ES2129835T3 - Purificacion de propofol. - Google Patents
Purificacion de propofol.Info
- Publication number
- ES2129835T3 ES2129835T3 ES95925780T ES95925780T ES2129835T3 ES 2129835 T3 ES2129835 T3 ES 2129835T3 ES 95925780 T ES95925780 T ES 95925780T ES 95925780 T ES95925780 T ES 95925780T ES 2129835 T3 ES2129835 T3 ES 2129835T3
- Authority
- ES
- Spain
- Prior art keywords
- propofol
- purification
- neutralization
- gross
- purity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/68—Purification; separation; Use of additives, e.g. for stabilisation
- C07C37/86—Purification; separation; Use of additives, e.g. for stabilisation by treatment giving rise to a chemical modification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
EL PROPOFOL SE PURIFICA MEDIANTE LA REACCION DEL 2,6DIISOPROPILFENOL BRUTO CON UN AGENTE ALCALINO, MEDIANTE EL AISLAMIENTO DE LA SAL DE METAL ALCALINO Y MEDIANTE LA NEUTRALIZACION DEL MISMO. EL PROPOFOL ASI OBTENIDO TIENE UNA PUREZA DE AL MENOS EL 99,90%.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI941377A IT1269977B (it) | 1994-07-01 | 1994-07-01 | Purificazione del propofol |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2129835T3 true ES2129835T3 (es) | 1999-06-16 |
Family
ID=11369202
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95925780T Expired - Lifetime ES2129835T3 (es) | 1994-07-01 | 1995-06-28 | Purificacion de propofol. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5696300A (es) |
EP (1) | EP0716645B1 (es) |
JP (1) | JP3751022B2 (es) |
AU (1) | AU2978595A (es) |
DE (1) | DE69508894T2 (es) |
DK (1) | DK0716645T3 (es) |
ES (1) | ES2129835T3 (es) |
IT (1) | IT1269977B (es) |
WO (1) | WO1996001243A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7991448B2 (en) | 1998-10-15 | 2011-08-02 | Philips Electronics North America Corporation | Method, apparatus, and system for removing motion artifacts from measurements of bodily parameters |
KR20000047871A (ko) * | 1998-12-04 | 2000-07-25 | 강재헌 | 고순도 2,6-디이소프로필페놀의 정제방법 |
WO2000034218A1 (en) * | 1998-12-04 | 2000-06-15 | Dong Kook Pharmaceutical Co., Ltd. | Process for purification of 2,6-diisopropyl phenol |
EP2516369B1 (en) | 2010-06-23 | 2015-07-22 | Harman Finochem Limited | Process for preparing extra pure 2, 6-diisopropyl phenol |
CN103360219B (zh) * | 2012-04-06 | 2015-08-19 | 辽宁诺康生物制药有限责任公司 | 一种高纯度丙泊酚的合成方法 |
US9045684B2 (en) * | 2012-07-30 | 2015-06-02 | Jnc Corporation | Liquid crystal composition, antioxidant and liquid crystal display device |
US8772209B2 (en) * | 2012-11-20 | 2014-07-08 | Chevron Oronite Company Lls | Process for preparing a salt of a sulfurized alkyl-substituted hydroxyaromatic composition |
WO2021156776A1 (en) * | 2020-02-06 | 2021-08-12 | Nandkumar Chodankar | Simple manufacturing and purification technology for high purity propofol |
CN114133318B (zh) * | 2021-12-09 | 2023-08-29 | 广东嘉博制药有限公司 | 一种降除丙泊酚产品中丙泊酚杂质o的方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2831898A (en) | 1954-04-29 | 1958-04-22 | Ethyl Corp | Phenol alkylation process |
GB855489A (en) * | 1959-04-23 | 1960-11-30 | Yorkshire Tar Distillers Ltd | Isolation of dimethyl phenol |
US3517072A (en) * | 1963-10-28 | 1970-06-23 | Consolidation Coal Co | High purity 2,6-xylenol |
GB1316276A (en) * | 1969-12-12 | 1973-05-09 | Coalite Chemical Products Ltd | Separation of chlorophenols |
US3630855A (en) * | 1970-05-04 | 1971-12-28 | Dow Chemical Co | Process for removing naphthalene from phenol by extractive distillation |
SU443019A1 (ru) | 1973-01-05 | 1974-09-15 | Предприятие П/Я Г-4740 | Способ получени 2,6-диизопропилфенола |
GB1472793A (en) | 1974-03-28 | 1977-05-04 | Ici Ltd | Pharmaceutical compositions |
US4103096A (en) | 1977-10-13 | 1978-07-25 | Stauffer Chemical Company | Preparation of meta-alkylphenols |
US4208537A (en) | 1977-10-27 | 1980-06-17 | Mitsui Toatsu Chemicals Incorporated | Process for the selective ortho-alkylation of phenolic compounds |
US4275248A (en) | 1979-06-25 | 1981-06-23 | Uop Inc. | Preparation of 2,4,6-triisopropylphenol |
FR2530877A1 (fr) | 1982-07-22 | 1984-01-27 | Marchal Equip Auto | Porte-balais et moteur electrique muni d'un tel porte-balais |
US4447657A (en) | 1982-11-10 | 1984-05-08 | Uop Inc. | Preparation of ortho-alkylated phenols |
DE3314372A1 (de) | 1983-04-20 | 1984-10-25 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von substituierten phenolen |
JPS62209034A (ja) | 1986-03-08 | 1987-09-14 | Maruzen Petrochem Co Ltd | 2,6−ジ−t−ブチルフエノ−ルの製造法 |
FI912102A (fi) * | 1991-04-30 | 1992-10-31 | Leiras Oy | Foerfarande foer rening av 2,6-diisopropylfenol |
FR2686293B1 (fr) | 1992-01-17 | 1995-03-24 | Oce Graphics France | Machine a dessiner a outils d'ecriture interchangeables a partir d'une reserve d'outils, avec possiblite de definition de groupes d'outils stockes, reserve d'outils et procede de definition de groupes d'outils pour une telle machine. |
-
1994
- 1994-07-01 IT ITMI941377A patent/IT1269977B/it active IP Right Grant
-
1995
- 1995-06-28 DK DK95925780T patent/DK0716645T3/da active
- 1995-06-28 AU AU29785/95A patent/AU2978595A/en not_active Abandoned
- 1995-06-28 EP EP95925780A patent/EP0716645B1/en not_active Expired - Lifetime
- 1995-06-28 JP JP50366196A patent/JP3751022B2/ja not_active Expired - Lifetime
- 1995-06-28 DE DE69508894T patent/DE69508894T2/de not_active Expired - Lifetime
- 1995-06-28 ES ES95925780T patent/ES2129835T3/es not_active Expired - Lifetime
- 1995-06-28 US US08/591,600 patent/US5696300A/en not_active Expired - Lifetime
- 1995-06-28 WO PCT/EP1995/002520 patent/WO1996001243A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ITMI941377A0 (it) | 1994-07-01 |
EP0716645B1 (en) | 1999-04-07 |
IT1269977B (it) | 1997-04-16 |
EP0716645A1 (en) | 1996-06-19 |
ITMI941377A1 (it) | 1996-01-01 |
JP3751022B2 (ja) | 2006-03-01 |
WO1996001243A1 (en) | 1996-01-18 |
DK0716645T3 (da) | 1999-10-18 |
US5696300A (en) | 1997-12-09 |
DE69508894D1 (de) | 1999-05-12 |
DE69508894T2 (de) | 1999-08-12 |
AU2978595A (en) | 1996-01-25 |
JPH09506904A (ja) | 1997-07-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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