ES2120506T3 - Nuevas amidas, sulfonamidas y sulfonamidas de piperidilo utilizadas como inhibidores de la biosintesis del colesterol. - Google Patents
Nuevas amidas, sulfonamidas y sulfonamidas de piperidilo utilizadas como inhibidores de la biosintesis del colesterol.Info
- Publication number
- ES2120506T3 ES2120506T3 ES93914338T ES93914338T ES2120506T3 ES 2120506 T3 ES2120506 T3 ES 2120506T3 ES 93914338 T ES93914338 T ES 93914338T ES 93914338 T ES93914338 T ES 93914338T ES 2120506 T3 ES2120506 T3 ES 2120506T3
- Authority
- ES
- Spain
- Prior art keywords
- inhibitors
- sulphonamides
- cholesterol biosynthesis
- amides
- sulfonamides used
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A CIERTAS NUEVAS AMIDAS PIPERIDILO, SULFONAMIDAS Y SULFOXAMIDAS DE LA FORMULA (I) Y (II) QUE SON UTILES COMO INHIBIDORES DE BIOSINTESIS DE COLESTEROL Y COMO AGENTES QUE BAJAN EL COLESTEROL TOTAL EN EL SUERO EN PACIENTES QUE LO NECESITAN, EN DONDE A ES ALQUILENO C2 ES UN METILENO, OXIGENO, AZUFRE, SULFUNILO O SULFONILO; B ES UN ALQUILENO C2 ENTERO 0, 1 O 2; Y R ES (CH2)MOH, CON LA CONDICION DE QUE CUANDO M ES 0, R NO PUEDE ESTAR EN LA POSICION 2 DEL ANILLO DE PIPERIDINA O UN RADICAL DE LA FORMULA (C), EN DONDE N ES UN ENTERO 0, 1, 2 O 3; Y R1 ES HIDROGENO, FENILO, VINILO O UN ALQUILO C1 RMULA (C), Y NO ES METILENO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91060492A | 1992-07-08 | 1992-07-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2120506T3 true ES2120506T3 (es) | 1998-11-01 |
Family
ID=25429048
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93914338T Expired - Lifetime ES2120506T3 (es) | 1992-07-08 | 1993-06-03 | Nuevas amidas, sulfonamidas y sulfonamidas de piperidilo utilizadas como inhibidores de la biosintesis del colesterol. |
Country Status (14)
Country | Link |
---|---|
US (2) | US5350758A (es) |
EP (1) | EP0650474B1 (es) |
JP (1) | JPH07508732A (es) |
KR (1) | KR100286410B1 (es) |
AT (1) | ATE169618T1 (es) |
AU (1) | AU678973B2 (es) |
CA (1) | CA2136841C (es) |
DE (1) | DE69320352T2 (es) |
ES (1) | ES2120506T3 (es) |
IL (1) | IL106237A0 (es) |
MX (1) | MX9304070A (es) |
NZ (1) | NZ253592A (es) |
WO (1) | WO1994001404A1 (es) |
ZA (1) | ZA934777B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6103733A (en) * | 1998-09-09 | 2000-08-15 | Bachmann; Kenneth A. | Method for increasing HDL cholesterol levels using heteroaromatic phenylmethanes |
KR100601501B1 (ko) * | 2004-09-24 | 2006-07-18 | 삼성에스디아이 주식회사 | 이차전지의 팩 케이스 |
US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
CN101663262B (zh) | 2006-12-01 | 2014-03-26 | 百时美施贵宝公司 | 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物 |
US20130072519A1 (en) | 2010-05-21 | 2013-03-21 | Edward Lee Conn | 2-phenyl benzoylamides |
EP2680874A2 (en) | 2011-03-04 | 2014-01-08 | Pfizer Inc | Edn3-like peptides and uses thereof |
CN105143203A (zh) | 2013-04-17 | 2015-12-09 | 辉瑞大药厂 | 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物 |
WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
CN113574055B (zh) | 2019-01-18 | 2024-07-23 | 阿斯利康(瑞典)有限公司 | Pcsk9抑制剂及其使用方法 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2580411A (en) * | 1948-10-23 | 1952-01-01 | Searle & Co | Dihexyl alanine dialkylamides |
FR1261160A (fr) * | 1955-07-28 | 1961-05-19 | Procédé de préparation de n-t-alkyl-dialkylamino-amides | |
NL109859C (es) * | 1957-09-27 | |||
US3185678A (en) * | 1961-08-04 | 1965-05-25 | Colgate Palmolive Co | Polymethyleniminoalkylamides |
US3178439A (en) * | 1963-05-06 | 1965-04-13 | Reilly Tar & Chem Corp | N-alkanoyl and alkenoyl hydroxy alkyl piperidides |
CH448086A (de) * | 1965-01-15 | 1967-12-15 | Geigy Ag J R | Verfahren zur Herstellung von neuen Derivaten des 1,2,3,6-Tetrahydro-pyridins |
