate, not legally binding)
WO1990014429A1 (en) * 1989-05-25 1990-11-29 Novo Nordisk A/S An enzyme-catalyzed process for preparing n-acyl amino acids and n-acyl amino acid amides

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001058860A1 (en) * 2000-02-11 2001-08-16 Consejo Superior De Investigaciones Cientificas 1-o-l-arginyl ester 3-o-monoacyl glycerides and 1-o-l-arginyl ester 2,3-o-diacyl glycerides type surface active agents
WO2001058849A1 (en) * 2000-02-11 2001-08-16 Consejo Superior De Investigaciones Cientificas SURFACE ACTIVE AGENTS DERIVED FROM 1-O-Nα-ACETYL-L-AMINOACYL ESTER 3-O-MONOACYL GLYCERIDES AND 1-O-Nα-ACETYL L-AMINOACYL ESTER 2,3-O-DIACYL GLYCERIDES TYPE AMINO ACIDS AND THE PREPARATION THEREOF
ES2163368A1 (en) * 2000-02-11 2002-01-16 Consejo Superior Investigacion 1-O-L-arginyl ester 3-O-monoacyl glycerides and 1-O-L-arginyl ester 2,3-O-diacyl glycerides type surface active agents
ES2163367A1 (en) * 2000-02-11 2002-01-16 Consejo Superior Investigacion New 1-O-N-acetylaminoacyl-glycerol ester derivatives are useful as antimicrobials with high surfactant activity and adjustable properties
US7015019B2 (en) 2000-02-11 2006-03-21 Consejo Superior De Investigaciones Cientificas 1-O-L-arginyl ester 3-O-monoacyl glycerides and 1-O-L-arginyl ester 2,3-O-diacyl glycerides type surface active agents

Also Published As

Publication number Publication date
ES2130980B1 (en) 2000-04-01

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