ES2119106T3 - Nuevos benzo-espiro-alquenos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. - Google Patents

Nuevos benzo-espiro-alquenos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2119106T3
ES2119106T3 ES94401549T ES94401549T ES2119106T3 ES 2119106 T3 ES2119106 T3 ES 2119106T3 ES 94401549 T ES94401549 T ES 94401549T ES 94401549 T ES94401549 T ES 94401549T ES 2119106 T3 ES2119106 T3 ES 2119106T3
Authority
ES
Spain
Prior art keywords
branched
linear
group
unsubstituted
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94401549T
Other languages
English (en)
Inventor
Alex Cordi
Jean-Michel Lacoste
Michel Laubie
Tony Verbeuren
Jean-Jacques Descombes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2119106T3 publication Critical patent/ES2119106T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Abstract

COMPUESTOS DE FORMULA (I): EN LA QUE: RE O UN GRUPO UN GRUPO DE ALQUILO (C1 ENTA UN ATOMO DE HIDROGENO, DE HALOGENO, UN GRUPO DE ALQUILO (C1 XI, UN GRUPO ALCOXI (C1 LQUILTIO (C1 MO DE HIDROGENO, DE HALOGENO, UN GRUPO ALQUILO (C1 EAL O RAMIFICADO O UN GRUPO ALQUILTIO (C1 C6) LINEAL O RAMIFICADO, QUE EN ESTE CASO R1 REPRESENTE UN ATOMO DE HIDROGENO), UN ATOMO DE HALOGENO, UN GRUPO ALQUILO (C1 (SUSTITUIDO O NO) O UN GRUPO HIDROXI, O BIEN 3, R3 Y R4 O R4 Y X FORMAN JUNTO CON LOS ATOMOS DE CARBONO QUE LOS LLEVAN, UN CICLO BENZENICO CON LA CONDICION DE QUE EN CASO DE QUE R1 Y R2 FORMEN UN CICLO BENZENICO, X TIENE QUE SER DIFERENTE DE ROGENO O UN GRUPO AMINO (SUSTITUIDO O NO), SIGNIFICADO QUE R1, SUS ISOMEROS ASI COMO SUS SALES DE ADICION A UN ACIDO FARMACEUTICAMENTE ACEPTABLE. MEDICAMENTOS.
ES94401549T 1993-07-20 1994-07-06 Nuevos benzo-espiro-alquenos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2119106T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9308861A FR2709306B1 (fr) 1993-07-20 1993-07-20 Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
ES2119106T3 true ES2119106T3 (es) 1998-10-01

Family

ID=9449388

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94401549T Expired - Lifetime ES2119106T3 (es) 1993-07-20 1994-07-06 Nuevos benzo-espiro-alquenos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.

Country Status (14)

Country Link
US (1) US5436261A (es)
EP (1) EP0635497B1 (es)
JP (1) JP3105138B2 (es)
AT (1) ATE166345T1 (es)
AU (1) AU674080B2 (es)
CA (1) CA2128359C (es)
CY (1) CY2158B1 (es)
DE (1) DE69410359T2 (es)
DK (1) DK0635497T3 (es)
ES (1) ES2119106T3 (es)
FR (1) FR2709306B1 (es)
HK (1) HK1009648A1 (es)
NZ (1) NZ264050A (es)
ZA (1) ZA945337B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2707981B1 (fr) * 1993-07-20 1995-09-01 Adir Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US6156783A (en) * 1996-04-30 2000-12-05 Smithkline Beecham P.L.C. Spiroazabicyclic compounds, processes for their preparation, and their pharmaceutical use
FR2787450B1 (fr) * 1998-12-18 2001-01-26 Adir Nouveaux derives spiroimidazoliniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2004222378B2 (en) 2003-03-14 2008-08-14 Merck Sharp & Dohme Corp. Carboxamide spirohydantoin CGRP receptor antagonists
US7115767B2 (en) * 2003-07-18 2006-10-03 Abbott Laboratories Tetraline derivatives as ghrelin receptor modulators
EP1951042B1 (en) * 2005-11-18 2012-10-10 Merck Sharp & Dohme Corp. Spirolactam tricyclic cgrp receptor antagonists
JP2009515975A (ja) 2005-11-18 2009-04-16 メルク エンド カムパニー インコーポレーテッド 二環式スピロヒダントインｃｇｒｐ受容体アンタゴニスト
EP1951051B1 (en) 2005-11-18 2012-10-03 Merck Sharp & Dohme Corp. Spirohydantoin tricyclic cgrp receptor antagonists
JP2009515976A (ja) * 2005-11-18 2009-04-16 メルク エンド カムパニー インコーポレーテッド スピロラクタム二環式ｃｇｒｐ受容体アンタゴニスト
AU2006316627A1 (en) * 2005-11-18 2007-05-31 Merck Sharp & Dohme Corp. Spirolactam aryl CGRP receptor antagonists
WO2007061676A2 (en) 2005-11-18 2007-05-31 Merck & Co., Inc. Spirohydantoin aryl cgrp receptor antagonists
US8324213B2 (en) 2008-10-07 2012-12-04 Merck Sharp & Dohme Corp. Biaryl-spiroaminooxazoline analogues as alpha 2C adrenergic receptor modulators
US20130079271A1 (en) * 2009-10-01 2013-03-28 Kevin D. McCormick Reversed biaryl spiroaminooxazoline analogues as alpha2c adrenergic receptor modulators

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2716648A (en) * 1955-08-30 Hydantoin derivatives
US3532744A (en) * 1967-07-28 1970-10-06 American Home Prod 1- and 2-amino substituted indane and tetralene carboxylic acids

Also Published As

Publication number Publication date
FR2709306A1 (fr) 1995-03-03
FR2709306B1 (fr) 1995-10-20
HK1009648A1 (en) 1999-06-04
EP0635497A3 (fr) 1995-02-22
AU6755094A (en) 1995-02-02
EP0635497B1 (fr) 1998-05-20
ZA945337B (en) 1995-03-01
JPH07304753A (ja) 1995-11-21
ATE166345T1 (de) 1998-06-15
DE69410359T2 (de) 1999-01-07
CY2158B1 (en) 2002-08-23
JP3105138B2 (ja) 2000-10-30
DK0635497T3 (da) 1999-03-08
CA2128359C (fr) 2002-03-19
DE69410359D1 (de) 1998-06-25
US5436261A (en) 1995-07-25
CA2128359A1 (fr) 1995-01-21
AU674080B2 (en) 1996-12-05
EP0635497A2 (fr) 1995-01-25
NZ264050A (en) 1995-07-26

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