DE1719388B2 (de) * | 1968-02-09 | 1976-04-29 | Bayer Ag, 5090 Leverkusen | Verfahren zum faerben von fasermaterialien aus polyacrylnitril oder acrylnitrilhaltigen mischpolymerisaten |
GB1415682A (en) * | 1972-06-30 | 1975-11-26 | Wyeth John & Brother Ltd | Amides and thioamides |
GB1420758A (en) * | 1972-07-12 | 1976-01-14 | Wyeth John & Brother Ltd | Anti-ulcer compositions |
US3968211A (en) * | 1974-02-11 | 1976-07-06 | The Upjohn Company | Compositions and methods of use of amidines for anti-arrhythmic purposes |
JPS5344573A (en) * | 1976-10-01 | 1978-04-21 | Teijin Ltd | Optical active 2-piperidineethanols and their preparation |
US4316903A (en) * | 1977-07-18 | 1982-02-23 | Merck & Co., Inc. | Anti-microbial piperidino buten-2-ones |
JPS55129255A (en) * | 1979-03-28 | 1980-10-06 | Kuraray Co Ltd | Farnesylacetamide compounds or their salts |
DE2947649A1 (de) * | 1979-11-27 | 1981-08-06 | C.F. Spiess & Sohn GmbH & Co, 6719 Kleinkarlbach | Insektizide mittel |
US4565819A (en) * | 1979-12-07 | 1986-01-21 | Adir | Substituted imino diacids, their preparation and pharmaceutical compositions which contain them |
US4326067A (en) * | 1980-12-03 | 1982-04-20 | The Dow Chemical Company | Process for making N-(2-aminoethyl)amides |
US4695575A (en) * | 1984-11-13 | 1987-09-22 | Janssen Pharmaceutica, N.V. | 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines |
DE3433036A1 (de) * | 1984-09-08 | 1986-03-20 | Basf Ag, 6700 Ludwigshafen | Piperidinderivate und diese enthaltende fungizide sowie verfahren zur bekaempfung von pilzen |
US4812451A (en) * | 1984-10-19 | 1989-03-14 | A. H. Robins Company, Incorporated | 1-(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-α,.alpha. |
US4906659A (en) * | 1985-06-18 | 1990-03-06 | Takeda Chemical Industries, Ltd. | Antibiotic tan-749, its derivatives, production and use thereof |
EP0235942B1 (en) * | 1986-02-01 | 1994-03-23 | Nippon Chemiphar Co., Ltd. | Alkylenediamine derivatives |
DE3814549A1 (de) * | 1987-10-30 | 1989-05-18 | Bayer Ag | N-substituierte derivate von 1-desoxynojirimycin und 1-desoxymannonojirimycin, verfahren zu deren herstellung und deren verwendung in arzneimitteln |
DK168069B1 (da) * | 1987-11-11 | 1994-01-31 | Hoffmann La Roche | Isoquinolinderivater og en fremgangsmaade til fremstilling af octahydroisoquinoliner ud fra derivaterne |
FR2649490B1 (fr) * | 1989-07-07 | 1991-09-20 | Thomson Csf | Capteur de rayonnement d'energie electromagnetique |
CA2025490C (en) * | 1989-09-22 | 2003-09-16 | James R. Mccarthy | Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis |
EP0421441B1 (en) * | 1989-10-06 | 1995-01-25 | Fujirebio Inc. | Pantothenic acid derivatives |
NZ239023A (en) * | 1990-07-24 | 1993-12-23 | Merrell Dow Pharma | N-substituted-hydroxyalkyl piperidine derivatives and pharmaceutical |
NZ239022A (en) * | 1990-07-25 | 1993-11-25 | Merrell Dow Pharma | Piperidyl ethers and thioethers; preparatory processes and pharmaceutical compositions |
ATE119774T1 (de) * | 1990-07-30 | 1995-04-15 | Takeda Chemical Industries Ltd | Imidazopyridinderivate und ihre verwendung. |
US5084461A (en) * | 1991-03-27 | 1992-01-28 | Merrell Dow Pharmaceuticals Inc. | Azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis |
-
1992
- 1992-12-18 US US07/993,497 patent/US5350758A/en not_active Expired - Fee Related
-
1993
- 1993-06-03 JP JP6502739A patent/JPH07508732A/ja active Pending
- 1993-06-03 AT AT93914338T patent/ATE169618T1/de not_active IP Right Cessation
- 1993-06-03 DE DE69320352T patent/DE69320352T2/de not_active Expired - Fee Related
- 1993-06-03 KR KR1019950700066A patent/KR100286410B1/ko not_active IP Right Cessation
