ES2124064T3 - Compuestos y composiciones con cadenas laterales nitrogenadas no basicas. - Google Patents

Compuestos y composiciones con cadenas laterales nitrogenadas no basicas.

Info

Publication number
ES2124064T3
ES2124064T3 ES96303910T ES96303910T ES2124064T3 ES 2124064 T3 ES2124064 T3 ES 2124064T3 ES 96303910 T ES96303910 T ES 96303910T ES 96303910 T ES96303910 T ES 96303910T ES 2124064 T3 ES2124064 T3 ES 2124064T3
Authority
ES
Spain
Prior art keywords
compounds
side chains
present
basic
nitrogenated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96303910T
Other languages
English (en)
Inventor
Jeffrey Alan Dodge
James Patrick Sluka
Kristin Sue Marron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2124064T3 publication Critical patent/ES2124064T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

LA PRESENTE INVENCION SUMINSTRA COMPUESTOS DE BENZOTIOFENO CON CADENAS LATERALES NO BASICAS QUE CONTIENEN NITROGENO. LA PRESENTE INVENCION TAMBIEN SUMINISTRA COMPOSICIONES FARMACEUTICAS QUE CONTIENEN DICHOS COMPUESTOS, CONTENIENDO OPCIONALMENTE ESTROGENO O PROGESTINA, Y EL USO DE TALES COMPUESTOS, SOLOS O EN COMBINACION CON ESTROGENO O PROGESTINA, PARA ALIVIAR LOS SINTOMAS DE LOS SINTOMAS POSMENOPAUSICOS, PARTICULARMENTE OSTEOPOROSIS, CONDICIONES CARDIOVASCULARES PATOLOGICAS RELACIONADAS,Y CANCER DEPENDIENTE DE LOS ESTROGENOSA. LA PRESENTE INVENCION ADEMAS SUMINISTRA EL USO DE LOS COMPUESTOS DE LA INVENCION PARA INHIBIR LA ENFERMEDAD FIBROIDE UTERINA Y ENDOMETRIOSIS EN LAS MUJERES Y LA PROLIFERACION DE CELULAS MUSCULARES LISAS AORTALES, PARTICULARMENTE LAS REESTENOSIS, EN LOS HUMANOS.
ES96303910T 1995-06-07 1996-05-30 Compuestos y composiciones con cadenas laterales nitrogenadas no basicas. Expired - Lifetime ES2124064T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47359895A 1995-06-07 1995-06-07

Publications (1)

Publication Number Publication Date
ES2124064T3 true ES2124064T3 (es) 1999-01-16

Family

ID=23880230

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96303910T Expired - Lifetime ES2124064T3 (es) 1995-06-07 1996-05-30 Compuestos y composiciones con cadenas laterales nitrogenadas no basicas.

Country Status (5)

Country Link
EP (1) EP0747380B1 (es)
JP (1) JPH08333366A (es)
CA (1) CA2178182A1 (es)
DE (1) DE69600709T2 (es)
ES (1) ES2124064T3 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0801066A1 (en) * 1996-03-12 1997-10-15 Eli Lilly And Company Heterocyclic substituted benzothiophenes and pharmaceutical compositions
US6090843A (en) * 1997-08-11 2000-07-18 Eli Lilly And Company Benzothiophenes compounds which have useful pharmaceutical activity
JP2001517664A (ja) * 1997-09-23 2001-10-09 イーライ・リリー・アンド・カンパニー ベンゾチオフェン類
KR100506513B1 (ko) 1997-12-27 2007-11-02 주식회사 하이닉스반도체 강유전체 캐패시터 형성 방법
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
AU3171099A (en) * 1998-04-17 1999-11-08 Senga Pharmaceutical Laboratory Inc. 1-heteroindene derivatives and medicinal composition containing the same
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6060488A (en) * 1998-09-22 2000-05-09 Eli Lilly And Company Benzothiophenes for treating estrogen deficiency
EP1395563B1 (en) 2001-05-22 2006-03-29 Eli Lilly And Company 2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods
ES2236536T3 (es) 2001-05-22 2005-07-16 Eli Lilly And Company Derivados tetrahidroquinolino para la inhibicion de enfermedades asociadas con la privacion de estrogenos o con una respuesta fisiologica aberrante a estrogenos endogenos.
CN116813603A (zh) * 2023-06-02 2023-09-29 成都市第三人民医院 一种选择性***受体α降解化合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230862A (en) * 1975-10-28 1980-10-28 Eli Lilly And Company Antifertility compounds
GB2097788B (en) * 1981-04-03 1985-04-24 Lilly Co Eli Benzothiophene compounds and process for preparing them
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
US5461065A (en) * 1993-10-15 1995-10-24 Eli Lilly And Company Methods for inhibiting endometriosis
US5492921A (en) * 1994-09-20 1996-02-20 Eli Lilly And Company Benzothiophene compounds, compositions, and methods for inhibiting aortal smooth muscle proliferation

Also Published As

Publication number Publication date
EP0747380B1 (en) 1998-09-30
DE69600709T2 (de) 1999-03-18
EP0747380A1 (en) 1996-12-11
CA2178182A1 (en) 1996-12-08
DE69600709D1 (de) 1998-11-05
JPH08333366A (ja) 1996-12-17

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