ES2130980A1 - Enzyme process for the preparation of lipoamino acids of the alkyl amide and ester type - Google Patents
Enzyme process for the preparation of lipoamino acids of the alkyl amide and ester typeInfo
- Publication number
- ES2130980A1 ES2130980A1 ES09700520A ES9700520A ES2130980A1 ES 2130980 A1 ES2130980 A1 ES 2130980A1 ES 09700520 A ES09700520 A ES 09700520A ES 9700520 A ES9700520 A ES 9700520A ES 2130980 A1 ES2130980 A1 ES 2130980A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- alkyl
- ester type
- chain
- chr1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Enzyme process for the preparation of lipoamino acids of the alkyl amide and ester type. This relates to a process for the synthesis of single- chain lipid derivatives of amino acids of general formula H2N-CHR1-CO-NH-R2 and H2N-CHR1-CO-O-R2, where R1 may be a hydrogen, a straight or branched optionally substituted saturated or unsaturated chain or an optionally substituted aromatic group and R2 is an alkyl chain of any length. It involves the use of hydrolytic enzyme to form amide and ester links between an amino acid derivative and an alkyl amine or alcohol respectively. The advantages offered are fundamentally that it eliminates the production of undesirable by-products, that it is stereospecific (regionally selective and enantioselective), the operating conditions are mild and it can be scaled to industrial level. For this reason this new process can be an alternative to the conventional synthesis for the preparation of these surfactants of natural origin and low toxicity.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9700520A ES2130980B1 (en) | 1997-03-10 | 1997-03-10 | ENZYMATIC PROCEDURE FOR THE PREPARATION OF LIPOAMINOACIDOS OF THE ALKYL AMID AND ESTER TYPE. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9700520A ES2130980B1 (en) | 1997-03-10 | 1997-03-10 | ENZYMATIC PROCEDURE FOR THE PREPARATION OF LIPOAMINOACIDOS OF THE ALKYL AMID AND ESTER TYPE. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2130980A1 true ES2130980A1 (en) | 1999-07-01 |
ES2130980B1 ES2130980B1 (en) | 2000-04-01 |
Family
ID=8298575
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9700520A Expired - Fee Related ES2130980B1 (en) | 1997-03-10 | 1997-03-10 | ENZYMATIC PROCEDURE FOR THE PREPARATION OF LIPOAMINOACIDOS OF THE ALKYL AMID AND ESTER TYPE. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2130980B1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001058860A1 (en) * | 2000-02-11 | 2001-08-16 | Consejo Superior De Investigaciones Cientificas | 1-o-l-arginyl ester 3-o-monoacyl glycerides and 1-o-l-arginyl ester 2,3-o-diacyl glycerides type surface active agents |
WO2001058849A1 (en) * | 2000-02-11 | 2001-08-16 | Consejo Superior De Investigaciones Cientificas | SURFACE ACTIVE AGENTS DERIVED FROM 1-O-Nα-ACETYL-L-AMINOACYL ESTER 3-O-MONOACYL GLYCERIDES AND 1-O-Nα-ACETYL L-AMINOACYL ESTER 2,3-O-DIACYL GLYCERIDES TYPE AMINO ACIDS AND THE PREPARATION THEREOF |
ES2163368A1 (en) * | 2000-02-11 | 2002-01-16 | Consejo Superior Investigacion | 1-O-L-arginyl ester 3-O-monoacyl glycerides and 1-O-L-arginyl ester 2,3-O-diacyl glycerides type surface active agents |
ES2163367A1 (en) * | 2000-02-11 | 2002-01-16 | Consejo Superior Investigacion | New 1-O-N-acetylaminoacyl-glycerol ester derivatives are useful as antimicrobials with high surfactant activity and adjustable properties |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2254554A1 (en) * | 1973-12-12 | 1975-07-11 | Ajinomoto Kk | |
ES8303312A1 (en) * | 1982-05-28 | 1983-02-16 | Consejo Superior Investigacion | New procedure for the preparation of N-acil-alkylaminoguanidic acids and any of their salts, as surgical agents of antimicrobial action. (Machine-translation by Google Translate, not legally binding) |
WO1990014429A1 (en) * | 1989-05-25 | 1990-11-29 | Novo Nordisk A/S | An enzyme-catalyzed process for preparing n-acyl amino acids and n-acyl amino acid amides |
-
1997
- 1997-03-10 ES ES9700520A patent/ES2130980B1/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2254554A1 (en) * | 1973-12-12 | 1975-07-11 | Ajinomoto Kk | |
ES8303312A1 (en) * | 1982-05-28 | 1983-02-16 | Consejo Superior Investigacion | New procedure for the preparation of N-acil-alkylaminoguanidic acids and any of their salts, as surgical agents of antimicrobial action. (Machine-translation by Google Translate, not legally binding) |
WO1990014429A1 (en) * | 1989-05-25 | 1990-11-29 | Novo Nordisk A/S | An enzyme-catalyzed process for preparing n-acyl amino acids and n-acyl amino acid amides |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001058860A1 (en) * | 2000-02-11 | 2001-08-16 | Consejo Superior De Investigaciones Cientificas | 1-o-l-arginyl ester 3-o-monoacyl glycerides and 1-o-l-arginyl ester 2,3-o-diacyl glycerides type surface active agents |
WO2001058849A1 (en) * | 2000-02-11 | 2001-08-16 | Consejo Superior De Investigaciones Cientificas | SURFACE ACTIVE AGENTS DERIVED FROM 1-O-Nα-ACETYL-L-AMINOACYL ESTER 3-O-MONOACYL GLYCERIDES AND 1-O-Nα-ACETYL L-AMINOACYL ESTER 2,3-O-DIACYL GLYCERIDES TYPE AMINO ACIDS AND THE PREPARATION THEREOF |
ES2163368A1 (en) * | 2000-02-11 | 2002-01-16 | Consejo Superior Investigacion | 1-O-L-arginyl ester 3-O-monoacyl glycerides and 1-O-L-arginyl ester 2,3-O-diacyl glycerides type surface active agents |
ES2163367A1 (en) * | 2000-02-11 | 2002-01-16 | Consejo Superior Investigacion | New 1-O-N-acetylaminoacyl-glycerol ester derivatives are useful as antimicrobials with high surfactant activity and adjustable properties |
US7015019B2 (en) | 2000-02-11 | 2006-03-21 | Consejo Superior De Investigaciones Cientificas | 1-O-L-arginyl ester 3-O-monoacyl glycerides and 1-O-L-arginyl ester 2,3-O-diacyl glycerides type surface active agents |
Also Published As
Publication number | Publication date |
---|---|
ES2130980B1 (en) | 2000-04-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19990701 Kind code of ref document: A1 Effective date: 19990701 |
|
FD2A | Announcement of lapse in spain |
Effective date: 20180807 |