- 1993-06-03 ES ES93914338T patent/ES2120506T3/es not_active Expired - Lifetime
- 1993-06-03 EP EP93914338A patent/EP0650474B1/en not_active Expired - Lifetime
- 1993-06-03 CA CA002136841A patent/CA2136841C/en not_active Expired - Fee Related
- 1993-06-03 NZ NZ253592A patent/NZ253592A/en unknown
- 1993-06-03 AU AU44037/93A patent/AU678973B2/en not_active Ceased
- 1993-06-03 WO PCT/US1993/005265 patent/WO1994001404A1/en active IP Right Grant
- 1993-07-02 ZA ZA934777A patent/ZA934777B/xx unknown
- 1993-07-05 IL IL106237A patent/IL106237A0/xx unknown
- 1993-07-07 MX MX9304070A patent/MX9304070A/es not_active IP Right Cessation
-
1994
- 1994-05-25 US US08/248,894 patent/US5489600A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69320352T2 (de) | 1998-12-17 |
AU4403793A (en) | 1994-01-31 |
JPH07508732A (ja) | 1995-09-28 |
IL106237A0 (en) | 1993-11-15 |
MX9304070A (es) | 1994-02-28 |
AU678973B2 (en) | 1997-06-19 |
CA2136841A1 (en) | 1994-01-20 |
EP0650474A1 (en) | 1995-05-03 |
EP0650474B1 (en) | 1998-08-12 |
ATE169618T1 (de) | 1998-08-15 |
KR100286410B1 (ko) | 2001-04-16 |
US5350758A (en) | 1994-09-27 |
NZ253592A (en) | 1996-04-26 |
WO1994001404A1 (en) | 1994-01-20 |
US5489600A (en) | 1996-02-06 |
CA2136841C (en) | 1998-10-06 |
KR950702534A (ko) | 1995-07-29 |
ZA934777B (en) | 1994-01-20 |
DE69320352D1 (de) | 1998-09-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2103488T3 (es) | N-(alcanoilamino-2-hidroxipropil)sulfonamidas utiles como inhibidores de proteasas retrovirales. | |
CY1108610T1 (el) | Πεπτιδια της il-2 και παραγωγα αυτων και χρηση αυτων ως θεραπευτικοι παραγοντες | |
DK0760848T3 (da) | Lactobacillusstammer af menneskelig oprindelse, deres sammensætninger og anvendelse deraf | |
DE69837393D1 (de) | Stimulierung von hämatopoietischen zellen im vitro | |
TR200101867T2 (tr) | CCR5 modülatörleri olarak piperidinler | |
DE69830404D1 (de) | P38-inhibitoren | |
BG102863A (en) | Benzasepins as antagonists of fibrinogen and pharmaceutical compositions containing the compounds | |
ES2117123T3 (es) | Derivados de aminocetilmercaptoacetilamida utilizados como inhibidores de la encefalinasa y del enzima de conversion de angiotensina. | |
BR9713338A (pt) | Benzonaftiridinas como terapêuticos brÈnquicos. | |
ATE214610T1 (de) | Neuartige pharmazeutische verwendungen von krill- enzymen | |
ES2120506T3 (es) | Nuevas amidas, sulfonamidas y sulfonamidas de piperidilo utilizadas como inhibidores de la biosintesis del colesterol. | |
ES2086436T3 (es) | Nuevos eteres y tioeteres de piperidilo inhibidores de la biosintesis de colesterol. | |
DE69614149D1 (de) | Chinolinderivate als antimalariamittel | |
ATE300300T1 (de) | Zusammensetzungen und verwendungvon benzamiden als entzuendungshemmende mittel | |
ES2088128T3 (es) | Aminosulfonilureas inhibidoras de acat. | |
DK0506836T3 (da) | BCRF1 proteiner som inhibitorer for interferon-gamma | |
DE60019117D1 (de) | Substituierte benzamide als inhibitoren von rhinovirus 3c protease | |
ATE28188T1 (de) | Antikonvulsive mittel. | |
ATE57526T1 (de) | P-acylaminobenzamide. | |
FI961339A (fi) | Triaryylieteenijohdannaiset käytettäväksi hoidossa | |
TR199901385T2 (xx) | Piperidin t�revleri. | |
DE59808166D1 (de) | Verwendung von 2-methyl-thiazolidin-2,4-dicarbonsäure als mukolytikum | |
BR9712332A (pt) | Composições detergentes contendo isopeptidade | |
ES2046217T3 (es) | Lanosteroles 14,15-sustituidos y su uso como agentes hipocolesterolemicos. | |
ATE194079T1 (de) | Verwendung von einer suspension auf der basis von sucralfatgel als antazidum |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 650474 Country of ref document: ES |